Patents Assigned to ViaCyte
  • Patent number: 8623650
    Abstract: The present invention provides compositions and methods for the culture and maintenance of pluripotent stem cells. More particularly, the present invention provides for compositions and methods for culturing, maintaining, growing and stabilizing primate pluripotent stem cells in a feeder-free defined media further comprising human serum, or a soluble attachment component of the human serum, for promoting cell attachment.
    Type: Grant
    Filed: October 19, 2007
    Date of Patent: January 7, 2014
    Assignee: Viacyte, Inc.
    Inventors: Allan J. Robins, Thomas C. Schulz
  • Patent number: 8623645
    Abstract: Disclosed herein are cell cultures comprising definitive endoderm cells and methods of producing the same. Also disclosed herein are cell populations comprising substantially purified definitive endoderm cells as well as methods for enriching, isolating and purifying definitive endoderm cells from other cell types.
    Type: Grant
    Filed: March 30, 2009
    Date of Patent: January 7, 2014
    Assignee: Viacyte, Inc.
    Inventors: Kevin Allen D'Amour, Alan D. Agulnick, Emmanuel E. Baetge
  • Patent number: 8603811
    Abstract: Disclosed herein are cell cultures and enriched cell populations of endocrine precursor cells, immature pancreatic hormone-expressing cells and mature pancreatic hormone-expressing cells. Also disclosed herein are methods of producing such cell cultures and cell populations.
    Type: Grant
    Filed: October 17, 2011
    Date of Patent: December 10, 2013
    Assignee: ViaCyte, Inc.
    Inventors: Kevin A. D'Amour, Anne Bang, Emmanuel E. Baetge
  • Publication number: 20130316357
    Abstract: Disclosed herein are cell cultures comprising dorsal and/or ventral PDX1-positive foregut endoderm cells and methods of producing the same. Also disclosed herein are cell populations comprising substantially purified dorsal and/or ventral PDX1-positive foregut endoderm cells as well as methods for enriching, isolating and purifying dorsal and/or ventral PDX1-positive foregut endoderm cells from other cell types. Methods of identifying differentiation factors capable of promoting the differentiation of dorsal and/or ventral PDX1-positive foregut endoderm cells, are also disclosed.
    Type: Application
    Filed: August 9, 2013
    Publication date: November 28, 2013
    Applicant: ViaCyte, Inc.
    Inventors: Kevin Allen D'Amour, Alan D. Agulnick, Susan Eliazer, Emmanuel E. Baetge
  • Patent number: 8586357
    Abstract: Disclosed herein are reagent-cell complexes comprising one or more definitive endoderm cells. Also described herein are compositions for detecting definitive endoderm. Method of enriching, isolating and/or purifying definitive endoderm cells are also disclosed.
    Type: Grant
    Filed: November 13, 2006
    Date of Patent: November 19, 2013
    Assignee: ViaCyte, Inc.
    Inventors: Kevin Allen D'Amour, Alan D Agulnick, Emmanuel Edward Baetge
  • Patent number: 8574905
    Abstract: Disclosed herein are methods for producing liver precursor cells as well as hepatocyte cells form pluripotent and/or multipotent cells. Also disclosed herein are methods of enriching isolating and/or purifying liver precursor cells and/or hepatocyte cells. Further disclosed are compositions comprising cell cultures and cell populations that are enriched for liver precursor cells or hepatocyte cells.
    Type: Grant
    Filed: August 2, 2011
    Date of Patent: November 5, 2013
    Assignee: ViaCyte, Inc.
    Inventors: Kevin D'Amour, Emmanuel E. Baetge
  • Publication number: 20130280802
    Abstract: The present invention relates to compositions and methods for inhibiting or suppressing undifferentiated or pluripotent stem cell growth and proliferation in a differentiated or differentiating cell population or culture.
    Type: Application
    Filed: December 8, 2010
    Publication date: October 24, 2013
    Applicant: ViaCyte, Inc
    Inventors: Thomas Schulz, Allan Robins
  • Publication number: 20130261568
    Abstract: The present invention relates to methods for encapsulating pancreatic progenitors in a biocompatible semi-permeable encapsulating device. The present invention also relates to production of human insulin in a mammal in response to glucose stimulation.
    Type: Application
    Filed: May 24, 2013
    Publication date: October 3, 2013
    Applicant: ViaCyte
    Inventors: Laura Martinson, Chad Green, Evert Kroon, Emmanuel Edward Baetge
  • Patent number: 8445273
    Abstract: The present invention relates to methods for production of undifferentiated or differentiated embryonic stem cell aggregate suspension cultures from undifferentiated or differentiated embryonic stem cell single cell suspensions and methods of differentiation thereof.
    Type: Grant
    Filed: August 29, 2011
    Date of Patent: May 21, 2013
    Assignee: ViaCyte, Inc.
    Inventors: Chad Green, Xiaojie Yu, Anne Bang, Eugene Brandon, Olivia Kelly, Alan D Agulnick, E Edward Baetge, Kevin A D'Amour, Thomas C Schulz, Allan J Robins
  • Patent number: 8425928
    Abstract: The present invention relates to methods for encapsulating pancreatic progenitors in a biocompatible semi-permeable encapsulating device. The present invention also relates to production of human insulin in a mammal in response to glucose stimulation.
    Type: Grant
    Filed: July 22, 2011
    Date of Patent: April 23, 2013
    Assignee: ViaCyte, Inc.
