Patents Assigned to Versitech Limited
  • Phosphorescent material, their preparations and applications
    Patent number: 8957217
    Abstract: The subject invention is directed to tetradentate bis-(NHC carbenes) alkylene ligand Pt(II) complexes, tetradentate bis-(NHC carbenes) alkylene ligands, and its ligand precursors, for preparation of the Pt(II) complexes. The Pt(II) complexes show a deep blue emission with an improved quantum efficiency and can be used for fabrication of OLEDs with an electroluminescence layer that comprise the bis-(NHC carbenes) alkylene ligand Pt(II) complexes.
    Type: Grant
    Filed: May 29, 2012
    Date of Patent: February 17, 2015
    Assignees: The University of Hong Kong, Versitech Limited
    Inventors: Chi Ming Che, Kai Li
  • Platinum (II) tetradentate ONCN complexes for organic light-emitting diode applications
    Patent number: 8877353
    Abstract: Described are novel platinum (II) containing organometallic materials. These materials show green to orange emissions with high emission quantum efficiencies. Using the materials as emitting materials; pure green emitting organic light-emitting diodes can be fabricated. Since the novel platinum (II) containing organometallic materials are soluble in common solvents, solution process methods such as spin coating and printing can be used for device fabrication.
    Type: Grant
    Filed: July 13, 2011
    Date of Patent: November 4, 2014
    Assignee: Versitech Limited
    Inventors: Chi Ming Che, Chi Fai Kui, Chi Chung Kwok
  • NOVEL COMPOUNDS AND USES THEREOF FOR TREATING INFLAMMATION AND MODULATING IMMUNE RESPONSES
    Publication number: 20140255450
    Abstract: The present invention provides compounds, and compositions comprising these compounds, which have immunomodulatory activity and/or anti-inflammatory activity.
    Type: Application
    Filed: February 18, 2013
    Publication date: September 11, 2014
    Applicants: VERSITECH LIMITED, PURAPHARM COMPANY LIMITED
    Inventors: ALLAN SY LAU, LAI HUNG CINDY YANG, CHI CHUNG STANLEY CHIK, CHUN BONG JAMES LI
  • Anti-viral carbamimidothioic acid esters
    Patent number: 8742156
    Abstract: Carbamimidothioic acid esters of formula (I) and 2-nitro-N-[4-(pyridin-4-ylamino)phenyl]-4-(quinolin-4-ylamino)benzamide are used for the treatment of influenza, and for the inhibition of a viral RNA-dependent RNA polymerase. Formulae (I), (II).
    Type: Grant
    Filed: August 12, 2011
    Date of Patent: June 3, 2014
    Assignees: British Columbia Cancer Agency Branch, Versitech Limited
    Inventors: Steven J. Jones, Allan Sik-Yin Lau, Jianghong An, Hing-Yee Law, Chun-Wai Davy Lee
  • METHOD TO INDUCE AND EXPAND THERAPEUTIC ALLOANTIGEN-SPECIFIC HUMAN REGULATORY T CELLS IN LARGE-SCALE
    Publication number: 20140134145
    Abstract: Methods for inducing, expanding, and/or generating alloantigen-specific regulatory T cells. Alloantigen-specific regulatory T cells can be induced, expanded, and/or generated from naive CD4+CD25? T cells by using CD40-activated B cells. The regulatory T cells can be human T cells. In one embodiment, the alloantigen-specific human regulatory T cells can be CD4highCD25+Foxp3+ regulatory T cells.
    Type: Application
    Filed: January 10, 2014
    Publication date: May 15, 2014
    Applicants: THE BOARD OF TRUSTEES OF THE LELAND STANFORD JUNIOR UNIVERSITY, VERSITECH LIMITED
    Inventors: Wenwei Tu, Yu-Lung Lau, David Bram Lewis
  • Anti-influenza compounds
    Patent number: 8673884
    Abstract: The present invention provides pyrimidinyl compounds of formula (I) and pharmaceutically acceptable salts thereof. These compounds may be used for the inhibition of influenza. In particular, the compounds of the invention may be used for the treatment or prophylaxis of influenza A, most particularly H1N1 or H5N1 influenza. The compounds of the invention can also be used for the treatment or prophylaxis of a disease caused by Vibrio cholerae, Clostridium perfringens, Streptococcus pneumoniae, Arthrobacter sialophilus, an orthomyxovirus, a paramyxovirus, a parainfluenza virus, mumps virus, Newcastle disease virus, fowl plague virus or Sendai virus.
    Type: Grant
    Filed: February 4, 2009
    Date of Patent: March 18, 2014
    Assignees: Versitech Limited, British Columbia Cancer Agency Branch
    Inventors: Steven J. Jones, Allan Sik-Yin Lau, Jianghong An, Hing Yee Law, Chun Wai Davy Lee, Lit Man Poon
  • Method to induce and expand therapeutic alloantigen-specific human regulatory T cells in large-scale
    Patent number: 8658159
    Abstract: Methods for inducing, expanding, and/or generating alloantigen-specific regulatory T cells. Alloantigen-specific regulatory T cells can be induced, expanded, and/or generated from naive CD4+CD25? T cells by using CD40-activated B cells. The regulatory T cells can be human T cells. In one embodiment, the alloantigen-specific human regulatory T cells can be CD4highCD25+Foxp3+ regulatory T cells.
