Patents Assigned to Vectura Limited
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Patent number: 8182791Abstract: A formulation for an inhaler device comprises carrier particles having a diameter of at least 50 ?m and a mass median diameter of at least 175 ?m; active particles; and additive material to which is able to promote release of the active particles from the carrier particles on actuation of the inhaler device. The formulation has excellent flowability even at relatively high fine particle contents.Type: GrantFiled: April 17, 2001Date of Patent: May 22, 2012Assignee: Vectura LimitedInventors: John Nicholas Staniforth, David Alexander Vodden Morton, Rajbir Gill, Gaetano Brambilla, Rossella Musa, Lorenzo Ferrarini
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Patent number: 8182838Abstract: The present invention relates to particles and to methods of making particles. In particular, the invention relates to methods of making composite active particles comprising a pharmaceutically active material for pulmonary inhalation, the method comprising a jet milling process.Type: GrantFiled: September 15, 2004Date of Patent: May 22, 2012Assignee: Vectura LimitedInventors: David Morton, John Staniforth
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Publication number: 20120114709Abstract: A formulation for use in an inhaler device comprises carrier particles having a diameter of at least 50 ?m and a mass median diameter of at least 175 ?m; fine particles of an excipient material having a mass median aerodynamic diameter of not more than 20 ?m; and active particles. The formulation has excellent flowability even at relatively high contents of fine particles.Type: ApplicationFiled: December 8, 2011Publication date: May 10, 2012Applicant: Vectura LimitedInventors: John Nicholas STANIFORTH, David Alexander Vodden Morton
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Patent number: 8137657Abstract: In a method of producing particles suitable for use as carrier particles in dry powder inhalers, particles (1) of a size suitable for use as carrier particles in dry powder inhalers are treated so as to dislodge small grains from the surface of the particles, without substantially changing the size of the particles during the treatment. The treatment gives improved efficiency of redispersion of active particles from the surfaces of carrier particles.Type: GrantFiled: May 16, 2003Date of Patent: March 20, 2012Assignee: Vectura LimitedInventor: John Nicholas Staniforth
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Publication number: 20120027863Abstract: The invention provides microparticles for use in a pharmaceutical composition for Pulmonary administration, each microparticle comprising a particle of an active substance having, on its surface, particles of a hydrophobic material suitable for delaying the dissolution of the active substance. The invention also provides a method for making the microparticles.Type: ApplicationFiled: October 7, 2011Publication date: February 2, 2012Applicant: Vectura LimitedInventors: John Nicholas STANIFORTH, Haggis Harris, David Alexander Vodden Morton, Robin Bannister
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Patent number: 8101160Abstract: A formulation for use in an inhaler device comprises carrier particles having a diameter of at least 50 ?m and a mass median diameter of at least 175 ?m; fine particles of an excipient material having a mass median aerodynamic diameter of not more than 20 ?m; and active particles. The formulation has excellent flowability even at relatively high contents of fine particles.Type: GrantFiled: April 17, 2001Date of Patent: January 24, 2012Assignee: Vectura LimitedInventors: John Nicholas Staniforth, David Alexander Vodden Morton
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Patent number: 8048451Abstract: The invention provides microparticles for use in a pharmaceutical composition for pulmonary administration, each microparticle comprising a particle of an active substance having, on its surface, particles of a hydrophobic material suitable for delaying the dissolution of the active substance. The invention also provides a method for making the microparticles.Type: GrantFiled: November 30, 2001Date of Patent: November 1, 2011Assignee: Vectura LimitedInventors: John Nicholas Staniforth, Haggis Harris, David Alexander Vodden Morton, Robin Bannister
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Publication number: 20110236492Abstract: The present invention is concerned with a refinement of the processing of particles that are to form a dry powder formulation which is to be administered to the lung using a dry powder inhaler (DPI) device. In particular, the present invention provides the processing of particles of active material and particles of carrier material in the presence of additive material to provide a powder composition which exhibits excellent powder properties and which is economical to produce.Type: ApplicationFiled: April 12, 2011Publication date: September 29, 2011Applicant: VECTURA LIMITEDInventor: David MORTON
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Publication number: 20110217339Abstract: The present invention relates to pharmaceutical compositions which are useful in the treatment of diseases where excess mucus is present in the respiratory tract, such as cystic fibrosis and chronic obstructive pulmonary disease. In particular, the invention relates to pharmaceutical compositions for administration by pulmonary inhalation.Type: ApplicationFiled: March 8, 2011Publication date: September 8, 2011Applicant: Vectura LimitedInventors: David MORTON, David GANDERTON, John STANIFORTH, Yorick KAMLAG
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Publication number: 20110182997Abstract: The present invention relates to suspension formulations, especially those for delivering a pharmaceutically active agent in aerosol form using a spray or aerosol device, such as a pressurised metered dose inhaler (pMDI). The formulations may be for pulmonary, nasal, buccal or topical administration, but are preferably for pulmonary inhalation.Type: ApplicationFiled: February 2, 2009Publication date: July 28, 2011Applicants: VECTURA LIMITED, INNOVATA BIOMED LIMITEDInventors: David Andrew Lewis, Christina Alexandra Keeble, Nicola Kim Whitfield, Tanya Church
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Patent number: 7928089Abstract: The present invention relates to mucoactive agents, such as heparin which are useful in the treatment of diseases where excess mucus is present in the respiratory tract, such as cystic fibrosis and chronic obstructive pulmonary disease. In particular, the invention relates to pharmaceutical compositions for administration by pulmonary inhalation. It also relates to methods for producing particles suitable for pulmonary inhalation, such as spray drying or jet milling.Type: GrantFiled: September 15, 2004Date of Patent: April 19, 2011Assignee: Vectura LimitedInventors: David Morton, David Ganderton, John Staniforth, Yorick Kamlag
