Patents Assigned to Vanderbilt University
  • Low resource sample processor containing heat-activated surface tension valves
    Patent number: 10190114
    Abstract: Systems and methods are described for isolation, separation and detection of a molecular species using a low resource device for processing of samples. Methods include isolation, separation and detection of whole cells as well as biomolecules including viruses, proteins, nucleic acids, carbohydrates and lipids.
    Type: Grant
    Filed: August 25, 2015
    Date of Patent: January 29, 2019
    Assignee: VANDERBILT UNIVERSITY
    Inventors: Rick Haselton, Nick Adams
  • Positive allosteric modulators of the muscarinic acetylcholine receptor M
    Patent number: 10189857
    Abstract: Disclosed herein are substituted 8-aminothieno[3,2-e][1,2,4]triazolo[4,3-b]pyridazine-7-carboxamide compounds, which may be useful as positive allosteric modulators of the muscarinic acetylcholine receptor M4 (mAChR M4). Also disclosed herein are methods of making the compounds, pharmaceutical compositions comprising the compounds, and methods of treating neurological and psychiatric disorders associated with muscarinic acetylcholine receptor dysfunction using the compounds and compositions.
    Type: Grant
    Filed: September 13, 2017
    Date of Patent: January 29, 2019
    Assignee: Vanderbilt University
    Inventors: Craig W. Lindsley, P. Jeffrey Conn, Darren W. Engers, Bruce J. Melancon, Alison R. Gregro
  • Methods for the production of collagen IV
    Patent number: 10183039
    Abstract: The method of the current disclosure provides for methods of increasing sulfilimine bonds in collagen IV using bromide containing agents and conditions that either promote peroxidasin cross-linking of collagen IV.
    Type: Grant
    Filed: July 14, 2014
    Date of Patent: January 22, 2019
    Assignee: VANDERBILT UNIVERSITY
    Inventors: Billy G. Hudson, Christopher F. Cummings, Gautam Bhave, A. Scott McCall
  • Dual interlocked logic circuits
    Patent number: 10181851
    Abstract: An electronic device with one or more gates that each include first circuit blocks configured for implementing a first N-type logic function and second circuit blocks configured for implementing a second N-type logic function that is a complement of the first N-type logic function. In the electronic device, a number of the of first circuit blocks and a number of the second circuit blocks are the same. Further, the first circuit blocks and the second circuit blocks each have a block feedback node, a block output node, and one or more block input logic nodes. Also, the block feedback node for each one of the first circuit blocks is singly coupled to the block output node of one of the second circuit blocks and the block output node of the one of the first circuit blocks is singly coupled to the block feedback node of another of the second circuit blocks.
    Type: Grant
    Filed: March 20, 2018
    Date of Patent: January 15, 2019
    Assignee: Vanderbilt University
    Inventors: Jeffrey Maharrey, Jeff Kauppila, Dennis Ball, W. Timothy Holman, Lloyd W. Massengill
  • Compression device, system, and method for decreasing abdominal venous pooling
    Patent number: 10179083
    Abstract: A compression device can include an adjustable belt, an inflation bladder, and a control module. The adjustable belt can be sized to fit circumferentially around a subject's abdomen. The inflatable bladder and the control module can be secured to the belt. The control module can include a housing that encloses at least one of a pump, a pressure relief valve, and a controller. The pump and the pressure relief valve can be in fluid communication with the bladder. The pump can be configured to inflate the bladder to a pre-determined pressure and apply a compressive pressure to the subject's abdomen. The pressure relief valve can be configured to decrease the pressure within the bladder. The controller can be configured to automatically adjust the compressive pressure in response to a change in the subject's posture. The controller can be in electrical communication with the pump and the pressure relief valve.
