Patents Assigned to Viacyte, Inc.
  • Methods of making and using PDX1-positive pancreatic endoderm cells
    Patent number: 11254916
    Abstract: Disclosed herein are cell cultures and enriched cell populations of endocrine precursor cells, immature pancreatic hormone-expressing cells and mature pancreatic hormone-expressing cells. Also disclosed herein are methods of producing such cell cultures and cell populations.
    Type: Grant
    Filed: June 18, 2019
    Date of Patent: February 22, 2022
    Assignee: ViaCyte, Inc.
    Inventors: Kevin A. D'Amour, Anne Bang, Emmanuel E. Baetge
  • Instruments and methods for loading cells into implantable devices
    Patent number: 11246979
    Abstract: Embodiments herein describe tools, instruments and methods for aseptic loading, dispensing and/or delivering cells into an implantable device and aseptically and selectively sealing a device inside a sterile package as well as and storing and preparing for shipment the cell-filled device.
    Type: Grant
    Filed: June 25, 2020
    Date of Patent: February 15, 2022
    Assignee: ViaCyte, Inc.
    Inventors: Chad Green, Laura Martinson, Erik Olson, Val Anthony Bellora, Leah Elliott, Richard Alexander Grant, Donald Koenig, Giacomo Strollo
  • 3-DIMENSIONAL LARGE CAPACITY CELL ENCAPSULATION DEVICE ASSEMBLY
    Publication number: 20220016406
    Abstract: Disclosed herein are implantable 3-dimensional large capacity device assemblies, specifically, large capacity device assemblies for encapsulating pancreatic progenitor cells for treatment of diabetes.
    Type: Application
    Filed: July 28, 2021
    Publication date: January 20, 2022
    Applicant: ViaCyte, Inc.
    Inventors: Vincent So, Laura Martinson, Chad Green, Michael Scott, Mario Zamarripa
  • TOOLS AND INSTRUMENTS FOR USE WITH IMPLANTABLE ENCAPSULATION DEVICES
    Publication number: 20210330414
    Abstract: Embodiments herein describe tools and instruments for holding, transferring, delivering, deploying an implantable device and methods and means of aseptically storing and shipping the implantable device including but not limited to a device case for protecting, housing and filling the device, a surgical sizer for preparing the implantable site, a deployer for transferring the implantable device from the device case and delivering or deploying the implantable device at the prepared implantable site.
    Type: Application
    Filed: July 2, 2021
    Publication date: October 28, 2021
    Applicant: ViaCyte, Inc.
    Inventors: Vincent So, Erik Olson, Michael Scott, Chad Green, Giacomo Strollo, Gustavo Prado, Craig McGreevy, Laura Martinson, Donald Koenig
  • 3-dimensional large capacity cell encapsulation device assembly
    Patent number: 11077289
    Abstract: Disclosed herein are implantable 3-dimensional large capacity device assemblies, specifically, large capacity device assemblies for encapsulating pancreatic progenitor cells for treatment of diabetes.
    Type: Grant
    Filed: November 11, 2016
    Date of Patent: August 3, 2021
    Assignee: ViaCyte, Inc.
    Inventors: Vincent So, Laura Martinson, Chad Green, Michael Scott, Mario Zamarripa
  • Tools and instruments for use with implantable encapsulation devices
    Patent number: 11051900
    Abstract: Embodiments herein describe tools and instruments for holding, transferring, delivering, deploying an implantable device and methods and means of aseptically storing and shipping the implantable device including but not limited to a device case for protecting, housing and filling the device, a surgical sizer for preparing the implantable site, a deployer for transferring the implantable device from the device case and delivering or deploying the implantable device at the prepared implantable site.
    Type: Grant
    Filed: April 16, 2014
    Date of Patent: July 6, 2021
    Assignee: ViaCyte, Inc.
    Inventors: Vincent So, Erik Olson, Michael Scott, Chad Green, Giacomo Strollo, Gustavo Prado, Craig McGreevy, Laura Martinson, Donald Koenig
  • Scalable primate pluripotent stem cell aggregate suspension culture
    Patent number: 11015170
    Abstract: The present invention relates to methods for production of undifferentiated or differentiated embryonic stem cell aggregate suspension cultures from undifferentiated or differentiated embryonic stem cell single cell suspensions and methods of differentiation thereof.
