Abstract: An inhaler for producing an inhalable aerosol of a powdered medicament comprises a cyclone (1) with a tangential air inlet (3) and an axial air outlet (4). The cyclone (1) aerosolises and retains an aerosol of powdered medicament in an airflow circulating between the inlet (3) and the outlet (4). The cyclone (1) has an exit port (2) which is open to atmosphere. When the aerosol is to be inhaled, the pressure in the cyclone (1) is increased by increasing the airflow to the inlet (3) which causes the aerosol to discharge through the exit port (2). The inhaler has the advantage that the rate of discharge of the aerosol can be controlled independently of the rate of airflow required to aerosolise the medicament.
Type:
Grant
Filed:
July 20, 2001
Date of Patent:
September 27, 2005
Assignee:
Vectura, Limited
Inventors:
Stephen William Eason, Quentin John Harmer, Matthew Neil Sarkar
Abstract: A multiple dose delivery device for delivering a medicament into an oral cavity of a patient is provided. The device includes a sachet pack including a plurality of unit doses of a medicament enclosed between a first strip and a second strip. The device further includes a sachet advance mechanism and a mouthpiece. Upon actuation by a user, the sachet advance mechanism, which is engaged with the sachet pack, separates the first strip from the second strip to release one of the plurality of the unit doses from the sachet pack. The mouthpiece includes an opening, and each released unit dose passes through the opening.
Type:
Application
Filed:
April 27, 2005
Publication date:
September 22, 2005
Applicant:
Vectura Limited
Inventors:
John Staniforth, Michael Tobyn, Nicholas Bowman, Matthew Wright, Gary Howard, David Brook Simpson
Abstract: Disclosed is a system for delivery of a drug comprising a multiple unit dosing device comprising a housing and an actuator, said device containing multiple doses of multiparticulates comprising drug particles, said device upon actuation delivering a unit dose of said multiparticulates, said drug particles having a mean diameter of greater than 10 ?m to about 1 mm such that an effective dose of said drug cannot be delivered into the lower lung of a human patient. Also disclosed are novel methods, devices and dosage forms for delivering a drug.
Abstract: A powder for use in a dry powder inhaler comprises active material and additive material. The additive material comprises an anti-adherent material and the powder includes at least 60% by weight of active material. The inclusion of the additive material in the powder has been found to give an increased respirable fraction of the active material.
Abstract: In certain embodiments the invention is directed to a drug formulation for gastrointestinal deposition comprising a non-compressed free flowing plurality of particles comprising a core comprising a drug and a pharmaceutically acceptable excipient, said core overcoated with a functional coating, said drug particles having a mean diameter of greater than 10 ?m to about 1 mm.
Type:
Application
Filed:
September 5, 2002
Publication date:
January 20, 2005
Applicant:
Vectura Limited
Inventors:
Michael Tobyn, John Staniforth, David Bradley Simpson
Abstract: In a method of producing particles suitable for use as carrier particles in dry powder inhalers, particles (1) of a size suitable for use as carrier particles in dry powder inhalers are treated so as to dislodge small grains from the surface of the particles, without substantially changing the size of the particles during the treatment. The treatment gives improved efficiency of redispersion of active particles from the surfaces of carrier particles.
Abstract: A powder for use in a dry powder inhaler includes active particles and carrier particles for carrying the active particles. The powder further includes additive material (4) on the surfaces of the carrier particles to promote the release of the active particles from the carrier particles on actuation of the inhaler. The powder is such that the active particles are not liable to be release from the carrier particles before actuation of the inhaler.
Abstract: In a method of producing particles suitable for use as carrier particles in dry powder inhalers, particles (1) of a size suitable for use as carrier particles in dry powder inhalers are treated so as to dislodge small grains from the surface of the particles, without substantially changing the size of the particles during the treatment. The treatment gives improved efficiency of redispersion of active particles from the surfaces of carrier particles.
Abstract: A powder for use in a dry powder inhaler includes active particles and carrier particles for carrying the active particles. The powder further includes additive material (4) on the surfaces of the carrier particles to promote the release of the active particles from the carrier particles on actuation of the inhaler. The powder is such that the active particles are not liable to be released from the carrier particles before actuation of the inhaler. The inclusion of additive material (4) in the powder has been found to give an increased respirable fraction of the active material.
Abstract: A powder for use in a dry powder inhaler comprises active material and additive material. The additive material comprises an anti-adherent material and the powder includes at least 60% by weight of active material. The inclusion of the additive material in the powder has been found to give an increased respirable fraction of the active material.
Abstract: In a method of producing particles suitable for use as carrier particles in dry powder inhalers, particles (1) of a size suitable for use as carrier particles in dry powder inhalers are treated so as to dislodge small grains from the surface of the particles, without substantially changing the size of the particles during the treatment. The treatment gives improved efficiency of redispersion of active particles from the surfaces of carrier particles.