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Publication number: 20110077272Abstract: A pharmaceutical composition includes triptans, such as sumatriptan, and may be used in therapy. The composition may be administered via the inhaled route.Type: ApplicationFiled: February 2, 2009Publication date: March 31, 2011Applicant: Vectura LimitedInventor: Mark Jonathan Main
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Publication number: 20100330188Abstract: A powder for use in a dry powder inhaler includes active particles and carrier particles for carrying the active particles. The powder further includes additive material on the surfaces of the carrier particles to promote the release of the active particles from the carrier particles on actuation of the inhaler. The powder is such that the active particles are not liable to be released from the carrier particles before actuation of the inhaler. The inclusion of additive material in the powder has been found to give an increased respirable fraction of the active material.Type: ApplicationFiled: March 26, 2010Publication date: December 30, 2010Applicant: Vectura LimitedInventor: John Nicholas Staniforth
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Patent number: 7845349Abstract: An inhaler (1) for the delivery of a dose of powdered medicament for inhalation by a user comprising a housing (2) containing a cylinder (5) defining a chamber (5a) and a piston (6) movably received in the cylinder to enable a user to generate a charge of compressed air in the chamber to entrain a dose when the charge is released, wherein the cylinder and the piston include co-operating means (8, 9) thereon operable to draw the piston into the cylinder to compress a charge of air in the chamber in response to rotation of the piston.Type: GrantFiled: March 30, 2005Date of Patent: December 7, 2010Assignee: Vectura LimitedInventors: Stephen William Eason, Michael Edgar Newton, Roger William Clarke, Matthew Neil Sarkar
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Publication number: 20100285142Abstract: A method for making composite excipient particles for use in a pharmaceutical composition comprises a milling step in which particles of an excipient material are milled in the presence of an additive material. The product particles are of small size and the milling requires relatively low input of time and energy. The composite particles are suitable for use in inhalable pharmaceutical compositions.Type: ApplicationFiled: May 18, 2010Publication date: November 11, 2010Applicant: Vectura LimitedInventors: John Nicholas Staniforth, David Alexander Vodden Morton, Rossella Musa
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Publication number: 20100258118Abstract: The present invention relates to inhaler devices and bespoke pharmaceutical dry powder composition to be dispensed using such inhaler devices for pulmonary administration. In particular, the present invention relates to the provision of passive inhaler devices and dry powder compositions which are specifically formulated and prepared to be efficiently dispensed by such devices to reproducibly achieve a high delivered dose of the pharmaceutically active agent.Type: ApplicationFiled: November 5, 2007Publication date: October 14, 2010Applicant: Vectura LimitedInventor: David Morton
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Patent number: 7810494Abstract: An Inhaler for delivering an aerosolized dose of a powdered drug for inhalation by a user is disclosed. The inhaler comprises a drug entrainment device vice to a receive a package having a piercable lid containing a dose to be delivered, the device including a drug outlet tube terminating with a primary piercing element to pierce an opening in said lid when a package is located in the inhaler, a secondary piercing member to pierce a plurality of peripheral openings in said lid and, an airflow path to enable the supply of a charge of gas into the package via said peripheral openings to scour the interior of a pierced package such that all or substantially all of the dose is entrained in the gas and flows out of the package via the drug outlet tube. A medicament pack is also disclosed.Type: GrantFiled: September 15, 2004Date of Patent: October 12, 2010Assignee: Vectura LimitedInventors: Quentin Harmer, Roger William Clarke, Stephen William Eason
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Publication number: 20100209358Abstract: The invention relates to a method for making composite active particles for use in a pharmaceutical composition for pulmonary administration, the method comprising a milling step in which particles of active material are milled in the presence of particles of an additive material which is suitable for the promotion of the dispersal of the composite active particles upon actuation of an inhaler. The invention also relates to compositions for inhalation prepared by the method.Type: ApplicationFiled: April 26, 2010Publication date: August 19, 2010Applicant: Vectura LimitedInventors: John Nicholas STANIFORTH, Matthew Michael James GREEN, David Alexander Vodden MORTON
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Patent number: 7744855Abstract: A method for making composite excipient particles for use in a pharmaceutical composition comprises a milling step in which particles of an excipient material are milled in the presence of an additive material. The product particles are of small size and the milling requires relatively low input of time and energy. The composite particles are suitable for use in inhalable pharmaceutical compositions.Type: GrantFiled: June 27, 2001Date of Patent: June 29, 2010Assignee: Vectura LimitedInventors: John Nicholas Staniforth, David Alexander Vodden Morton, Rosella Musa
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Patent number: 7736670Abstract: The invention relates to a method for making composite active particles for use in a pharmaceutical composition for pulmonary administration, the method comprising a milling step in which particles of active material are milled in the presence of particles of an additive material which is suitable for the promotion of the dispersal of the composite active particles upon actuation of an inhaler. The invention also relates to compositions for inhalation prepared by the method.Type: GrantFiled: November 30, 2001Date of Patent: June 15, 2010Assignee: Vectura LimitedInventors: John Nicholas Staniforth, Matthew Michael James Green, David Alexander Vodden Morton