Abstract: The instant invention is based, at least in part, on the dentification of a mechanism by which T-bet modulates IL2 production. The present invention pertains to methods of identifying agents that modulate the kinase-mediated interaction of T-bet with RelA, as well as methods of use therefore.

Abstract: A method for creating a magnetic resonance image of an object with at least a first species and a second species, wherein the first species has a first T2 time and the second species has a second T2 time longer than the first T2 time is provided. An excitation with an ultra short echo time using a pulse is provided, comprising a first subpulse that creates a transverse magnetization component for the first species and the second species and a second subpulse that creates a transverse magnetization for the first species and substantially returns the second species to a longitudinal axis, wherein the transverse magnetization component substantially decays for the first species during an interval between the first subpulse and the second subpulse. At least one echo is read. A magnetic resonance image is created from the at least one echo.

Abstract: A visualization system for heterogeneous data sets comprises: a unique visualization interface created by a visualization engine. The visualization interface comprises a first area defining a center of attention, second area defining a parameter space and a plurality of correlation elements. The first area is a two-dimensional space for the display of items of interest. The second area provides a space in which parameters associated with the items of interest can be displayed. The correlation elements indicate relationships and their strength between items of interest and parameters in the second area. The visualization engine preferably comprises an input module, a control module, a retrieving module, a rendering module, and an analysis module. These components are coupled together to receive input from a user, retrieve data from a data source, and present the unique visualization interface to the user.

Abstract: Approaches to operating a multi-user, multi-carrier communication system involve allocating a target bit rate across user channels and subchannels to adjust the power. The target bit rate is allocated among subchannels of the user channels as a function of system power associated with the subchannel bit rate allocation. The target bit is allocated among user channels of the communication system as a function of system power associated with the user bit rate allocation. The power allocation for each user channel is determined based on the bit rate allocation.

Abstract: The present invention relates to isolated polypeptides which comprise an amino acid sequence consisting of a mutated functional Abl kinase domain, said mutated functional kinase domain being resistant to inhibition of its tyrosine kinase activity by N-[4-methyl-3-(4-pyridin-3-yl-pyrimidin-2-ylamino)-phenyl]-4-(4-methyl-piperazin-1-ylmethyl)-benzamide or a salt thereof, to the use of such polypeptides to screen for compounds which inhibit the tyrosine kinase activity of such polypeptides, to nucleic acid molecules encoding such polypeptides, to recombinant vectors and host cells comprising such nucleic acid molecules and to the use of such nucleic acid molecules in the production of such polypeptides for use in screening for compounds which inhibit the tyrosine kinase activity of such polypeptides.

Abstract: The invention relates to fusion proteins and bacteria encoding them. The fusion proteins include a ligand-binding domain interposed between the splicing domains of an intein. An auxotroph-relieving protein domain is fused to one of the splicing domains so that the auxotroph-relieving function of the domain is activated upon ligand binding. The fusion proteins can be expressed in bacterial cells and used as sensors of binding of compounds with the ligand-binding domain of proteins such as the human estrogen receptors or the human thyroid hormone receptor. The bacterially expressed fusion proteins can detect and report agonist and antagonist activity characteristic of the naturally-occurring hormone with the ability to modulate the function of the protein from which the ligand-binding domain of the fusion protein is derived.

Abstract: Methods and compositions are provided for the identification and isolation of mammalian mesenchymal stem cells. The methods of the invention provide a means to obtain substantially homogeneous MSC populations. In some embodiments, the homogeneous MSC composition is stable in non-differentiating culture conditions, where the proportion of cells in the composition that have an MSC phenotype are maintained over multiple passages.

Abstract: A method and apparatus for a structure of a flip-flop that is tolerant to the noise pulses occurring due to the presence of crosstalk faults by sampling the input data multiple times before and after the active clock edge. The final stored value at the flip-flop is determined by the resolution of a counter circuit residing in the flip-flop, which is activated at the change of the sampled input data. This counter based resolution mechanism allows for the detection and filtering of the noise pulse induced at the input of the flip-flop due to a crosstalk fault.

Abstract: The present invention provides a system and methods for analyzing the function of nucleotide integrases and modified group II introns. The system comprises a donor plasmid comprising a wild-type or modified group II intron, a recipient plasmid comprising a DNA recognition site and a promoterless reporter gene downstream of the DNA target site, and a host cell. The method comprises the steps of transforming a host cell with the donor and recipient plasmids, assaying for expression of the reporter gene, isolating plasmid DNA from the cotransformed cells, and analyzing the plasmid DNA to confirm that the group II intron has been inserted into the target sequence. The present invention also provides a method for simultaneously analyzing the activity of two or more modified nucleotide integrases. The present invention also relates to methods of preparing a library of donor plasmids containing a plurality of diverse modified group II intron DNA sequences.

Abstract: A field emission backplate formed by laser crystallizing of an area of amorphous semiconductor based material. Emitter sites result from the rough surface texture caused by the crystallization process. The crystallization may be localized using laser interferometry, and profiled emitter tips grown on the localized crystalline areas. Such backplates can be used in field emission devices emitting into either a vacuum or a wide band gap light-emitting polymer. Furthermore, a backplate having self-aligned gates can be formed by depositing an insulator layer and a metal layer over the emitter tips, removing the top of the metal layer and etching away the insulator, leaving each tip surrounded by a metal rim. A planarizing agent can be used to refine this process.

