Abstract: A Gires-Tournois etalon (GTE) (10) comprising an optical fiber (12) in which a primary chirped fiber Bragg grating (FBG) (16) is provided, an RF signal generator (20), a piezoelectric transducer (22), and a glass horn (24), for coupling an acoustic wave (26) into the fiber (12). The acoustic wave (26) causes a periodic compression within the fiber (12), which induces a low frequency periodic refractive index modulation within the grating section (14) of the fiber (12). This causes two side frequency components to be generated for each high-frequency component of the FBG (16). Two secondary grating are thus excited, having the same spectral bandwidth as the FBG (16), but a lower reflectivity and different central wavelengths. The free spectral range of the GTE (10) can be adjusted by varying the frequency of the acoustic wave (26). The reflectivity of the excited secondary gratings can be adjusted by adjusting the amplitude of the acoustic wave (26).

Abstract: In a method of monitoring two-phase fluid flow a vortex flowmeter is used to generate a signal indicative of the flow regime using the signal components and its fluctuations to determine the phase status of the fluid flow.

Abstract: The present invention relates to organic light emitting devices (OLEDs), and more specifically to OLEDS that emit light using a combination of fluorescent emitters and phosphorescent emitters. The emissive region of the devices of the present invention comprise at least one phosphor-sensitized layer which has a combined emission from a phosphorescent emitter and a fluorescent emitter. In preferred embodiments, the invention relates to white-emitting OLEDS (WOLEDs).

Abstract: A pro-inflammatory T cell response is specifically suppressed by the injection into a recipient of DNA encoding an autoantigen associated with autoimmune disease. The recipient may be further treating by co-vaccination with a DNA encoding a Th2 cytokine, particularly encoding IL4. In response to the vaccination, the proliferation of autoantigen-reactive T cells and the secretion of Th1 cytokines, including IL-2, IFN-? and IL-15, are reduced.

Abstract: The present invention provides a method for decoding corrupt codestreams for encoded digital imagery and video and, in particular, JPEG2000 codestreams with improved error resilience properties. The decoding techniques apply to a class of coding algorithms in which the data from underlying images are partitioned, typically to allow decoding of different spatial sections of the image, and the rules governing the dependencies within and perhaps between partitioned sets are known. Corrupt codestreams are decoded with improved image quality by observing the partitions imposed by the underlying algorithm (200), detecting an error in a partition set (202), analyzing the dependencies within and perhaps between the partitions (204), determining what sections of encoded data that follow the error in the partition set can be salvaged (206), and decoding those sections (208).

Abstract: A polarization lidar system capable of remotely identifying characteristics of atmospheric aerosol particles by transmitting a polarized beam of light and analyzing polarization characteristics of received backscatter is disclosed. The transmitter features high pulse energy to remotely identify aerosol particles with substantially one pulse. The transmitter employs a thin film plate polarizer and a Raman wavelength shifter to achieve eye-safe, single-plane linearly polarized energy. The transmit beam and receiver field of view are coaxial. The receiver employs a telescope, a collimating lens, and a beam splitter. The beam splitter splits the received backscatter into a single-plane polarized beam whose polarization plane is parallel to the plane of transmission and a single-plane polarized beam whose polarization plane is perpendicular to the plane of transmission. Each split beam is directed through separate focusing lenses onto separate detectors.

Abstract: An immune modulator composition and/or pharmaceutical composition comprising a whole cell of a bacterium from the genera Rhodococcus, Gordonia, Nocardia, Dietzia, Tsukamurella and Nocardioides, wherein said immune modulator composition in use modifies a cellular immune response.

Abstract: 1H-Pyrrolo-1,4-thiazines and a process for the preparation thereof are described. These compounds are useful as enzyme inhibitors in cells, particularly for medical uses.

Abstract: Transglutaminase inhibitors and methods of use thereof are provided.

Abstract: The present invention relates to a single-chain or chimeric polypeptide comprising a cytokine and a growth factor linked by at least one amino acid residue, and wherein the chimeric polypeptide enhances the proliferation and/or differentiation of hematopoietic precursor cells. In particular the invention relates to, a chimeric polypeptide comprising the beta-chain of hepatocyte growth factor, and IL-7 linked by at least one amino acid, and wherein the chimeric polypeptide demonstrates pre-pro-B proliferation and growth stimulating activity.

