Abstract: The invention discloses the nanoparticles composed of chitosan, poly-glutamic acid, and at least one anti-hemophilic factor or bioactive agent characterized with a positive surface charge and their enhanced permeability in oral drug delivery.
Type:
Grant
Filed:
February 20, 2009
Date of Patent:
March 1, 2011
Assignees:
GP Medical, Inc., National Tsing Hua University
Abstract: An apparatus for delivering air through a powered axle assembly and an improved powered axle assembly which incorporates the apparatus. The apparatus comprises: a base attachable to a non-rotating structure within the axle assembly and a rotor mountable in the axle assembly for rotating with the drive axle and for forming an air chamber between the rotor and the base. The base includes at least one air inlet for delivering air to the air chamber and the rotor includes at least one air outlet for air flow out of the chamber.
Type:
Grant
Filed:
November 13, 2006
Date of Patent:
March 1, 2011
Assignee:
The Board of Regents for Oklahoma State University
Inventors:
John B. Solie, Marvin L. Stone, Anthony Ingram
Abstract: A device and a method for facilitating the deposition and patterning of organic materials onto substrates utilizing the vapor transport mechanisms of organic vapor phase deposition is provided. The device includes one or more nozzles, and an apparatus integrally connected to the one or more nozzles, wherein the apparatus includes one or more source cells, a carrier gas inlet, a carrier gas outlet, and a first valve capable of controlling the flow of a carrier gas through the one or more source cells. The method includes moving a substrate relative to an apparatus, and controlling the composition of the organic material and/or the rate of the organic material ejected by the one or more nozzles while moving the substrate relative to the apparatus, such that a patterned organic layer is deposited over the substrate.
Type:
Grant
Filed:
May 25, 2010
Date of Patent:
March 1, 2011
Assignee:
The Trustees of Princeton University
Inventors:
Max Shtein, Stephen R. Forrest, Jay B. Benzinger
Abstract: A method and apparatus for ameliorating high-field image distortion in magnetic resonance imaging of tissue. Two separate scans of a target region are taken with different phase and amplitude values for each scan. The phase and amplitude values of each scan are selected to be complimentary so as to provide scans that have improved SNR when averaged using, for example, sum-of-squares averaging.
Type:
Grant
Filed:
March 9, 2006
Date of Patent:
March 1, 2011
Assignee:
University of Queensland
Inventors:
Stuart Crozier, Feng Liu, Bing Keong Li
Abstract: The present invention discloses compositions and methods to measure an amount of Anti-Mullerian Hormone (AMH) in a sample, including a mammalian sample such as a primate, rodent, equine, or bovine sample. The compositions and methods herein also provide antibodies that bind to epitopes on AMH that are stable to proteolysis of AMH.
Type:
Grant
Filed:
May 24, 2006
Date of Patent:
March 1, 2011
Assignees:
Beckman Coulter, Inc., Oxford Brookes University
Inventors:
Nigel Patrick Groome, Mark Cranfield, Axel P. N. Themmen, Gopal V. Savjani, Ketusha Mehta
Abstract: Apparatus and methods for second harmonic generation with a waveguide. In one embodiment, a method includes the steps of providing a waveguide, wherein the waveguide has a substrate, and a polydomain epitaxial thin film on the substrate, wherein the polydomain epitaxial thin film defines a plane and has a first surface and a second, opposite surface defining a body portion of the polydomain epitaxial thin film therebetween with a film thickness, l, and wherein the polydomain epitaxial thin film has a coherence length, lc, and exposing the waveguide to an incident photon beam with a wavelength and a focal point such that the incident photon beam is incident to the plane of the polydomain epitaxial thin film with an angle ? that is formed between the incident beam and the plane of the polydomain epitaxial thin film and satisfies the condition of 0<?<90, wherein the polydomain epitaxial thin film is formed with the following condition satisfied: l<lc.
Abstract: A semiconductor device includes a semiconductor substrate, a photon avalanche detector in the semiconductor substrate. The photon avalanche detector includes an anode of a first conductivity type and a cathode of a second conductivity type. A guard ring is in the semiconductor substrate and at least partially surrounds the photon avalanche detector. A passivation layer of the first conductivity type is in contact with the guard ring to reduce an electric field at an edge of the photon avalanche detector.
