Abstract: Disclosed herein are methods for increasing the production of definitive endoderm cells from pluripotent stem cells. Also disclosed herein are agents capable of increasing definitive endoderm cell production.
Type:
Grant
Filed:
April 12, 2010
Date of Patent:
August 9, 2011
Assignee:
Viacyte, Inc.
Inventors:
Alan Agulnick, Kevin D'Amour, Emmanuel Edward Baetge
Abstract: Disclosed herein are methods of producing pancreatic hormone-expressing cells by first differentiating pluripotent cells in cell culture so as to produce endodermal cells, the endodermal cells being competent to further differentiate into hormone-expressing cells capable of secreting at least one pancreatic hormone in response to a physiological signal, and then, transplanting the cultured endodermal cells into an organism, such as an organism in need of an endocrine cell therapy.
Type:
Grant
Filed:
April 12, 2010
Date of Patent:
August 9, 2011
Assignee:
Viacyte, Inc.
Inventors:
Laura Martinson, Evert Kroon, Kevin D'Amour, Emmanuel Edward Baetge
Abstract: Disclosed herein are methods for producing liver precursor cells as well as hepatocyte cells form pluripotent and/or multipotent cells. Also disclosed herein are methods of enriching isolating and/or purifying liver precursor cells and/or hepatocyte cells. Further disclosed are compositions comprising cell cultures and cell populations that are enriched for liver precursor cells or hepatocyte cells.
Abstract: This disclosure relates to compositions comprising human preprimitive streak cells and/or human mesendoderm cells as well as methods for their production. Additionally, disclosed herein are methods of identifying factors useful in the further differentiation of preprimitive streak and mesendoderm cell types.
Type:
Grant
Filed:
June 23, 2006
Date of Patent:
July 26, 2011
Assignee:
Viacyte, Inc.
Inventors:
Kevin Allen D'Amour, Alan D. Agulnick, Emmanuel E. Baetge
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