Patents Assigned to Viacyte, Inc.
  • Cell compositions derived from dedifferentiated reprogrammed cells
    Patent number: 9988604
    Abstract: Disclosed herein are cell culture compositions, for example, pancreatic cell culture compositions, derived from dedifferentiated human reprogrammed pluripotent stem cells, such as induced pluripotent stem (iPS) cells, and methods for producing and using such cell culture compositions.
    Type: Grant
    Filed: July 23, 2015
    Date of Patent: June 5, 2018
    Assignee: ViaCyte, Inc.
    Inventors: Alan D. Agulnick, Olivia Kelly, Yuki Ohi, Allan Robins, Thomas Schulz
  • Methods of producing pancreatic hormones
    Patent number: 9980986
    Abstract: Disclosed herein are methods of producing pancreatic hormone-expressing cells by first differentiating pluripotent cells in cell culture so as to produce endodermal cells, the endodermal cells being competent to further differentiate into hormone-expressing cells capable of secreting at least one pancreatic hormone in response to a physiological signal, and then, transplanting the cultured endodermal cells into an organism, such as an organism in need of an endocrine cell therapy.
    Type: Grant
    Filed: March 26, 2015
    Date of Patent: May 29, 2018
    Assignee: ViaCyte, Inc.
    Inventors: Laura Martinson, Evert Kroon, Kevin D'Amour, Emmanuel Edward Baetge
  • Cell compositions derived from dedifferentiated reprogrammed cells
    Patent number: 9982235
    Abstract: Disclosed herein are cell culture compositions, for example, pancreatic cell culture compositions, derived from dedifferentiated human reprogrammed pluripotent stem cells, such as induced pluripotent stem (iPS) cells, and methods for producing and using such cell culture compositions.
    Type: Grant
    Filed: July 7, 2015
    Date of Patent: May 29, 2018
    Assignee: ViaCyte, Inc.
    Inventors: Alan D. Agulnick, Olivia Kelly, Yuki Ohi, Allan Robins, Thomas Schulz
  • Encapsulation of pancreatic cells derived from human pluripotent stem cells
    Patent number: 9913930
    Abstract: Described herein are methods for implanting cells into a host comprising the steps of implanting into the host a device comprising a cell encapsulation chamber with at least one seal, allowing the device to vascularize, and loading the device with a human embryonic stem (hES) cell-derived pancreatic progenitor cell population.
    Type: Grant
    Filed: November 13, 2015
    Date of Patent: March 13, 2018
    Assignee: VIACYTE, INC.
    Inventors: Laura Martinson, Chad Green, Evert Kroon, Emmanuel Edward Baetge
  • CRYOPRESERVATION, HIBERNATION AND ROOM TEMPERATURE STORAGE OF ENCAPSULATED PANCREATIC ENDODERM CELL AGGREGATES
    Publication number: 20180064763
    Abstract: Disclosed herein are methods for cryopreserving, hibernation and room temperature storage of PEC aggregates, implantable semipermeable devices and the VC combination product.
    Type: Application
    Filed: October 26, 2017
    Publication date: March 8, 2018
    Applicant: ViaCyte, Inc.
    Inventors: Alan Agulnick, Laura Martinson, Evert Kroon, Michael Scott, Chad Green
  • ENCAPSULATION OF PANCREATIC CELLS DERIVED FROM HUMAN PLURIPOTENT STEM CELLS
    Publication number: 20170354760
    Abstract: The present invention relates to methods for encapsulating pancreatic progenitors in a biocompatible semi-permeable encapsulating device. The present invention also relates to production of human insulin in a mammal in response to glucose stimulation.
    Type: Application
    Filed: August 16, 2017
    Publication date: December 14, 2017
    Applicant: ViaCyte, Inc.
    Inventors: Laura Martinson, Chad Green, Evert Kroon, Emmanuel Edward Baetge
  • PREPRIMITIVE STREAK AND MESENDODERM CELLS
    Publication number: 20170313979
    Abstract: This disclosure relates to compositions comprising human preprimitive streak cells and/or human mesendoderm cells as well as methods for their production. Additionally, disclosed herein are methods of identifying factors useful in the further differentiation of preprimitive streak and mesendoderm cell types.
    Type: Application
    Filed: July 19, 2017
    Publication date: November 2, 2017
    Applicant: ViaCyte, Inc.
