Abstract: The invention is drawn to a method of using nanoparticle aggregates to form sensors and optical filters. Properly sized (60 and 200 nm) nanoparticle aggregates with cores having a sulfur-oxygen molecular species and a shell with a surface in contact with the core are obtained. Those nanoparticle aggregates have a first resonance profile to wavelengths between 350 nm and 1075 nm. A modified resonance profile for those nanoparticle aggregates is determined. The nanoparticle aggregates are then selectively sized by irradiating them with electromagnetic energy at sufficient intensity and spectral content to modify the first resonance profile towards the modified resonance profile. The resulting nanoparticle aggregates can be used as sensors or optical filters at a selected wavelength.

Abstract: In one aspect, the invention relates to methods for treating muscle atrophy by providing to an animal in need thereof an effective amount of a compound. The compound can modulate the expression levels of multiple mRNA of a muscle atrophy signature. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present invention.

Abstract: A nerve graft includes a carbon nanotube film structure, a protein layer, and a nerve network. The protein layer is located on a surface of the carbon nanotube film structure. The nerve network is positioned on a surface of the protein layer and far away from the carbon nanotube film structure.

Abstract: Systems and methods for receiving a blurred two-dimensional image captured using an optic system. The blurred two-dimensional image is deconvoluted using a point spread function for the optic system. A stack of non-blurred two-dimensional images is generated, each non-blurred image having a z-axis coordinate. A three-dimensional image is constructed from the stack of two-dimensional images.

Abstract: A powered exoskeleton configured to be coupled to lower limbs of a person is controlled to impart a movement desired by the person. The intent of the person is determined by a controller based on monitoring at least one of: positional changes in an arm portion of the person, positional changes in a head of the person, an orientation of a walking aid employed by the person, a contact force between a walking aid employed by the person and a support surface, a force imparted by the person on the walking aid, a force imparted by the person on the walking aid, a relative orientation of the exoskeleton, moveable components of the exoskeleton and the person, and relative velocities between the exoskeleton, moveable components of the exoskeleton and the person.

Abstract: This disclosure is directed to mixed micelle compositions for administration of e.g., therapeutic agents or imaging agents to a subject.

Abstract: This invention concerns compositions and methods of treating or diagnosing inflammatory disorders and other disorders, as well as compositions and methods of treating HIV.

Abstract: Disclosed are methods for activating an NKT cell, methods of stimulating an immune response in a subject, methods of improving vaccine efficacy, and methods of treating an infection. Also disclosed are methods of promoting tumor rejection, treating cancer, modulating autoimmunity and inhibiting allergen-induced hypersensitivity in subjects. The methods include contacting an NKT cell with a bacterial glycolipid complexed with a CD1 molecule to activate the NKT cell. The bacterial glycolipid may be derived from a member of the Class Alphaproteobacteria.

Abstract: A method of delivering a radioactive liquid includes, performing an initialization, including; extracting at least a first amount of a radioactive liquid from a source of radioactive liquid, measuring a radioactivity level for the first amount of radioactive liquid, and performing a calibration phase. The calibration phase includes, extracting a second amount of radioactive liquid from the source of radioactive liquid wherein the second amount is calculated based on the radioactivity level of the first amount to provide a total dose of radioactive liquid having a predetermined radioactivity level, and delivering the total dose and performing at least one more calibration and delivery phases.

Abstract: A cylinder head for an internal combustion engine has a body, a rigid center spacedly surrounded by the body, an annular outer valve seat on the body, and an annular inner valve seat on the center. A ring-shaped valve has an outer seat face and an inner seat face and is displaceable along an axis into a closed position bearing on the outer valve seat with the outer seat face and on the inner valve seat with the inner seat face. The inner valve seat or outer valve seat is slidable axially. A seal member set in a groove in the center or in the body engages the one slidable seat. At least one biasing member connected to the one slidable valve seat urges same toward the ring-shaped valve.

Abstract: Combinations of agents that have a synergistic effect for the treatment of a tumor are disclosed herein. These combinations of agents can be used to treat tumors, wherein the cells of the cancer express a mutated BRAF. Methods are disclosed for treating a subject diagnosed with a tumor that expresses a mutated BRAF. The methods include administering to the subject (1) a therapeutically effective amount of an antibody or antigen binding fragment thereof that specifically binds high molecular weight melanoma associated antigen (HMW-MAA), also known as CSPG4; and (2) a therapeutically effective amount of a BRAF inhibitor. In some embodiments, the tumor is melanoma. In some embodiments the method includes selecting a subject with primary or secondary resistance to a BRAF inhibitor. In further embodiments, treating the tumor comprises decreasing the metastasis of the tumor. In additional embodiments, the BRAF inhibitor comprises PLX4032 or PLX4720.

