Abstract: A polymer-free synthesis method is provided for preparation of monodisperse nanostars. The nanostars can be used for treating and imaging cells in in vivo or ex vivo. The modes of treatment include use of a nanostar modified with a photo-activatable drug, which drug is activated by the photo-response of the nanostar to electromagnetic stimulation; use of a nanostar modified with a thermally-activatable drug, which drug is activated by a thermal response of the nanostar to electromagnetic stimulation; and the thermal response of the nanostar itself to electromagnetic stimulation, which can directly or indirectly cause the death of an undesirable cell.
Type:
Grant
Filed:
August 20, 2013
Date of Patent:
February 7, 2017
Assignee:
Duke University
Inventors:
Tuan Vo-Dinh, Hsiangkuo Yuan, Andrew Fales, Christopher Khoury
Abstract: Disclosed are nanoparticle compositions comprising nanoparticles prepared from denatured, cross-linked albumin and a therapeutic agent for treating a neutrophil-mediated inflammation, and methods of treating neutrophil-mediated inflammation using the compositions.
Type:
Grant
Filed:
June 26, 2014
Date of Patent:
February 7, 2017
Assignee:
The Board of Trustees of the University of Illinois
Inventors:
Zhenjia Wang, Jaehyung Cho, Asrar Malik
Abstract: The fish food composition includes pea meal, corn meal, soy bean meal, corn oil, and fish meal. The fish food composition can include less than 17% by weight fish meal and between about 2.0% and 4.0% by weight pea meal. The fish food composition can also include carboxymethyl cellulose and a vitamin and mineral mix.
Type:
Grant
Filed:
April 11, 2016
Date of Patent:
February 7, 2017
Assignee:
KING SAUD UNIVERSITY
Inventors:
Muzzammil Iqbal Siddiqui, Promy Virk, Mohammad Iqbal Siddiqui
Abstract: The present invention comprises compounds and compositions thereof for enhanced drug delivery. Pro-drug and double pro-drug derivatives of corticosteroids non-steroid anti-inflammatory drugs (NSAIDs), and ruboxistaurin for delivery to the eye are provided. The compounds and compositions are useful for treating various ocular diseases, including ocular diseases effecting the posterior segments of the eye. In addition, the present invention is directed to particle in particle carrier formulations for sustained release of therapeutic agents.
Type:
Grant
Filed:
November 16, 2012
Date of Patent:
February 7, 2017
Assignee:
THE REGENTS OF THE UNIVERSITY OF COLORADO, A BODY
Abstract: Porous metal-organic frameworks (MOFs) and metallated porous MOFs are provided. Also provided are methods of metallating porous MOFs using atomic layer deposition and methods of using the metallated MOFs as catalysts and in remediation applications.
Type:
Grant
Filed:
July 17, 2014
Date of Patent:
February 7, 2017
Assignee:
Northwestern University
Inventors:
Wojciech Bury, Omar K. Farha, Joseph T. Hupp, Joseph E. Mondloch
Abstract: A de-noising method for remote images of ground buildings using spectrum constraints. The method includes: 1) obtaining a reference image of ground buildings from a remote image database of the ground buildings, performing a Fourier transformation on the reference image to obtain an amplitude spectrum, and performing a threshold segmentation, an erosion operation and a dilation operation successively on the amplitude spectrum to obtain a binary template of spectrum of the ground buildings; and 2) obtaining a real-time image of the ground buildings by a high-speed aircraft, performing a Fourier transformation on the real-time image to obtain a spectrum, filtering the spectrum of the real-time image in frequency domain by the binary template of spectrum of the ground buildings, and performing an inverse Fourier transformation thereon to generate a filtered real-time image of the ground buildings.
Type:
Grant
Filed:
December 9, 2015
Date of Patent:
February 7, 2017
Assignee:
HUAZHONG UNIVERSITY OF SCIENCE AND TECHNOLOGY
Inventors:
Tianxu Zhang, Zheng Wang, Li He, Li Liu, Xuan Hou, Chuan Zhang, Sufei Fan, Yimeng Chen
Abstract: Active-RC low-pass filters based on R-0.5R ladders are implemented to provide high linear and low power design solutions for integrated biomedical applications. Among various R-?R ladders family, R-0.5R ladders provide the best low frequency selectivity characteristics. The filters exhibit ultra-low pole frequencies and occupy relatively compact silicon areas by using the R-0.5R ladders.
Type:
Grant
Filed:
September 2, 2015
Date of Patent:
February 7, 2017
Assignee:
King Fahd University of Petroleum and Minerals
Inventors:
Hussain Abdullah Alzaher, Mohammad Khalaf Alghamdi
Abstract: An apparatus to measure surface orientation maps of an object may include a light source that is configured to illuminate the object with a controllable field of illumination. One or more cameras may be configured to capture at least one image of the object. A processor may be configured to process the image(s) to extract the reflectance properties of the object including an albedo, a reflection vector, a roughness, and/or anisotropy parameters of a specular reflectance lobe associated with the object. The controllable field of illumination may include limited-order Spherical Harmonics (SH) and Fourier Series (FS) illumination patterns with substantially similar polarization. The SH and FS illumination patterns are used with different light sources.