Type:
Grant
Filed:
December 3, 2008
Date of Patent:
March 1, 2011
Assignees:
STMicroelectronics (Research & Development) Limited, The University Court of the University of Edinburgh, Ecole Polytechnique Federale De Lausanne
Inventors:
Justin Richardson, Lindsay Grant, Marek Gersbach, Edoardo Charbon, Cristiano Niclass, Robert Henderson
Abstract: Compositions and methods are disclosed for inhibiting the release of a proinflammatory cytokine from a vertebrate cell, and for inhibiting an inflammatory cytokine cascade in a patient. The compositions comprise a vertebrate HMGB A box, and an antibody preparation that specifically binds to a vertebrate HMGB B box. The methods comprise treating a cell or a patient with sufficient amounts of the composition to inhibit the release of the proinflammatory cytokine, or to inhibit the inflammatory cytokine cascade.
Type:
Grant
Filed:
September 19, 2007
Date of Patent:
March 1, 2011
Assignees:
The Feinstein Institute for Medical Research, The General Hospital Corporation, University of Pittsburgh of the Commonwealth System of Higher Education
Inventors:
Kevin J. Tracey, Huan Yang, Howland Shaw Warren, Jr., Mitchell P. Fink
Abstract: A radiation detection, localization, and identification system uses a searching algorithm to identify geometric correlation of hypothetical solutions to Compton Imaging. Geometric correlation of correct associations of gamma ray energies with each detected event yields the identity and location of radiation sources. The system's detector is an array of radiation detectors networked to act as a single detection system. This network has wide area of view and high sensitivity to radiation sources since no collimation is required.
Abstract: Disclosed are methods of making BMP-2 microparticles and methods of using the microparticles. These microparticles are prepared, for example, by mixing a solution containing BMP-2 with a second solution whose ionic concentration and pH results in the precipitation of the BMP-2.
Type:
Grant
Filed:
February 10, 2003
Date of Patent:
March 1, 2011
Assignees:
University of Erlangen-Nurnberg, Wyeth Inc.
Inventors:
Susan J. Sofia, Daniel Schwartz, Wolfgang Friess
Abstract: The present invention relates to a novel target to control the apoptotic process, and to the use of this target to identify compounds capable of affecting the apoptotic process, The invention also relates to the use of such identified compounds in the treatment of cancer, stroke, neurodegenerative diseases, viral diseases and other diseases and conditions involving apoptosis.
Abstract: In some embodiments, the present invention is directed to processes for the combination of injecting charge in a material electrochemically via non-faradaic (double-layer) charging, and retaining this charge and associated desirable properties changes when the electrolyte is removed. The present invention is also directed to compositions and applications using material property changes that are induced electrochemically by double-layer charging and retained during subsequent electrolyte removal. In some embodiments, the present invention provides reversible processes for electrochemically injecting charge into material that is not in direct contact with an electrolyte. Additionally, in some embodiments, the present invention is directed to devices and other material applications that use properties changes resulting from reversible electrochemical charge injection in the absence of an electrolyte.
Type:
Grant
Filed:
October 13, 2006
Date of Patent:
March 1, 2011
Assignee:
Board of Regents, The University of Texas System
Inventors:
Dong-Seok Suh, Ray Henry Baughman, Anvar Abdulahadovic Zakhidov
Abstract: Inhibitors of the enzyme prenylated methylated protein methyl esterase (PMPMEase), the last step in the prenylation process for many eukaryotic proteins, having the general structure R1-X-A-B(R2)-Y or R1-X-A(R2)-B-Y, where R1 is preferably a polyisoprenyl group, X is a linking group, Y is a group that promotes affinity interactions to the active site of PMPMEase and imparts hydrolysis resistance to the inhibitor, A and B are bridge atoms, and R2 is a characteristic-providing substituent.
Type:
Grant
Filed:
April 7, 2008
Date of Patent:
March 1, 2011
Assignee:
Florida Agricultural and Mechanical University
Abstract: Thermoplastic surface modification is achieved with photocatalysts, such as titanium dioxide, tungsten oxide and mixtures thereof. A uniform coating of a powdered photocatalyst is applied to a thermoplastic surface that is wetted with an organic solvent. The coating is in a range between approximately 1.5 mg/cm2 to approximately 2.5 mg/cm2. After the uniform coating of photocatalyst is dried, the thermoplastic surface is heated to a temperature above its softening temperature, usually in a range between approximately 80° C. to approximately 130° C.; then, a mild pressure is applied to imbed the photocatalyst into the surface of the thermoplastic sheet. The method of modification is inexpensive, long-lasting and non-detrimental to the thermoplastic surface. A surface is provided with improved aesthetic appearance, extended lifetime and sustained protection from undesirable growth of nuisance organisms, such as algae, fungus, bacteria, mold, mildew and the like.
