Abstract: Disclosed herein are methods of enhancing repair of vascular lesions involving the administration of cells in which PAI-1 expression and/or activity has been transiently blocked. Other methods involve the administration of a PAI-1 blocking agent to a subject who has a vascular lesion or is at risk of developing a vascular lesion. Alternatively, a PAI-1 blocking agent and treated cells are co-administered to a subject in need thereof.

Abstract: A battery management system for use with a battery under test is disclosed. The system includes a container configured to hold the battery. The system also includes a stress/strain sensor. The container is configured to hold the battery in fixed relationship with respect to the stress/strain sensor. A processor is coupled to the stress/strain sensor, the processor being configured to measure the stress/strain on the battery and determine the state of health (SOH) of the battery based on the measured stress/strain and previously stored SOH relationship data for the battery. The processor may be configured to determine a state of charge (SOC) of the battery based on the measured stress/strain, the SOH of the battery and previously stored SOC relationship data for the battery.

Abstract: A magnetic recording medium is disclosed in which, on a non-magnetic substrate 1, at least an orientation control layer that controls orientation of a layer immediately above and a vertical magnetic layer in which an easy axis of magnetization is mainly vertically oriented with respect to the non-magnetic substrate are laminated. The orientation control layer includes an Ru-containing layer containing Ru or Ru alloy, and a diffusion prevention layer provided on the Ru-containing layer on the side of the vertical magnetic layer, is made of a material having a melting point of 1500° C. or higher and 4215° C. or lower and formed by a covalent bond or an ionic bond, and prevents thermal diffusion of Ru atoms of the Ru-containing layer.

Abstract: This disclosure relates to a method that involves reacting an azide with an alkyne in the presence of deuterated water and a copper-containing catalyst, thereby forming a deuterated 1,2,3-triazole.

Abstract: The invention relates to the treatment and prevention of type I diabetes. More specifically, the invention relates to compounds that treat or prevent the body's immune system from destroying ?-cells (i.e., insulin-producing cells in the pancreatic islets of Langerhans) by inhibition of JNK2, selective inhibition of JNK2, or inhibition of the expression of the MAPK9 gene or gene product. In one embodiment, the present invention contemplates the diagnosis, identification, production, and use of compounds which modulate MAPK9 gene expression or the activity of the MAPK9 gene product including but not limited to, JNK2, the nucleic acid encoding MAPK9 and homologues, analogues, and deletions thereof, as well as antisense, ribozyme, triple helix, antibody, and polypeptide molecules as well as small inorganic molecules. The present invention contemplates a variety of pharmaceutical formulations and routes of administration for such compounds.

Abstract: A tunable, achromatizing optical system for use with a broadband imaging modality system for imaging objects having a range of longitudinal chromatic aberration (LCA) values. The optical system includes an achromatizing component and a parfocal component, for example, a zoom system. A method for tuning the wavefront curvature of different chromatic components of objects having a range of longitudinal chromatic aberration (LCA) values when imaged by a broadband imaging modality system includes the steps of providing a broadband imaging modality system having an entrance pupil, for imaging an object having longitudinal chromatic aberration; providing a tunable, achromatizing optical system; and varying the focal length of the parfocal component while maintaining a conjugate relationship between the achromatizing component and the entrance pupil of the broadband imaging modality system.

Abstract: Treatment planning methods are provided that determine the variability of relative biological effectiveness (RBE) along a beam line and calculate, among other things, what intensity of hadron beam such as a proton or a carbon ion beam should be applied to achieve a desired biological dose at treatment site of a patient afflicted with a medical condition. Typically, three or four RBE values at three or four corresponding spacially-dispersed intervals along the beam line are calculated. In one embodiment, two RBE values for the spread-out Bragg peak (SOBP) region of the treatment site; one for the proximal section and one for the declining distal section is calculated. A third and different RBE value may be determined for the distal edge region of the SOBP. A fourth value may also be calculated for a pre-SOBP region.

Abstract: A method of determining functional brain connectivity and its application as a biomarker is presented. Brain activity signals are measured to detect a functional connection between a first region of a brain and a second region of said brain. The direction of the functional connection is determined by determining whether said first region excites or inhibits the second region more strongly than the second region excites or inhibits the first region. The functional connectivity is then used as a biomarker to predict the existence of a condition, such as epilepsy or autism. The functional connection may be measured while said brain is in a resting state.

Abstract: The system for detecting volatile organic compounds (VOCs) of this present invention comprises a detecting material made by blending a nano-material and a conductive polymer. The system for detecting VOCs presents the property of high sensitivity, high sensing accuracy, quick response, and real-time VOC detecting, and is demonstrated in the present work for commercialization usage. The system for detecting VOCs can be easily operated to detect VOC without electronic detecting method, and hence this invention can reduce a lot of operation energy and procedure. Furthermore, when adding inorganic nanoparticles, the area of VOC exposure of this invention is increased and the molecular morphology variation of the detecting material is enhanced, and hence the detecting activity of the system for detecting VOCs is improved.

