Patents Assigned to Uniwersytet Jagiellonski
  • Patent number: 9804274
    Abstract: A hybrid TOF-PET/CT tomograph comprising a detection chamber, gamma radiation detectors, X-ray detectors and a movable X-ray source, wherein the gamma radiation detectors (150, 250, 350, 450, 550) and the X-ray detectors (170, 270, 370, 470, 570) surround the detection chamber (102, 202, 302, 402, 502) around the whole perimeter of the detection chamber (102, 202, 302, 402, 502), and wherein the gamma radiation detectors (150, 250, 350, 450, 550) are located closer to the longitudinal axis (115, 215, 315, 415, 515) of the detection chamber (102, 202, 302, 402, 502) than the X-ray detectors (170, 270, 370, 470, 570), and wherein the gamma radiation detectors (150, 250, 350, 450, 550) comprise polymer strips (151, 251, 351, 451, 551) made of a scintillation material having a density lower than the density of the X-ray radiation detectors (171, 271, 371, 471, 571).
    Type: Grant
    Filed: August 29, 2014
    Date of Patent: October 31, 2017
    Assignee: UNIWERSYTET JAGIELLONSKI
    Inventor: Pawel Moskal
  • Patent number: 9804279
    Abstract: A method for determining parameters of a reaction of a gamma quantum within a scintillator of a PET scanner, comprising transforming a signal measured in the scintillator using at least one converter into an electric measurement signal, wherein the method comprises the steps of: obtaining access to a reference parameters memory (10) comprising reference signals represented in a time-voltage (Wt-v) coordinate system and in a time-amplitude fraction (Wt-f) coordinate system and having associated reaction parameters; sampling the electric measurement signal (S) measured in the time-voltage (PT-V) coordinate system and in the time-amplitude fraction (Pt-f) coordinate system; comparing results of the sampling (PT-V, PM) of the electric measurement signal (S) with the reference signals (Wt-V, Wt-f) and selecting reference shape parameters so that the reference (W) is best fitted to the results of the sampling (PT-V, PM) of the electric measurement signal (S); and determining the parameters of the reaction of the ga
    Type: Grant
    Filed: August 29, 2014
    Date of Patent: October 31, 2017
    Assignee: UNIWERSYTET JAGIELLONSKI
    Inventor: Pawel Moskal
  • Patent number: 9804206
    Abstract: A method for measuring parameters of an analog signal to determine times at which the analog signal (S) crosses predetermined voltage thresholds (VA, VB, VC, VD), the method comprising the steps of: splitting the analog signal (S) into a number of interim signals (SA, SB, SC, SD), the number of the interim signals corresponding to the number of the preset voltage thresholds (VA, VB, VC, VD); providing an FPGA system (10) comprising differential buffers (11 A, 11 B, 11 C, 11 D) with outputs connected to a number of sequences (20A, 20B, 20C, 20D) of delay elements (21, 22, 23), the number of sequences of delay elements corresponding to the number of the preset voltage thresholds (VA, VB, VC, VD); inputting, to an input of each differential buffer (11 A, 11 B, 11 C, 11 D), one interim signal (SA, SB, SC, SD) and a reference voltage corresponding to a particular preset voltage threshold (VA, VB, VC, VD); reading, by means of vector generators (31 A, 31 B, 31 C, 31 D), assigned separately to each of the sequences
    Type: Grant
    Filed: August 29, 2014
    Date of Patent: October 31, 2017
    Assignee: UNIWERSYTET JAGIELLONSKI
    Inventors: Marek Palka, Pawel Moskal
  • Patent number: 9798021
    Abstract: A method for calibration of TOF-PET detectors comprising polymeric scintillator strips and photoelectric converters, wherein cosmic radiation is used as a source of radiation, the method comprising the steps of: recording times of reactions of particles of cosmic radiation with the scintillator strips (101, 411, 421, 511, 521); determining spectra (301) of distribution of differences in the times at which pulses are recorded at ends of the scintillator strips (101, 411, 421, 511, 521) connected to photoelectric converters (102, 103, 412, 413, 422, 423, 512, 513, 522, 523); using the determined spectra (301) to determine timing synchronization constants of the photoelectric converters (102, 103, 412, 413, 422, 423, 512, 513, 522, 523), the constants being related to: delays within the electronics; speed of light propagation within the scintillator strip of the detection module; and resolution of the difference in times of the signals recorded at the ends of the module.