    Type: Grant
    Filed: April 30, 2009
    Date of Patent: February 25, 2014
    Assignees: Versitech Limited, The Board of Trustees of the Leland Stanford Junior University
    Inventors: Wenwei Tu, Yu-Lung Lau, David Bram Lewis
  • Efficient isolation of cimiracemate A, and methods of use
    Patent number: 8633332
    Abstract: A method for isolating cimiracemate A from a Cimicifuga species is disclosed, comprising the steps of a) providing a sufficient quantity of raw materials from the Cimicifuga species, b) mixing the raw materials from the Cimicifuga species with an aqueous polar solvent at a temperature of about 20° C. to about 28° C. to obtain a solvent extract comprising cimiracemate A, and c) isolating cimiracemate A from the solvent extract.
    Type: Grant
    Filed: June 21, 2010
    Date of Patent: January 21, 2014
    Assignees: Purapharm Company Limited, Versitech Limited
    Inventors: Lai Hung Cindy Yang, Allan Sy Lau
  • CORIOLUS VERSICOLOR EXTRACTS, METHODS OF PREPARATION AND USES THEREOF
    Publication number: 20140017275
    Abstract: The subject invention provides Coriolus versicolor extracts, pharmaceutical compositions comprising the Coriolus versicolor extracts, methods of preparation, and therapeutic uses thereof. Advantageously, the subject Coriolus versicolor extract has immunomodulatory, anti-tumor, anti-microbial, and antiviral effects. In a preferred embodiment, the subject invention can be used to inhibit the metastatic spread of cancer cells. In certain preferred embodiments, the subject invention can be used to treat glioblastoma multiforme, nasopharyngeal carcinoma, breast carcinoma, lung carcinoma, prostate cancer, and colon carcinoma, as well as bacterial, viral, fungal, protozoan, and/or other microbial infection.
    Type: Application
    Filed: October 6, 2011
    Publication date: January 16, 2014
    Applicants: VERSITECH LIMITED, PURAPHARM COMPANY LIMITED
    Inventor: Maureen Lau
  • USES OF CIMIRACEMATE A AND RELATED COMPOUNDS FOR TREATING INFLAMMATION AND MODULATING IMMUNE RESPONSES
    Publication number: 20130324605
    Abstract: The present invention pertains to Cimiracemate A and related compounds that are useful as inhibitors of 5-lipoxygenase (5-1. OX) activity and various proinflammatory mediators such as lipoxins, leukotrienes (e.g., LTA4, LTB4, LTC4, LTD4, and LTE4), prostaglandins, and thromboxanes. The present invention also provides therapeutic methods and compositions for treatment of inflammation and inflammatory conditions, including allergenic reactions, diseases associated with cell proliferation, neoangiogenesis, and cardiovascular diseases.
    Type: Application
    Filed: July 29, 2011
    Publication date: December 5, 2013
    Applicants: VERSITECH LIMITED, PURAPHARM COMPANY LIMITED
    Inventors: Allan Sik Yin Lau, Cindy Lai Hung Yang
  • MATERIALS AND METHODS FOR PREVENTION AND TREATMENT OF VIRAL INFECTIONS
    Publication number: 20130281393
    Abstract: The present invention provides novel and advantageous materials and methods for preventing and treating viral infection.
    Type: Application
    Filed: April 16, 2013
    Publication date: October 24, 2013
    Applicants: VERSITECH LIMITED, PURAPHARM COMPANY LIMITED
    Inventors: ALLAN SIK YIN LAU, LAI HUNG CINDY YANG
  • CORIOLUS VERSICOLOR EXTRACTS, METHODS OF ISOLATING BIOLOGICALLY-ACTIVE COMPOUNDS, AND USES THEREOF
    Publication number: 20130274333
    Abstract: The subject invention provides efficient and convenient methods of isolating 9-oxo-10E, 12E-octadecadienoic acid methyl ester (9-KODE methyl ester) from C. versicolor. In addition, the subject invention provides therapeutic uses of Coriolus versicolor extracts, biologically-active chemical substituents isolated from C. versicolor, as well as 9-KODE methyl ester and related compounds. In a preferred embodiment, the subject invention can be used to inhibit the metastatic spread of cancer cells.
    Type: Application
    Filed: March 14, 2013
    Publication date: October 17, 2013
    Applicants: VERSITECH LIMITED, PURAPHARM COMPANY LIMITED
    Inventors: ALLAN SIK YIN LAU, LAI HUNG CINDY YANG, STANLEY CHI CHUNG CHIK
  • Synthetic Ion Channels
    Publication number: 20130244944
    Abstract: Provided herein are self-assembling compounds that can form ion channels in lipid bilayers or cell membranes and ion-channel-forming compositions comprising the self-assembling compounds. Also provided are methods of making and using the ion channels formed from a plurality of molecules of the self-assembling compounds. Further, provided are methods of treating or preventing conditions and diseases that are related to the dysfunction of ion channels, including chloride channels.
