Abstract: A semiconductor device may include a substrate and an insulating layer formed on the substrate. A multi-layer fin may be formed on the insulating layer and may include two semiconducting layers isolated by an insulating layer in vertical direction. A first MOS type device comprising a first source region, a first channel region and a first drain region is arranged on the first semiconducting layer in the multi-layer fin. A second MOS type device comprising a second source region, a second channel region and a second drain region is arranged on the second semiconducting layer in the multi-layer fin. A gate electrode is provided so as to be vertically adjacent to the first and second channel regions.

Abstract: The present invention broadly comprises an automated pill crusher comprising a container operatively arranged to hold at least one pill, means for producing a linear force in a first direction upon at least one pill in the container, and, means for producing a spring force in a second direction upon at least one pill in the container. The pill crusher further comprises means for pulverizing at least one pill in the container.

Abstract: The present invention is directed to an isolated peptide that functionally mimics a binding site for a monoclonal antibody, the monoclonal antibody recognizing an epitope within the human platelet glycoprotein Ib/IX complex. This peptide is called a mimotope. The invention also provides an isolated molecule capable of binding to the peptide, or the mimotope, which molecule can be an antibody, a second peptide, a carbohydrate, a DNA molecule, an RNA molecule, or other naturally or chemically synthesized molecules. This isolated molecule is called an anti-mimotope. Mimotopes mimicking the binding site for monoclonal antibody C-34 and SZ-2, as well as anti-mimotopes to the C-34 mimotopes, are specifically provided.

Abstract: Amphiphilic peptide compounds comprising one or more epitope sequences for binding interaction with one or more corresponding growth factors, micellar assemblies of such compounds and related methods of use.

Abstract: A process for producing a class of polyarylenes having p-bis-(chlorodifluoromethyl) benzene or p-bis(bromodifluoromethyl) benzene as a comonomer. The p-bis-(chlorodifluoromethyl) benzene or the p-bis(bromodifluoromethyl)benzene act as precursors in a polycondensation reaction with a difunctional monomer.

Abstract: This invention provides a method of treating or preventing a disease in an animal associated with one or more self-protein(s), -polypeptide(s), or -peptide(s) that is present or involved in a non-physiologic process in the animal comprising administering to the animal a self-vector comprising a polynucleotide encoding the self-protein(s), -polypeptide(s) or -peptide(s) associated with the disease. Administration of the self-vector comprising a polynucleotide encoding the self-protein(s), -polypeptide(s) or -peptide(s) modulates an immune response to the self-protein(s), -polypeptide(s) or -peptide(s) expressed from administration of the self-vector.

Abstract: The present invention provides methods and devices for the knowledge-based discovery and optimization of differences between cell types. In particular, the present invention provides visual servoing optical microscopy, as well as analysis methods. The present invention provides means for the close monitoring of hundreds of individual, living cells over time: quantification of dynamic physiological responses in multiple channels; real-time digital image segmentation and analysis; intelligent, repetitive computer-applied cell stress and cell stimulation; and the ability to return to the same field of cells for long-term studies and observation. The present invention further provides means to optimize culture conditions for specific subpopulations of cells.

Abstract: A distributed arbitrary waveform generator (DAWG) synthesizes the target waveform using a series of narrow pulses generated by a number of pulse generators. To achieve this, it uses an input trigger signal to control all the pulse generators, each of which generates a narrow pulse (impulses) at a specific sample time, and then all the impulses are combined to generate the output waveform. The input trigger signal is distributed to each pulse generator by a trigger distribution network. Impulses generated by pulse generators can be tuned in both pulse amplitude and width, and the spacing between them can be tuned by the trigger distribution network. Therefore the waveforms generated are completely reconfigurable.

Abstract: Disclosed are embodiments of apparatus and methods for separating particles in a fluid stream by size. In one embodiment of an apparatus for separating such particles, a housing is provided, which defines a channel for a fluid stream containing particles. A suction channel is also provided, which terminates at a suction port. The suction port is positioned adjacent to the fluid stream. The suction channel may be configured to create a low pressure region and thereby redirect particles in the first fluid stream such that they may be sorted by size.

Abstract: The present invention provides a method for identifying repeat insertion mutation, a method for identifying or classifying genetic diseases characterized by genome rearrangement, as well as a method for mapping complex traits controlled by repeat insertion mutations in a plant or mammalian subject.

Abstract: A vehicle includes a motorized belt track directly or indirectly connected to a frame. The belt track frictionally contacts a drive surface on which the vehicle moves, such as any form of road or off-road surface. The belt track moves forward and backward in a direction parallel to a centerline of the belt track to move the vehicle backward and forward along the drive surface. A steering appendage is also directly or indirectly connected to the frame. The steering appendage is also adapted to frictionally contact the drive surface. The steering appendage is off the centerline of the belt track. The steering appendage causes the vehicle to turn from the centerline of the belt track when in contact with the drive surface.