    Type: Grant
    Filed: November 26, 2018
    Date of Patent: May 25, 2021
    Assignee: VIACYTE, INC.
    Inventor: Thomas C Schulz
  • CELL ENCAPSULATION DEVICE COMPRISING A PANCREATIC PROGENITOR CELL POPULATION
    Publication number: 20210102173
    Abstract: Disclosed herein are cell culture compositions, for example, pancreatic cell culture compositions, derived from dedifferentiated human reprogrammed pluripotent stem cells, such as induced pluripotent stem (iPS) cells, and methods for producing and using such cell culture compositions.
    Type: Application
    Filed: December 18, 2020
    Publication date: April 8, 2021
    Applicant: ViaCyte, Inc.
    Inventors: Alan D. Agulnick, Olivia Kelly, Yuki Ohi, Allan Robins, Thomas Schulz
  • Methods and compositions for feeder-free pluripotent stem cell media containing human serum
    Patent number: 10808223
    Abstract: The present invention provides compositions and methods for the culture and maintenance of pluripotent stem cells. More particularly, the present invention provides for compositions and methods for culturing, maintaining, growing and stabilizing primate pluripotent stem cells in a feeder-free defined media further comprising human serum, or a soluble attachment component of the human serum, for promoting cell attachment.
    Type: Grant
    Filed: April 1, 2019
    Date of Patent: October 20, 2020
    Assignee: VIACYTE, INC.
    Inventors: Allan J Robins, Thomas C Schulz
  • INSTRUMENTS AND METHODS FOR LOADING CELLS INTO IMPLANTABLE DEVICES
    Publication number: 20200324043
    Abstract: Embodiments herein describe tools, instruments and methods for aseptic loading, dispensing and/or delivering cells into an implantable device and aseptically and selectively sealing a device inside a sterile package as well as and storing and preparing for shipment the cell-filled device.
    Type: Application
    Filed: June 25, 2020
    Publication date: October 15, 2020
    Applicant: ViaCyte, Inc.
    Inventors: Chad Green, Laura Martinson, Erik Olson, Val Anthony Bellora, Leah Elliott, Richard Alexander Grant, Donald Koenig, Giacomo Strollo
  • METHODS OF PRODUCING PANCREATIC HORMONES
    Publication number: 20200316135
    Abstract: Disclosed herein are methods of producing pancreatic hormone-expressing cells by first differentiating pluripotent cells in cell culture so as to produce endodermal cells, the endodermal cells being competent to further differentiate into hormone-expressing cells capable of secreting at least one pancreatic hormone in response to a physiological signal, and then, transplanting the cultured endodermal cells into an organism, such as an organism in need of an endocrine cell therapy.
    Type: Application
    Filed: November 8, 2019
    Publication date: October 8, 2020
    Applicant: ViaCyte, Inc.
    Inventors: Laura Martinson, Evert Kroon, Kevin D'Amour, Emmanuel Edward Baetge
  • CRYOPRESERVATION AND STORAGE OF AN IMPLANTABLE ENCAPSULATION DEVICE LOADED WITH AN ENDOCRINE CELL POPULATION
    Publication number: 20200281987
    Abstract: Disclosed herein are methods for cryopreserving, hibernation and room temperature storage of PEC aggregates, implantable semipermeable devices and the VC combination product.
    Type: Application
    Filed: May 19, 2020
    Publication date: September 10, 2020
    Applicant: ViaCyte, Inc.
    Inventors: Alan Agulnick, Laura Martinson, Evert Kroon, Michael Scott, Chad Green
  • METHODS OF MAKING HUMAN PRIMITIVE ECTODERM CELLS
    Publication number: 20200248137
    Abstract: This disclosure relates to compositions comprising human preprimitive streak cells and/or human mesendoderm cells as well as methods for their production. Additionally, disclosed herein are methods of identifying factors useful in the further differentiation of preprimitive streak and mesendoderm cell types.
    Type: Application
    Filed: December 17, 2019
    Publication date: August 6, 2020
    Applicant: ViaCyte, Inc.
    Inventors: Kevin Allen D'Amour, Alan D. Agulnick, Susan Eliazer, Evert Kroon, Emmanuel E. Baetge
  • Instruments and methods for loading cells into implantable devices
    Patent number: 10722644
    Abstract: Embodiments herein describe tools, instruments and methods for aseptic loading, dispensing and/or delivering cells into an implantable device and aseptically and selectively sealing a device inside a sterile package as well as and storing and preparing for shipment the cell-filled device.