Abstract: The present invention provides a new 18-residue homodimerized peptide, designated PIP [59-67] dimer (SEQ ID NO: 1), which is a mutant of the optimized anti-inflammatory peptide P-NT.II, the patent for which has recently been filed [1]. P-NT.II has the potential to modulate both the inflammatory and bone damaging components of rheumatoid arthritis, and was originally designed on the basis of the primary structure of the anti-inflammatory protein termed ‘Phospholipase Inhibitor from Python (PIP)’ [2]. Using solid phase chemistry, variants of P-NT.II were designed and examined for inhibitory activity against secretory phospholipase A2 (sPLA2), a key enzyme involved in the inflammatory pathway, and matrix metalloproteinases (MMPs) that are involved in the remodeling and degradation of the extracellular matrix in rheumatoid arthritis (RA) and cancer. Among the family of mutants tested, the dimerized peptide was found to be the most potent inhibitor against sPLA2 as well as the human recombinant MMP-1.

Abstract: Stable genetically engineered bacterial strains that overproduce coronatine are provided. The stable strains can be successfully cultivated to overproduce coronatine at temperatures that are suitable for large scale, commercial preparations of coronatine. The overproducing strains are also non-pathogenic. An exemplary strain is Pseudomonas syringae APV1, which successfully overproduces coronatine at 26° C. Methods of optimizing culture conditions for coronatine production from the novel stable overproducing strains are provided, as are methods for using the overproducing strains to induce abscission and increase taxane production.

Abstract: The invention provides polypeptides encoded by open reading frames present in the genome of Mycobacterium tuberculosis but absent from the genome of BCG and diagnostic and prophylactic methodologies using these polypeptides.

Abstract: The present invention encompasses novel mesoporous compositions comprising vitamin E and alumina, and methods for their synthesis. The mesoporous compositions of the present invention have applications as drug-delivery vehicles.

Abstract: The present invention relates to methodology for polymer grafting by a polysaccharide synthase and, more particularly, polymer grafting using the hyaluronate or chondroitin or heparin/heparosan synthases from Pasteurella, in order to create a variety of glycosaminoglycan oligosaccharides having a natural or chimeric or hybrid sugar structure with a targeted size that are substantially monodisperse in size.

Abstract: A thermal compressive device provides energy-efficient heating or cooling by exploiting heat regeneration in a sorption system. The device comprises an array of generator modules (7) arranged in two banks (10, 11) to either side of a heating zone (13). Heat carrier fluid is driven past the modules in a reversible direction. During one phase, generators in the first bank (10) are cooled and therefore in various stages of sorbate re-adsorption. Sorbate in associated evaporator region(s) (26) will boil, enabling cooling of surrounding fluid (33). Generators (7) in the other bank (11) will be in various stages of desorption. Sorbate in associated condenser region(s) (21) will condense, enabling heating of its environment. During the other phase, each generator (7) switches function, but cooling remains at evaporator regions (26) and heating at condenser regions (21). Each module may be a self-contained unit comprising generator (7), condenser (21) and evaporator (26) sections.

Abstract: The invention provides a method of ameliorating a Th1-mediated immune pathology in a mammal. The method is practiced by administering a low dose of estrogen to the mammal. Optionally, an immunotherapeutic agent can also be administered to the mammal. Also provided are kits containing a low dose of estrogen and an immunotherapeutic agent.

Abstract: The present invention discloses methods of screening a subject for increased likelihood or risk of certain diseases or disorders. This method comprises detecting the presence or absence of at least one mutation in the MSR1 gene wherein the presence or absence of such mutation indicates an increased risk for certain diseases, such as cancer asthma and/or cardiovascular diseases.

Abstract: The present invention provides an improved system for linking nucleic acids to one another. In particular, the present invention provides techniques for producing DNA product molecules that may be easily and directly ligated to recipient molecules. The product molecules need not be cleaved with restriction enzymes in order to undergo such ligation. In preferred embodiments of the invention, the DNA product molecules are produced through iterative DNA synthesis reactions, so that the product molecules are amplified products. The invention further provides methods for directed ligation of product molecules (i.e., for selective ligation of certain molecules within a collection of molecules), and also for methods of exon shuffling, in which multiple different product molecules are produced in a single ligation reaction. Preferred embodiments of the invention involve ligation of product molecules encoding functional protein domains, particularly domains naturally found in conserved gene families.

Abstract: Compositions of biodegradable polymers and hyperbranched dendritic polymer (HBP) are described. The compositions can also include anhydride modified HBP. The resulting compositions have superior elongation at break and can be as cast or blown films for packaging, for example.