Abstract: This invention provides a novel purified mammalian protein having the ability to bind the cytoplasmic region or domain of a CD40 receptor and the nucleic acid molecules coding for this protein. Also provided by this invention are antibodies which specifically bind CD40bp. Methods of using the proteins, nucleic acids and antibodies described above are further provided herein.

Abstract: A method for low-cost arsenic removal from drinking water using chemically prepared bottom ash pre-treated with ferrous sulfate and then sodium hydroxide. Deposits on the surface of particles of bottom ash form of activated iron adsorbent with a high affinity for arsenic. In laboratory tests, a miniscule 5 grams of pre-treated bottom ash was sufficient to remove the arsenic from 2 liters of 2400 ppb (parts per billion) arsenic-laden water to a level below 50 ppb (the present United States Environmental Protection Agency limit). By increasing the amount of pre-treated bottom ash, even lower levels of post-treatment arsenic are expected. It is further expected that this invention supplies a very low-cost solution to arsenic poisoning for large population segments.

Abstract: The invention relates to the regulation of gene expression, particularly to methods and compositions for regulating gene expression in plants. Expression cassettes comprising a polynucleotide molecule of interest operably linked to the Brachytic2 (Br2) promoter, or a functional fragment or variant thereof, are provided. Methods of using such expression cassettes, as well as plant cells, plant tissues, plants, and seeds transformed with these expression cassettes, are additionally provided. The methods and compositions find use in regulating the expression of a polynucleotide molecule of interest in a plant.

Abstract: Ghrelin is acylated by ghrelin O-acyltransferase. Ghrelin O-acyltransferase assays comprise contacting a mixture of ghrelin and recombinant ghrelin O-acyltransferase with an agent; and detecting a resultant decrease in acylation of the ghrelin by the acyltransferase.

Abstract: This invention provides method and apparatus for performing chemical and biochemical reactions in solution using in situ generated photo-products as reagent or co-reagent. In particular, the present invention provides methods and devices for generating a photogenerated reaction in solution on a substrate comprising generating a light beam using an optical device system comprising a light source and a computer-controlled spatial optical modulator comprising a digital micromirror device and using the spatial optical modulator to direct light to fluidly isolated reaction sites under conditions such that a photogenerated reaction takes place. The method and apparatus of the present invention have applications in parallel synthesis of molecular sequence arrays on solid surfaces.

Abstract: A method and system for predicting a trajectory of an air-to-surface target missile is provided, including detecting a plurality of echo wave signals from the target missile through a plurality of sensors deployed at various locations relative to the target missile, extracting at least one range distance and at least one radial velocity, respectively, from the detected echo wave signals from the sensors by using a hybrid FSK/LFM unit, using a two-stage Kalman filter to filter the computed range distance and radial velocity to obtain a relative distance, a relative velocity and a relative acceleration, respectively, of the target missile, and finally applying trilateration on the relative distance, relative velocity and relative acceleration of the target missile from each two-stage Kalman filter to obtain a location, velocity and acceleration along the x, y, z directions.

Abstract: A high intensity lighting apparatus (400) includes an outer housing (402); a curved support disk (414) having an array of diode or laser-based integrated light source (410) attached thereto disposed within the housing. Each of the light source (110) includes a tube (112) having a laser or diode chip (111) at one end of the tube. The tubes each have at least one concave shaped exit surface (113) on an end opposite the chip, wherein the concave exit surface converges light emitted from each of the light source to focal points within the housing (402). A shape of the curved support disk (414) converges the respective focal points into a light beam having a common focal plane (441). Adjustable secondary optics (431) are disposed in the housing after the focal plane (441) for creating various angles of transmission of the light beam. The laser can be a diode laser, while the diode can be a light-emitting diode (LED).

Abstract: An electronic circuit capable of carrying out communications by inductive coupling with minimum power consumption between substrates. Although the amplification factor of the amplifier 10a is 1, the amplification factors of the amplifiers 10b through 10d are, respectively, 2, 4 and 8. Amplification is carried out at the amplification factors 1 through 15 (=1+2+4+8) as a whole by a combination thereof. The transmit power control register 21 outputs ON and OFF signals to the respective amplifiers 10a through 10d so as to bring about transmit power responsive to the distance to a substrate having a receiver coil which is a destination of transmission (that is, the distance between a transmitter coil and a receiver coil), in further detail, so as to have an amplification factor by which transmit power proportionate to the distance can be obtained, and selects a combination of the amplifiers 10b through 10d.

Abstract: Engineered fluorescent proteins, nucleic acids encoding them and methods of use.