Patents Assigned to Velico Medical, Inc.
  • Publication number: 20190246629
    Abstract: The present invention relates to methods and compositions for reducing sialidase activity and inhibiting bacterial proliferation of one or more bacteria in a platelet product preparation from one or more donors. In general, the method includes contacting the platelet product preparation with an amount of a sialidase inhibitor, to thereby obtain a sialidase inhibitor-treated platelet product preparation. Sialidase activity is reduced and the proliferation of one or more bacteria is inhibited, as compared to a platelet product preparation not subjected to the sialidase inhibitor treatment.
    Type: Application
    Filed: April 22, 2019
    Publication date: August 15, 2019
    Applicants: Velico Medical, Inc., The Brigham and Women's Hospital, Inc.
    Inventors: Qiyong Peter Liu, Karin Hoffmeister, Robert Sackstein
  • Publication number: 20190203175
    Abstract: The present invention relates to a platelet protection solution (PPS) having an amount of one or more ?-galactosidase inhibitors with or without an amount of one or more sialidase inhibitors, and optionally one or more glycan-modifying agents; and one or more of PPS components that include a salt, a citrate source, a carbon source, or any combination thereof.
    Type: Application
    Filed: September 10, 2018
    Publication date: July 4, 2019
    Applicant: Velico Medical, Inc.
    Inventor: Qiyong Peter Liu
  • Publication number: 20190200602
    Abstract: The present invention relates to a platelet additive solution (PAS) having an amount of one or more ?-galactosidase inhibitors with or without an amount of one or more sialidase inhibitors, and optionally one or more glycan-modifying agents; and one or more of PAS components that include a salt, a citrate source, a carbon source, or any combination thereof.
    Type: Application
    Filed: March 5, 2019
    Publication date: July 4, 2019
    Applicants: Velico Medical, Inc., The Brigham and Women's Hospital, Inc.
    Inventors: Qiyong Peter Liu, Karin Hoffmeister, M, Robert Sackstein
  • Patent number: 10271541
    Abstract: The present invention relates to a platelet additive solution (PAS) having an amount of one or more ?-galactosidase inhibitors with or without an amount of one or more sialidase inhibitors, and optionally one or more glycan-modifying agents; and one or more of PAS components that include a salt, a citrate source, a carbon source, or any combination thereof.
    Type: Grant
    Filed: February 17, 2017
    Date of Patent: April 30, 2019
    Assignees: Velico Medical, Inc, The Brigham and Women's Hospital, Inc.
    Inventors: Qiyong Peter Liu, Karin Hoffmeister, Robert Sackstein
  • Patent number: 9788539
    Abstract: The present invention relates to a platelet protection solution (PPS) having an amount of one or more ?-galactosidase inhibitors with or without an amount of one or more sialidase inhibitors, and optionally one or more glycan-modifying agents; and one or more of PPS components that include a salt, a citrate source, a carbon source, or any combination thereof.
    Type: Grant
    Filed: February 2, 2016
    Date of Patent: October 17, 2017
    Assignees: Velico Medical, Inc., The Brigham and Women's Hospital, Inc.
    Inventors: Qiyong Peter Liu, Karin Hoffmeister, Robert Sackstein
  • Publication number: 20170259186
    Abstract: A spray drier system is provided for spray drying a liquid sample such as blood plasma. The spray drier system may include a spray drier device adapted to couple with a spray drier assembly. The assembly may include an enclosure mounted to a frame. The assembly may receive a flow of drying gas which is directed by the enclosure shape towards a spray drying head mounted within the enclosure to the frame. Flows of a liquid sample may be further received by the head, which aerosolizes the liquid sample. Aerosolized liquid sample and drying air may be mixed within a drying chamber of the enclosure to produce dried sample and humid air. The dried sample and humid air may also be separated in a collection chamber of the enclosure, with the humid air exhausted from the enclosure.
    Type: Application
    Filed: May 24, 2017
    Publication date: September 14, 2017
    Applicant: Velico Medical, Inc.
    Inventors: Abdul Wahid Khan, Dennis Brian Hubbard
  • Publication number: 20170100339
    Abstract: A method of treatment of plasma with a physiologically compatible spray dry stable acidic substance (SDSAS) prior to or contemporaneously with spray drying of the plasma that results in greater recovery and greater long-term stabilization of the dried plasma proteins as compared to spray dried plasma that has not be subject to the formulation method of the present invention, as well as compositions related to plasma dried by the methods of the present invention.
    Type: Application
    Filed: December 19, 2016
    Publication date: April 13, 2017
    Applicant: Velico Medical, Inc.
    Inventors: Qiyong Peter Liu, Junqing Cui, Rud Karly Lucien, Ryan Carney, Jihae Sohn, Michelle Arya
  • Patent number: 9609861
    Abstract: The present invention relates to a platelet additive solution (PAS) having an amount of one or more ?-galactosidase inhibitors with or without an amount of one or more sialidase inhibitors, and optionally one or more glycan-modifying agents; and one or more of PAS components that include a salt, a citrate source, a carbon source, or any combination thereof.
