Abstract: Homogeneous and dense arrays of nanowires are described. The nanowires can be formed in solution and can have average diameters of 40-300 nm and lengths of 1-3 ?m. They can be formed on any suitable substrate. Photovoltaic devices are also described.
Type:
Grant
Filed:
February 9, 2007
Date of Patent:
June 9, 2009
Assignee:
The Regents of the University of California
Inventors:
Peidong Yang, Lori E. Greene, Matthew Law
Abstract: Analytical reagents and mass spectrometry-based methods using these reagents for the rapid, and quantitative analysis of proteins or protein function in mixtures of proteins. The methods employ affinity labeled protein reactive reagents having three portions: an affinity label (A) covalently linked to a protein reactive group (PRG) through a linker group (L). The linker may be differentially isotopically labeled, e.g., by substitution of one or more atoms in the linker with a stable isotope thereof. These reagents allow for the selective isolation of peptide fragments or the products of reaction with a given protein (e.g., products of enzymatic reaction) from complex mixtures. The isolated peptide fragments or reaction products are characteristic of the presence of a protein or the presence of a protein function in those mixtures. Isolated peptides or reaction products are characterized by mass spectrometric (MS) techniques.
Type:
Grant
Filed:
November 23, 2004
Date of Patent:
June 9, 2009
Assignee:
University of Washington
Inventors:
Rudolf Hans Aebersold, Michael H. Gelb, Steven P. Gygi, C. Ronald Scott, Frantisek Turecek, Scott A. Gerber, Beate Rist
Abstract: N-fatty acid-amino acid conjugates and J2 prostanoid-amino acid conjugates are disclosed along with methods for making such conjugates and methods of using these conjugates in the treatment of conditions that involve dysfunctional lipid metabolism, insulin sensitivity, glucose homeostasis, and/or inflammation.
Abstract: A mutant virus is provided which contains a mutation at a phosphorylation site in one or more of the proteins of the virus, which mutation causes the virus to be attenuated, and therefore, an improved vaccine composition can be produced therewith. The invention also relates to vaccine compositions which contain the mutant virus, as well as to methods of inducing an immune response, and of protecting mammals from infection by rabies virus. Also included in the invention are methods of producing the mutant virus and mutant viral proteins, including producing the mutant virus in a host cell which produces or even overproduces a wild-type counterpart of the mutant viral protein, which complements the other viral proteins such that production of the mutant viral particle is optimized.
Type:
Grant
Filed:
February 1, 2007
Date of Patent:
June 9, 2009
Assignee:
University of Georgia Research Foundation, Inc.
Abstract: The invention provides novel amino acid compounds of use in detecting and evaluating brain and body tumors. These compounds combine the advantageous properties of ?-aminoisobutyric acid (AIB) analogs namely, their rapid uptake and prolonged retention in tumors with the properties of halogen substituents, including certain useful halogen isotopes such as fluorine-18, iodine-123, iodine-124, iodine-125, iodine-131, bromine-75, bromine-76, bromine-77, bromine-82, astatine-210, astatine-211, and other astatine isotopes. In addition the compounds can be labeled with technetium and rhenium isotopes using known chelation complexes. The amino acid compounds disclosed herein have a high specificity for target sites when administered to a subject in vivo. The labeled amino acid compounds are useful as imaging agents in detecting and/or monitoring tumors in a subject by Positron Emission Tomography (PET) and Single Photon Emission Computer Tomography (SPECT).
Abstract: The present invention provides methods for measuring the metabolism of a central nervous system derived biomolecule implicated in a neurological and neurodegenerative disease or disorder. In particular, the method comprises measuring the in vivo metabolism of the biomolecule in the central nervous system of a subject. Also provided is a method for determining whether a therapeutic agent affects the in vivo metabolism of a central nervous system derived biomolecule.
Type:
Application
Filed:
November 10, 2008
Publication date:
June 4, 2009
Applicant:
Washington University in St. Louis
Inventors:
David Holtzman, Randall Bateman, Jungsu Kim
Abstract: In a liquid container used in an automatic analyzer, a float that makes it possible to prevent liquid from making contact with a liquid collection opening of the liquid container to form a film thereon is provided. A float is floated on the liquid surface of a reagent placed in a reagent container for use with an automatic analyzer. The float is equipped with a float body and a required number of buoyancy adjusters. The float body is equipped with a liquid surface cover that covers substantially the entire liquid surface, and a side wall portion positioned so as to project beneath the liquid surface from the liquid surface cover. The side wall portion constitutes a device for the purpose of suppressing swaying motions of the liquid surface cover by making contact with or engaging an inner wall of the reagent container when the reagent sways.