    Type: Grant
    Filed: November 4, 2013
    Date of Patent: January 15, 2019
    Assignee: Vanderbilt University
    Inventors: Franz Baudenbacher, Italo Biaggioni, Rene Harder, Andre Diedrich, Luis Okamoto
  • Enhanced method for correcting data for deformations during image guided procedures
    Patent number: 10178955
    Abstract: Systems and methods are provided for collecting and processing physical space data for use while performing an image-guided surgical (IGS) procedure. A method includes performing a rigid alignment of a computer model of a non-rigid structure of interest in a patient and surface data in a patient space associated with at least a portion of said non-rigid structure, and computing a deformation of the computer model that provides a non-rigid alignment of said computer model and an organ geometric representation of data, said deformation computed using a set of boundary conditions and field variables defined for said computer model based on said rigid alignment and a parameterization function.
    Type: Grant
    Filed: August 6, 2013
    Date of Patent: January 15, 2019
    Assignee: VANDERBILT UNIVERSITY
    Inventors: Daniel Caleb Rucker, Michael I. Miga
  • Polymeric nanoparticles
    Patent number: 10172956
    Abstract: The presently-disclosed subject matter includes nanoparticles that comprise a plurality of assembled polymers. In some embodiments the polymers comprise a first block that includes hydrophilic monomers, the first block substantially forming an outer shell of the nanoparticle, and a second block that includes cationic monomers and hydrophobic monomers, the second block substantially forming a core of the nanoparticle. In some embodiments a polynucleotide is provided that is bound to the cationic monomers of the nanoparticle. The presently-disclosed subject matter also comprises methods for using the present nanoparticles to include RNAi in a cell as well as methods for making the present nanoparticles.
    Type: Grant
    Filed: October 28, 2013
    Date of Patent: January 8, 2019
    Assignee: Vanderbilt University
    Inventors: Craig L. Duvall, Christopher E. Nelson, James Kintzing, Joshua M. Shannon, Mukesh K. Gupta, Scott A. Guelcher, Elizabeth J. Adolph, Jeffrey M. Davidson
  • Ferroelectric agglomerates and methods and uses related thereto
    Patent number: 10167193
    Abstract: Disclosed herein are ferroelectric agglomerates and methods related thereto. In certain aspects, the ferroelectric agglomerates can be made from particles that have been treated with SbX3 or SbX5, wherein X is a halogen. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present invention.
    Type: Grant
    Filed: September 23, 2015
    Date of Patent: January 1, 2019
    Assignee: Vanderbilt University
    Inventors: Sandra J. Rosenthal, Toshia Wrenn
  • Methods of preventing platelet activation
    Patent number: 10166248
    Abstract: A method of preventing or reducing the occurrence of malondiadehyde and/or levuglandin protein modification in a subject in need thereof, comprising administering to said subject an effective amount of at least one ?-KA scavenger compound, or a pharmaceutically acceptable salt thereof.
    Type: Grant
    Filed: December 21, 2016
    Date of Patent: January 1, 2019
    Assignee: Vanderbilt University
    Inventors: John A. Oates, Olivier Boutaud, Irene Zagol-Ikapitte
  • Gamma ray spectroscope for determining a composition of an asteroid or the regolith of the asteroid
    Patent number: 10162065
    Abstract: Disclosed and described herein are embodiments and methods of use of a gamma ray spectroscope. In one aspect the gamma ray spectroscope comprises a scintillator for receiving radiation and a solid-state photomultiplier for detecting and amplifying light emitted by the scintillator in response to the received radiation, wherein an electrical output signal is provided by the photomultiplier that is proportional to the received radiation.
    Type: Grant
    Filed: January 27, 2017
    Date of Patent: December 25, 2018
    Assignee: Vanderbilt University
    Inventors: Keivan Stassun, Arnold Burger
  • WDR5 inhibitors and modulators
    Patent number: 10160763
    Abstract: Described are compounds that disrupt the WDR5-MLL1 protein-protein interaction, pharmaceutical compositions including the compounds, and methods of using the compounds and compositions for treating disorders and conditions in a subject.