Abstract: A method of detecting network intrusion based on improved support vector machine is disclosed. The method comprises the steps of identifying a plurality of features; computing information gain of each of the features; selecting a pre-determined number of features based on the computed information gain and augmenting that set of pre-determined number of features with special features to form a set of selected features; and classifying a network connection based on the selected features using support vector machine. In order to achieve better detection accuracy, cross-validation and grid-search are applied to select the radial basis function for the support vector machine.

Abstract: In one aspect, a nonvolatile magnetic logic device comprises an electrically insulating layer, a write path, and a read path. The write path comprises a plurality of write path terminals and a magnetic layer having a uniform magnetization direction that is indicative of a direction of magnetization of the magnetic layer in a steady state. A logic state is written to the nonvolatile magnetic logic device by passing a current through the plurality of write path terminals. The read path comprises a plurality of read path terminals for evaluation of the logic state. The electrically insulating layer promotes electrical isolation between the read path and the write path and magnetic coupling of the read path to the write path.

Abstract: Exemplary drill tools for placement in a drill string may include a body; a plurality of reamer cutters; and a plurality of ball and socket connectors configured to attach the plurality of reamer cutters to the body. Each of the plurality of reamer cutters may be replaceable by removing at least one of the plurality of ball and socket connectors from the reamer body. Each of the ball and socket connectors may be attached to the reamer body with bolts. Each of the ball and socket connectors may include titanium dioxide and/or titanium carbide coatings where the connectors interface with the reamer cutters.

Abstract: Particles of a macro-porous ion exchange resin are dispersed in a solution of a transition metal compound, such as a compound of molybdenum, tungsten, or vanadium. The resin may be composed for anion exchange or cation ion exchange and, correspondingly, anions or cations of the metal are exchanged onto active ion exchange sites on the molecular chains of the resin. The resin is then carbonized and graphitized to form nanometer-size particles of transition metal carbide on particles of graphite. The composite metal carbide and graphite particles are electrically conductive and serve well as support particles for later deposited particles of a platinum group metal or other catalyst material in, for example, a catalytic electrode member in an electrochemical cell.

Abstract: The present invention provides devices and associated methods to facilitate multiplexed staining on a slide. The use of multiplexed staining on a single slide allows for more accurate disease diagnosis while also conserving sample. A PDMS based cytology overlay was created that is capable of coupling on-chip morphological, cytochemical, and immunological staining. Morphological and cytochemical staining of blood smears, along with immunostaining of lymph node imprints, was carried out to demonstrate the application of this microfluidic cytology chip (?CC) device.

Abstract: Various embodiments of the invention disclose that the uptake of LiOiPr in Mg2(dobdc) (dobdc4?=1,4-dioxido-2,5-benzenedicarboxylate) followed by soaking in a typical electrolyte solution leads to a new solid lithium electrolyte Mg2(dobdc).0.35LiOiPr.0.25LiBF4.EC.DEC. Two-point ac impedance data show a pressed pellet of this material to have a conductivity of 3.1×10?4 S/cm at 300 K. In addition, the results from variable-temperature measurements reveal an activation energy of approximately 0.15 eV, while single-particle data suggest that intraparticle transport dominates conduction.

Abstract: A method and apparatus for determining an inattentive state of an operator of a vehicle and for providing information to the operator of the vehicle by obtaining face images of the operator of the vehicle, obtaining images of an environment of the vehicle, determining one or more areas of interest in the environment of the vehicle based on the images of the environment, obtaining, from a relevance and priority database, relevance and priority values corresponding to the one or more areas of interest, determining a probability of attention of the operator of the vehicle to the one or more areas of interest based on the images of the environment and the relevance and priority values, determining an attention deficiency based on the determined probability of attention and the face images, and providing the information to the operator of the vehicle based on the determined attention deficiency.

Abstract: Several mutated strains of Scheffersomyces stipitis are generated by repetitive culturing of the parent strain on two types of concentrated hydrolyzates and with ethanol-challenged xylose-fed continuous culture. Isolates collected from various enriched populations are screened and ranked based on relative xylose uptake rate and ethanol yield. Ranking on hydrolyzates with and without nutritional supplementation is used to identify those isolates with best performance across diverse conditions.

Abstract: This invention provides a nucleotide analog comprising (i) a base selected from the group consisting of adenine, guanine, cytosine, thymine and uracil, (ii) a deoxyribose, (iii) an allyl moiety bound to the 3?-oxygen of the deoxyribose and (iv) a fluorophore bound to the base via an allyl linker, and methods of nucleic acid sequencing employing the nucleotide analog.