Abstract: The present invention provides methods, systems, and apparatus of improved fiber-based optical parametric oscillators (FOPOs). These oscillators can be used in the creation of short pulsed laser radiation, which are useful in numerous applications, such as characterization of materials and molecules. A relationship between fiber length and performance is realized, where shorter lengths counterintuitively provide greater power and width of output bands. This relationship is used to develop improved FOPOs. For example, fibers of 10 cm or less may be used to obtain superior performance in terms of wavelength tunability (e.g. bandwidth of 200 nm and greater) and output power (e.g. pulse power of 1 nJ). Other realized relationships between length and wavelength position of output bands are also used to select the wavelength range output from the FOPO. The diameter of the fiber may be selected to provide positioning (e.g. a centering) of the range of attainable output wavelengths.
Type:
Application
Filed:
November 20, 2008
Publication date:
June 4, 2009
Applicant:
Regents of the University of California
Inventors:
Jay E. Sharping, Mark Foster, Alexander Gaeta
Abstract: The present invention provides systems for isolating, characterizing, and modulating brain dendritic cells. The invention may allow a better understanding of and opportunities to modulate neurodevelopmental processes (such as, for example, neurogenesis) and neurological diseases (such as, for example, Alzheimer's Disease).
Type:
Application
Filed:
September 15, 2008
Publication date:
June 4, 2009
Applicant:
The Rockefeller University
Inventors:
Karen Bulloch, Bruce McEwen, Ralph Steinman, Ulrike Waltraud Kaunzner, Jennifer C. Felger, Judit Gal Toth, Melinda M. Miller, Andres C. Gottfried-Blackmore
Abstract: A filter includes a carbon nanotube film. The carbon nanotube film includes a plurality of linear carbon nanotubes, the linear carbon nanotubes being entangled with each other to form a number of micropores, wherein the diameters of the micropores are less than 10 nanometers. The method for making the filter includes the following steps: (a) providing a carbon nanotube array formed on a substrate; (b) removing the carbon nanotube array from the substrate to obtain a raw material of carbon nanotubes; (c) adding the raw material of carbon nanotubes into a solvent to obtain a flocculent structure; and (d) separating the flocculent structure from the solvent and shaping the flocculent structure to obtain a filter.
Type:
Application
Filed:
July 17, 2008
Publication date:
June 4, 2009
Applicants:
Tsinghua University, HON HAI Precision Industry CO., LTD.
Inventors:
Chang-Hong Liu, Ding Wang, Shou-Shan Fan
Abstract: This invention relates to multipotent stem cells, purified from the peripheral tissue of mammals, and capable of differentiating into neural and non-neural cell types. These stem cells provide an accessible source for autologous transplantation into CNS, PNS, and other damaged tissues.
Type:
Application
Filed:
May 5, 2008
Publication date:
June 4, 2009
Applicant:
McGill University
Inventors:
Jean Toma, Mahnaz Akhavan, Karl J. L. Fernandes, Mathieu Fortier, Freda Miller, Andrew Gloster
Abstract: Devices and methods for controlling myopia are provided. The devices and methods relate to the inventors discovery of the relationship between near work, the forces applied to the eye by the eyelids and myopia. The devices include a contact lens comprising a region that disperses force applied to the eye by an eyelid. The devices also include a device designed by measuring first wavefront aberrations of an eye before pre-near work and measuring second measured wavefront aberrations of the eye post-near work. The methods include a method for controlling myopia including identifying optical changes associated with near work and correcting the optical changes with an optical device.
Type:
Application
Filed:
February 14, 2006
Publication date:
June 4, 2009
Applicant:
Queensland University of Technology
Inventors:
Michael Collins, Tobias Buehren, Leo Carney, Brett Davis, D. Robert Iskander, Ross Franklin, Stephanie Buehren
Abstract: Perforin-2 (P2) molecule is a pore forming protein. The 5? untranslated region of the perforin-2 protein controls translational activity. Compositions include the perforin protein and the 5? untranslated region. Methods of use include high-throughput screening assays for identification of therapeutic compounds in treatment of diseases.
