Abstract: A method of identifying the ALL molecular subtype with rearrangements within the KMT2A gene was disclosed, which consists in measuring the ratio of the intensity of the Raman 1040/1008 cm?1 Raman bands in leukemia cells (lymphoblasts) isolated from the peripheral blood (when blastosis >90%) or bone marrow of patients during the diagnosis of acute lymphoblastic leukemia, and fixed with an aldehyde reagent.

Abstract: The present invention relates to a sulfonated polystyrene derivative of formula I for use in the treatment and/or prophylaxis of cat flu, especially infection caused by feline calicivirus or feline herpesvirus, alone or in combination therapy.

Abstract: A multifunctional hydrogel hybrid material and a method of its preparation and use in the treatment or prophylaxis of bone tissue loss is disclosed.

Abstract: The invention discloses the method of differentiating human induced Pluripotent Stem cells (iPS cells) to obtain pigmented cells which produce melanin. The protocol described is much more efficient than any other method used to obtain melanin in vitro.

Abstract: A method for synthesising a molecular magnetic material from a paramagnetic reactant including a d-electron metal in a paramagnetic form, a diamagnetic reactant comprising a d-electron metal in a diamagnetic form, and at least one donor of cyanide (CN—) ligands being a separate compound and/or contained in the paramagnetic reactant and/or in the diamagnetic reactant.

Abstract: The subject of the invention is the method of detecting and diagnosing the progression of diabetes using Raman spectroscopy which involves the examination of the changes in the composition of urinary extracellular vesicles which confirm the existence of the condition and its progression. The invention can be applied in clinical practice, in particular in the early clinical diagnostics of diabetes and in the monitoring of its progression, in particular diabetic nephropathy and advanced renal impairment caused by diabetes.

Abstract: The present invention relates to the reduction of the side-effects induced by tetrabenazine or other inhibitors of vesicular monoamine transporter (VMAT), in the treatment of central nervous system disorders such as Huntington's disease, L-DOPA-induced dyskinesias in Parkinson's disease, Tourette's syndrome or tardive dyskinesia. The invention comprises administering to a patient in need thereof an effective amount of activates selective serotonin 5-HT1A receptors agonist, whereby the side-effects of depression or Parkinsonism induced by tetrabenazine or other VMAT inhibitors are minimized.

Abstract: The invention relates to a method for reconstruction of an image of a morphometric parameter being a ratio of the frequency of annihilation of an electron with a positron to three and two quanta. The device for imaging the interior of the studied object comprises a series of TOF-PET detection modules (110), a data acquisition subsystem (111), a data selection subsystem (113) configured so as to record and identify all types of quanta emitted from the studied object after administration of an isotopic marker, the data processing system being characterised in that it allows for reconstructing (121, 123, 131, 133, 141) and visualising (143) of a ?3?(x,y,z) image of the ration of two-quantum and three-quantum annihilations without the necessity to measure the deexcitation quanta.

Abstract: Carbogel anode materials and method for their preparation are disclosed. The described carbogels exhibit, at a temperature of 20° C., an electrical conductance of at least 0.5 S/cm and a reversible electrochemical capacity in relation to lithium of at least 350 mAh/g under a C/2 discharge current, enabling their use for preparation of anode materials, particularly those intended for preparation of lithium-ion cells.

Abstract: The invention provides a modular modelling kit for drawing geometric structures using a handheld 3D printing pen, comprising construction modules (1), and is characterized in that each construction module (1) has a basically flat base (2) and at least one substantially vertical post (4) protruding from the base (2), having a contact point (4a).

Abstract: LKMNO cathode materials based on a lithium-manganese spinel modified synergetically with potassium and nickel, and a method of production thereof are disclosed. The LKMNO cathode materials are characterised by a reversible gravimetric capacity in relation to lithium of at least 250 mAh/g after 80 operation cycles under a current load of 1 C, so that they are suitable for application in lithium-ion batteries with a high energy density.

Abstract: A method for simultaneous removal of NO and carbonic particles and inorganic dust from flue gases in a reactor with a catalyst for direct decomposition of nitric oxide located on a metallic monolith, includes tangential introduction of flue gases to the reactor circumference. Flue gases flow rotationally and downwards in the reactor in contact with an undulating surface of metallic foil located on an inner wall of the reactor chamber and in contact with the catalyst on a spiral band falling to the lower part of the reactor, and next flue gases jet direction counter-currently to a cylindrical inner chamber containing slices of the monolithic catalyst disturbing laminar flow of the flue gases jet. The reactor arrangement provides for simultaneous removal of NO and carbon particles and inorganic dust from flue gases.