    Type: Grant
    Filed: August 29, 2014
    Date of Patent: October 24, 2017
    Assignee: UNIWERSYTET JAGIELLONSKI
    Inventors: Eryk Czerwinski, Pawel Moskal, Michal Silarski
  • Patent number: 9784778
    Abstract: A system for measuring electrical charge, comprising a capacitance detector (110) connected to a charge integrator (120) being an operational amplifier with capacitance (Cf) feedback (130), wherein the input stage (121) of the charge integrator (120) comprises a pair of symmetrically connected complementary JFET transistors (T1, T2), the gates of which are connected to the input of the charge integrator (120), characterized in that an n-type transistor (T1) of the complementary pair of transistors (T1, T2) has its drain connected to a voltage regulating system (122).
    Type: Grant
    Filed: December 14, 2014
    Date of Patent: October 10, 2017
    Assignee: Uniwersytet Jagiellonski
    Inventors: Zbigniew Sosin, Marek Adamczyk, Maciej Sosin, Pawel Lasko
  • Publication number: 20170260447
    Abstract: New composition of polymeric scintillator was revealed, which can be used particularly in medical diagnostics especially in productions of CT scanners, PET scanners and SPECT scanners.
    Type: Application
    Filed: June 8, 2015
    Publication date: September 14, 2017
    Applicant: Uniwersytet Jagiellonski
    Inventors: Anna Wieczorek, Andrzej Danel, Tomasz Uchacz, Pawel Moskal
  • Publication number: 20170216347
    Abstract: The subject of the invention is an N-sulfonic polyallylamine derivative (NSPAH) with Formula 1, wherein R is —SO3? or —H, and n is an integer from 150 to 15000; an application of the N-sulfonic polyallylamine derivative as a medicine, particularly for prevention and treatment of respiratory tract infections caused by the human metapneumovirus (hMPV), respiratory tract infections caused by the human rhinoviruses (HRV), and infections caused by the influenza A virus; as well as a pharmaceutical composition comprising the N-sulfonic polyallylamine derivative and application thereof.
    Type: Application
    Filed: July 29, 2015
    Publication date: August 3, 2017
    Applicant: UNIWERSYTET JAGIELLONSKI
    Inventors: MARIA NOWAKOWSKA, KRZYSZTOF SZCZUBIALKA, KRZYSZTOF PYRC, JUSTYNA CIEJKA, MAGDALENA WYTRWAL, ALEKSANDRA MILEWSKA
  • Patent number: 9636661
    Abstract: The present invention relates to the method of synthesising large-area oxide catalysts on the base of exfoliated layered aluminosilicates. As layered aluminosilicate are used bentonite, montmorillonite, nontronite and saponite.
    Type: Grant
    Filed: May 2, 2013
    Date of Patent: May 2, 2017
    Assignee: UNIWERSYTET JAGIELLONSKI
    Inventors: Piotr Kustrowski, Piotr Natkanski, Anna Bialas, Paula Janus
  • Patent number: 9504707
    Abstract: The subject of the invention is the use of cationically modified polysaccharides, except for chitosan, for direct neutralization of heparin in blood and physiological fluids in a mammal. Cationic modification of the polysaccharides is achieved using compound containing cationic ammonium groups and/or the polysaccharides are grafted with a polymer containing amine and/or ammonium groups.
    Type: Grant
    Filed: April 20, 2011
    Date of Patent: November 29, 2016
    Assignee: UNIWERSYTET JAGIELLONSKI
    Inventors: Maria Nowakowska, Krzysztof Szczubiałka, Kamil Kamiński
  • Publication number: 20160209449
    Abstract: A method for measuring parameters of an analog signal to determine times at which the analog signal (S) crosses pre-determined voltage thresholds (VA, VB, VC, VD), the method comprising the steps of: splitting the analog signal (S) into a number of interim signals (SA, SB, SC, SD), the number of the interim signals corresponding to the number of the preset voltage thresholds (VA, VB, VC, VD); providing an FPGA system (10) comprising differential buffers (11A, 11B, 11C, 11D) with outputs connected to a number of sequences (20A, 20B, 20C, 20D) of delay elements (21, 22, 23), the number of sequences of delay elements corresponding to the number of the preset voltage thresholds (VA, VB, VC, VD); inputting, to an input of each differential buffer (11A, 11B, 11C, 11D), one interim signal (SA, SB, SC, SD) and a reference voltage corresponding to a particular preset voltage threshold (VA, VB, VC, VD); reading, by means of vector generators (31A, 31B, 31C, 31D), assigned separately to each of the sequences (20A, 20B,
    Type: Application
    Filed: August 29, 2014
    Publication date: July 21, 2016
    Applicant: Uniwersytet Jagiellonski
    Inventors: Marek PALKA, Pawel MOSKAL
  • Publication number: 20160209523
    Abstract: A method for determining parameters of reaction of a gamma quantum within a scintillation detector of a PET scanner, wherein the signal measured by the scintillator is transformed in at least one photomultiplier into an electric measured signal.