Type:
Grant
Filed:
March 14, 2014
Date of Patent:
February 7, 2017
Assignee:
UNIVERSITY OF SOUTHERN CALIFORNIA
Inventors:
Paul E. Debevec, Xueming Yu, Graham Leslie Fyffe, Abhijeet Ghosh
Abstract: The present invention relates to an energy router for an energy internet, which comprises a three-phase three-level bi-directional rectifying unit, a six-phase interleaved DC/DC bi-directional conversion unit, a self-excitation soft start push-pull full-bridge DC/DC bi-directional conversion unit, a three-phase resonant soft switching bi-directional inversion unit, a single-phase full-bridge bi-directional inversion unit, a high-voltage DC bus and a low-voltage DC bus. The three-phase three-level bi-directional rectifying unit, the six-phase interleaved DC/DC bi-directional conversion unit, the self-excitation soft start push-pull full-bridge DC/DC bi-directional conversion unit, the three-phase resonant soft switching bi-directional inversion unit and the single-phase full-bridge bi-directional inversion unit each have three energy flow operating modes: a forward conduction, a reverse conduction and a non-conduction.
Type:
Grant
Filed:
May 20, 2015
Date of Patent:
February 7, 2017
Assignee:
NORTHEASTERN UNIVERSITY
Inventors:
Qiuye Sun, Huaguang Zhang, Dazhong Ma, Bonan Huang, Lei Chen, Heng Du, Zhenwei Liu, Fei Teng, Guotao Hui
Abstract: Herein provided is a new wheat cultivar designated ‘GA 041293-11E54’ as well as the seeds, plants and derivatives of the new wheat variety ‘GA 041293-11E54’ (such as cultivars and hybrids related thereto). This cultivar is a high grain yielding, medium maturing, good test weight, medium height line that has good resistance to races of leaf rust and stripe rust in Georgia and the Southeast, powdery mildew, Hessian flies, and wheat soil-borne mosaic virus. Also provided are tissue cultures of the new wheat variety ‘GA 041293-11E54’ and the plants regenerated therefrom. Methods for producing wheat plants by crossing the new wheat variety ‘GA 041293-11E54’ with itself or another wheat variety and plants produced by such methods are also provided.
Type:
Grant
Filed:
October 5, 2015
Date of Patent:
February 7, 2017
Assignee:
University of Georgia Research Foundation, Inc.
Inventors:
Jerry W. Johnson, G. David Buntin, James W. Buck
Abstract: An optical waveguide structure and a manufacturing method thereof are disclosed. The optical waveguide structure has a first waveguide layer, a binding layer, and a second waveguide layer. The first waveguide layer has a taper portion, a connecting portion, and a strip portion. The manufacturing method of the optical waveguide structure has steps of etching to form the first waveguide layer, and then etching to form the second waveguide layer under the first waveguide layer.
Type:
Grant
Filed:
December 7, 2015
Date of Patent:
February 7, 2017
Assignee:
National Sun Yat-sen University
Inventors:
Yi-Jen Chiu, Yi-Jhe Chen, Chung-Yi Lin, Wei Lin
Abstract: A reactor includes a reactor chamber and a carbon nanotube catalyst composite layer. The reactor chamber has an inlet and an outlet. The carbon nanotube catalyst composite layer is suspended in the reactor chamber, wherein the carbon nanotube catalyst composite layer defines a number of apertures, gases in the reactor chamber penetrate the carbon nanotube catalyst composite layer through the plurality of apertures.
Type:
Grant
Filed:
April 25, 2013
Date of Patent:
February 7, 2017
Assignees:
Tsinghua University, HON HAI PRECISION INDUSTRY CO., LTD.
Inventors:
Yang Wu, Peng Liu, Yang Wei, Jia-Ping Wang, Kai-Li Jiang, Shou-Shan Fan
Abstract: A template-free reverse micelle (RM) based method is used to synthesize pyrochlore nanostructures having photocatalytic activity. In one embodiment, the method includes separately mixing together a first acid stabilized aqueous solution including pyrochlore precursor A and a second acid stabilized aqueous solution including pyrochlore precursor B with an organic solution including a surfactant to form an oil-in-water emulsion. Next, equimolar solutions of the first and second acid stabilized oil-in-water emulsions are mixed together. Then, the mixture of the first and second acid stabilized oil-in-water emulsion is treated with a base to produce a precipitate including pyrochlore precursors A and B. After which, the precipitate is dried to remove volatiles. The precipitate is then calcined in the presence of oxygen to form a pyrochlore nanostructure, such as a bismuth titanate (Bi2Ti2O7) pyrochlore nanorod. The method of synthesizing the pyrochlore nanorod is template-free.
