Abstract: The use of cobalt porphyrins for the manufacture of an agent for mobilizing bone marrow cells to peripheral blood, preferably used to treat congenital neutropenia, for the treatment and prevention of neutropenia caused by chemotherapy, radiotherapy and pharmacologically-induced neutropenia, for the treatment of acute myeloid leukemia, acute lymphocytic leukemia, myelodysplastic syndromes, and to increase the amount of circulating hematopoietic stem cells in peripheral blood for subsequent isolation in the process of apheresis and allogeneic or autologous transplantation.
Type:
Grant
Filed:
June 26, 2018
Date of Patent:
June 25, 2019
Assignee:
UNIWERSYTET JAGIELLONSKI
Inventors:
Agata Szade, Krzysztof Szade, Alicja Jozkowicz, Jozef Dulak
Abstract: New composition of polymeric scintillator was revealed, which can be used particularly in medical diagnostics especially in productions of CT scanners, PET scanners and SPECT scanners.
Type:
Grant
Filed:
June 8, 2015
Date of Patent:
June 25, 2019
Assignees:
UNIWERSYTET JAGIELLONSKI, UNIWERSYTET ROLNICZY IM. HUGONA KOLLATAJA W KRAKOWIE
Inventors:
Anna Wieczorek, Andrzej Danel, Tomasz Uchacz, Pawel Moskal
Abstract: 1,2,3-triazolyl cyclohexanol derivatives have been disclosed and their use as ligands accelerating the copper(I)-catalyzed azide-alkyne cycloaddition and the zinc(II)-catalyzed azide-nitrile cycloaddition.
Type:
Grant
Filed:
June 7, 2016
Date of Patent:
April 2, 2019
Assignee:
UNIWERSYTET JAGIELLONSKI
Inventors:
Przemyslaw Szafranski, Patryk Kasza, Marek Cegla
Abstract: Carbogel anode materials and method for their preparation are disclosed. The described carbogels exhibit, at a temperature of 20° C., an electrical conductance of at least 0.5 S/cm and a reversible electrochemical capacity in relation to lithium of at least 350 mAh/g under a C/2 discharge current, enabling their use for preparation of anode materials, particularly those intended for preparation of lithium-ion cells.
Type:
Application
Filed:
February 3, 2017
Publication date:
March 7, 2019
Applicant:
UNIWERSYTET JAGIELLONSKI
Inventors:
Monika BAKIERSKA, Marcin MOLENDA, Agnieszka CHOJNACKA, Michal SWIETOSLAWSKI
Abstract: A nanocomposite material with antimicrobial properties, based on cellulose packed with a mineral filler (zeolite) exchanged with silver, characterised in that the mineral filler is made up of Y-type zeolites, while silver occurs in a form bound with the zeolite matrix in the form of cations and, optionally, nanoparticles of reduced silver, as well as a method for preparation of such a material and its application for the wrapping of plants, works of art, archives and antique objects, as well as food, pharmaceuticals and animal fodder.
Type:
Grant
Filed:
May 9, 2015
Date of Patent:
January 8, 2019
Assignees:
Uniwersytet Jagiellonski, Instytut Inzynierii Chemicznej Pan
Inventors:
Joanna Lojewska, Tomasz Lojewski, Jacob L. Thomas, Roman J. Jedrzejczyk, Dominika Pawcenis, Barbara Gil, Jakub M. Milczarek, Katarzyna Turnau, Andrzej Kolodziej
Abstract: The present invention is a device and method for the non-invasive detection of hazardous materials in an aquatic environment, wherein the device comprises a sealed housing, in which there is a fast neutron generator (101) surrounded by ? particle detectors (106), and gamma quantum detector (111), wherein the fast neutron generator (101) emits neutrons in the direction of the tested object (107) through the neutron and/or gamma quanta guide (108), and the gamma quanta detector records gamma quanta emitted by the nuclei of the tested object (107) transmitted through neutron and/or gamma quanta guide (110).