    Type: Application
    Filed: August 29, 2014
    Publication date: July 21, 2016
    Applicant: Uniwersytet Jagiellonski
    Inventor: Pawel MOSKAL
  • Publication number: 20160209483
    Abstract: A hybrid TOF-PET/MRI tomograph comprising a TOF-PET tomograph and an MRI tomograph, wherein the TOF-PET tomograph (120) comprises polymer scintillation strips (121) arranged circumferentially inside the working area of the magnetic field of the receiving-transmitting coil (131) of the MRI tomograph (130) and photoelectric converters (122) for converting light signals from the scintillation strips (121) to electrical signals, wherein the photoelectric converters (122) are arranged outside the working area of magnetic field of the MRI tomograph (130).
    Type: Application
    Filed: August 29, 2014
    Publication date: July 21, 2016
    Applicant: UNIWERSYTET JAGIELLONSKI
    Inventor: Pawel MOSKAL
  • Publication number: 20160159790
    Abstract: This invention concerns pyrroloquinoline derivatives as antagonists of 5-HT6 receptors, to methods for the preparation of these compounds and to novel intermediates useful for their synthesis. The invention also relates to the uses of such compounds and compositions, particularly their use in administering them to patients to achieve a therapeutic effect in schizophrenia, anxiety, depression, maniac depression, epilepsy, obsessive compulsive disorders, mood disorders, migraine, Alzheimer's disease, age related cognitive decline, mild cognitive impairment, sleep disorders, eating disorders, anorexia, bulimia, panic attacks, attention deficit hyperactivity disorder, attention deficit disorder, Parkinson's disease, Huntington's disease, withdrawal from abuse of cocaine, ethanol, nicotine or benzodiazepines, pain, obesity and type-2 diabetes, functional bowel disorder, Irritable Bowel Syndrome. The compounds have the general formula (XIV), wherein the symbols have the meanings given in the description.
    Type: Application
    Filed: July 25, 2013
    Publication date: June 9, 2016
    Applicants: Uniwersytet Jagiellonski, Instytut Farmakologii Polskiej Akademii Nauk, Centre National De La Recherche Scientifique, Universite de Montpellier
    Inventors: Pawel ZAJDEL, Katarzyna GRYCHOWSKA, Maciej PAWLOWSKI, Anna PARTYKA, Anna WESOLOWSKA, Andrzej J. BOJARSKI, Piotr POPIK, Tomasz KOS, Grzegorz SATALA, Frederic LAMATY, Evelina COLACINO, Jean MARTINEZ, Giles SUBRA, Xavier BANTREIL
  • Patent number: 9302252
    Abstract: The method of obtaining the CMK-3-type carbon replica, consisting of the introduction of SBA-15-type molecular sieve to a mixture of furfuryl alcohol and a solvent, the subsequent polycondensation of furfuryl alcohol, carbonization of the prepared, composite and removal of the hard template, according to the invention, is characterized in that the reaction of furfuryl alcohol polycondensation is carried out by the precipitation method in a slurry containing SBA-15 silica sieve, water, furfuryl alcohol and concentrated solution of hydrochloric acid in mass ratios, respectively, in the range from 1.00:32.33:1.00:6.65 to 1.00:30.83:2.50:16.64, whereas the ratio of the total mass of furfuryl alcohol and water to the mass of SBA-15 as well as the mass ratio of the concentrated HCl solution to the mass of furfuryl alcohol are kept at the constant value every time.