    Inventors: Kevin Allen D'Amour, Alan D. Agulnick, Susan Eliazer, Evert Kroon, Emmanuel E. Baetge
  • Encapsulation of pancreatic cells derived from human pluripotent stem cells
    Patent number: 9764062
    Abstract: The present invention relates to methods for encapsulating pancreatic progenitors in a biocompatible semi-permeable encapsulating device. The present invention also relates to production of human insulin in a mammal in response to glucose stimulation.
    Type: Grant
    Filed: August 7, 2015
    Date of Patent: September 19, 2017
    Assignee: ViaCyte, Inc.
    Inventors: Laura Martinson, Chad Green, Evert Kroon, Emmanuel Edward Baetge
  • Preprimitive streak and mesendoderm cells
    Patent number: 9732318
    Abstract: This disclosure relates to compositions comprising human preprimitive streak cells and/or human mesendoderm cells as well as methods for their production. Additionally, disclosed herein are methods of identifying factors useful in the further differentiation of preprimitive streak and mesendoderm cell types.
    Type: Grant
    Filed: July 25, 2011
    Date of Patent: August 15, 2017
    Assignee: ViaCyte, Inc.
    Inventors: Kevin Allen D'Amour, Alan D. Agulnick, Susan Eliazar, Evert Kroon, Emmanuel E. Baetge
  • MARKERS OF DEFINITIVE ENDODERM
    Publication number: 20170216365
    Abstract: Disclosed herein are reagent-cell complexes comprising one or more definitive endoderm cells. Also described herein are compositions for detecting definitive endoderm. Method of enriching, isolating and/or purifying definitive endoderm cells are also disclosed.
    Type: Application
    Filed: February 8, 2017
    Publication date: August 3, 2017
    Applicant: ViaCyte, Inc.
    Inventors: Kevin Allen D'Amour, Alan D. Agulnick, Emmanuel Edward Baetge
  • IN VITRO DIFFERENTIATION OF PLURIPOTENT STEM CELLS TO PANCREATIC ENDODERM CELLS (PEC) AND ENDOCRINE CELLS
    Publication number: 20170202885
    Abstract: A human immature endocrine cell population and methods for making an immature endocrine cell population are provided. Specifically, immature beta cells and methods for production of immature beta cells are described. Immature beta cells co-express INS and NKX6.1 and are uni-potent and thereby develop into mature beta cells when implanted in vivo. The mature beta cells in vivo are capable of producing insulin in response to glucose stimulation.
    Type: Application
    Filed: April 3, 2017
    Publication date: July 20, 2017
    Applicant: ViaCyte, Inc.
    Inventor: Alan D. Agulnick
  • DEFINITIVE ENDODERM
    Publication number: 20170159011
    Abstract: Disclosed herein are cell cultures comprising definitive endoderm cells and methods of producing the same. Also disclosed herein are cell populations comprising substantially purified definitive endoderm cells as well as methods for enriching, isolating and purifying definitive endoderm cells from other cell types.
    Type: Application
    Filed: February 13, 2017
    Publication date: June 8, 2017
    Applicant: ViaCyte, Inc.
    Inventors: Kevin Allen D'Amour, Alan D. Agulnick, Emmanuel E. Baetge
  • In vitro differentiation of pluripotent stem cells to pancreatic endoderm cells (PEC) and endocrine cells
    Patent number: 9650610
    Abstract: A human immature endocrine cell population and methods for making an immature endocrine cell population are provided. Specifically, immature beta cells and methods for production of immature beta cells are described. Immature beta cells co-express INS and NKX6.1 and are uni-potent and thereby develop into mature beta cells when implanted in vivo. The mature beta cells in vivo are capable of producing insulin in response to glucose stimulation.
    Type: Grant
    Filed: August 8, 2014
    Date of Patent: May 16, 2017
    Assignee: ViaCyte, Inc.
    Inventor: Alan D. Agulnick
  • Markers of definitive endoderm
    Patent number: 9605243
    Abstract: Disclosed herein are reagent-cell complexes comprising one or more definitive endoderm cells. Also described herein are compositions for detecting definitive endoderm. Method of enriching, isolating and/or purifying definitive endoderm cells are also disclosed.
    Type: Grant
    Filed: October 29, 2013
    Date of Patent: March 28, 2017
    Assignee: ViaCyte, Inc.