Abstract: A monolithic catalyst for simultaneous removal of NOx and carbon particles, especially from off-gases of carbon power plants contains the monolith is made from acid-proof austenitic steel. The catalyst is a two-phase one; moreover, it contains the phases NiFe2O4 and Fe2O3(Mh) with spinel structure, and these phases form microcrystallites, additionally containing Mn. The manner of production of the monolithic catalyst for simultaneous removal of NOx and carbon particles, especially from off-gases of carbon power plants depends on the monolith is subject to oxidation after which the resulting oxide layers are washed with the solution of nickel salts; later the monolith is baked in the oxidising atmosphere with the view to inserting nickel ions into the oxide layer; finally this obtained oxide layers are subject to reduction.
Type:
Grant
Filed:
June 5, 2014
Date of Patent:
October 23, 2018
Assignee:
UNIWERSYTET JAGIELLONSKI
Inventors:
Mieczyslawa Najbar, Jaroslaw Dutkiewicz, Tomasz Wilkosz, Elzbieta Bielanska, Aleksandra Weselucha-Birczynska, Józef Camra, Janusz Danko, Jakub Bartyzel
Abstract: A method for determining parameters of reaction of a gamma quantum within a scintillation detector of a PET scanner, wherein the signal measured by the scintillator is transformed in at least one photomultiplier into an electric measured signal.
Abstract: The subject of the invention is use of block polymers with a block of poly(3-methacryloylpropyltrimethylammonium chloride) to direct neutralization of heparin, especially unfractionated heparin and low molecular weight heparins in the blood and other body fluids.
Type:
Grant
Filed:
June 9, 2016
Date of Patent:
August 21, 2018
Assignees:
UNIWERSYTET JAGIELLONSKI, UNIWERSYTET MEDYCZNY W BIALYMSTOKU
Inventors:
Andrzej Mogielnicki, Bartlomiej Kalaska, Dariusz Pawlak, Emilia Sokolowska, Maria Nowakowska, Krzysztof Szczubialka, Kamil Kaminski
Abstract: The method of the invention allows confirmation of infections caused by Streptococcus agalactiae bacterial species. The method employs a specific reaction of immunoreactive proteins obtained from clinical isolates of Streptococcus agalactiae with antibodies present in the serum of patients.
Type:
Grant
Filed:
March 28, 2014
Date of Patent:
August 14, 2018
Assignees:
Uniwersytet Jagiellonski, Instytut Immunologii I Terapii Doswiadczainej Im. Ludwika Hirszfelds Pan
Inventors:
Monika Brzychczy-Wloch, Sabina Górska, Ewa Brzozowska, Andrzej Gamian, Piotr Heczko
Abstract: A detector device for determining a position of reaction of gamma quanta, the device comprising: a detection layer comprising: at least one polymeric or inorganic scintillator (12, 22) for absorbing gamma quanta and for emitting and propagating scintillation photons; and photoelectric converters (14,24) for converting light signals of the scintillation photons into electric signals; and at least one additional layer comprising: strips of material (13, 23) for absorbing the scintillation photons and for emitting and propagating secondary photons; and photoelectric converters (15, 25) for converting the light signals for the scintillation photons into electric signals.
Abstract: The invention relates to biocompatible polysaccharide-based nanocapsule templated on oil core of diameter not exceeding 1 ?m, stabilized without low molecular weight surfactants. The nanocapsule shows long-term stability in an aqueous suspension and is able to highly efficient encapsulation of hydrophobic compounds.
Abstract: A DNA aptamer was obtained which has an affinity for His-tag, and contains a nucleotide sequence selected from SEQ ID No. 1 and SEQ ID No. 2, which has clear applications.
Type:
Grant
Filed:
May 17, 2014
Date of Patent:
July 17, 2018
Assignee:
UNIWERSYTET JAGIELLONSKI
Inventors:
Filip Bartnicki, Ewa Kowalska, Katarzyna Pels, Wojciech Strzalka
Abstract: The use of cobalt porphyrins for the manufacture of an agent for mobilizing bone marrow cells to peripheral blood, preferably used to treat congenital neutropenia, for the treatment and prevention of neutropenia caused by chemotherapy, radiotherapy and pharmacologically-induced neutropenia, for the treatment of acute myeloid leukemia, acute lymphocytic leukemia, myelodysplastic syndromes, and to increase the amount of circulating hematopoietic stem cells in peripheral blood for subsequent isolation in the process of apheresis and allogeneic or autologous transplantation.
