Patents Assigned to Velico Medical, Inc.
  • Publication number: 20250108315
    Abstract: The present invention relates to a spray dried plasma composition having one or more of the following characteristics: when reconstituted, largely amorphous and has no cholesterol crystals; when reconstituted, the number of large particulates is reduced; has low residual moisture; reconstitutes rapidly in under four minutes; highly stable when stored under refrigeration, at room temperature or at elevated temperatures and allows for storage for longer periods of time; when reconstituted, exhibits recovery of the most fragile of proteins, including von Willebrand's factor; when reconstituted with Sterile Water for Injection (SWFI), reconstituted plasma is at a pH that is near normal plasma pH, and does so without treatment or storage in CO2 or other pH adjustment; and when reconstituted, has reduced complement activation (C5A, C3A).
    Type: Application
    Filed: December 12, 2024
    Publication date: April 3, 2025
    Applicant: Velico Medical, Inc.
    Inventors: Robert R. Andrews, Herman E. Snyder, William J. Merritt, Evan P. Ordway, Clair Strohl, Qiyong Peter Liu, Jihae Sohn, Lisa A. Buckley, Mark A. Popovsky
  • Publication number: 20250099868
    Abstract: The present invention includes a spray drying disposable device for use in a spray drying system. The disposable has a spray drying head and a plasma drying chamber. The head has a spray dry nozzle assembly in fluid communication with the plasma source and the pressurized aerosol gas source. The pressurized gas flows in a vortex pattern that atomizes plasma droplets in the chamber. The head also includes a plenum has uniform air pressure of the drying gas. A baffle plate forms the floor of the plenum having drying gas jets that supply drying gas to the chamber. The atomized plasma droplets evaporate in the presence of the drying gas emitted from the jets to obtain dried plasma particles and humid air. A capture filter captures the dried plasma particles and allows the humid air to pass. The humid air passes through the gas outlet and the exhaust port.
    Type: Application
    Filed: December 9, 2024
    Publication date: March 27, 2025
    Applicant: Velico Medical, Inc.
    Inventors: Richard Meehan, Robert R. Andrews, Herman E. Snyder, William J. Merritt, Evan P. Ordway, Clair Strohl, Mark A. Popovsky, Lisa A. Buckley, Jihae Sohn
  • Patent number: 12253308
    Abstract: The present invention includes a spray drying disposable device for use in a spray drying system. The disposable has a spray drying head and a plasma drying chamber. The head has a spray dry nozzle assembly in fluid communication with the plasma source and the pressurized aerosol gas source. The pressurized gas flows in a vortex pattern that atomizes plasma droplets in the chamber. The head also includes a plenum has uniform air pressure of the drying gas. A baffle plate forms the floor of the plenum having drying gas jets that supply drying gas to the chamber. The atomized plasma droplets evaporate in the presence of the drying gas emitted from the jets to obtain dried plasma particles and humid air. A capture filter captures the dried plasma particles and allows the humid air to pass. The humid air passes through the gas outlet and the exhaust port.
    Type: Grant
    Filed: June 18, 2024
    Date of Patent: March 18, 2025
    Assignee: Velico Medical Inc.
    Inventors: Robert R. Andrews, Herman E. Snyder, William J. Merritt, Evan P. Ordway, Clair Strohl, Russell Barron
  • Patent number: 12246266
    Abstract: The present invention includes a spray drying disposable device for use in a spray drying system. The disposable has a spray drying head and a plasma drying chamber. The head has a spray dry nozzle assembly in fluid communication with the plasma source and the pressurized aerosol gas source. The pressurized gas flows in a vortex pattern that atomizes plasma droplets in the chamber. The head also includes a plenum has uniform air pressure of the drying gas. A baffle plate forms the floor of the plenum having drying gas jets that supply drying gas to the chamber. The atomized plasma droplets evaporate in the presence of the drying gas emitted from the jets to obtain dried plasma particles and humid air. A capture filter captures the dried plasma particles and allows the humid air to pass. The humid air passes through the gas outlet and the exhaust port.