Abstract: An organic semiconductor material is provided. The organic semiconductor material includes a polyacene derivative expressed by the following general formula (1): where each of R1 to R10 may be independently the same substituents or different substituents but all of R1, R4, R5, R6, R9 and R10 may never be hydrogen atoms at the same time, and where each of R1 to R10 is at least one kind of substituent selected from the group consisting of an aliphatic hydrocarbon group having a substituent and of which number of carbon atoms ranges of from 1 to 20, an aromatic hydrocarbon group having a substituent, a complex aromatic group having a substituent, a carboxyl group, a hydride, an ester group, a cyano group, a hydroxyl group, a halogen atom and a hydrogen atom. The organic semiconductor material can be dissolved into an organic solvent at low temperature (for example, room temperature) and is suitable for use with a coating process.
Type:
Application
Filed:
February 3, 2009
Publication date:
June 4, 2009
Applicants:
Sony Corporation, National University Corporation Hokkaido University
Abstract: The present provides the improved structure of a chip package, comprising an electrical contact surface of at least a chip configured with a under fill layer, the first solder mask layer, the first metal layer, dielectric material layer, the second metal layer, the second solder mask layer, and metal ball layer, characterized in the electrical contact surfaces among the first metal layer, the second metal layer, and the chip accomplish the electrical connection by employing the contacts of the surfaces of the conducting layers
Type:
Application
Filed:
December 1, 2008
Publication date:
June 4, 2009
Applicant:
Lunghwa University of Science and Technology
Abstract: The present invention relates to the production and use of phosphate-specific marker ions labeled with one or more stable oxygen isotopes for analysis of phosphopeptides and other phosphorylated biological and synthetic molecules.
Abstract: The present invention is directed to methods and compositions for inducing, promoting or otherwise facilitating pain relief. More particularly the present invention discloses the combination of a nitric oxide donor and an opioid analgesic in the therapeutic management of vertebrate animals including humans, for the prevention or alleviation of pain, particularly moderate to severe pain. In particular, the nitric oxide donor is a slow-release nitric oxide donor or is formulated to provide a sustained release of a low dose of nitric oxide.
Type:
Application
Filed:
December 23, 2005
Publication date:
June 4, 2009
Applicant:
The University of Queensland
Inventors:
Maree Therese Smith, Craig McKenzie Williams
Abstract: A process for the preparation of a multi-dimensional microporous metal-organic compound comprising the steps of providing a first reactant which includes at least one metal in ionic form, providing a second reactant which includes a bridging organic ligand, grinding the first and second reactants together, wholly or substantially in the absence of solvent.
Type:
Application
Filed:
August 25, 2006
Publication date:
June 4, 2009
Applicant:
The Queen's University of Belfast
Inventors:
Stuart Lloyd James, Ana Lazuen-Garay, Anne Pichon
Abstract: A locally gated graphene nanostructure is described, along with methods of making and using the same. A graphene layer can include first and second terminal regions separated by a substantially single layer gated graphene nanoconstriction. A local first gate region can be separated from the graphene nanoconstriction by a first gate dielectric. The local first gate region can be capacitively coupled to gate electrical conduction in the graphene nanoconstriction. A second gate region can be separated from the graphene nanoconstriction by a second gate dielectric. The second gate region can be capacitively coupled to provide a bias to a first location in the graphene nanoconstriction and to a second location outside of the graphene nanoconstriction. Methods of making and using locally gated graphene nanostructures are also described.
Type:
Application
Filed:
October 31, 2008
Publication date:
June 4, 2009
Applicant:
The Trustees of Columbia University in the City of New York
Inventors:
Barbaros Ozyilmaz, Dmitri Efetov, Pablo Jarillo-Herrero, Melinda Y. Han, Philip Kim
Abstract: The present invention discloses a touch screen system comprising LED infrared transceivers installed at appropriate positions on left and right sides of the screen respectively, and a transmitter end of the transceiver transmits LED infrared waves and spreads spherical waves all over the surface of the screen. If the surface of the screen receives an intrusion from a touch control element, the spherical waves will be interfered, interrupted and reflected, and the wave frequency of the reflection will be detected by the receiver end of the transceiver. After the receiver end has received a reflection signal, the position coordinates of the touch control element can be analyzed through the operation of a core logical unit. A display module is provided for showing the movement path of the touch control element in images or lines, so as to provide a touch screen with low manufacturing cost and long life expectancy.
Type:
Application
Filed:
November 30, 2008
Publication date:
June 4, 2009
Applicant:
Lunghwa University of Science and Technolgy