Type:
Grant
Filed:
March 20, 2008
Date of Patent:
March 1, 2011
Assignee:
University of Central Florida Research Foundation, Inc.
Abstract: A semiconductor device according to this invention is provided with a MOS transistor of at least one type, wherein the MOS transistor has a semiconductor layer (SOI layer) provided on an SOI substrate and a gate electrode provided on the SOI layer and is normally off by setting the thickness of the SOI layer so that the thickness of a depletion layer caused by a work function difference between the gate electrode and the SOI layer becomes greater than that of the SOI layer.
Type:
Grant
Filed:
June 16, 2006
Date of Patent:
March 1, 2011
Assignees:
Tohoku University, Foundation for Advancement of International Science
Abstract: A method for measuring tastes, which can better simulate the human gustation than known methods, as well as a taste sensor, computer program and an apparatus for measuring tastes, is disclosed. In this method, data processing is carried out by a two-phase radial basis function neural network. That is, by sensors, each of which sensors can quantify at least one component representing, individually or cooperatively, the taste of saltiness, sourness, sweetness, umami or bitterness, to obtain a response value from each sensor, and each of the obtained response values is input to a first phase radial basis function neural network to calculate the concentration of each component from each response value.
Type:
Grant
Filed:
May 22, 2006
Date of Patent:
March 1, 2011
Assignee:
Keio University
Inventors:
Koji Suzuki, Saeko Ishihara, Atsushi Ikeda, Yoshio Araki, Kenichi Maruyama, Daniel Citterio, Masafumi Hagiwara
Abstract: According to an embodiment of the present invention, an OLED display includes a substrate, a first electrode, a hole transport layer, a hole blocking layer, an emitting layer, and a second electrode. The first electrode is formed on the substrate. The hole transport layer is formed on the first electrode and includes a first material having a first highest occupied molecular orbital (HOMO) level and a first lowest unoccupied molecular orbital (LUMO) level. The hole blocking layer is formed on the hole transport layer and includes a second material having a second HOMO level and a second LUMO level. The emitting layer is formed on the hole blocking layer and includes a third material having a third HOMO level and a third LUMO level. The second electrode is formed on the emitting layer. Herein, the second HOMO level is higher than the first HOMO level and the third HOMO level.
Type:
Grant
Filed:
December 29, 2006
Date of Patent:
March 1, 2011
Assignees:
Samsung Electronics Co., Ltd., Industry-University Cooperation Foundation Hanyang University
Inventors:
Tae-Whan Kim, Dong-Chul Choo, Chang-Uk Kim
Abstract: Described is a system including a sensor and a processing arrangement. The sensor measures data corresponding to a patient's breathing patterns. The processing arrangement analyzes the breathing patterns to determine whether the breathing patterns are indicative of a REM sleep state. In another embodiment, the processing arrangement analyzes the breathing patterns to determine whether the breathing patterns are indicative of one of the following states: (i) a wake state and (ii) a sleep state. In another embodiment, a neural network analyzes the data to determine whether the breathing patterns are indicative of one of the following states: (i) a REM sleep state, (ii) a wake state and (iii) a sleep state. In another embodiment, the processing arrangement analyzes the data to determine whether the breathing pattern is indicative of an arousal.
Abstract: A method for raising a demagnetization temperature of a permanent magnet is disclosed. The method provides a ferromagnetic arrangement around the magnet to increase demagnetization thresholds for the duration of soldering, or any other process requiring high temperatures. Using the method disclosed, it is possible to apply high levels of heat directly to permanent magnets without demagnetization, and more particularly to create permanent magnetic assemblies fit for any environment.
Abstract: ‘NCORNSP-011MNLC’ is a new and distinct variety of ornamental sweetpotato having a very compact, semi-upright, densely-mounding cultivar producing many, short shoots; the instant variety is distinguishable from other cultivars by its purple leaves that have 5 to 7 extremely deep lobes, a very compact habit and erect architecture; and ‘NCORNSP-011MNLC’ has a good vigor, very well-branched, well-suited for production as a landscape or containerized plant and the production of flowers is rare, even under short day conditions.