    Type: Grant
    Filed: September 14, 2023
    Date of Patent: March 11, 2025
    Assignee: Velico Medical, Inc.
    Inventors: Robert R. Andrews, Herman E. Snyder, William J. Merritt, Evan P. Ordway, Clair Strohl
  • Patent number: 12247784
    Abstract: The present invention includes a spray drying disposable device for use in a spray drying system. The disposable has a spray drying head and a plasma drying chamber. The head has a spray dry nozzle assembly in fluid communication with the plasma source and the pressurized aerosol gas source. The pressurized gas flows in a vortex pattern that atomizes plasma droplets in the chamber. The head also includes a plenum has uniform air pressure of the drying gas. A baffle plate forms the floor of the plenum having drying gas jets that supply drying gas to the chamber. The atomized plasma droplets evaporate in the presence of the drying gas emitted to from the jets to obtain dried plasma particles and humid air. A capture filter captures the dried plasma particles and allows the humid air to pass. The humid air passes through the gas outlet and the exhaust port.
    Type: Grant
    Filed: January 12, 2024
    Date of Patent: March 11, 2025
    Assignee: Velico Medical, Inc.
    Inventors: Robert R. Andrews, Herman E. Snyder, William J. Merritt, Evan P. Ordway, Clair Strohl
  • Patent number: 12246093
    Abstract: The present invention relates to spray drying plasma methodology that includes pretreating a donated liquid plasma unit, drying the liquid plasma using a spray drying apparatus with the spray drying disposable device that results in a disposable having the dried plasma, finishing the disposable using the finishing apparatus that is designed to seal and separate the disposable, and transform the disposable into a dried plasma unit. The methods of the present invention include storing the dried plasma unit and, when ready for use, reconstituting the dried plasma unit with reconstitution solution to obtain a plasma unit ready for transfusion into a recipient.
    Type: Grant
    Filed: September 15, 2022
    Date of Patent: March 11, 2025
    Assignee: Velico Medical, Inc.
    Inventors: Robert R. Andrews, Herman E. Snyder, William J. Merritt, Kyle D. Erickson, Evan P. Ordway, Clair Strohl, Russell Barron
  • Patent number: 12208121
    Abstract: The technology relates to spray dried plasma and methods of making the same. The method includes providing plasma to a spray drying apparatus, spray drying the plasma, at the spray drying apparatus, to form physiologically active plasma powder, the spray drying apparatus configured utilizing one or more parameters, and storing the physiologically active plasma powder.
    Type: Grant
    Filed: March 1, 2023
    Date of Patent: January 28, 2025
    Assignee: Velico Medical, Inc.
    Inventors: Joseph DaCorta, Keith Rosiello
  • Patent number: 12201920
    Abstract: The present invention relates to a spray dried plasma composition having one or more of the following characteristics: when reconstituted, largely amorphous and has no cholesterol crystals; when reconstituted, the number of large particulates is reduced; has low residual moisture; reconstitutes rapidly in under four minutes; highly stable when stored under refrigeration, at room temperature or at elevated temperatures and allows for storage for longer periods of time; when reconstituted, exhibits recovery of the most fragile of proteins, including von Willebrand's factor; when reconstituted with Sterile Water for Injection (SWFI), reconstituted plasma is at a pH that is near normal plasma pH, and does so without treatment or storage in CO2 or other pH adjustment; and when reconstituted, has reduced complement activation (C5A, C3A).
    Type: Grant
    Filed: January 17, 2023
    Date of Patent: January 21, 2025
    Assignee: Velico Medical, Inc.
