Patents Assigned to Vanderbilt University
  • Compound, composition, and method for detecting caspase activity and/or apoptosis
    Patent number: 10294271
    Abstract: Molecular probe suitable for quantification of caspase activity in vivo using positron emission tomography (PET). Embodiments of the present invention can detect apoptosis in tumors and as a novel, potentially translatable biomarker for predicting response to personalized medicine.
    Type: Grant
    Filed: February 18, 2014
    Date of Patent: May 21, 2019
    Assignee: Vanderbilt University
    Inventors: H. Charles Manning, Matthew R. Hight
  • Apparatus and methods for measuring peripheral venous pressure and applications of same
    Patent number: 10293118
    Abstract: In one aspect, an apparatus for measuring peripheral venous pressure includes a tubing having two ends with one end connectable to a fluid source and the other end connectable to a vein, a fluid controlling device configured to have an on position and an off position, and at least one pressure sensor configured to measure fluid pressures therein. When the fluid controlling device is in the on position, fluid flow in the tubing is allowed to pass through the fluid controlling device, such that the at least one pressure sensor measures both a fluid pressure from the fluid source and a distal venous pressure from the vein. When the fluid controlling device is in the off position, no fluid flow in the tubing is allowed to pass through the fluid controlling device, such that the at least one pressure sensor measures the distal venous pressure from the vein only.
    Type: Grant
    Filed: July 13, 2012
    Date of Patent: May 21, 2019
    Assignee: VANDERBILT UNIVERSITY
    Inventors: Susan Eagle, Kevin Sexton, Colleen Brophy, Kyle Mitchell Hocking
  • Positive allosteric modulators of human melanocortin-4 receptor
    Patent number: 10294214
    Abstract: Disclosed herein are positive allosteric modulators of melanocortin receptor and methods of using such modulators.
    Type: Grant
    Filed: June 7, 2017
    Date of Patent: May 21, 2019
    Assignees: Vanderbilt University, King's College London, Glaxo Group Limited
    Inventors: Roger D. Cone, Michael J. Bishop, Eugene L. Stewart, Lawrence A. Wolfe, Jaques Pantel, Julien Sebag, C. David Weaver, Savannah Williams, Helen Cox, Iain Tough, Luis Diaz Gimenez, Subramanian Baskaran
  • Benzomorpholine and benzomorpholine-substituted compounds as MGLUR4 allosteric potentiators, compositions, and methods of treating neurological dysfunction
    Patent number: 10294222
    Abstract: Compounds which are useful as allosteric potentiators/positive allosteric modulators of the metabotropic glutamate receptor subtype 4 (mGluR4); synthetic methods for making the compounds; pharmaceutical compositions comprising the compounds; and methods of using the compounds, for example, in treating neurological and psychiatric disorders or other disease state associated with glutamate dysfunction.
    Type: Grant
    Filed: September 1, 2017
    Date of Patent: May 21, 2019
    Assignee: Vanderbilt University
    Inventors: P. Jeffrey Conn, Craig W. Lindsley, Andrew Felts
  • Compositions and methods for treating and preventing hyperlipidemia, fatty liver, atherosclerosis and other disorders associated with metabolic syndrome
    Patent number: 10272133
    Abstract: The present invention relates to compositions and methods for treating diseases associated with dyslipidemia, including hypercholesterolemia, hypertriglyceridemia, steatohepatitis, atherosclerosis, obesity, hyperglycemia, metabolic syndrome, and related aspects of and conditions associated with metabolic syndrome. The compositions and methods disclosed herein are useful for regulating the lipid balance (lipid homeostasis) in a subject. Compositions and methods including a Nuclear Transport Modifier may be administered to a subject to modulate the transport of transcription factors, mediated by nuclear import adaptors, into the nucleus of a cell resulting in a decrease in cholesterol and triglyceride levels in the blood and liver, a decrease in atherosclerotic lesion size, a decrease in body weight and in hyperglycemia, a reduction of fatty liver inflammation, and an improvement in liver function.
