Patents Assigned to Velico Medical, Inc.
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Patent number: 8359766Abstract: The technology relates to spray dried plasma and methods of making the same. The method includes providing plasma to a spray drying apparatus, spray drying the plasma, at the spray drying apparatus, to form physiologically active plasma powder, the spray drying apparatus configured utilizing one or more parameters, and storing the physiologically active plasma powder.Type: GrantFiled: March 8, 2012Date of Patent: January 29, 2013Assignee: Velico Medical, Inc.Inventors: Dennis Brian Hubbard, Jr., Michael Haley
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Patent number: 8356421Abstract: Described herein are devices and techniques for spray drying a fluid to produce a dried powder. Assemblies include a spray drying head attachable to a gas supplier and a liquid sample, such as a standard unit of blood product. The spray drying head can be adapted to provide an aerosolized flow of liquid sample exposed to a drying gas. The assembly also includes a drying chamber adapted to separate the aerosolized flow of liquid sample into a dried powder and humid air. The assembly can be disposable, provided in a sterilized kit and having simplified attachments allowing quick connect and disconnect from the gas and liquid sample. Separation of the powder from the humid air exiting the drying chamber occurs within a filtered collection bag. In some embodiments, one or more of the drying chamber and collection bag are formed form a thin-walled, collapsible material.Type: GrantFiled: October 28, 2011Date of Patent: January 22, 2013Assignee: Velico Medical, Inc.Inventors: Dennis Brian Hubbard, Jr., Michael Haley, John Charles Rosenfelder, George T. Perivolotis
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Publication number: 20130000774Abstract: A system for transferring blood product between a blood storage bag and a processing bag. The system includes an airtight containment chamber for supporting therein one or more blood storage bags. A door is provided for access to the chamber and there is included an airtight fixture that allows tubing from the blood storage bag to exit the chamber. A fluid pump is coupled to the containment chamber for establishing either pressure or vacuum within the containment chamber. A controller controls the air pump to, in turn, control the transfer of a blood product.Type: ApplicationFiled: April 5, 2012Publication date: January 3, 2013Applicant: VELICO MEDICAL, INC.Inventor: Keith Rosiello
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Publication number: 20120222326Abstract: Described herein are devices and techniques for spray drying a fluid to produce a dried powder. Assemblies include a spray drying head attachable to a gas supplier and a liquid sample, such as a standard unit of blood product. The spray drying head can be adapted to provide an aerosolized flow of liquid sample exposed to a drying gas. The assembly also includes a drying chamber adapted to separate the aerosolized flow of liquid sample into a dried powder and humid air. The assembly can be disposable, provided in a sterilized kit and having simplified attachments allowing quick connect and disconnect from the gas and liquid sample. Separation of the powder from the humid air exiting the drying chamber occurs within a filtered collection bag. In some embodiments, one or more of the drying chamber and collection bag are formed form a thin-walled, collapsible material.Type: ApplicationFiled: May 17, 2012Publication date: September 6, 2012Applicant: VELICO MEDICAL, INC.Inventors: Dennis Brian Hubbard, JR., Michael Haley, John Charles Rosenfelder, George T. Perivolotis
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Patent number: 8221745Abstract: The present invention provides modified platelets having a reduced platelet clearance and methods for reducing platelet clearance. Also provided are compositions for the preservation of platelets. The invention also provides methods for making a pharmaceutical composition containing the modified platelets and for administering the pharmaceutical composition to a mammal to mediate hemostasis.Type: GrantFiled: July 14, 2008Date of Patent: July 17, 2012Assignee: Velico Medical, Inc.Inventors: Keith M. Rosiello, Henrik Clausen, Hans Wandall, Thomas P. Stossel, John H. Hartwig, Karin M. Hoffmeister
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Patent number: 8216120Abstract: A centrifuge (10) including a first rotatable mechanism (60) having a rotation axis with a fluid retentive housing (20) being coaxially mounted on the first rotatable mechanism for co-rotation therewith; a second rotatable mechanism (90) having a rotation axis with the first and second rotatable mechanisms being coaxially interconnected for co-rotation around a common axis; and fluid tubing (70) connected to the axis of the fluid retentive housing and having a distal length that extends axially outwardly from the fluid retentive housing. A support arm (50) is mounted to the second rotatable mechanism a support tube (80) receives therethrough at least a part of the distal length of the fluid tubing and a bearing member (82) rotatably supports the support tube in the support arm whereby upon rotation of the first and second rotatable mechanisms the fluid tubing is free to one of rotate with and rotate relative to the support tube.Type: GrantFiled: November 13, 2008Date of Patent: July 10, 2012Assignee: Velico Medical, Inc.Inventors: William Aitkenhead, Glen Jorgensen, Robert L. Standley