Abstract: A thermoelectric material of the general formula Ag1?XMmM?Q2+m, wherein M is selected from the group consisting of Pb, Sn, Ca, Sr, Ba, divalent transition metals, and combinations thereof; M? is selected from the group consisting of Bi, Sb, and combinations thereof; Q is selected from the group consisting of Se, Te, S, and combinations thereof; 8?m?24; and 0.01?x?0.7. In embodiments of the invention, the compositions exhibit n-type semiconductor properties. In preferred embodiments, x is from 0.1 to 0.3, and m is from 10 to 18. The compositions may be synthesized by adding stoichiometric amounts of starting materials comprising Ag, M, M?, and Q to a reaction vessel, heating the starting materials to a temperature and for a period of time sufficient to melt the materials, and cooling the reaction product at a controlled rate of cooling.

Abstract: A novel system and method for restoring functional movement of a paralyzed limb(s) or a prosthetic device. Stimulating one or more muscles of a patient using an implanted neuromuscular implants and sensing the response of the stimulated muscle by the implants, wherein the sensing the response is not limited to data related to patient's movement intention, the posture, muscle extension, M-Wave and EMG. A communication and control protocol to operate the system safely and efficiently, use of forward and reverse telemetry channels having a limited bandwidth capacity, and minimizing the adverse consequences caused by errors in data transmission and intermittent loss of power to the implants. Adjusting stimulation rates and phases of the stimulator in order to achieve an efficient control of muscle force while minimizing fatigue and therefore providing for smooth movements and dynamic increase of the strength in patient's muscle contraction.

Abstract: The light emitting surface of an image display light box is formed of multi-layer optical film having a reflectance greater than 95% and preferably about 99% or greater. This more efficiently utilizes light rays emitted by the light box's internal light source, since the multi-layer optical film reflects the light rays many times before the rays are absorbed and lost. Consequently, the light emitting surface can have a light transmissivity characteristic which is macroscopically invariant as a function of position on the light emitting surface. Light boxes utilizing prior art reflective materials require cumbersome, time-consuming, iterative trial and error techniques which must be customized for each light box in order to compensate for light absorption losses by imparting a variable transmissivity characteristic to the reflective material.

Abstract: A digital communication system based on the use of chaotic carriers is disclosed. For each symbol to be sent, the transmitter sends a reference chaotic signal followed by a transformed version of the reference chaotic signal. For different symbols, different transformations are performed. Also, the transformations are designed such that the transformed versions of the reference chaotic signal do not resemble the original reference chaotic signal. As a consequence, little information can be deduced by inspecting the frequency spectrum of the transmitted signal. Moreover, even if the communication could be detected, it is difficult to decode the messages because there are numerous transformations possible.

Abstract: The present invention provides a high-capacity and low-cost non-aqueous electrolyte secondary battery, comprising: a negative electrode containing, as a negative electrode active material, a ssubstance capable of absorbing/desorbing lithium ions and/or metal lithium; a separator; a positive electrode; and an electrolyte, wherein the positive electrode active material contained in the positive electrode is composed of crystalline particles of an oxide containing two kinds of transition metal elements, the crystalline particles having a layered crystal structure, and oxygen atoms constituting the oxide forming a cubic closest packing structure.

Abstract: A photosensor with customizable angular-response characteristics is presented. This photosensor includes a light-modifier located between the photosensor and a target area to be monitored by the photosensor, wherein the light-modifier provides a customizable angular response for light received at the photosensor from the target area.

Abstract: Selective occlusion of a blood vessel is achieved by selectively damaging endothelial cells at a target location in the blood vessel, resulting in the formation of a fibrin clot proximate to the damaged endothelial cells. Additional fibrinogen can then be introduced into the blood vessel if occlusion is not achieved, as the fibrinogen is converted to fibrin by enzymes released by the exposed thrombogenic tissue and activated platelets. Endothelial cells are selectively damaged using thermal effects induced by ultrasound, by mechanical effects induced by ultrasound, or by mechanical effects produced by a tool introduced into the blood vessel (such as a catheter-based tool). A particularly preferred technique for selectively damaging endothelial cells involves introducing an ultrasound activatable agent into the blood vessel, and causing cavitation in that agent using pulses of high-intensity focused ultrasound having a duration insufficient to induce thermal damage in adjacent perivascular tissue.

Abstract: Single, acentric, hexagonal, beryllium borate crystals having the formula Sr2Be2B2O7 and of a size sufficient for use in a variety of laser and non-optical applications are formed by a hydrothermal method. Alternate structures are formed by partially substituting the strontium ion with at least one other divalent metal ion.

Abstract: Improved methods and preparations are provided for ocular administration of therapeutic drugs. The preparations include respective quantities of a drug and a peptide which enhances transport of the drug across ocular tissues. The drug and peptide components may be separately administered or used as a mixture. The preferred peptide is NC-1059 (SEQ. ID NO. 1).

Abstract: Portable devices for treating stuttering or communication disorders include a circuit configured to automatically electronically select sua sponte different signal parameters and/or sound effect algorithms used to generate varied altered auditory feedback signals to a user over time.