    Type: Grant
    Filed: November 6, 2017
    Date of Patent: April 30, 2019
    Assignee: Vanderbilt University
    Inventors: Jack J. Hawiger, Ruth Ann Veach, Jozef Zienkiewicz, Yan Liu, Robert D. Collins, Amy S. Major
  • Sequelae of cardiopulmonary bypass-induced pulmonary injury
    Patent number: 10265286
    Abstract: A method for administering citrulline to a patient during surgery without filtration of the hemolysis to reduce the uncoupling of eNOS enzyme dimer that leads to cardiopulmonary bypass-induced pulmonary injury.
    Type: Grant
    Filed: December 22, 2017
    Date of Patent: April 23, 2019
    Assignee: Vanderbilt University
    Inventors: Marshall L. Summar, Frederick W. Barr
  • Antibodies to GRP78
    Patent number: 10259884
    Abstract: The present invention is directed towards isolated antibodies that bind to GRP78.
    Type: Grant
    Filed: June 20, 2017
    Date of Patent: April 16, 2019
    Assignees: Washington University, Vanderbilt University
    Inventors: Dennis E. Hallahan, Heping Yan
  • Robust interferometer and methods of using same
    Patent number: 10261013
    Abstract: Provided are improved optical detection systems and methods for using same, which systems and methods comprise single channel interferometric detection systems and methods for determining a characteristic property of samples. Such interferometric detection systems and methods employ a light beam that impinges two or more discrete zones along a channel, thereby avoiding variations that can result in increases in detection limits and/or measurement errors.
    Type: Grant
    Filed: June 30, 2016
    Date of Patent: April 16, 2019
    Assignee: Vanderbilt University
    Inventors: Darryl J. Bornhop, Michael Kammer
  • Methods and systems for intra-operatively providing anatomical guidance in surgery
    Patent number: 10258275
    Abstract: In one aspect, the present invention relates to a process for intra-operatively providing anatomical guidance in endocrine surgery. In one embodiment, the process includes the steps of illuminating tissues in the neck area of a living subject with a beam of light having a predetermined wavelength, obtaining Raman data from light scattered from the illuminated tissues, finding Raman signatures corresponding to thyroid or parathyroid tissues from the obtained Raman data, and identifying the thyroid or parathyroid tissues from the corresponding Raman signatures.
    Type: Grant
    Filed: December 27, 2016
    Date of Patent: April 16, 2019
    Assignee: VANDERBILT UNIVERSITY
    Inventors: Anita Mahadevan-Jansen, Lisa White, John Phay, Constantine A. Paras, Elizabeth Kanter Bartz, Matthew D. Keller, Nicole Mathews, Jennifer Whisenant Amundson, Isaac J. Pence
  • System and method for endoscopic deployment of robotic concentric tube manipulators for performing surgery
    Patent number: 10238457
    Abstract: An apparatus (20) for performing endoscopic surgery on a patient (12) includes at least two concentric tube manipulators (150) adapted to carry devices (152, 154) for performing a surgical operation. A transmission (200) operates the concentric tube manipulators (150). An endoscope tube (106) has a proximal end portion fixed to the transmission (200). The concentric tube manipulators (150) extend from the transmission (200) through an inner lumen (102) of the endoscope tube (106) and are operable to extend from a distal end (104) of the endoscope tube.