Type:
Grant
Filed:
May 9, 2015
Date of Patent:
July 3, 2018
Assignee:
UNIWERSYTET JAGIELLONSKI
Inventors:
Agata Szade, Krzysztof Szade, Alicja Jozkowicz, Jozef Dulak
Abstract: A system for acquisition of tomographic measurement data from measurement signals (S) of positron emission tomography (PET) or single-photon emission computed tomography (SPECT) detectors, the system comprising: a front-end electronic assembly (2) configured to convert the measurement signals (S) into digital and analog signals (DAS); a measurement electronics assembly (3) comprising time to digital converter (TDC) modules (31) configured to determine times (T) of pulses in digital signals (DS).
Type:
Grant
Filed:
August 29, 2014
Date of Patent:
June 26, 2018
Assignee:
UNIWERSYTET JAGIELLONSKI
Inventors:
Grzegorz Korcyl, Pawel Moskal, Marcin Kajetanowicz, Marek Palka
Abstract: Coordination polymers of MOF type, comprising a repeating unit of the general formula [M2(dcx)2L2], wherein M represents a metal cation (M2+), dcx represents an anion of a dicarboxylic acid and L represents a neutral molecule of hydrazone. A method for preparation of coordination polymers of MOF type, wherein in the first step a compound of aldehyde or ketone group is condensed with a hydrazide, and in the second step the condensation product is reacted using a metal compound and a dicarboxylic acid. An application of coordination polymers of MOF type for the detection, capturing, separation, or storage of molecules, for the fabrication of ionic conductors, for the construction of batteries and fuel cells, as well as drug carriers.
Abstract: The subject of the invention is an N-sulfonic polyallylamine derivative (NSPAH) with Formula 1, wherein R is —SO3? or —H, and n is an integer from 150 to 15000; an application of the N-sulfonic polyallylamine derivative as a medicine, particularly for prevention and treatment of respiratory tract infections caused by the human metapneumovirus (hMPV), respiratory tract infections caused by the human rhinoviruses (HRV), and infections caused by the influenza A virus; as well as a pharmaceutical composition comprising the N-sulfonic polyallylamine derivative and application thereof.
Type:
Grant
Filed:
October 25, 2017
Date of Patent:
March 27, 2018
Assignee:
UNIWERSYTET JAGIELLONSKI
Inventors:
Maria Nowakowska, Krzysztof Szczubialka, Krzysztof Pyrc, Justyna Ciejka, Magdalena Wytrwal, Aleksandra Milewska
Abstract: The invention solves the problem of the development of microporous layered MOF-type manganese materials based on isonicotinate anions, their synthesis and modification with selected ionic substances and application associated with the adsorption of the molecules and the construction of solid superionic conductors.
Abstract: A method allows the simultaneous isolation of bacterial and fungal DNA from blood. The method uses the enzymatic, mechanical and thermal lysis.
Type:
Grant
Filed:
August 23, 2013
Date of Patent:
January 30, 2018
Assignee:
UNIWERSYTET JAGIELLONSKI
Inventors:
Tomasz Gosiewski, Monika Brzychczy-Włoch
Abstract: A tomograph for imaging an interior of an examined object, the tomograph comprising: TOF-PET detection modules configured to register annihilation quanta and deexcitation quanta and a data reconstruction system (103, 203, 303) configured to reconstruct an ortho-positronium to-ps(x,y,z) lifetime image and a probability of production of positronium Ppoz(x,y,z) as a function of position in the imaged object, on the basis of a difference (At) between a time of annihilation (ta) and a time of emission of a deexcitation quantum (te), wherein the TOF-PET detection modules (101, 201, 301) comprise scintillators having a time resolution of less than 100 ps.
Type:
Grant
Filed:
August 29, 2014
Date of Patent:
December 26, 2017
Assignee:
UNIWERSYTET JAGIELLONSKI
Inventors:
Pawel Moskal, Ines Moskal, Gabriel Moskal