Abstract: This invention provides vaccines comprising two or more recombinant Herpes Simplex Virus (HSV) proteins selected from a gD protein, a gC protein and a gE protein; and methods of vaccinating a subject against HSV and treating, impeding, inhibiting, reducing the incidence of, or suppressing an HSV infection or a symptom or manifestation thereof, comprising administration of a vaccine of the present invention.
Type:
Grant
Filed:
December 27, 2007
Date of Patent:
March 15, 2016
Assignee:
THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA
Inventors:
Harvey Friedman, Sita Awashi, John Lubinski
Abstract: A method for moving object detection based on a Fisher's Linear Discriminant-based Radial Basis Function Network (FLD-based RBF network) includes the following steps. A sequence of incoming frames of a fixed location delivered over a network are received. A plurality of discriminant patterns are generated from the sequence of incoming frames based on a Fisher's Linear Discriminant (FLD) model. A background model is constructed from the sequence of incoming frames based on a Radial Basis Function (RBF) network model. A current incoming frame is received and divided into a plurality of current incoming blocks. Each of the current incoming blocks is classified as either a background block or a moving object block according to the discriminant patterns. Whether a current incoming pixel of the moving object blocks among the current incoming blocks is a moving object pixel or a background pixel is determined according to the background model.
Type:
Grant
Filed:
March 14, 2014
Date of Patent:
March 15, 2016
Assignee:
National Taipei University of Technology
Abstract: A compound of the formula A-B-C, is provided, wherein: A is a first nucleic acid that specifically binds to an extracellular surface protein expressed by a cell of interest, B is an alkyl linker; and C is a second nucleic acid that hybridizes to a complementary nucleic acid. In some embodiments, the first nucleic acid is an aptamer. In some embodiments, the nucleic acid comprises an active compound, particularly cytotoxic nucleotides such as poly-FdUMP. Compositions and methods of using such compounds for treating and/or detecting cancer are also described.
Abstract: Cyano-substituted anthracene containing polyamines were synthesized and shown to be efficient polyamine transporter ligands. Moreover, these compounds (3 and 4) had improved fluorescence properties over previously known anthryl-polyamine conjugates, which facilitated their intracellular trafficking by confocal microscopy and fluorescence methods. These cytotoxic fluorescent agents may find use as molecular probes which traffic into cells via the polyamine transport system and may also be viable anticancer drugs which are readily quantified in human tissues due to their excellent fluorescence properties: (excitation: ? 405 nm) and emission (420 nm) occurs in the visible light range. The ability to excite and emit in the visible range provides an advantage to these probes as these wavelengths are considered non-toxic to human cells (versus ultraviolet mediated excitations, ?<400 nm) and visible light lasers are less costly to purchase and operate than UV laser sources.
Type:
Grant
Filed:
March 15, 2013
Date of Patent:
March 15, 2016
Assignee:
University of Central Florida Research Foundation, Inc.
Abstract: A system and method to target a biological rhythm disorder, such as a heart rhythm disorder, include processing cardiac signals via a computing device to determine a shape in a region of tissue defined by a source associated with the biological rhythm disorder that migrates spatially on or within the shape, and identifying at least one portion of the tissue proximate to the shape to enable selective modification of the at least one portion of tissue in order to terminate or alter the heart rhythm disorder.
Type:
Grant
Filed:
May 2, 2012
Date of Patent:
March 15, 2016
Assignees:
The Regents of the University of California, Topera, Inc., The United States of America as Represented by the Department of Veterans Affairs, Office of the General Counsel
Abstract: The present invention discloses a solar cell having a multi-layered structure that is used to generate, transport, and collect electric charges. The multi-layered nanostructure comprises a cathode, a conducting metal layer, a photo-active layer, a hole-transport layer, and an anode. The photo-active layer comprises a tree-like nanostructure array and a conjugate polymer filler. The tree-like nanostructure array is used as an electron acceptor while the conjugate polymer filler is as an electron donor. The tree-like nanostructure array comprises a trunk part and a branch part. The trunk part is formed in-situ on the surface of the conducting metal layer and is used to provide a long straight transport pathway to transport electrons. The large contact area between the branch part and the conjugate polymer filler provides electron-hole separation.