    Type: Grant
    Filed: April 18, 2014
    Date of Patent: March 26, 2019
    Assignee: VANDERBILT UNIVERSITY
    Inventors: S. Duke Herrell, Robert J. Webster, III, Trevor Bruns, Philip J. Swaney, Richard Hendrick
  • Positive allosteric modulators of the muscarinic acetylcholine receptor M4
    Patent number: 10239887
    Abstract: Disclosed herein are tricyclic compounds, including pyrimido[4?,5?:4,5]thieno[2,3-c]pyridazine-8-amine, pyrido[3?,2?:4,5]thieno[3,2-d]pyrimidine-4-amine, pyrazino[2?,3?:4,5]thieno[3,2-d]pyrimidin-4-amine, pyrido[3?,2?:4,5]furo[3,2-d]pyrimidin-4-amine, and pyrimido[4?,5?:4,5]furo[2,3-c]pyridazin-8-amine compounds, which may be useful as positive allosteric modulators of the muscarinic acetylcholine receptor M4 (mAChR M4). Also disclosed herein are methods of making the compounds, pharmaceutical compositions comprising the compounds, and methods of treating neurological and psychiatric disorders associated with muscarinic acetylcholine receptor dysfunction using the compounds and compositions.
    Type: Grant
    Filed: June 22, 2017
    Date of Patent: March 26, 2019
    Assignee: Vanderbilt University
    Inventors: Craig W. Lindsley, P. Jeffrey Conn, Darren W. Engers, Sean Bollinger, James C. Tarr, Paul Spearing, Julie L. Engers, Madeline Long, Thomas M. Bridges
  • Isoquiniline and napthalene-substituted compounds as mGluR4 allosteric potentiators, compositions, and methods of treating neurological dysfunction
    Patent number: 10227343
    Abstract: Compounds which are useful as allosteric potentiators/positive allosteric modulators of the metabotropic glutamate receptor subtype 4 (mGluR4); pharmaceutical compositions comprising the compounds; and methods of using the compounds, for example, in treating neurological and psychiatric disorders or other disease state associated with glutamate dysfunction.
    Type: Grant
    Filed: February 1, 2016
    Date of Patent: March 12, 2019
    Assignee: Vanderbilt University
    Inventors: P. Jeffrey Conn, Craig W. Lindsley, Colleen M. Niswender, Corey R. Hopkins, Joanne Bronson, Yong-Jin Wu, Kyle Emmitte, Joe Panarese, Darren W. Engers, Julie Engers
  • Alphaa-crystallin mimetic peptides and uses thereof
    Patent number: 10220070
    Abstract: This invention relates to ?A-crystallin protein modulating compounds (e.g., phosphomimetic peptides), compositions comprising such modulating compounds, and their use as therapeutics for the treatment and prevention of conditions involving neurodegeneration and neuroinflammation.
    Type: Grant
    Filed: September 18, 2017
    Date of Patent: March 5, 2019
    Assignees: The Regents of the University of Michigan, Vanderbilt University
    Inventors: Patrice E. Fort, Kevin Schey
  • Substituted pyrrolo[3,4-e]indolizines, imidazo[1,2-a]pyrrolo[3,4-e]pyridines, pyrrolo[3,4-e][1,2,4]triazolo[1,5-a]pyridines and pyrrolo[3,4-e][1,2,4]triazolo[4,3-a]pyridines as positive allosteric modulators of muscarinic acetylcholine receptor M1
    Patent number: 10221175
    Abstract: Substituted pyrrolopyridine, imidazopyridine and triazolopyridine compounds having a formula are positive allosteric modulators of the muscarinic acetylcholine receptor M1 (mAChR M1) and the compounds and their pharmaceutical compositions may be useful in treating neurological and psychiatric disorders associated with muscarinic acetylcholine receptor dysfunction. Compounds of the invention may be prepared in several steps from 2-halo-5,6-dihydro-7H-pyrrolo[3,4-b]pyridin-7-one intermediates.
    Type: Grant
    Filed: April 22, 2016
    Date of Patent: March 5, 2019
    Assignee: Vanderbilt University
    Inventors: P. Jeffrey Conn, Craig W. Lindsley, Kyle A. Emmitte, Changho Han, Julie L. Engers, Aaron M. Bender
  • Benzothiazole and benzisothiazole-substituted compounds as mGluR4 allosteric potentiators, compositions, and methods of treating neurological dysfunction
    Patent number: 10221172
    Abstract: Compounds which are useful as allosteric potentiators/positive allosteric modulators of the metabotropic glutamate receptor subtype 4 (mGluR4); synthetic methods for making the compounds; pharmaceutical compositions comprising the compounds; and methods of using the compounds, for example, in treating neurological and psychiatric disorders or other disease state associated with glutamate dysfunction.
