Abstract: A system for providing cardiac support to a patient and for promoting myocardial repair and recovery, comprises a device for connecting to a vasculature of the patient and a control module. The device includes a pump, defining a blood-receiving volume, and a cannula, in fluid communication with the blood-receiving volume, for anatomizing to the vasculature of the patient such that the blood-receiving volume may receive blood from and return blood to the vasculature of the patient through the cannula. The control module is for controlling the device and includes a means for establishing user-defined parameters, and a means for operating the pump of the device, which is in communication with the means for establishing user-defined parameters such that the operation of the pump is in response to the established user-defined parameters.

Abstract: A method for processing signals, such as a tomography signal, in the time domain provides both high spatial resolution and high frequency resolution but at low cost. The method uses non-linear regression with a sinusoidal model to fit a sine wave to a portion of the signal that is less than a full cycle of a wave of the signal.

Abstract: A novel nanocarbon composite structure is provided having trapped ruthenium oxide. By using Ketjen black, and through chemical-mechanical effect utilizing an ultracentrifugal reaction field, both the specific surface area of ruthenium oxide and space of electrode material are expanded to have nanoparticles of ruthenium oxide highly dispersed in a graphene layer. This nanocarbon composite structure having trapped ruthenium oxide exhibits high electrochemical activity and is suitable for use as an electrical energy storing device, such as a large-capacity capacitor.

Abstract: A microdischarge device that includes one or more electrodes encapsulated in a nanoporous dielectric. The devices include a first electrode encapsulated in the nanoporous dielectric and a second electrode that may also be encapsulated with the dielectric. The electrodes are configured to ignite a microdischarge in a microcavity when an AC or a pulsed DC excitation potential is applied between the first and second electrodes. The devices include linear and planar arrays of microdischarge devices. The microcavities in the planar arrays may be selectively excited for display applications.

Abstract: A system and method comprising providing a plurality of signature strings, inputting a plurality of strings, separating the signature strings into a plurality of signature groups, respectively detecting common features for the signature strings for each of the signature groups and the input strings, comparing the detected common features for each of the signature groups with those of the input strings, and matching the input strings and the signature groups if the detected common features for the signature groups match those of the input strings. In one aspect, the string matching further comprises matching the input strings with the signature strings for those of the signature groups having common features that match the common features of the input strings. In another aspect, the common features comprise distances or gaps between characters in the input strings and the signature strings.

Abstract: A method and apparatus to create two dimensional and three dimensional structures using a maskless photolithography system is provided. In an embodiment, the pattern generator comprises a micromirror array wherein the positioning of the mirrors in the micromirror array and the time duration of exposure can be modulated to produce patterns to photoform photosensitive material. The desired pattern can be designed and stored using conventional computer aided drawing techniques and can be used to control the positioning of the individual mirrors in the micromirror array to reflect the corresponding desired pattern. A fixture for mounting of the substrate can be incorporated and can allow the substrate to be moved three dimensions. The fixture can be rotated in one, two, or three directions.

Abstract: Described are methods of detecting G-protein coupled receptor (GPCR) activity in vivo and in vitro; methods of assaying GPCR activity; and methods of screening for GPCR ligands, G protein-coupled receptor kinase (GRK) activity, and compounds that interact with components of the GPCR regulatory process. Constructs useful in such methods are described.

Abstract: Methods of forming polynucleotides are disclosed.

Abstract: The present invention pertains to certain ketones and reduced ketones and derivatives thereof which, inter alia, inhibit osteoclast survival, formation, and/or activity; and/or inhibit bone resorption, and more particularly to compounds of the formulae: (1) (2) wherein: Ar1 is independently a biphenyl, phenanthryl, fluorenyl, or carbazolyl, and is optionally substituted; Ralk is independently a C2-10alkylene group, and is optionally substituted; —ORO, if present, is independently —OH or —ORK; —ORK, if present, is independently selected from: —O—RK1; —O—C(?O)RK2; —O—C(?O)ORK3; —O—S(?O)2ORK4; Q is independently —OH or —OROT; wherein: —OROT, if present, is independently selected from: —O—RE1; —O—C(?O)—RE2; —O—C(?O)—O—RE3; —O—C(?O)—O—SO3RE4; —O—C(?O)—O—(CH2)n—COORE5; —O—C(?O)—(CH2)n—NRN1RN2; —O—C(?O)—(CH2)n—NH—C(?O)RE6; —O—C(?O)—(CH2)n—C(?O)—NRN3RN4; —O—P(?O)(ORE7)(ORE8); —O—RPA; RPA, if present, is an organic group which incorporates a phosphonic acid group; with the proviso that if —OROT is —O—RE1, then RE1 is

Abstract: In various embodiments of the invention, novel compositions having a polynucleotide bound to a substrate via a cleavable linker are provided, and methods of cleaving a polynucleotide from a substrate are provided.