    Type: Grant
    Filed: February 8, 2013
    Date of Patent: April 5, 2016
    Assignee: UNIWERSYTET JAGIELLONSKI
    Inventors: Piotr Kustrowski, Rafal Janus, Paula Niebrzydowska
  • Patent number: 9162216
    Abstract: The oxide catalyst for the direct NO decomposition to N2 and 02 is deposited on the austenitic acid-proof steel substrate and contains the phase with aFe203 structure and the phase with spinel structure and the lattice parameters close to the lattice parameters of NiFe204. Those phases form the micro-crystallites that additionally contain Cr and Mn and eventually Si. The catalyst according to the invention is manufactured by the at least twice heating of the austenitc acid-proof steel substrate in the atmosphere containing oxygen, up to the temperature from the 600-850° C. range, with the rate of 2-6° C./min, followed by the annealing at that temperature for 2-6 hours.
    Type: Grant
    Filed: August 8, 2012
    Date of Patent: October 20, 2015
    Assignee: UNIWERSYTET JAGIELLONSKI
    Inventors: Mieczyslawa Najbar, Jaroslaw Dutkiewicz, Aleksandra Weselucha, Józef Camra, Stanislaw Janiga, Iga Nazarczuk, Mateusz Kozicki, Pawel Kornelak, Wieslaw Lasocha, Alicja Lasocha
  • Patent number: 9103860
    Abstract: A system for measuring electrical charge, comprising a capacitance detector (110) connected to a charge integrator (120) being an operational amplifier with a capacitance feedback (130), in which the input stage (121) of the charge integrator (120) comprises a pair of symmetrically connected JFET-type transistors (T1; T2), having gates connected to the input of the charge integrator (120).
    Type: Grant
    Filed: February 22, 2012
    Date of Patent: August 11, 2015
    Assignee: UNIWERSYTET JAGIELLONSKI
    Inventors: Zbigniew Sosin, Maciej Sosin, Marek Adamczyk
  • Publication number: 20150174569
    Abstract: The invention relates to visible-light active photocatalytic coatings of titanium oxide (IV) on polymer surfaces, characterized in that are applied to a substrate which is the organic polymer material used in medicine, food and pharmaceutical packaging, and the coating is nanocrystalline titanium oxide (IV) or nanocrystalline titanium oxide (IV) surface-modified with organic compound. The invention also includes a method for the preparation of photocatalytic coatings of titanium oxide (IV) according to the invention, comprising the step of activating the surface of a polymeric material with low-temperature plasma technology, and then the synthesis of nanocrystalline titanium oxide (IV) coating and the modification of the surface layer with organic compounds.
    Type: Application
    Filed: July 22, 2013
    Publication date: June 25, 2015
    Applicant: Uniwersytet Jagiellonski
    Inventors: Wojciech Macyk, Rafal Sadowski, Przemyslaw Labuz, Marta Buchalska
  • Patent number: 8969817
    Abstract: The subject matters of the invention is a matrix device and method for determining the place and time of the gamma quanta interaction as well as the use of the device for determining the place and time of the gamma quanta interaction in positron emission tomography.
    Type: Grant
    Filed: July 15, 2010
    Date of Patent: March 3, 2015
    Assignee: Uniwersytet Jagiellonski
    Inventor: Pawel Moskal
  • Publication number: 20150010459
    Abstract: The method of obtaining the CMK-3-type carbon replica, consisting of the introduction of SBA-15-type molecular sieve to a mixture of furfuryl alcohol and a solvent, the subsequent polycondensation of furfuryl alcohol, carbonization of the prepared, composite and removal of the hard template, according to the invention, is characterised in that the reaction of furfuryl alcohol polycondensation is carried out by the precipitation method in a slurry containing SBA-15 silica sieve, water, furfuryl alcohol and concentrated solution of hydrochloric acid in mass ratios, respectively, in the range from 1.00:32.33:1.00:6.65 to 1.00:30.83:2.50:16.64, whereas the ratio of the total mass of furfuryl alcohol and water to the mass of SBA-15 as well as the mass ratio of the concentrated HCl solution to the mass of furfuryl alcohol are kept at the constant value every time.
    Type: Application
    Filed: February 8, 2013
    Publication date: January 8, 2015
    Applicant: UNIWERSYTET JAGIELLONSKI
    Inventors: Piotr Kustrowski, Rafal Janus, Paula Niebrzydowska
  • Patent number: 8859973
    Abstract: The subject of the invention is a strip device and method for determining the place and time of the gamma quanta interaction as well as the use of the device for determining the place and time of the gamma quanta interaction in positron emission tomography.
    Type: Grant
    Filed: July 16, 2010
    Date of Patent: October 14, 2014
    Assignee: Uniwersytet Jagiellonski
    Inventor: Pawel Moskai