Abstract: The procedure of dielectric electrophoresis (dielectrophoresis or DEP) utilizes field-polarized particles that move under the application of positive (attractive) and/or negative (repulsive) applied forces. This invention uses negative dielectric electrophoresis (negative dielectrophoresis or nDEP) within a microchannel separation apparatus to make particles move (detached) or remain stationary (attached). In an embodiment of the present invention, the nDEP force generated was strong enough to detach Ag-Ab (antigen-antibody) bonds, which are in the order of 400 pN (piconewtons) while maintaining the integrity of the system components.

Abstract: Devices and methods are provided for a nanocomposite having a phase change polymer matrix and conductive nanoparticles to provide greatly enhanced responsivity to temperature and/or humidity. A sensing film includes carbon nanotubes (CNTs) and the polymer. Operation near the transition temperature increases the TCR by over an order of magnitude, thus providing a new platform for devices such as IR sensors, bolometers and imaging elements, MEMS devices, compensating or uncompensated circuit elements and other electronic devices. Nanocomposite films may be under about one micron thick, and coatings, constant environment chambers or mounts, and other engineered improvements and variations may be provided to further enhance the response, range, response times or sensitivity of the film-based devices. One embodiment employs a nanocomposite film under one micron in thickness to operate as an uncooled but highly sensitive infrared bolometer under ambient conditions.

Abstract: A computer-based method of creating a gene expression barcode includes the steps of determining an intensity of expression for each gene in a set of genes in a plurality of samples for at least one type; selecting genes in the set of genes that have at least two expression modes, based on the intensity; and creating a gene expression reference barcode, wherein each barcode bar corresponds to a selected gene and wherein the bar value is coded according to whether an intensity value for a selected gene is below or above a threshold value. The gene expression reference barcodes may then be compared with a similarly created barcode for a sample, for the purposes of identifying the sample, diagnosing a disease, and/or predicting a prognosis of a disease.

Abstract: An apparatus for inhibiting melatonin synthesis in a horse comprises a blinker having an internal surface of which at least a part is diffusing. A source of light is positioned for direction into the horse's eye by the diffusing-surface. The light source and diffusing surface are configured such that the light directed into the horse's eye is blue.

Abstract: The present disclosure includes an electrochemical proximity assay (ECPA) which leverages two aptamer or antibody-oligonucleotide probes and proximity-dependent DNA hybridization to move a redox active molecule near an electrically conductive base. The ECPA of the present disclosure produces rapid, quantitative results, enabling point-of-care use in the detection of biomarkers of disease.

Abstract: Disclosed are an articulated hydraulic machine supporting, control system and control method for same. The articulated hydraulic machine has an end effector for performing useful work. The control system is capable of controlling the end effector for automated movement along a preselected trajectory. The control system has a position error correction system to correct discrepancies between an actual end effector trajectory and a desired end effector trajectory. The correction system can employ one or more absolute position signals provided by one or more acceleration sensors supported by one or more movable machine elements. Good trajectory positioning and repeatability can be obtained. A two joystick controller system is enabled, which can in some cases facilitate the operator's task and enhance their work quality and productivity.

Abstract: A magnetic device includes a pinned magnetic layer having a first fixed magnetization vector with a first fixed magnetization direction. The magnetic device also includes a free magnetic layer having a variable magnetization vector having at least a first stable state and a second stable state. The magnetic device also has a first non-magnetic layer and a reference. The first non-magnetic layer spatially separates the pinned magnetic layer and the free magnetic layer. The magnetic device also includes a second non-magnetic layer spatially separating the free magnetic layer and the reference magnetic layer. A magnetic tunnel junction, located below the pinned magnetic layer, is formed by the free magnetic layer, the second non-magnetic layer, and the reference magnetic layer. Application of a current pulse, having either positive or negative polarity and a selected amplitude and duration, through the magnetic device switches the variable magnetization vector.

Abstract: A first device is provided. The first device includes a print head, and a first gas source hermetically sealed to the print head. The print head further includes a first layer further comprising a plurality of apertures, each aperture having a smallest dimension of 0.5 to 500 microns. A second layer is bonded to the first layer. The second layer includes a first via in fluid communication with the first gas source and at least one of the apertures. The second layer is made of an insulating material.

Abstract: This invention relates to synthetic oligo- or multivalent beta-1-2-linked mannooligosaccharide compounds and to their use for modulating T helper (Th) and T regulatory (Treg) cell-mediated immune responses.

Abstract: Disclosed herein are methods and compositions for reducing the recurrence of prostate cancer and for treating prostate cancer.

Abstract: The present invention provides methods for the generation of xenochimaeric animals; for example, xenochimaeric mice, comprising bone marrow progenitor cells and tumors from a heterologous animal. In some aspects, the invention provides xenochimaeric mice bearing humanized bone marrow and human tumors. Such animals are a model system for the study of human tumor stroma, for drug discovery, and for the treatment of human cancers.