    Type: Grant
    Filed: October 7, 2013
    Date of Patent: April 4, 2017
    Assignees: Velico Medical Inc., The Brigham and Women's Hospital, Inc.
    Inventors: Qiyong Peter Liu, Karin Hoffmeister, Robert Sackstein
  • Patent number: 9561184
    Abstract: Disclosed are methods of spray drying blood plasma using a two-step drying process.
    Type: Grant
    Filed: March 26, 2015
    Date of Patent: February 7, 2017
    Assignee: Velico Medical, Inc.
    Inventors: Abdul Wahid Khan, Michael Wilt, Rud Karly Lucien, Jihae Sohn, Qiyong Peter Liu
  • Patent number: 9545379
    Abstract: A method of treatment of plasma with a physiologically compatible spray dry stable acidic substance (SDSAS) prior to or contemporaneously with spray drying of the plasma that results in greater recovery and greater long-term stabilization of the dried plasma proteins as compared to spray dried plasma that has not be subject to the formulation method of the present invention, as well as compositions related to plasma dried by the methods of the present invention.
    Type: Grant
    Filed: September 18, 2015
    Date of Patent: January 17, 2017
    Assignee: Velico Medical, Inc.
    Inventors: Qiyong Peter Liu, Junqing Cui, Rud Karly Lucien, Ryan Carney, Jihae Sohn, Michelle Arya
  • Publication number: 20160174543
    Abstract: The present invention relates to a platelet additive solution (PAS) having an amount of one or more ?-galactosidase inhibitors with or without an amount of one or more sialidase inhibitors, and optionally one or more glycan-modifying agents; and one or more of PAS components that include a salt, a citrate source, a carbon source, or any combination thereof.
    Type: Application
    Filed: October 7, 2013
    Publication date: June 23, 2016
    Applicants: The Brigham and Women's Hospital, Inc., Velico Medical, Inc.
    Inventors: Qiyong Peter Liu, Karin Hoffmeister, Robert Sackstein
  • Patent number: 9034626
    Abstract: This invention relates to novel ?-galactosidases for the enzymatic removal of the immunodominant monosaccharides on blood products and tissues. Specifically this invention provides a novel family of ?3 glycosidases, used for the enzymatic removal of type B antigens from blood group B and AB reactive blood products, and the Galili antigen from non-human animal tissues, thereby converting these to non-immunogenic cells and tissues suitable for transplantation.
    Type: Grant
    Filed: October 6, 2014
    Date of Patent: May 19, 2015
    Assignee: Velico Medical, Inc.
    Inventors: Qiyong Peter Liu, Henrik Clausen
  • Publication number: 20140220553
    Abstract: This invention relates to enzymatic removal of type A and B antigens from blood group A, B, and AB reactive cells in blood products, and thereby converting these to non-A and non-B reactive cells. The invention further relates to using unique ?-N-acetylgalactosaminidases and ?-galactosidases with superior kinetic properties for removing the immunodominant monosaccharides of the blood group A and B antigens and improved performance in enzymatic conversion of red blood cells. The preferred unique ?-N-acetylgalactosaminidases and ?-galactosidases exhibit the following characteristics: (i) exclusive, preferred or no less than 10% substrate specificity for the type A and B branched polysaccharide structures relative to measurable activity with simple mono- and disaccharide structures and aglycon derivatives hereof: (ii) optimal performance at neutral pH with blood group oligosaccharides and in enzymatic conversion of cells: and (iii) a favorable kinetic constant Km with mono- and oligosaccharide substrates.
    Type: Application
    Filed: March 7, 2014
    Publication date: August 7, 2014
    Applicant: Velico Medical, Inc.
    Inventors: Henrik Clausen, Humberto de la Vega, Cheryl Hill, Qiyong Peter Liu
  • Publication number: 20140154665
    Abstract: The present invention provides modified platelets having a reduced platelet clearance and methods for reducing platelet clearance. Also provided are compositions for the preservation of platelets. The invention also provides methods for making a pharmaceutical composition containing the modified platelets and for administering the pharmaceutical composition to a mammal to mediate hemostasis.
    Type: Application
    Filed: July 19, 2013
    Publication date: June 5, 2014
    Applicant: Velico Medical, Inc.
    Inventors: Keith Rosiello, Henrik Clausen
  • Patent number: 8697411
    Abstract: This invention relates to enzymatic removal of type A and B antigens from blood group A, B, and AB reactive cells in blood products, and thereby converting these to non-A and non-B reactive cells. The invention further relates to using unique ?-N-acetylgalactosaminidases and ?-galactosidases with superior kinetic properties for removing the immunodominant monosaccharides of the blood group A and B antigens and improved performance in enzymatic conversion of red blood cells. The preferred unique ?-N-acetylgalactosaminidases and ?-galactosidases exhibit the following characteristics: (i) exclusive, preferred or no less than 10% substrate specificity for the type A and B branched polysaccharide structures relative to measurable activity with simple mono- and disaccharide structures and aglycon derivatives hereof; (ii) optimal performance at neutral pH with blood group oligosaccharides and in enzymatic conversion of cells; and (iii) a favorable kinetic constant Km with mono- and oligosaccharide substrates.