    Type: Grant
    Filed: September 13, 2017
    Date of Patent: December 25, 2018
    Assignee: Vanderbilt University
    Inventors: Stephen W. Fesik, Shaun R. Stauffer, William P. Tansey, Edward T. Olejniczak, Jason Phan, Feng Wang, KyuOk Jeon, Rocco D. Gogliotti
  • ANTI-FACTOR XI MONOCLONAL ANTIBODIES AND METHODS OF USE THEREOF
    Publication number: 20180355057
    Abstract: Compositions and methods for inhibiting thrombosis without compromising hemostasis are described. Compositions include anti-factor XI monoclonal antibodies (aXIMabs) capable of binding to an epitope on the heavy chain of human FXI, particularly the A3 domain of the heavy chain of human FXI. Compositions also include epitope-binding fragments, variants, and derivatives of the monoclonal antibodies, cell lines producing these antibody compositions, and isolated nucleic acid molecules encoding the amino acid sequences of the antibodies. The disclosure further includes pharmaceutical compositions comprising the disclosed anti-factor XI monoclonal antibodies, or epitope-binding fragments, variants, or derivatives thereof, in a pharmaceutically acceptable carrier.
    Type: Application
    Filed: July 30, 2018
    Publication date: December 13, 2018
    Applicants: Oregon Health & Science University, Vanderbilt University
    Inventors: Andras Gruber, Erik I. Tucker, Stephen Raymond Hanson, David Gailani
  • Energy balance mechanism for flexure joint
    Patent number: 10149694
    Abstract: Systems and method are described for counterbalancing the force required to deform a flexure joint. The system includes an elastically deformable flexure joint, a control joint, and an energy balance system. The control joint is mechanically linked to the flexure joint such that movement of the control joint causes a corresponding deformation of the flexure joint. The energy balance system provides a spring force to aid movement of the control joint and to overcome an elastic force required to deform the flexure joint.
    Type: Grant
    Filed: September 12, 2014
    Date of Patent: December 11, 2018
    Assignee: Vanderbilt University
    Inventors: Ray A. Lathrop, Robert J. Webster
  • Methods and compositions for vein harvest and autografting
    Patent number: 10149470
    Abstract: The leading cause of graft failure is the subsequent development of intimal hyperplasia, which represents a response to injury that is thought to involve smooth muscle proliferation, migration, phenotypic modulation, and extracellular matrix (ECM) deposition. Surgical techniques typically employed for vein harvest—stretching the vein, placing the vein in low pH, solutions, and the use of toxic surgical skin markers—are shown here to cause injury. The invention therefore provides for non-toxic surgical markers than also protect against stretch-induced loss of functional viability, along with other additives. Devices and compositions for reducing physical stress or protecting from the effects flowing therefrom, also are provided.
    Type: Grant
    Filed: September 27, 2016
    Date of Patent: December 11, 2018
    Assignees: VANDERBILT UNIVERSITY, THE UNITED STATES GOVERNMENT AS REPRESENTED BY THE DEPARTMENT OF VETERNS AFFAIRS
    Inventors: Colleen M. Brophy, Padmini Komalavilas, Joyce Cheung-Flynn, Kyle M. Hocking, Susan S. Eagle
  • Multi-platform modular device
    Patent number: 10148036
    Abstract: A multi-platform modular device including a plurality of platforms or modules. Each module implements a different function and can be connected to another module via a plurality of magnetic contacts. The magnetic contacts can be used for synchronization, communication, and power delivery between the modules.
    Type: Grant
    Filed: June 23, 2017
    Date of Patent: December 4, 2018
    Assignee: Vanderbilt University
    Inventors: Ekawahyu Susilo, Nicolo Garbin, Pietro Valdastri
  • Composite membranes, methods of making same, and applications of same
    Patent number: 10141593
    Abstract: A method of fabricating a composite membrane, includes the steps of: forming a first solution comprising a charged polymer and a first uncharged polymer having a repeat unit of a formula of: where each of X and Y is a non-hydroxyl group; forming a second solution comprising a second uncharged polymer; electrospinning, separately and simultaneously, the first solution and the second solution to form a dual fiber mat; and processing the dual fiber mat to form the composite membrane.