    Type: Grant
    Filed: November 20, 2014
    Date of Patent: July 28, 2020
    Assignee: Viacyte, Inc.
    Inventors: Chad Green, Laura Martinson, Erik Olson, Val Anthony Bellora, Leah Elliott, Richard Alexander Grant, Donald Koenig, Giacomo Strollo
  • Cryopreservation of encapsulated pancreatic endoderm cells
    Patent number: 10695380
    Abstract: Disclosed herein are methods for cryopreserving, hibernation and room temperature storage of PEC aggregates, implantable semipermeable devices and the VC combination product.
    Type: Grant
    Filed: October 26, 2017
    Date of Patent: June 30, 2020
    Assignee: ViaCyte, Inc.
    Inventors: Alan Agulnick, Laura Martinson, Evert Kroon, Michael Scott, Chad Green
  • Methods of making human primitive ectoderm cells
    Patent number: 10550367
    Abstract: This disclosure relates to compositions comprising human preprimitive streak cells and/or human mesendoderm cells as well as methods for their production. Additionally, disclosed herein are methods of identifying factors useful in the further differentiation of preprimitive streak and mesendoderm cell types.
    Type: Grant
    Filed: October 2, 2018
    Date of Patent: February 4, 2020
    Assignee: ViaCyte, Inc.
    Inventors: Kevin Allen D'Amour, Alan D. Agulnick, Susan Eliazer, Evert Kroon, Emmanuel E. Baetge
  • ANTERIOR ENDODERM CELLS AND METHODS OF PRODUCTION
    Publication number: 20200017824
    Abstract: Disclosed herein are cell cultures comprising PDX1-positive endoderm cells and methods of producing the same. Also disclosed herein are cell populations comprising substantially purified PDX1-positive endoderm cells as well as methods for enriching, isolating and purifying PDX1-positive endoderm cells from other cell types. Methods of identifying differentiation factors capable of promoting the differentiation of endoderm cells, such as PDX1-positive foregut endoderm cells and PDX1-negative definitive endoderm cells, are also disclosed.
    Type: Application
    Filed: September 25, 2019
    Publication date: January 16, 2020
    Applicant: ViaCyte, Inc.
    Inventors: Kevin Allen D'Amour, Alan D. Agulnick, Susan Eliazer, Emmanuel E. Baetge
  • Methods of lowering blood glucose levels in a mammal
    Patent number: 10517901
    Abstract: Disclosed herein are methods of producing pancreatic hormone-expressing cells by first differentiating pluripotent cells in cell culture so as to produce endodermal cells, the endodermal cells being competent to further differentiate into hormone-expressing cells capable of secreting at least one pancreatic hormone in response to a physiological signal, and then, transplanting the cultured endodermal cells into an organism, such as an organism in need of an endocrine cell therapy.
    Type: Grant
    Filed: April 24, 2018
    Date of Patent: December 31, 2019
    Assignee: ViaCyte, Inc.
    Inventors: Laura Martinson, Evert Kroon, Kevin D'Amour, Emmanuel Edward Baetge
  • DEFINITIVE ENDODERM
    Publication number: 20190376028
    Abstract: Disclosed herein are cell cultures comprising definitive endoderm cells and methods of producing the same. Also disclosed herein are cell populations comprising substantially purified definitive endoderm cells as well as methods for enriching, isolating and purifying definitive endoderm cells from other cell types.
    Type: Application
    Filed: August 13, 2019
    Publication date: December 12, 2019
    Applicant: ViaCyte, Inc.
    Inventors: Kevin Allen D'Amour, Alan D. Agulnick, Emmanuel E. Baetge
  • ENDOCRINE PRECURSOR CELLS, PANCREATIC HORMONE-EXPRESSING CELLS AND METHODS OF PRODUCTION
    Publication number: 20190359943
    Abstract: Disclosed herein are cell cultures and enriched cell populations of endocrine precursor cells, immature pancreatic hormone-expressing cells and mature pancreatic hormone-expressing cells. Also disclosed herein are methods of producing such cell cultures and cell populations.
    Type: Application
    Filed: June 18, 2019
    Publication date: November 28, 2019
    Applicant: ViaCyte, Inc.
    Inventors: Kevin A. D'Amour, Anne Bang, Emmanuel E. Baetge