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Publication number: 20120167405Abstract: The technology relates to spray dried plasma and methods of making the same. The method includes providing plasma to a spray drying apparatus, spray drying the plasma, at the spray drying apparatus, to form physiologically active plasma powder, the spray drying apparatus configured utilizing one or more parameters, and storing the physiologically active plasma powder.Type: ApplicationFiled: March 8, 2012Publication date: July 5, 2012Applicant: VELICO MEDICAL, INC.Inventors: Dennis Brian Hubbard, JR., Michael Haley
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Patent number: 8191280Abstract: Described herein are devices and techniques for spray drying a fluid to produce a dried powder. Assemblies include a spray drying head attachable to a gas supplier and a liquid sample, such as a standard unit of blood product. The spray drying head can be adapted to provide an aerosolized flow of liquid sample exposed to a drying gas. The assembly also includes a drying chamber adapted to separate the aerosolized flow of liquid sample into a dried powder and humid air. The assembly can be disposable, provided in a sterilized kit and having simplified attachments allowing quick connect and disconnect from the gas and liquid sample. Separation of the powder from the humid air exiting the drying chamber occurs within a filtered collection bag. In some embodiments, one or more of the drying chamber and collection bag are formed form a thin-walled, collapsible material.Type: GrantFiled: October 28, 2011Date of Patent: June 5, 2012Assignee: Velico Medical, Inc.Inventors: Dennis Brian Hubbard, Jr., Michael Haley, John Charles Rosenfelder, George T. Perivolotis
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Publication number: 20120103536Abstract: Described herein are devices and techniques for spray drying a fluid to produce a dried powder. Assemblies include a spray drying head attachable to a gas supplier and a liquid sample, such as a standard unit of blood product. The spray drying head can be adapted to provide an aerosolized flow of liquid sample exposed to a drying gas. The assembly also includes a drying chamber adapted to separate the aerosolized flow of liquid sample into a dried powder and humid air. The assembly can be disposable, provided in a sterilized kit and having simplified attachments allowing quick connect and disconnect from the gas and liquid sample. Separation of the powder from the humid air exiting the drying chamber occurs within a filtered collection bag. In some embodiments, one or more of the drying chamber and collection bag are formed form a thin-walled, collapsible material.Type: ApplicationFiled: October 28, 2011Publication date: May 3, 2012Applicant: VELICO MEDICAL, INC.Inventors: Dennis Brian Hubbard, JR., Michael Haley, John Charles Rosenfelder, George T. Perivolotis
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Patent number: 8133165Abstract: A flexible processing and/or expressor chamber for a biological cell processing apparatus is provided which may include a first side and a second side and having a expandable wall, wherein a first end of the expandable wall is attached to a circumference of the first side of the flexible chamber and a second end of the expandable wall is attached to a circumference of the second side of the flexible chamber. Either or both sides of the chamber may include an axial opening.Type: GrantFiled: January 4, 2010Date of Patent: March 13, 2012Assignee: Velico Medical, Inc.Inventor: Keith M. Rosiello
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Patent number: 8052667Abstract: The present invention provides modified platelets having a reduced platelet clearance and methods for reducing platelet clearance. Also provided are compositions for the preservation of platelets. The invention also provides methods for making a pharmaceutical composition containing the modified platelets and for administering the pharmaceutical composition to a mammal to mediate hemostasis.Type: GrantFiled: September 7, 2005Date of Patent: November 8, 2011Assignee: Velico Medical, Inc.Inventors: Keith Rosiello, Henrik Clausen