    Type: Grant
    Filed: May 23, 2016
    Date of Patent: November 27, 2018
    Assignee: VANDERBILT UNIVERSITY
    Inventors: Peter N. Pintauro, Andrew Park, Jason Ballengee
  • Coordinating operation of multiple lower limb devices
    Patent number: 10137010
    Abstract: Systems and methods for operating autonomous lower limb devices, including at least one adjustable joint and configured for at least supporting a body are provided. A method includes collecting real-time sensor information associated with the autonomous lower limb device. The method also includes receiving, over a communications link, remote data for at least one other lower limb device configured for supporting the body. The method further includes generating control data for transitioning the autonomous lower limb device from a current state in a current finite state model for operating the autonomous lower limb device to a different state in the current finite state model, where the different state is selected based on the real-time sensor information and the remote data.
    Type: Grant
    Filed: February 26, 2016
    Date of Patent: November 27, 2018
    Assignee: VANDERBILT UNIVERSITY
    Inventors: Michael Goldfarb, Brian Lawson
  • Identification of cattle at risk of high altitude pulmonary hypertension
    Patent number: 10138522
    Abstract: Provided herein are methods and compositions for determining the susceptibility of cattle to High Altitude Pulmonary Hypertension. Also provide are kits and reagents for performing such methods.
    Type: Grant
    Filed: January 21, 2015
    Date of Patent: November 27, 2018
    Assignees: VANDERBILT UNIVERSITY, COLORADO STATE UNIVERSITY RESEARCH FOUNDATION
    Inventors: John H. Newman, Rizwan Hamid, John A. Phillips, Joy Cogan, Timothy N. Holt
  • INTEGRATED THIN-FILM OPTRODE
    Publication number: 20180325379
    Abstract: An optrode may provide a cylindrical substrate two or more electrodes deposited said cylindrical substrate. The cylindrical substrate and electrodes may be coated by an insulating layer with openings or vias over certain portions of the electrodes that may provide a contact for the neural probe or may be utilized to connect lead lines. Manufacturing of an optrode may utilize a jig that secures a cylindrical substrate coated by a conductive material and a resist. A first mask may be positioned in an opening provided by the jig, and the cylindrical substrate may be exposed ions or neutral particles to define one or more electrode patterns. After regions of the resist and conductive material are removed to form the electrodes, a second mask may be utilized to define vias regions in which portions of the electrodes are exposed and uncoated by an insulating layer.
    Type: Application
    Filed: May 7, 2018
    Publication date: November 15, 2018
    Applicants: University of Houston System, Vanderbilt University
    Inventors: John C. Wolfe, Mufaddal Gheewala, Wei-Chuan Shih, Gopathy Purushothaman
  • Organ on chip integration and applications of the same
    Patent number: 10119622
    Abstract: A rotary planar peristaltic micropump (RPPM) includes an actuator having a shaft engaged with a motor such that activation of the motor causes the shaft to rotate, and a bearing assembly engaged with the shaft. The bearing assembly has a bearing cage defining a plurality of spaced-apart openings thereon, and a plurality of rolling-members accommodated in the plurality of spaced-apart openings of the bearing cage, such that when the shaft rotates, the plurality of rolling-members of the bearing assembly rolls along a circular path. The RPPM also includes a fluidic path in fluidic communication with first and second ports. The fluidic path is positioned under the actuator and coincident with the circular path, such that when the shaft of the actuator rotates, the plurality of rolling-members of the bearing assembly rolls along the fluidic path to cause a fluid to transfer between the first and second ports.
    Type: Grant
    Filed: November 29, 2017
    Date of Patent: November 6, 2018
    Assignee: VANDERBILT UNIVERSITY
    Inventors: Frank E. Block, III, Philip C. Samson, Erik M. Werner, Dmitry A. Markov, Ronald S. Reiserer, Jennifer R. Mckenzie, David E. Cliffel, William J. Matloff, Frank E. Block, Jr., Joseph R. Scherrer, W. Hunter Tidwell, John P. Wikswo