    Inventors: Robert R. Andrews, Herman E. Snyder, William J. Merritt, Evan P. Ordway, Clair Strohl, Qiyong Peter Liu, Jihae Sohn, Lisa A. Buckley, Mark A Popovsky
  • Publication number: 20240390816
    Abstract: An alignment system that allows a spray drying disposable to align in both spray drying apparatus and finishing apparatus. The first instance is a locating arrangement wherein a locator is disposed on the spray drying apparatus and/or finishing apparatus and another locator is on the spray drying head of the disposable such that the locators allow for alignment of the disposable with the spray drying apparatus or finishing apparatus. A second instance of an alignment element includes a guide that is offset as positioned on the spray drying head of the disposable. Yet a third instance of the alignment arrangement relates to the gas exhaust port. In a fourth instance, the alignment system includes a positioning arrangement to reversibly attach the outer wall of the disposable to the finishing apparatus. In a fifth and sixth instance, a retaining device that retains the spray drying head in the spray drying apparatus and/or finishing apparatus.
    Type: Application
    Filed: August 1, 2024
    Publication date: November 28, 2024
    Applicant: Velico Medical, Inc.
    Inventors: Robert R. Andrews, Herman E. Snyder, Kyle D. Erickson, William J. Merritt, Clair Strohl, Evan P. Ordway, Russell Barron
  • Publication number: 20240374522
    Abstract: A method of treatment of plasma with a physiologically compatible spray dry stable acidic substance (SDSAS) prior to or contemporaneously with spray drying of the plasma that results in greater recovery and greater long-term stabilization of the dried plasma proteins as compared to spray dried plasma that has not be subject to the formulation method of the present invention, as well as compositions related to plasma dried by the methods of the present invention.
    Type: Application
    Filed: June 17, 2024
    Publication date: November 14, 2024
    Applicant: Velico Medical, Inc.
    Inventors: Qiyong Peter Liu, Junqing Cui, Rud Karly Lucien, Ryan Carney, Jihae Sohn, Michelle Arya, Wahid W Khan
  • Publication number: 20240359113
    Abstract: The present invention relates to a spray dried plasma composition having one or more of the following characteristics: when reconstituted, largely amorphous and has no cholesterol crystals; when reconstituted, the number of large particulates is reduced; has low residual moisture; reconstitutes rapidly in under four minutes; highly stable when stored under refrigeration, at room temperature or at elevated temperatures and allows for storage for longer periods of time; when reconstituted, exhibits recovery of the most fragile of proteins, including von Willebrand's factor; when reconstituted with Sterile Water for Injection (SWFI), reconstituted plasma is at a pH that is near normal plasma pH, and does so without treatment or storage in CO2 or other pH adjustment; and when reconstituted, has reduced complement activation (C5A, C3A).
    Type: Application
    Filed: March 13, 2024
    Publication date: October 31, 2024
    Applicant: Velico Medical, Inc
    Inventors: Qiyong Peter Liu, Herman E. Snyder, Evan P. Ordway, William J. Merritt, Robert R. Andrews, Clair Strohl, Jihae Sohn, Lisa A. Buckley, Mark A. Popovsky
  • Patent number: 12092397
    Abstract: The present invention includes a spray drying disposable device for use in a spray drying system. The disposable has a spray drying head and a plasma drying chamber. The head has a spray dry nozzle assembly in fluid communication with the plasma source and the pressurized aerosol gas source. The pressurized gas flows in a vortex pattern that atomizes plasma droplets in the chamber. The head also includes a plenum has uniform air pressure of the drying gas. A baffle plate forms the floor of the plenum having drying gas jets that supply drying gas to the chamber. The atomized plasma droplets evaporate in the presence of the drying gas emitted from the jets to obtain dried plasma particles and humid air. A capture filter captures the dried plasma particles and allows the humid air to pass. The humid air passes through the gas outlet and the exhaust port.
    Type: Grant
    Filed: October 27, 2023
    Date of Patent: September 17, 2024
    Assignee: Velico Medical, Inc.