Abstract: Pharmaceutical composition comprising an aqueous solution of a taxane and an aqueous solution of a hydrophobic statin intended for use in treatment or prevention of human melanoma.

Abstract: A device for producing polymer films having a predefined spatial structure. The device includes: a linear stage, a platform for a substrate, a cylinder for spreading a polymer solution layer over the substrate to deposit a polymer film onto the substrate, a cylinder height adjustment system, a control system for adjusting a height and tilt of the cylinder in relation to the substrate, a controllable voltage source, one or more metallic electrodes fixed onto the cylinder. The substrate onto which the polymer film is deposited is conductive for electric current. Electric voltage from the controllable voltage source is applied between the metallic electrode and the substrate during deposition of the polymer film onto the substrate.

Abstract: A Time-of-Flight Positron Emission Tomography (TOF-PET) tomography insert. The insert includes detection modules and photoelectric converters. Each of the photoelectric converters is connected to an electronic signal processing circuit protected by a housing and comprising an electronic signal processing unit and a computer operable to control the electronic signal processing unit and to reconstruct and store images. Each of the detection modules further includes a liquid marker visible in a magnetic resonance image. The insert also includes a liquid marker device visible in the magnetic resonance image. Adjacent detection modules are detachably connected via coupling elements.

Abstract: The invention relates to a method for reconstruction of an image of a morphometric parameter being a ratio of the frequency of annihilation of an electron with a positron to three and two quanta. The device for imaging the interior of the studied object comprises a series of TOF-PET detection modules (110), a data acquisition subsystem (111), a data selection subsystem (113) configured so as to record and identify all types of quanta emitted from the studied object after administration of an isotopic marker, the data processing system being characterised in that it allows for reconstructing (121, 123, 131, 133, 141) and visualising (143) of a ?3?(x,y,z) image of the ration of two-quantum and three-quantum annihilations without the necessity to measure the deexcitation quanta.

Abstract: A hybrid tomograph that includes a chamber for examining an object, a TOF-PET tomograph and an MRI tomograph. The MRI tomograph has a magnet for producing a magnetic field and a receiving-transmitting coil. The TOF-PET tomograph has polymer scintillation strips to transmit scintillation photons outside the magnet of the MRI tomograph and outside the chamber of the hybrid TOF-PET/MRI tomograph. The polymer scintillation strips are arranged circumferentially inside the magnetic field produced by the magnet of the MRI tomograph. Photoelectric converters for converting light signals from the polymer scintillation strips to electrical signals are arranged outside the magnet of the MRI tomograph and outside the chamber of the hybrid TOF-PET/MRI tomograph.

Abstract: An exemplary embodiment describes a method for detection of bacteria and fungi in a sample of biological material, wherein the DNA contained in the sample of biological material is subjected to amplification in multiplex real-time PCR, with the use of primers specific for bacteria in the first stage and primers specific for fungi, and in the second stage, the resulting DNA is amplified using primers and probes differentiating fungi into a group of mold fungi and yeast fungi and bacteria into Gram-positive and Gram-negative bacteria. Another exemplary embodiment refers to oligonucleotide primers for the detection of bacteria and fungi by PCR and a kit for simultaneous detection of bacteria and fungi.

Abstract: A method for preparation of high-quality graphene on the surface (0001) of silicon carbide by superficial graphitisation of the compound in a stream of silicon atoms from an external sublimation source is disclosed.

Abstract: A method for reconstructing multi-tracer metabolic and morphometric images. The method includes the steps of: (a) receiving a plurality of events from positron annihilation centers obtained during measurements conducted by TOF-PET tomography; (b) reconstructing the time coordinates and the three-dimensional spatial coordinates for the plurality of events; (c) determining a common decay plane for gamma quanta originating from the positron-electron annihilation; (d) transforming the three-dimensional spatial coordinates for the gamma quanta to a two-dimensional frame of reference of the common decay plane; (e) determining the time coordinates and the spatial coordinates of a place of the annihilation in the common decay plane; and (f) transforming the time coordinates and the spatial coordinates of the place of the annihilation in the two-dimensional frame of reference of the common decay plane to three-dimensional spatial coordinates in a detector coordinate system.