Type:
Grant
Filed:
April 26, 2012
Date of Patent:
March 15, 2016
Assignee:
NATIONAL TAIWAN UNIVERSITY
Inventors:
Wei-Fang Su, Chun-Wei Chen, Jih-Jen Wu, Yun-Yue Lin
Abstract: The subject disclosure relates to motion estimation and compensation of feature-motion decorrelation. In an aspect, coupled filtering can be employed to solve feature-motion decorrelation problems. In further aspects, a linear convolution model can be employed to model image variation caused by motion, and an image before motion and a warped image after motion can be filtered with a pair of filters having motion parameters shared with a tissue motion model. Compensation of feature-motion decorrelation in ultrasound images demonstrates various aspects of the subject disclosure.
Type:
Grant
Filed:
April 12, 2010
Date of Patent:
March 15, 2016
Assignee:
THE HONG KONG UNIVERSITY OF SCIENCE AND TECHNOLOGY
Abstract: In an embodiment, a method for manufacturing a thin layer chromatography (“TLC”) plate is disclosed. The method includes forming a layer of elongated nanostructures (e.g., carbon nanotubes), and at least partially coating the elongated nanostructures with a coating. The coating includes a stationary phase and/or precursor of a stationary phase for use in chromatography. The stationary phase may be functionalized with hydroxyl groups by exposure to acidified water vapor or immersion in a concentrated acid bath (e.g., HCl and methanol). At least a portion of the elongated nanostructures may be removed after being coated. Embodiments for TLC plates and related methods are also disclosed.
Type:
Grant
Filed:
February 25, 2011
Date of Patent:
March 15, 2016
Assignee:
BRIGHAM YOUNG UNIVERSITY
Inventors:
Matthew R. Linford, Robert C. Davis, Richard R. Vanfleet, David Scott Jensen, Li Yang, Jun Song
Abstract: A thermoelectric material including: a two dimensional nanostructure having a core and a shell on the core. Also, a thermoelectric element and a thermoelectric apparatus including the thermoelectric material, and a method of preparing the thermoelectric material.
Type:
Grant
Filed:
November 13, 2013
Date of Patent:
March 15, 2016
Assignees:
SAMSUNG ELECTRONICS CO., LTD., INDUSTRY-ACADEMIC COOPERATION FOUNDATION, YONSEI UNIVERSITY
Abstract: A pathological diagnosis assisting apparatus according to the present invention provides the diagnosis assisting information for assisting diagnosis of tissue fibrosis from the image of the stained sample, and includes an image reading unit configured to read the image of the stained sample and an image processing unit configured to process the image. The image processing unit includes an image classification unit configured to classify the collagenous fiber and the elastic fiber, a tissue area extraction unit configured to extract a tissue area, an occupancy rate calculation unit configured to calculate the occupancy rates of the collagenous fiber and the elastic fiber in the tissue area, and a diagnosis assisting information providing unit configured to provide the diagnosis assisting information based on the calculated occupancy rates of the collagenous fiber and the elastic fiber.
Abstract: A method of producing projections on a patch including providing a mask on a substrate and etching the substrate using an etchant and a passivant to thereby control the etching process and form the projections, wherein the passivant does not include oxygen.
Type:
Grant
Filed:
October 7, 2014
Date of Patent:
March 15, 2016
Assignee:
The University of Queensland
Inventors:
Mark Anthony Fernance Kendall, Derek William Kenneth Jenkins
Abstract: The present disclosure relates to a light emitting device using a graphene quantum dot, and an organic light emitting device including the same.
Type:
Grant
Filed:
November 27, 2013
Date of Patent:
March 15, 2016
Assignee:
RESEARCH & BUSINESS FOUNDATION SUNGKYUNKWAN UNIVERSITY
Inventors:
Hyoyoung Lee, Jung Hyun Lee, Yong Hun Shin
Abstract: A fluid catalytic cracking catalyst for increased production of propylene and gasoline from heavy hydrocarbon feedstock, the catalyst comprising between 10 and 20% by weight of an ultra-stable Y-type zeolite, between 10 and 20% by weight of a phosphorous modified sub-micron ZSM-5, between 20 and 30% by weight of a pseudoboehmite alumina, and between 30 and 40% by weight kaolin.
