Abstract: A method has been developed to produce stable cell-matrix microspheres with up to 100% encapsulation efficiency and high cell viability, using matrix or biomaterial systems with poor shape and mechanical stability for applications including cell therapeutics via microinjection or surgical implantation, 3D culture for in vitro expansion without repeated cell splitting using enzymatic digestion or mechanical dissociation and for enhanced production of therapeutic biomolecules, and in vitro modeling for morphogenesis studies. The modified droplet generation method is simple and scalable and enables the production of cell-matrix microspheres when the matrix or biomaterial system used has low concentration, with slow phase transition, with poor shape and mechanical stability.
Type:
Grant
Filed:
February 18, 2014
Date of Patent:
October 11, 2016
Assignee:
Versitech Limited
Inventors:
Barbara Pui Chan, Godfrey Chi-Fung Chan, Hoi Ling Wong, Pik To Cheung, Song-Eng Kathryn Cheah, Danny Chan
Abstract: Compositions that include nanoscale structured materials or precursors thereof (e.g., self-assembling peptides) are described. The compositions can include other substances (e.g., a vasoconstrictor). Also described are methods for using the compositions to promote hemostasis, to protect the skin or wounds from contamination, to decontaminate a site upon removal of previously applied compositions that provided a protective coating, and to inhibit the movement of bodily substances other than blood. The compositions are also useful in isolating tissue, removing tissue, preserving tissue (for, e.g., subsequent transplantation or reattachment), and as bulking, stabilizing or hydrating agents. Medical devices that include the compositions (e.g., a stent or catheter), bandages or other wound dressings, sutures, and kits that include the compositions are also described.
Type:
Grant
Filed:
August 27, 2008
Date of Patent:
June 14, 2016
Assignees:
Maasachusetts Institute of Technology, Versitech Limited
Inventors:
Rutledge Ellis-Behnke, Shuguang Zhang, Gerald Schneider, Kwok-Fai So, David Tay, Yu-Xiang Liang
Abstract: Compositions that include nanoscale structured materials or precursors thereof (e.g., self-assembling peptides) are described. The compositions can include other substances (e.g., a vasoconstrictor). Also described are methods for using the compositions to promote hemostasis, to protect the skin or wounds from contamination, to decontaminate a site upon removal of previously applied compositions that provided a protective coating, and to inhibit the movement of bodily substances other than blood. The compositions are also useful in isolating tissue, removing tissue, preserving tissue (for, e.g., subsequent transplantation or reattachment), and as bulking, stabilizing or hydrating agents. Medical devices that include the compositions (e.g., a stent or catheter), bandages or other wound dressings, sutures, and kits that include the compositions are also described.
Type:
Grant
Filed:
April 25, 2006
Date of Patent:
May 3, 2016
Assignees:
Massachusetts Institute of Technology, Versitech Limited
Inventors:
Rutledge Ellis-Behnke, Shuguang Zhang, Gerald Schneider, Kwok-Fai So, David Tay, Yu-Xiang Liang
Abstract: The current invention relates to novel platinum(II) based organometallic materials. These materials show high emission quantum efficiencies and low self-quenching constant. Also provided are high efficiency, green to orange emitting organic light-emitting diode (OLED) that are fabricated using platinum(II) based organometallic materials as the light-emitting material. The organometallic materials of the invention are soluble in common solvents; therefore, solution process methods such as spin coating and printing can be used for device fabrication. The devices fabricated from these materials show low efficiency roll-off.
Type:
Grant
Filed:
April 11, 2013
Date of Patent:
April 5, 2016
Assignees:
THE UNIVERSITY OF HONG KONG, VERSITECH LIMITED
Inventors:
Chi Ming Che, Chi Fai Kui, Chi Chung Kwok
Abstract: Water-soluble derivatives and/or prodrugs of acacetin are described herein. The compounds can be used as cardioprotection agents against myocardial infarction induced by ischemia-reperfusion. In one embodiment the compounds are used to treat ischemic cardiac diseases. In the preferred embodiment, the compounds are used to treat and/or prevent myocardial infarction in humans.
Abstract: An optical transmission system comprises at least one first connection point and one second connection point arranged to transmit and receive at least one channel signal transmitted via at least one optical means connecting the first connection point and the second connection, wherein each of the at least one channel signal is reversibly configurable to be transmitted in either a first direction or a second direction between the first connection point and the second connection point. A method of transmitting at least one channel signal between a first connection point and a second connection point via at least one optical media in an optical transmission system, wherein each of the at least one channel signal is reversibly configurable to be transmitted in either a first direction or a second direction between the first and the second connection points.
