Abstract: An isolated canine peripheral T-cell lymphoma cell line, where the cell line is a canine-lymphoma cell line and uses thereof are disclosed. An isolated canine peripheral T-cell lymphoma cell line where the cell line is the canine-lymphoma cell line designated OSW (ATCC No. PTA-9116) is also disclosed.

Abstract: A method of forming a composite of embedded nanofibers in a polymer matrix is disclosed. The method includes incorporating nanofibers in a plastic matrix forming agglomerates, and uniformly distributing the nanofibers by exposing the agglomerates to hydrodynamic stresses. The hydrodynamic said stresses force the agglomerates to break apart. In combination or additionally elongational flow is used to achieve small diameters and alignment. A nanofiber reinforced polymer composite system is disclosed. The system includes a plurality of nanofibers that are embedded in polymer matrices in micron size fibers. A method for producing nanotube continuous fibers is disclosed. Nanofibers are fibrils with diameters of 100 nm, multiwall nanotubes, single wall nanotubes and their various functionalized and derivatized forms. The method includes mixing a nanofiber in a polymer; and inducing an orientation of the nanofibers that enables the nanofibers to be used to enhance mechanical, thermal and electrical properties.

Abstract: The present invention relates to a bone graft material and a scaffold for tissue engineering applications, which have an osteogenesis-promoting peptide immobilized on the surface. More particularly, the invention relates to a bone graft material and a scaffold for tissue engineering applications, which have a cell adhesion-inducing peptide and/or tissue growth factor-derived peptide immobilized on the surface. By the osteogenesis-promoting peptide immobilized on the surface, the inventive bone graft material and scaffold for tissue engineering applications can promote the transition, proliferation and differentiation of cells associated with regeneration, and eventually maximize the regeneration of tissue. Moreover, the peptide immobilized on the surface has low molecular weight, indicating a reduced risk of immune responses upon its application in the body, and can be present in a stable form within the body, thus showing lasting effects.

Abstract: A multimode millimeter-wave frequency divider circuit with multiple selectable frequency dividing modes is proposed, which is designed for integration with a millimeter wave (MMW) circuit system, such as a phase-locked loop (PLL) circuit, for providing multimode frequency dividing functions. In actual application, the millimeter wave frequency divider circuit of multi frequency dividing mode provides at least three frequency dividing operational modes, including modes of dividing two, dividing 3 and dividing four. In practice, the millimeter wave frequency divider circuit of multi frequency divider mode may be integrated with a millimeter wave phase-locked circuit to provide a frequency synthetic function having multi frequency sections, such as including 38 GHZ, 60 GHZ and 77 GHZ, and may use reduced circuit layout surfaces and operational power.

Abstract: The present invention provides methods, systems, and apparatus of improved fiber-based optical parametric oscillators (FOPOs). These oscillators can be used in the creation of short pulsed laser radiation, which are useful in numerous applications, such as characterization of materials and molecules. A relationship between fiber length and performance is realized, where shorter lengths counterintuitively provide greater power and width of output bands. This relationship is used to develop improved FOPOs. For example, fibers of 10 cm or less may be used to obtain superior performance in terms of wavelength tunability (e.g. bandwidth of 200 nm and greater) and output power (e.g. pulse power of 1 nJ). Other realized relationships between length and wavelength position of output bands are also used to select the wavelength range output from the FOPO. The diameter of the fiber may be selected to provide positioning (e.g. a centering) of the range of attainable output wavelengths.

Abstract: A process and device to capture of CO2 at its originating source, such as a power plant, is disclosed. Absorbent material is recharged by desorbing CO2, so that it may be sequestered or used in another application. Continual recharging results in loss of absorbent surface area, due to pore plugging and sintering of particles. Calcium oxide or calcium hydroxide was immobilized to a fibrous ceramic-based fabric substrate as a thin film and sintered, creating an absorbent material. The samples were characterized, showing continuous cyclic carbonation conversions between about 62% and 75% under mild calcination conditions at 750° C. and no CO2 in N2. Under the more severe calcination condition at 850° C. and 20 wt % CO2 in N2, yttria fabric was superior to alumina as a substrate for carbon dioxide capture and the reactivity of the calcium oxide absorbent immobilized to yttria was maintained at the same level in the 12 cycles.

Abstract: The present invention relates generally to a method of treatment and in particular a method of treating disorders of the nervous system such as arising from or during disease or injury. The method of the present invention involves manipulating expression of Eph receptors or their functional equivalents to increase or decrease expression or function depending on the condition being treated.

Abstract: An object of the present invention is to provide a novel means for stably and surely inducing cell apoptosis using the c-myc gene as a target. The present invention relates to an apoptosis-inducing agent containing a protein that interacts with an FBP protein or a polynucleotide encoding the protein as an active ingredient and a method for inducing apoptosis, which comprises a step of causing the apoptosis-inducing agent to come into contact with cells.

Abstract: The invention relates to the treatment and prevention of type I diabetes. More specifically, the invention relates to compounds that treat or prevent the body's immune system from destroying ?-cells (i.e., insulin-producing cells in the pancreatic islets of Langerhans) by inhibition of JNK2, selective inhibition of JNK2, or inhibition of the expression of the MAPK9 gene or gene product. In one embodiment, the present invention contemplates the diagnosis, identification, production, and use of compounds which modulate MAPK9 gene expression or the activity of the MAPK9 gene product including but not limited to, JNK2, the nucleic acid encoding MAPK9 and homologues, analogues, and deletions thereof, as well as antisense, ribozyme, triple helix, antibody, and polypeptide molecules as well as small inorganic molecules. The present invention contemplates a variety of pharmaceutical formulations and routes of administration for such compounds.