Type:
Grant
Filed:
May 23, 2013
Date of Patent:
March 15, 2016
Assignees:
SAUDI ARABIAN OIL COMPANY, KING FAHD UNIVERSITY OF PETROLEUM AND MINERALS
Inventors:
Musaed Salem Al-Ghrami, Cemal Ercan, Sulaiman S. Al-Khattaf, Mohammed Abdul Bari Siddiqui, Abdullah M. Aitani
Abstract: A thin film transistor is provided. The thin film transistor includes a source electrode, a drain electrode, a semiconducting layer, an insulating layer and a gate electrode. The insulating layer has a first surface and a second surface opposite to the first surface. The gate electrode is located on the first surface of the insulating layer. The source electrode, the drain electrode, and the semiconductor layer are located on the second surface of the insulating layer. The gate electrode, the source electrode, and the drain electrode include a first carbon nanotube layer. The semiconductor layer includes a second carbon nanotube layer. A first film resistor of the first carbon nanotube layer is smaller than or equal to 10 k? per square. A second film resistor of the second carbon nanotube layer is greater than or equal to 100 k? per square.
Type:
Grant
Filed:
December 24, 2013
Date of Patent:
March 15, 2016
Assignees:
Tsinghua University, HON HAI PRECISION INDUSTRY CO., LTD.
Abstract: Aggregated graphene oxide includes a range of specific surface area, and a method of preparing aggregated graphene oxide includes dispersing graphene oxide in an organic solvent and adding an anti-solvent. Aggregated graphene includes a range of specific surface area, and a method of preparing aggregated graphene includes dispersing graphene oxide in an organic solvent, adding an anti-solvent, and reducing the aggregated graphene oxide. Aggregated and nitrogen-doped includes a range of specific surface area, and a method of preparing aggregated and nitrogen-doped graphene includes dispersing graphene oxide in an organic solvent, adding an anti-solvent, and photo-reacting the aggregated graphene oxide.
Type:
Grant
Filed:
January 30, 2014
Date of Patent:
March 15, 2016
Assignee:
RESEARCH & BUSINESS FOUNDATION SUNGKYUNKWAN UNIVERSITY
Inventors:
Hyoyoung Lee, Yeo Heung Yoon, Chul Baik, Keun Sik Lee
Abstract: Human cystathionine ?-synthase variants are disclosed, as well as a method to produce recombinant human cystathionine ?-synthase and variants thereof. More particularly, the role of both the N-terminal and C-terminal regions of human CBS has been studied, and a variety of truncation mutants and modified CBS homologues are described. In addition, a method to express and purify recombinant human cystathionine ?-synthase (CBS) and variants thereof which have only one or two additional amino acid residues at the N-terminus are described.
Type:
Grant
Filed:
March 20, 2015
Date of Patent:
March 15, 2016
Assignee:
THE REGENTS OF THE UNIVERSITY OF COLORADO, A BODY CORPORATE
Abstract: The presently-disclosed subject matter includes methods for producing liquid hydrocarbons from syngas. In some embodiments the syngas is obtained from biomass and/or comprises a relatively high amount of nitrogen and/or carbon dioxide. In some embodiments the present methods can convert syngas into liquid hydrocarbons through a one-stage process. Also provided are catalysts for producing liquid hydrocarbons from syngas, wherein the catalysts include a base material, a transition metal, and a promoter. In some embodiments the base material includes a zeolite-iron material or a cobalt-molybdenum carbide material. In still further embodiments the promoter can include an alkali metal.
Type:
Grant
Filed:
January 23, 2014
Date of Patent:
March 15, 2016
Assignee:
Mississippi State University Research and Technology Corporation
Abstract: A junction-less transistor having an reverse polarity structure includes a substrate, a semiconductor body, a gate and a gate insulation layer. The substrate has a first polarity. The semiconductor body is disposed on the substrate, and includes a drain, a source and a channel section connected between the drain and the source. The gate covers one side of the channel section away from the substrate. The semiconductor body has a second polarity opposite to the first polarity. With the semiconductor body and the substrate respectively having the opposite second polarity and first polarity, a leakage current can be reduced while also lowering element production costs.