    Type: Grant
    Filed: January 13, 2016
    Date of Patent: March 5, 2019
    Assignee: Vanderbilt University
    Inventors: P. Jeffrey Conn, Corey R. Hopkins, Craig W. Lindsley, Colleen M. Niswender, Darren W. Engers, Sean Bollinger
  • Mammalian genes involved in toxicity and infection
    Patent number: 10202615
    Abstract: The present invention relates to cellular proteins that are involved in toxicity and infection or are otherwise associated with the life cycle of one or more pathogens.
    Type: Grant
    Filed: December 11, 2011
    Date of Patent: February 12, 2019
    Assignee: VANDERBILT UNIVERSITY
    Inventors: Donald Rubin, Dana Borden Lacy
  • Method for identifying subjects with increased risk of ST-segment elevation myocardial infarction (STEMI) and identifying subjects likely to respond to particular treatments
    Patent number: 10203322
    Abstract: A method for identifying an increased risk of developing ST-Segment Elevation Myocardial Infarction (STEMI) in a subject involves obtaining a platelet-containing plasma sample from the subject; determining a Prostaglandin E2 (PGE2) phenotype of the platelets of the subject; and identifying the subject has having an increased risk of developing STEMI when the subject has a potentiating phenotype, as compared to the risk of a subject having an inhibitory phenotype.
    Type: Grant
    Filed: January 16, 2018
    Date of Patent: February 12, 2019
    Assignee: Vanderbilt University
    Inventors: Olivier Boutaud, Elias V. Haddad, Eitan Friedman
  • Fused heterocyclic compounds as selective BMP inhibitors
    Patent number: 10196392
    Abstract: The present invention provides small molecule inhibitors of BMP signaling. These compounds may be used to modulate cell growth, differentiation, proliferation, and apoptosis, and thus may be useful for treating diseases or conditions associated with BMP signaling, including inflammation, cardiovascular disease, hematological disease, cancer, and bone disorders, as well as for modulating cellular differentiation and/or proliferation.
    Type: Grant
    Filed: July 17, 2017
    Date of Patent: February 5, 2019
    Assignee: Vanderbilt University
    Inventors: Corey R. Hopkins, Charles C. Hong, Craig W. Lindsley, Darren W. Engers
  • Metabolism probes for therapy and diagnosis
    Patent number: 10189805
    Abstract: Novel 2-substituted glutamylanides useful as modulators of ASCT2 inhibitors. Compounds of the present invention can be used to treat patients suffering from diseases caused or influenced by abnormal ASCT2 transporter dysfunction.
    Type: Grant
    Filed: September 9, 2015
    Date of Patent: January 29, 2019
    Assignee: Vanderbilt University
    Inventors: H. Charles Manning, Michael Schulte
  • Compositions for inhibition of insect sensing
    Patent number: 10188105
    Abstract: In one aspect, the invention relates to chemical modulators of insect olfactory receptors. In particular, compounds and compositions are provided that can inhibit sensory (e.g., host targeting) functions in airborne insects such as mosquitoes. Method of employing such agents, and articles incorporating the same, are also provided. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present invention.
    Type: Grant
    Filed: February 27, 2017
    Date of Patent: January 29, 2019
    Assignee: Vanderbilt University
    Inventors: Laurence Zwiebel, Gregory M. Pask, David C. Rinker, Ian M. Romaine, Gary A. Sulikowski, Paul R. Reid, Alex G. Waterson, Kwangho Kim, Patrick L. Jones, Robert W. Taylor