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Patent number: 7993310Abstract: A needle structure having proximal and distal ends and including a collection needle section at a more proximal end of the needle structure and a skin plug retainer section at the very distal end and integral with the collection needle section. The collection needle section includes a generally hollow tubular member having an external surface, an inner lumen and a port through the tubular member so as to enable fluid flow from about the tubular member to the inner lumen for collection therefrom. The skin plug retainer section includes a hollow tubular piece having an external surface and an inner lumen. The hollow tubular piece is beveled at its distal end to form a needle tip. A barrier wall may be disposed intermediate the collection needle section and the skin plug retainer section.Type: GrantFiled: April 13, 2007Date of Patent: August 9, 2011Assignee: Velico Medical, Inc.Inventor: Keith M. Rosiello
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Patent number: 7993896Abstract: This invention relates to enzymatic removal of type A and B antigens from blood group A, B, and AB reactive cells in blood products, and thereby converting these to non-A and non-B reactive cells. The invention further relates to using unique ?-N-acetylgalactosaminidases and ?-galactosidases with superior kinetic properties for removing the immunodominant monosaccharides of the blood group A and B antigens and improved performance in enzymatic conversion of red blood cells. The preferred unique ?-N-acetylgalactosaminidases and ?-galactosidases exhibit the following characteristics: (i) exclusive, preferred or no less than 10% substrate specificity for the type A and B branched polysaccharide structures relative to measurable activity with simple mono- and disaccharide structures and aglycon derivatives hereof; (ii) optimal performance at neutral pH with blood group oligosaccharides and in enzymatic conversion of cells; and (iii) a favorable kinetic constant Km with mono- and oligosaccharide substrates.Type: GrantFiled: May 28, 2010Date of Patent: August 9, 2011Assignee: Velico Medical, Inc.Inventors: Henrik Clausen, Humberto de la Vega, Cheryl Hill, Qiyong Peter Liu
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Patent number: 7951552Abstract: This invention relates to novel ?-galactosidases for the enzymatic removal of the immunodominant monosaccharides on blood products and tissues. Specifically this invention provides a novel family of ?3 glycosidases, used for the enzymatic removal of type B antigens from blood group B and AB reactive blood products, and the GaIiIi antigen from non-human animal tissues, thereby converting these to non-immunogenic cells and tissues suitable for transplantation.Type: GrantFiled: October 31, 2006Date of Patent: May 31, 2011Assignee: Velico Medical, Inc.Inventors: Qiyong Peter Liu, Henrik Clausen
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Patent number: 7858295Abstract: The present invention provides modified platelets having a reduced platelet clearance and methods for reducing platelet clearance. Also provided are compositions for the preservation of platelets. The invention also provides methods for making a pharmaceutical composition containing the modified platelets and for administering the pharmaceutical composition to a mammal to mediate hemostasis.Type: GrantFiled: June 29, 2007Date of Patent: December 28, 2010Assignee: Velico Medical, Inc.Inventors: Thomas P. Stossel, John H. Hartwig, Karin M. Hoffmeister, Henrik Clausen
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Patent number: 7824558Abstract: A centrifugal processing bag, system and method for separating the components of a mixed material is presented. The processing bag includes a hub and a first port for receiving the mixed material, where the first port includes an outlet positioned within the processing bag at a perimeter of the bag. The processing bag also including a second port having a second port inlet spaced proximate the hub and away from a central axis of the hub. The second port directs a separated material collected from the second port inlet out of the processing bag.Type: GrantFiled: June 26, 2006Date of Patent: November 2, 2010Assignee: Velico Medical, Inc.Inventor: Keith M. Rosiello
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Patent number: 7767415Abstract: This invention relates to enzymatic removal of type A and B antigens from blood group A, B, and AB reactive cells in blood products, and thereby converting these to non-A and non-B reactive cells. The invention further relates to using unique ?N-acetylgalactosaminidases and ?-galactosidases with superior kinetic properties for removing the immunodominant monosaccharides of the blood group A and B antigens and improved performance in enzymatic conversion of red blood cells. The preferred unique ?-N-acetylgalactosaminidases and ?-galactosidases exhibit the following characteristics: (i) exclusive, preferred or no less than 10% substrate specificity for the type A and B branched polysaccharide structures relative to measurable activity with simple mono- and disaccharide structures and aglycon derivatives hereof; (ii) optimal performance at neutral pH with blood group oligosaccharides and in enzymatic conversion of cells; and (iii) a favorable kinetic constant Km with mono- and oligosaccharide substrates.Type: GrantFiled: September 20, 2002Date of Patent: August 3, 2010Assignee: Velico Medical, Inc.Inventors: Henrik Clausen, Humberto de la Vega, Cheryl Hill, Qiyong Peter Liu