Abstract: The present invention is generally directed to a novel, economic synthesis of oxide ceramic composites. Methods of the present invention, referred to as carbon combustion synthesis of oxides (CCSO), are a modification of self-propagating high-temperature synthesis (SHS) methods in which the heat needed for the synthesis is generated by combustion of carbon in oxygen rather than that of a pure metal. This enables a more economic production of the ceramic material and minimizes the presence of intermediate metal oxides in the product. The reactant mixture generally comprises at least one oxide precursor (e.g., a metal or non metal oxide, or super oxide, or nitride, or carbonate, or chloride, or oxalate, or halides) as a reactant, but no pure metal. Pure carbon in the form of graphite or soot is added to the reactant mixture to generate the desired heat (upon ignition). The mixture is placed in a reactor and exposed to gaseous oxygen.

Abstract: This document discusses trajectory guides that include an instrument guide with at least one lumen angled with respect to an orthogonal or other through-axis. In one example, patterned lumens on the instrument guide provide a mirror image pattern of trajectory axes intersecting a target plane. In another example, height adjustment of the instrument guide extends these or other targeting techniques to a three-dimensional volume. This document also describes a method of manufacturing such an instrument guide, which is also applicable to manufacturing an instrument guide providing parallel lumens.

Abstract: The invention further relates to polycationic multichromophores, which may be conjugated polymers, and methods, articles and compositions employing them as described herein. In some aspects, the invention relates to methods, articles and compositions for the detection and analysis of biomolecules in a sample. Provided assays include those determining the presence of a target biomolecule in a sample or its relative amount, or the assays may be quantitative or semi-quantitative. The methods can be performed on a substrate. The methods can be performed in an array format on a substrate, which can be a sensor. In some embodiments, detection assays are provided employing sensor biomolecules that do not comprise a fluorophore that can exchange energy with the cationic multichromophore.

Abstract: Disclosed is a low dielectric constant plasma polymerized thin film using linear organic/inorganic precursors and a method of manufacturing the low dielectric constant plasma polymerized thin film through plasma enhanced chemical vapor deposition and annealing using an RTA apparatus. The low dielectric constant plasma polymerized thin film is effective for the preparation of multilayered metal thin films having a thin film structure with very high thermal stability, a low dielectric constant, and superior mechanical properties.

Abstract: Methods and systems for constructing microfabricated devices including a microknife and methods and devices for a three-dimensional microstructure constructed from a plurality of separable planar components using one or more microfabrication techniques and optionally using one or more interlock structures.

Abstract: A medical instrument for grasping an object, in particular a surgical needle holder, including an elongated shaft, two jaw parts arranged at a distal end of the shaft, at least one of the jaw parts being pivotable with respect to the other of the jaw parts between a grasp state for grasping the object between the jaw parts and a release state for releasing the object. A handle is arranged at a proximal end of the shaft and has at least one operating element for moving the at least one pivotable jaw part between the grasp state and the release state via an axially movable force transmission element operatively connected with the at least one operating element and with the at least one pivotable jaw part via an articulated joint. The instrument further includes a latching mechanism for immobilizing the at least one pivotable jaw part in the grasp state.

Abstract: A device having the capability for electrical, thermal, optical, and fluidic interconnections to various layers. Through-substrate vias in the interconnect device are filled to enable electrical and thermal connection or optionally hermetically sealed relative to other surfaces to enable fluidic or optical connection. Optionally, optical components may be placed within the via region in order to manipulate optical signals. Redistribution of electrical interconnection is accomplished on both top and bottom surfaces of the substrate of the interconnect chip.

Abstract: A PHSRN-RGD-containing oligopeptide and a composition for promoting bone formation, which contains such oligopeptide as an effective ingredient. The oligopeptide promotes osteoblastic cell adhesion and differentiation and enhances bone regenerative ability, so that the inventive oligopeptide can be effectively used in regenerative treatment of bone tissue and periodontal tissue.

Abstract: A method of controlling the effective impedance of a low-impedance high-temperature superconducting cable (“HTS cable”). Passive or active control circuitry is used to create a current in the shielding conductor of the HTS cable which opposes the current in the primary conductor. In the case of a three-phase conductor, magnetic cross-coupling between the phases is exploited. The magnitude of the magnetic field is used to alter the HTS cable's effective impedance. The result is the creation of a controlled and substantially-higher effective impedance for the HTS cable. The creation of the higher impedance allows the HTS cable to be connected in parallel with conventional lines while regulating the amount of current flowing through the HTS cable.

Abstract: Methods and compositions for reducing, preventing or reversing organ damage and/or enhancing organ preservation by administration of a peroxisome-proliferator activated receptor-alpha (PPAR?) agonist to the organ.

Abstract: The invention relates to a method for determining whether a compound is a neurotrypsin inhibitor, characterized in that the compound is incubated together with neurotrypsin, a variant thereof or a fragment comprising the protease domain and with a protein or peptide comprising agrin, a variant thereof or a fragment comprising the ?- or the ?-cleavage site of agrin, in an aqueous buffer solution, and the amount of cleavage of agrin is measured. Additionally, the invention relates to inhibitors of neurotrypsin found by this method, in particular to compounds of formula wherein Hal1 and Hal2 are fluorine, chlorine or bromine, and the use of such inhibitors for the treatment and/or prophylaxis of diseases caused by deficiency of synapses, for example skeletal muscle atrophy, schizophrenia, and cognitive disturbance.