Abstract: A method and associated system 300 for delivering intensity-modulated radiation therapy (IMRT) uses variable feathering field splitting for intensity modulated fields of large size. A processor controls a beam-shaping device that splits the radiation beam into a plurality of radiation fields delivered to a patient. The processor in cooperation with the beam-shaping device implements a variable feathering method which includes providing an intensity matrix for the treatment of a patient, the intensity matrix having a plurality of rows and columns for spanning a prescribed radiation field including a prescribed field width. The prescribed width is compared to a maximum field width provided by the radiation treatment system.

Abstract: A compound capable of specifically binding to pathogen EF-1? but not host EF-1?, wherein the compound binds to any part of an amino acid sequence having at least 70% sequence identity to amino acids 240-230 of SEQ ID NO:22.

Abstract: The present invention relates to maskless photolithography using a patterned light generator for creating 2-D and 3-D patterns on objects using etching and deposition techniques. In an embodiment, the patterned light generator uses a micromirror array to direct pattern light on a target object. In an alternate embodiment, the patterned light generator uses a plasma display device to generate and direct patterned light onto a target object. Specifically, the invention provides a maskless photolithography system and method for photo stimulated etching of objects in a liquid solution, patterning glass, and photoselective metal deposition. For photo stimulated etching of objects in a liquid solution, the invention provides a system and method for immersing a substrate in an etchant solution, exposing the immersed substrate to patterned light, and etching the substrate according to the pattern of incident light.

Abstract: An active layer having a p-type quantum dot structure is disposed over a lower cladding layer made of semiconductor material of a first conductivity type. An upper cladding layer is disposed over the active layer. The upper cladding layer is made of semiconductor material, and includes a ridge portion and a cover portion. The ridge portion extends in one direction, and the cover portion covers the surface on both sides of the ridge portion. A capacitance reducing region is disposed on both sides of the ridge portion and reaching at least the lower surface of the cover portion. The capacitance reducing region has the first conductivity type or a higher resistivity than that of the ridge portion, and the ridge portion has a second conductivity type. If the lower cladding layer is an n-type, the capacitance reducing region reaches at least the upper surface of the lower cladding layer.

Abstract: An infrared transmissive article includes an infrared transmissive substrate and a single layer anti-reflective (AR) composite broadband sol gel coating on a surface of the substrate. The AR coating includes a first chalcogenide including compound, and a second chalcogenide including compound intermixed with the first chalcogenide including compound. The percentages of the first chalcogenide and the second chalcogenide in the AR coating are selected to provide a refractive index of the AR coating that approximates the square root of a refractive index of the substrate.

Abstract: This invention provides an anti-cancer immunogenic agent(s) (e.g. vaccines) that elicit an immune response specifically directed against renal cell cancers expressing a G250 antigenic marker. Preferred immunogenic agents comprise a chimeric molecule comprising a kidney cancer specific antigen (G250) attached to a granulocyte-macrophage colony stimulating factor (GM-CSF). The agents are useful in a wide variety of treatment modalities including, but not limited to protein vaccination, DNA vaccination, and adoptive immunotherapy.

Abstract: According to various aspects, exemplary embodiments are provided of thermopneumatic capillary micropumps and manufacturing methods thereof. In one exemplary embodiment, a thermopneumatic capillary micropump generally includes a lower substrate having a pump-entrance for injecting fluids and a pump-exit for exhausting the fluids. The micropump also includes one or more micro-heaters for generating heat and electrodes for applying voltage to the micro-heaters. One or more air chambers substantially cover the micro-heaters. A pump chamber unit, which is capable of being filled up with the fluids, is coupled to the air chambers, the pump-entrance, and the pump-exit. An airing channel is coupled to the air chambers for helping maintain the pressure of the air in the air chambers at about the same level. An oxide layer is deposited on an upper substrate of the micropump. The upper and lower substrates are thermopneumatically coupled to each other.

Abstract: The present invention provides a conditionally replicating viral vector, methods of making, modifying, propagating and selectively packaging, and using such a vector, isolated molecules of specified nucleotide and amino acid sequences relevant to such vectors, a pharmaceutical composition and a host cell comprising such a vector, the use of such a host cell to screen drugs. The methods include the prophylactic and therapeutic treatment of viral infection, in particular HIV infection, and, thus, are also directed to viral vaccines and the treatment of cancer, in particular cancer of viral etiology. Other methods include the use of such conditionally replicating viral vectors in gene therapy and other applications.

Abstract: A fiber wrap and a method of rotating the fiber wrap without twisting a data cable are disclosed. The fiber wrap includes a sun gear, a sun cylinder coupled to the sun gear, a planetary gear in contact with the sun gear, a planetary cylinder coupled to the planetary gear, an outer housing in contact with the planetary gear, and a data cable coupled to the sun cylinder, the planetary cylinder, and the outer housing. The data cable is coupled in such a way as to only bend the data cable during use of the fiber wrap.

Abstract: The present invention relates to systems and methods for fabricating microscanners. The fabrication processes employed pursuant to some embodiments are compatible with well known CMOS fabrication techniques, allowing devices for control, monitoring and/or sensing to be integrated onto a single chip. Both one- and two-dimensional microscanners are described. Applications including optical laser surgery, maskless photolithography, portable displays and large scale displays are described.