Type:
Application
Filed:
October 1, 2015
Publication date:
February 4, 2016
Applicants:
VERSITECH LIMITED, THE HONG KONG POLYTECHNIC UNIVERSITY
Inventors:
Chun-yin Li, Ping-Kong Alexander Wai, Victor On-Kwok Li
Abstract: Transgenic plants having increased growth rate and increase yield are disclosed, and methods for making the same. In one embodiment, the method comprises: transforming a plant or plant cell with a nucleic acid molecule comprising a plant kinase and/or phosphatase gene selected from NG6, NG21, NG24, NG28, and NG32, and over-expressing said kinase and/or phosphatase gene in the plant or plant cell.
Abstract: The present invention provides compounds, and compositions comprising these compounds, which have immunomodulatory activity and/or anti-inflammatory activity.
Type:
Grant
Filed:
March 8, 2013
Date of Patent:
December 22, 2015
Assignees:
BAGI RESEARCH LIMITED, VERSITECH LIMITED
Inventors:
Allan Sik Yin Lau, Lai Hung Cindy Yang, Stanley Chi Chung Chik
Abstract: Compounds which exhibit antiviral activity, particularly against influenza virus, and methods of making and using thereof are described herein. In one embodiment, the compounds are heterocyclic amides containing piperazine and isozazole rings and optionally substituted with one or more substituents. The compounds can be formulated with one or more pharmaceutically acceptable excipients to form compositions suitable for enteral or parenteral administration. The compounds are preferably used to treat or prevent Influenza A infections, such as H1N1, H2N2, H3N2, H5N1, H7N7, H1N2, H9N2, H7N2, H7N3, and H10N7.
Type:
Grant
Filed:
August 5, 2010
Date of Patent:
December 15, 2015
Assignee:
Versitech Limited
Inventors:
Yi Tsun Richard Kao, Dan Yang, Kwok-Yung Yuen
Abstract: Compositions which self-assemble under physiological conditions are formulated for application to wounds. The formulations include a pharmaceutically acceptable carrier or are provided as part of a medical device or coating. The formulations may also include other therapeutic, prophylactic or diagnostic agents. The formulation can be administered as appropriate for treatment of one or more disorders or conditions. For example, the formulation may be applied to repair an injury or during surgery of the lung, eye or dura, or following an epidural or spinal tap, to stop leakage of blood, interstitial fluid, or cerebrospinal fluid. The formulation may be administered to a burn or ulcer. The formulation may be dispersed in a suture or adhesive for administration at the time of or as released following suturing or gluing of a wound, thereby limiting bleeding, loss of tissue fluids, or other fluids such as those produced by parenchymal tissues such as the liver, pancreas, and gastrointestinal tract.
Type:
Application
Filed:
June 23, 2015
Publication date:
November 19, 2015
Applicants:
Massachusetts Institute of Technology, Versitech Limited
Inventors:
Rutledge Ellis-Behnke, Yu-Xiang Liang, Gerald E. Schneider, Kwok-Fai So, David K.C. Tay
Abstract: Provided is a current mirror circuit (1) for balancing respective currents in a plurality of parallel circuit branches (2) in a target circuit (3), the current mirror circuit (1) including: a plurality of balancing transistors (4), each having a connector (5), an emitter (6), and a base (7), the collector (5) and emitter (6) of each balancing transistor (4) connected in series with a respective circuit branch (2); a selection circuit (8) that connects the circuit branch (2) having the smallest current amongst the circuit branches (2) to the bases (7) of each balancing transistor; and an isolation circuit (9) that isolates circuit branches (2) having an open circuit fault from the rest of the target circuit (3). An associated method of balancing respective currents in a plurality of parallel circuit branches (2) in a target circuit (3) is also provided.
Abstract: The present invention provides compounds, and compositions comprising these compounds, which have immunomodulatory activity and/or anti-inflammatory activity.
Type:
Grant
Filed:
February 18, 2013
Date of Patent:
November 3, 2015
Assignees:
VERSITECH LIMITED, BAGI RESEARCH LIMITED
Inventors:
Allan Sy Lau, Lai Hung Cindy Yang, Chi Chung Stanley Chik, Chun Bong James Li
Abstract: Described herein are isolated paramyxovirus, a morbillivirus (FmoPV), nucleic acid molecules, polypeptides and antibodies related to FmoPV and uses thereof. In certain embodiments, the FmoPV is a feline morbillivirus. Also described herein is a recombinant FmoPV comprising a modified FmoPV gene or gene segments and uses thereof. Also described is a recombinant FmoPV for the prevention and/or treatment of diseases related to FmoPV or a delivery vector. Also described herein is a diagnostic assay for FmoPV, natural or artificial variants, analogs, or derivatives thereof. Also described herein is a vaccine and a kit containing the vaccine for the prevention and treatment of FmoPV infection. Also provided is a diagnostic kit comprising nucleic acid molecules for the detection of FmoPV.