    Type: Grant
    Filed: August 8, 2011
    Date of Patent: April 15, 2014
    Assignee: Velico Medical, Inc.
    Inventors: Henrik Clausen, Humberto de la Vega, Cheryl Hill, Qiyong Peter Liu
  • Publication number: 20140099629
    Abstract: The present invention relates to a platelet additive solution (PAS) having an amount of one or more ?-galactosidase inhibitors with or without an amount of one or more sialidase inhibitors, and optionally one or more glycan-modifying agents; and one or more of PAS components that include a salt, a citrate source, a carbon source, or any combination thereof.
    Type: Application
    Filed: October 7, 2013
    Publication date: April 10, 2014
    Applicants: The Brigham and Women's Hospital, Inc., Velico Medical, Inc.
    Inventors: Qiyong Peter Liu, Karin Hoffmeister, Robert Sackstein
  • Patent number: 8601712
    Abstract: Described herein are devices and techniques for spray drying a fluid to produce a dried powder. Assemblies include a spray drying head attachable to a gas supplier and a liquid sample, such as a standard unit of blood product. The spray drying head can be adapted to provide an aerosolized flow of liquid sample exposed to a drying gas. The assembly also includes a drying chamber adapted to separate the aerosolized flow of liquid sample into a dried powder and humid air. The assembly can be disposable, provided in a sterilized kit and having simplified attachments allowing quick connect and disconnect from the gas and liquid sample. Separation of the powder from the humid air exiting the drying chamber occurs within a filtered collection bag. In some embodiments, one or more of the drying chamber and collection bag are formed form a thin-walled, collapsible material.
    Type: Grant
    Filed: October 25, 2012
    Date of Patent: December 10, 2013
    Assignee: Velico Medical, Inc.
    Inventors: Dennis Brian Hubbard, Jr., Michael Haley, John Charles Rosenfelder, George T. Perivolotis
  • Patent number: 8595950
    Abstract: Described herein are devices and techniques for spray drying a fluid to produce a dried powder. Assemblies include a spray drying head attachable to a gas supplier and a liquid sample, such as a standard unit of blood product. The spray drying head can be adapted to provide an aerosolized flow of liquid sample exposed to a drying gas. The assembly also includes a drying chamber adapted to separate the aerosolized flow of liquid sample into a dried powder and humid air. The assembly can be disposable, provided in a sterilized kit and having simplified attachments allowing quick connect and disconnect from the gas and liquid sample. Separation of the powder from the humid air exiting the drying chamber occurs within a filtered collection bag. In some embodiments, one or more of the drying chamber and collection bag are formed form a thin-walled, collapsible material.
    Type: Grant
    Filed: May 17, 2012
    Date of Patent: December 3, 2013
    Assignee: Velico Medical, Inc.
    Inventors: Dennis Brian Hubbard, Jr., Michael Haley, John Charles Rosenfelder, George T. Perivolotis
  • Patent number: 8533971
    Abstract: Described herein are devices and techniques for spray drying a fluid to produce a dried powder. Assemblies include a spray drying head attachable to a gas supplier and a liquid sample, such as a standard unit of blood product. The spray drying head can be adapted to provide an aerosolized flow of liquid sample exposed to a drying gas. The assembly also includes a drying chamber adapted to separate the aerosolized flow of liquid sample into a dried powder and humid air. The assembly can be disposable, provided in a sterilized kit and having simplified attachments allowing quick connect and disconnect from the gas and liquid sample. Separation of the powder from the humid air exiting the drying chamber occurs within a filtered collection bag. In some embodiments, one or more of the drying chamber and collection bag are formed form a thin-walled, collapsible material.
    Type: Grant
    Filed: October 28, 2011
    Date of Patent: September 17, 2013
    Assignee: Velico Medical, Inc.
    Inventors: Dennis Brian Hubbard, Jr., Michael Haley, John Charles Rosenfelder, George T. Perivolotis
  • Patent number: 8533972
    Abstract: Described herein are devices and techniques for spray drying a fluid to produce a dried powder. Assemblies include a spray drying head attachable to a gas supplier and a liquid sample, such as a standard unit of blood product. The spray drying head can be adapted to provide an aerosolized flow of liquid sample exposed to a drying gas. The assembly also includes a drying chamber adapted to separate the aerosolized flow of liquid sample into a dried powder and humid air. The assembly can be disposable, provided in a sterilized kit and having simplified attachments allowing quick connect and disconnect from the gas and liquid sample. Separation of the powder from the humid air exiting the drying chamber occurs within a filtered collection bag. In some embodiments, one or more of the drying chamber and collection bag are formed form a thin-walled, collapsible material.
    Type: Grant
    Filed: October 25, 2012
    Date of Patent: September 17, 2013
    Assignee: Velico Medical, Inc.
    Inventors: Dennis Brian Hubbard, Jr., Michael Haley, John Charles Rosenfelder, George T. Perivolotis