    Inventors: Kevin Allen D'Amour, Alan D. Agulnick, Emmanuel Edward Baetge
  • Methods of producing pancreatic hormones
    Patent number: 9585917
    Abstract: Disclosed herein are methods of producing pancreatic hormone-expressing cells by first differentiating pluripotent cells in cell culture so as to produce endodermal cells, the endodermal cells being competent to further differentiate into hormone-expressing cells capable of secreting at least one pancreatic hormone in response to a physiological signal, and then, transplanting the cultured endodermal cells into an organism, such as an organism in need of an endocrine cell therapy.
    Type: Grant
    Filed: August 8, 2011
    Date of Patent: March 7, 2017
    Assignee: ViaCyte, Inc.
    Inventors: Laura Martinson, Evert Kroon, Kevin D'Amour, Emmanuel Edward Baetge
  • METHODS FOR PURIFYING ENDODERM AND PANCREATIC ENDODERM CELLS DERIVED FROM HUMAN EMBRYONIC STEM CELLS
    Publication number: 20170044498
    Abstract: The present disclosure relates to compositions and methods comprising cell surface markers for hES-derived cells, in particular, endoderm lineage cells including pancreatic endoderm-type cells, derived from hES cells.
    Type: Application
    Filed: October 28, 2016
    Publication date: February 16, 2017
    Applicant: ViaCyte, Inc.
    Inventors: Olivia Kelly, Anne Bang
  • Anterior endoderm cells
    Publication number: 20170029769
    Abstract: Disclosed herein are cell cultures comprising PDX1-positive endoderm cells and methods of producing the same. Also disclosed herein are cell populations comprising substantially purified PDX1-positive endoderm cells as well as methods for enriching, isolating and purifying, PDX1-positive endoderm cells to other cell types. Methods of identifying differentiation factors capable of promoting the differentiation of endoderm cells, such as PDX1-positive foregut endoderm cells and PDX1-negative definitive endoderm cells, are also disclosed.
    Type: Application
    Filed: November 20, 2015
    Publication date: February 2, 2017
    Applicant: ViaCyte, Inc.
    Inventors: Kevin Allen D'Amour, Alan D. Agulnick, Susan Eliazer, Emmanuel E. Baetge
  • PDX1-EXPRESSING DORSAL AND VENTRAL FOREGUT ENDODERM
    Publication number: 20170022474
    Abstract: Disclosed herein are cell cultures comprising dorsal and/or ventral PDX1-positive foregut endoderm cells and methods of producing the same. Also disclosed herein are cell populations comprising substantially purified dorsal and/or ventral PDX1-positive foregut endoderm cells as well as methods for enriching, isolating and purifying dorsal and/or ventral PDX1-positive foregut endoderm cells from other cell types. Methods of identifying differentiation factors capable of promoting the differentiation of dorsal and/or ventral PDX1-positive foregut endoderm cells, are also disclosed.
    Type: Application
    Filed: October 11, 2016
    Publication date: January 26, 2017
    Applicant: ViaCyte, Inc.
    Inventors: Kevin Allen D'Amour, Alan D. Agulnick, Susan Eliazer, Emmanuel E. Baetge
  • 3-dimensional large capacity cell encapsulation device assembly
    Patent number: 9526880
    Abstract: Disclosed herein are implantable 3-dimensional large capacity device assemblies, specifically, large capacity device assemblies for encapsulating pancreatic progenitor cells for treatment of diabetes.
    Type: Grant
    Filed: March 7, 2014
    Date of Patent: December 27, 2016
    Assignee: VIACYTE, INC.
    Inventors: Vincent So, Laura Martinson, Chad Green, Michael Scott, Mario Zamarripa
  • ENDOCRINE PRECURSOR CELLS, PANCREATIC HORMONE-EXPRESSING CELLS AND METHODS OF PRODUCTION
    Publication number: 20160355787
    Abstract: Disclosed herein are cell cultures and enriched cell populations of endocrine precursor cells, immature pancreatic hormone-expressing cells and mature pancreatic hormone-expressing cells. Also disclosed herein are methods of producing such cell cultures and cell populations.
    Type: Application
    Filed: June 3, 2016
    Publication date: December 8, 2016
    Applicant: ViaCyte, Inc.
    Inventors: Kevin A. D'Amour, Anne Bang, Emmanuel E. Baetge