Type:
Grant
Filed:
November 24, 2014
Date of Patent:
February 7, 2017
Assignee:
Board of Regents of the Nevada System of Higher Education, on Behalf of the University of Nevada, Reno
Abstract: The invention is a process for absorbing sulfur dioxide from a gaseous stream with the aid of an ionic liquid, followed by the release of sulfur dioxide from the ionic liquid on addition of a polar solvent and the regeneration of the ionic liquid.
Type:
Grant
Filed:
July 13, 2015
Date of Patent:
February 7, 2017
Assignee:
YISSUM RESEARCH DEVELOPMENT COMPANY OF THE HEBREW UNIVERSITY OF JERUSALEM LTD.
Abstract: A set of target peptides are presented by HLA A*0101, A*0201, A*0301, B*4402, B*2705, B*1402, and B*0702 on the surface of disease cells. They are envisioned to among other things (a) stimulate an immune response to the proliferative disease, e.g., cancer, (b) to function as immunotherapeutics in adoptive T cell therapy or as a vaccine, (c) facilitate antibody recognition of tumor boundaries in surgical pathology samples, (d) act as biomarkers for early detection and/or diagnosis of the disease, and (e) act as targets in the generation antibody-like molecules which recognize the target-peptide/MHC complex.
Type:
Grant
Filed:
September 3, 2013
Date of Patent:
February 7, 2017
Assignees:
University of Virginia Patent Foundation, The University of Birmingham
Inventors:
Donald F. Hunt, Jeffrey Shabanowitz, Stacy A. Malaker, Victor H. Engelhard, Angela Zarling, Kara L. Cummings, Rebecca C. Obeng, Mark Cobbold
Abstract: Provided is a method of forming a thin film of a semiconductor device. The method includes forming a precursor layer on a surface of a substrate by supplying a precursor gas into a chamber, discharging the precursor gas remaining in the chamber to an outside of the chamber by supplying a purge gas into the chamber, supplying a reactant gas into the chamber, generating plasma based on the reactant gas, forming a thin film by a chemical reaction between plasma and the precursor layer and radiating extreme ultraviolet (EUV) light into the chamber, and discharging the reactant gas and the plasma remaining in the chamber by supplying a purge gas into the chamber.
Type:
Grant
Filed:
August 14, 2014
Date of Patent:
February 7, 2017
Assignees:
Samsung Electronics Co., Ltd., The Board of Trustees of the Leland Stanford Junior University
Inventors:
Sam Hyung Sam Kim, Andrei Teodor Iancu, Friedrich B. Prinz, Michael C. Langston, Peter Schindler, Ki-Hyun Kim, Stephen P. Walch, Takane Usui
Abstract: The invention provides compounds of formula I: wherein A, B, X, and Y have any of the values defined in the specification, as well as pharmaceutical compositions comprising such compounds, processes for preparing such compounds, and therapeutic methods for treating cancer and other topoisomerase mediated conditions.
Type:
Grant
Filed:
March 5, 2010
Date of Patent:
February 7, 2017
Assignee:
Rutgers, the State University of New Jersey
Inventors:
Edmond J. LaVoie, Wei Feng, Leroy F. Liu
Abstract: The present invention provides an optically active poly(diphenylacetylene) compound represented by the following formula (I): [wherein each symbol is as described in the DESCRIPTION], and a production method thereof, an optical isomer separating agent containing the poly(diphenylacetylene) compound, and a packing material for a chiral column, containing the optical isomer separating agent coated on a carrier. According to the present invention, a practical optical isomer separation agent having a high optical resolution ability for a wide variety of racemic compounds and an optical isomer separation method can be provided.
Type:
Grant
Filed:
February 10, 2014
Date of Patent:
February 7, 2017
Assignee:
NATIONAL UNIVERSITY CORPORATION KANAZAWA UNIVERSITY
Abstract: An isotope labeled asymmetric cross-linker is provided for the detection of cross-linked peptides. A cross-linking and mass spectrometry strategy, referred to as isotope tagging of interacting proteins (iTIP), improves the specificity of detecting cross-linked peptides and accurate identification of the interacting peptide sequences via the incorporation of isotopic signatures that are readily observed in the MS/MS spectrum. Isotope tagged peptides can be identified using mass spectrometry based on doublet peaks in a spectrum. Spectra can be subjected to database search strategies available for the sequencing of linear or non-cross-linked peptides.
Type:
Grant
Filed:
January 22, 2014
Date of Patent:
February 7, 2017
Assignee:
The University of North Carolina at Chapel Hill