    Type: Application
    Filed: December 31, 2012
    Publication date: September 19, 2013
    Applicants: VERSITECH LIMITED, THE UNIVERSITY OF HONG KONG
    Inventors: Dan Yang, Xiang Li, Huiyan Zha
  • COMPOUNDS AND USES THEREOF FOR TREATING INFLAMMATION AND MODULATING IMMUNE RESPONSES
    Publication number: 20130237599
    Abstract: The present invention provides compounds, and compositions comprising these compounds, which have immunomodulatory activity and/or anti-inflammatory activity.
    Type: Application
    Filed: March 8, 2013
    Publication date: September 12, 2013
    Applicants: VERSITECH LIMITED, PURAPHARM COMPANY LIMITED
    Inventors: ALLAN SIK YIN LAU, LAI HUNG CINDY YANG, STANLEY CHI CHUNG CHIK
  • Use of acacetin and related compounds as potassium channel inhibitors
    Patent number: 8461198
    Abstract: This invention provides a method for treating or preventing human atrial arrhythmia (fibrillation) using the leading flavone compound acacetin, and its derivatives and analogues that inhibit the ultra-rapidly-activating delayed rectifier potassium current (IKur or IKsus), transient outward potassium (Ito), and acetylcholine-activated potassium current (IK.Ach).
    Type: Grant
    Filed: September 7, 2010
    Date of Patent: June 11, 2013
    Assignees: Versitech Limited, Shanghai Institute of Materia Medica, Chinese Academy of Sciences
    Inventors: Gui-Rong Li, Chu-Pak Lau, Guo-Wei Qin, Hong-Bing Wang
  • ANTI-VIRAL CARBAMIMIDOTHIOIC ACID ESTERS
    Publication number: 20130143961
    Abstract: Carbamimidothioic acid esters of formula (I) and 2-nitro-N-[4-(pyridin-4-ylamino)phenyl]-4-(quinolin-4-ylamino)benzamide are used for the treatment of influenza, and for the inhibition of a viral RNA-dependent RNA polymerase. Formulae (I), (II).
    Type: Application
    Filed: August 12, 2011
    Publication date: June 6, 2013
    Applicants: British Columbia Cancer Agency, Versitech Limited
    Inventors: Steven J. Jones, Allan Sik-Yin Lau, Jianghong An, Hing-Yee Law, Chun-Wai Davy Lee
  • Luminescent gold(III) compounds for organic light-emitting devices and their preparation
    Patent number: 8415473
    Abstract: A class of luminescent gold(III) compounds containing a tridentate ligand with one strong ?-donating group having the chemical structure depicted by generic formula (I): wherein: (a) X is selected from nitrogen; (b) Y and Z selected from carbon; (c) A is cyclic structure derivative of pyridine group; (d) B and C are cyclic structure derivative of phenyl groups; (e) R1 is an optionally substituted carbon donor ligand attached to the gold atom; (f) n is zero, a positive integer or a negative integer.
    Type: Grant
    Filed: June 30, 2009
    Date of Patent: April 9, 2013
    Assignee: Versitech Limited
    Inventors: Vivian Wing-Wah Yam, Vonika Ka-Man Au, Mei-Yee Chan, Keith Man-Chung Wong, Hoi-Sing Kwok
  • Nitridoosmium(VI) complexes for treatment of cancer
    Patent number: 8383673
    Abstract: The invention relates to nitridoosmium complexes and methods of using these compounds as treatments for cancer.
    Type: Grant
    Filed: March 19, 2010
    Date of Patent: February 26, 2013
    Assignees: City University of Hong Kong, Versitech Limited
    Inventors: Tai Chu Lau, Yun Wah Lam, Wai Lun Man, Wen Xiu Ni, Chi-Ming Che
  • Compounds and uses thereof for treating inflammation and modulating immune responses
    Patent number: 8377987
    Abstract: The present invention provides compounds, and compositions comprising these compounds, which have immunomodulatory activity and/or anti-inflammatory activity.
    Type: Grant
    Filed: December 28, 2009
    Date of Patent: February 19, 2013
    Assignees: PuraPharm Company Limited, Versitech Limited
    Inventors: Allan Sy Lau, Lai Hung Cindy Yang, Chi Chung Stanley Chik, Chun Bong James Li
  • Synthetic ion channels
    Patent number: 8378138
    Abstract: Provided herein are self-assembling compounds that can form ion channels in lipid bilayers or cell membranes and ion-channel-forming compositions comprising the self-assembling compounds. Also provided are methods of making and using the ion channels formed from a plurality of molecules of the self-assembling compounds. Further, provided are methods of treating or preventing conditions and diseases that are related to the dysfunction of ion channels, including chloride channels.
    Type: Grant
    Filed: December 19, 2007
    Date of Patent: February 19, 2013
    Assignee: The University of Hong Kong & Versitech Limited
    Inventors: Dan Yang, Xiang Li