    Inventors: Robert R. Andrews, Herman E. Snyder, William J. Merritt, Evan P. Ordway, Clair Strohl, Russell Barron
  • Patent number: 12083447
    Abstract: An alignment system that allows a spray drying disposable to align in both spray drying apparatus and finishing apparatus. The first instance is a locating arrangement wherein a locator is disposed on the spray drying apparatus and/or finishing apparatus and another locator is on the spray drying head of the disposable such that the locators allow for alignment of the disposable with the spray drying apparatus or finishing apparatus. A second instance of an alignment element includes a guide that is offset as positioned on the spray drying head of the disposable. Yet a third instance of the alignment arrangement relates to the gas exhaust port. In a fourth instance, the alignment system includes a positioning arrangement to reversibly attach the outer wall of the disposable to the finishing apparatus. In a fifth and sixth instance, a retaining device that retains the spray drying head in the spray drying apparatus and/or finishing apparatus.
    Type: Grant
    Filed: September 15, 2022
    Date of Patent: September 10, 2024
    Assignee: Velico Medical, Inc.
    Inventors: Robert R. Andrews, Herman E. Snyder, William J. Merritt, Kyle D. Erickson, Evan P. Ordway, Clair Strohl, Russell Barron
  • Publication number: 20240293759
    Abstract: The present invention includes an ease-of-use system that allows the spray drying disposable device to fit (e.g., align) in both spray drying apparatus and the spray drying finishing apparatus to safely operate the system. The system includes locating arrangements between the spray drying disposable and the spray drying apparatus and/or spray drying finishing apparatus, a first retainer and second retainer, a shorter disposable device that allows for effective spray drying of plasma, a feedback indicators of correct installment, redundant indicators of correct installment, easily accessible operator controls and emergency shut offs.
    Type: Application
    Filed: April 30, 2024
    Publication date: September 5, 2024
    Applicant: Velico Medical, Inc.
    Inventors: Robert R. Andrews, Herman E. Snyder, William J. Merritt, Kyle D. Erickson, Evan P. Ordway, Clair Strohl, Russell Barron
  • Patent number: 12064518
    Abstract: A method of treatment of plasma with a physiologically compatible spray dry stable acidic substance (SDSAS) prior to or contemporaneously with spray drying of the plasma that results in greater recovery and greater long-term stabilization of the dried plasma proteins as compared to spray dried plasma that has not be subject to the formulation method of the present invention, as well as compostions related to plasma dried by the methods of the present invention.
    Type: Grant
    Filed: October 22, 2021
    Date of Patent: August 20, 2024
    Assignee: Velico Medical, Inc.
    Inventors: Qiyong Peter Liu, Junqing Cui, Rud Karly Lucien, Ryan Carney, Jihae Sohn, Michelle Arya, Abdul W. Khan
  • Publication number: 20240191943
    Abstract: The present invention includes a spray drying disposable device for use in a spray drying system. The disposable has a spray drying head and a plasma drying chamber. The head has a spray dry nozzle assembly in fluid communication with the plasma source and the pressurized aerosol gas source. The pressurized gas flows in a vortex pattern that atomizes plasma droplets in the chamber. The head also includes a plenum has uniform air pressure of the drying gas. A baffle plate forms the floor of the plenum having drying gas jets that supply drying gas to the chamber. The atomized plasma droplets evaporate in the presence of the drying gas emitted from the jets to obtain dried plasma particles and humid air. A capture filter captures the dried plasma particles and allows the humid air to pass. The humid air passes through the gas outlet and the exhaust port.
    Type: Application
    Filed: January 13, 2024
    Publication date: June 13, 2024
    Applicant: Velico Medical, Inc.