Type:
Grant
Filed:
January 22, 2013
Date of Patent:
September 22, 2015
Assignees:
THE GOVERNMENT OF THE HONG KONG SPECIAL ADMINISTRATIVE REGION OF THE PEOPLE'S REPUBLIC OF CHINA, VERSITECH LIMITED
Inventors:
Kwok-Yung Yuen, Patrick Chiu-Yat Woo, Susanna Kar-Pui Lau
Abstract: Water-soluble derivatives and/or prodrugs of acacetin are described herein. The compounds can be used as cardioprotection agents against myocardial infarction induced by ischemia-reperfusion. In one embodiment the compounds are used to treat ischemic cardiac diseases. In the preferred embodiment, the compounds are used to treat and/or prevent myocardial infarction in humans.
Type:
Application
Filed:
February 3, 2014
Publication date:
August 6, 2015
Applicants:
Shanghai Institute of Pharmaceutical Industry, Versitech Limited
Abstract: A method is provided to functionally select cells with enhanced characteristics relevant to cell engraftment, including both spontaneous migration and directional migration towards specific chemo-attractants. The cells are preferably undifferentiated cells, such as mesenchymal stem cells. The method involves entrapping or encapsulating the cells in a biomaterial barrier, optionally inducing cell migration, and selecting cells that migrated through the barrier. The cells selected by this method have better migratory activities and enhanced in vivo engraftment to injured tissues when they are supplemented systemically.
Type:
Grant
Filed:
June 14, 2011
Date of Patent:
August 4, 2015
Assignee:
Versitech Limited
Inventors:
Barbara Pui Chan, Hoi Ling Wong, Mei Yi Wong, Godfrey Chi-Fung Chan, Zhen Fan Yang
Abstract: Compositions which self-assemble under physiological conditions are formulated for application to wounds. The formulations include a pharmaceutically acceptable carrier or are provided as part of a medical device or coating. The formulations may also include other therapeutic, prophylactic or diagnostic agents. The formulation can be administered as appropriate for treatment of one or more disorders or conditions. For example, the formulation may be applied to repair an injury or during surgery of the lung, eye or dura, or following an epidural or spinal tap, to stop leakage of blood, interstitial fluid, or cerebrospinal fluid.
Type:
Grant
Filed:
April 25, 2007
Date of Patent:
July 21, 2015
Assignees:
Massachusetts Institute of Technology, Versitech Limited The University of Hong Kong
Inventors:
Rutledge Ellis-Behnke, Yu-Xiang Liang, Gerald E. Schneider, Kwok-Fai So, David Tay
Abstract: The invention provides organometallic complexes comprising an extended ?-conjugated tridentate ligand having a platinum center in which chemical and/or physical properties of the complexes may be modified by changing the structure of the ligands. The complex finds use in devices incorporated into electroluminescent devices, flat panel displays, organic light emitting devices, polymer light emitting devices, transistors, serrors, and lasers.
Abstract: A power compensator for compensating voltage at a location along a power transmission line, the compensator having a controller for controlling a voltage generated across the compensator, wherein the voltage is controlled to maintain a power transmission line voltage at a value dependent on the power transmission line location.
Abstract: An optical transmission system comprises at least one first connection point and one second connection point arranged to transmit and receive at least one channel signal transmitted via at least one optical means connecting the first connection point and the second connection, wherein each of the at least one channel signal is reversibly configurable to be transmitted in either a first direction or a second direction between the first connection point and the second connection point. A method of transmitting at least one channel signal between a first connection point and a second connection point via at least one optical media in an optical transmission system, wherein each of the at least one channel signals is reversibly configurable to be transmitted in either a first direction or a second direction between the first and the second connection points.
Type:
Application
Filed:
October 3, 2013
Publication date:
April 9, 2015
Applicants:
VERSITECH LIMITED, THE HONG KONG POLYTECHNIC UNIVERSITY
Inventors:
Chun-Yin Li, Ping-Kong Alexander Wai, Victor On-Kwok Li