    Inventors: Laura Martinson, Chad Green, Evert Kroon, Alan Agulnick, Olivia Kelly, Emmanuel E. Baetge
  • Patent number: 8415158
    Abstract: The present invention relates to cell culture methods and compositions that are essentially serum-free and comprise a basal salt nutrient solution and an ErbB3 ligand.
    Type: Grant
    Filed: February 29, 2012
    Date of Patent: April 9, 2013
    Assignee: ViaCyte, Inc.
    Inventors: Allan J Robins, Thomas C Schulz
  • Patent number: 8338170
    Abstract: The present disclosure relates to compositions and methods comprising cell surface markers for hES-derived cells, in particular, endoderm lineage cells including pancreatic endoderm-type cells, derived from hES cells.
    Type: Grant
    Filed: April 21, 2008
    Date of Patent: December 25, 2012
    Assignee: Viacyte, Inc.
    Inventors: Olivia Kelly, Anne Bang
  • Patent number: 8334138
    Abstract: The present invention provides compositions and methods for the culture and maintenance of pluripotent stem cells. More particularly, the present invention provides for compositions and methods for culturing, maintaining, growing and stabilizing primate pluripotent stem cells in a feeder-free defined media further comprising human serum, or a soluble attachment component of the human serum, for promoting cell attachment.
    Type: Grant
    Filed: August 15, 2010
    Date of Patent: December 18, 2012
    Assignee: ViaCyte, Inc.
    Inventors: Allan J Robins, Thomas C Schulz
  • Patent number: 8278106
    Abstract: The present invention relates to methods for encapsulating pancreatic progenitors in a biocompatible semi-permeable encapsulating device. The present invention also relates to production of human insulin in a mammal in response to glucose stimulation.
    Type: Grant
    Filed: November 13, 2009
    Date of Patent: October 2, 2012
    Assignee: Viacyte, Inc.
    Inventors: Laura Martinson, Chad Green, Evert Kroon, Alan Agulnick, Olivia Kelly, Emmanuel E. Baetge
  • Patent number: 8216836
    Abstract: Disclosed herein are methods of identifying one or more differentiation factors that are useful for differentiating cells in a cell population comprising definitive endoderm cells into cells which are capable of forming tissues and/or organs that are derived from the gut tube.
    Type: Grant
    Filed: June 2, 2009
    Date of Patent: July 10, 2012
    Assignee: Viacyte, Inc.
    Inventors: Kevin Allen D'Amour, Alan D. Agulnick, Susan Eliazer, Emmanuel E. Baetge
  • Patent number: 8211699
    Abstract: The present invention relates to cell culture methods and compositions that are essentially serum-free and comprise a basal salt nutrient solution and an ErbB3 ligand.
    Type: Grant
    Filed: August 13, 2007
    Date of Patent: July 3, 2012
    Assignee: ViaCyte, Inc.
    Inventors: Allan J. Robins, Thomas C. Schulz
  • Patent number: 8187878
    Abstract: The present invention provides compositions and methods for the production of differentiated mammalian cells. More particularly, the present invention provides cellular differentiation methods employing culturing the cells on a feeder layer or under feeder-free conditions in cell culture and further contacting the cells with an inhibitor of the PI3-kinase pathway and a member of the TGFb family for the generation of differentiated mammalian cells from pluripotent mammalian stem cells. Preferably, the differentiated cell is selected from the group consisting of a mesendodermal cell, a mesodermal cell, and an endodermal cell.
    Type: Grant
    Filed: August 15, 2005
    Date of Patent: May 29, 2012
    Assignees: University of Georgia Research Foundation, Inc., ViaCyte, Inc.
    Inventors: Stephen Dalton, Allan Sheppard, Karen Jones, E. Edward Baetge, Kevin A. D'Amour, Alan D. Agulnick
  • Patent number: 8153429
    Abstract: The present invention relates to cell culture methods and compositions that are essentially serum-free and comprise a basal salt nutrient solution and an ErbB3 ligand.
    Type: Grant
    Filed: February 23, 2007
    Date of Patent: April 10, 2012
    Assignee: ViaCyte, Inc.
    Inventors: Allan J. Robins, Thomas C. Schulz
  • Patent number: 8129182
    Abstract: Disclosed herein are cell cultures and enriched cell populations of endocrine precursor cells, immature pancreatic hormone-expressing cells and mature pancreatic hormone-expressing cells. Also disclosed herein are methods of producing such cell cultures and cell populations.
    Type: Grant
    Filed: March 2, 2007
    Date of Patent: March 6, 2012
    Assignee: Viacyte, Inc.
    Inventors: Kevin A. D'Amour, Anne Bang, Emmanuel E. Baetge
  • Patent number: 8008075
    Abstract: The present invention relates to methods for production of undifferentiated or differentiated embryonic stem cell aggregate suspension cultures from undifferentiated or differentiated embryonic stem cell single cell suspensions and methods of differentiation thereof.
    Type: Grant
    Filed: November 4, 2008
    Date of Patent: August 30, 2011
    Assignee: ViaCyte, Inc.
    Inventors: Chad Green, Xiaojie Yu, Anne Bang, Eugene Brandon, Olivia Kelly, Alan D. Agulnick, E. Edward Baetge, Kevin A. D'Amour, Thomas C. Schulz, Allan J. Robins