    Inventors: Robert R. Andrews, Herman E. Snyder, William J. Merritt, Evan P. Ordway, Clair Strohl
  • Patent number: 11998861
    Abstract: The present invention includes an ease-of-use system that allows the spray drying disposable device to fit (e.g., align) in both spray drying apparatus and the spray drying finishing apparatus to safely operate the system. The system includes locating arrangements between the spray drying disposable and the spray drying apparatus and/or spray drying finishing apparatus, a first retainer and second retainer, a shorter disposable device that allows for effective spray drying of plasma, a feedback indicators of correct installment, redundant indicators of correct installment, easily accessible operator controls and emergency shut offs.
    Type: Grant
    Filed: September 15, 2022
    Date of Patent: June 4, 2024
    Assignee: Velico Medical, Inc.
    Inventors: Robert R. Andrews, Herman E. Snyder, William J. Merritt, Kyle D. Erickson, Evan P. Ordway, Clair Strohl, Russell Barron
  • Publication number: 20240167764
    Abstract: The present invention includes a spray drying disposable device for use in a spray drying system. The disposable has a spray drying head and a plasma drying chamber. The head has a spray dry nozzle assembly in fluid communication with the plasma source and the pressurized aerosol gas source. The pressurized gas flows in a vortex pattern that atomizes plasma droplets in the chamber. The head also includes a plenum has uniform air pressure of the drying gas. A baffle plate forms the floor of the plenum having drying gas jets that supply drying gas to the chamber. The atomized plasma droplets evaporate in the presence of the drying gas emitted from the jets to obtain dried plasma particles and humid air. A capture filter captures the dried plasma particles and allows the humid air to pass. The humid air passes through the gas outlet and the exhaust port.
    Type: Application
    Filed: October 27, 2023
    Publication date: May 23, 2024
    Applicant: Velico Medical, Inc.
    Inventors: Robert R. Andrews, Herman E. Snyder, William J. Merritt, Evan P. Ordway, Clair Strohl, Russell Barron
  • Publication number: 20240159462
    Abstract: The present invention includes a spray drying disposable device for use in a spray drying system. The disposable has a spray drying head and a plasma drying chamber. The head has a spray dry nozzle assembly in fluid communication with the plasma source and the pressurized aerosol gas source. The pressurized gas flows in a vortex pattern that atomizes plasma droplets in the chamber. The head also includes a plenum has uniform air pressure of the drying gas. A baffle plate forms the floor of the plenum having drying gas jets that supply drying gas to the chamber. The atomized plasma droplets evaporate in the presence of the drying gas emitted to from the jets to obtain dried plasma particles and humid air. A capture filter captures the dried plasma particles and allows the humid air to pass. The humid air passes through the gas outlet and the exhaust port.
    Type: Application
    Filed: January 12, 2024
    Publication date: May 16, 2024
    Applicant: Velico Medical, Inc.
    Inventors: Robert R. Andrews, Herman E. Snyder, William J. Merritt, Evan P. Ordway, Clair Strohl
  • Patent number: 11975274
    Abstract: The present invention relates to a spray dried plasma composition having one or more of the following characteristics: when reconstituted, largely amorphous and has no cholesterol crystals; when reconstituted, the number of large particulates is reduced; has low residual moisture; reconstitutes rapidly in under four minutes; highly stable when stored under refrigeration, at room temperature or at elevated temperatures and allows for storage for longer periods of time; when reconstituted, exhibits recovery of the most fragile of proteins, including von Willebrand's factor; when reconstituted with Sterile Water for Injection (SWFI), reconstituted plasma is at a pH that is near normal plasma pH, and does so without treatment or storage in CO2 or other pH adjustment; and when reconstituted, has reduced complement activation (C5A, C3A).
    Type: Grant
    Filed: September 15, 2022
    Date of Patent: May 7, 2024
    Assignee: Velico Medical, Inc.
    Inventors: Qiyong Peter Liu, Herman E. Snyder, Kyle D. Erickson, Evan P. Ordway, William J. Merritt, Richard Meehan, Robert R. Andrews, Clair Strohl, Jihae Sohn, Mark A. Popovsky, Lisa A. Buckley