Patents Assigned to Virginia Commonwealth University
  • Polysubstituted pyrroles having microtubule-disrupting, cytotoxic and antitumor activities and methods of use thereof
    Patent number: 9944597
    Abstract: The present invention provides polysubstituted pyrrole compounds, pharmaceutically effective salts, prodrugs, solvates and hydrates thereof, having antimitotic, antiproliferative and cytotoxic activity, activity against cells expressing the drug efflux protein, P-glycoprotein, or cells expressing the ?-III isotype of tubulin and antitumor activity. Also provided are methods of utilizing these compounds for inhibiting the proliferation of cancer cells as well as their medical use, in particular for treating cancer, including drug resistant cancer.
    Type: Grant
    Filed: September 16, 2014
    Date of Patent: April 17, 2018
    Assignees: THE BOARD OF REGENTS OF THE UNIVERSITY OF TEXAS SYSTEM, VIRGINIA COMMONWEALTH UNIVERSITY, UNIVERSITY OF RICHMOND
    Inventors: Glen E. Kellogg, Chenxiao Da, Ashutosh Tripathi, John T. Gupton, Nakul Telang, James A. Sikorski, Susan L. Mooberry, Cristina Rohena
  • OmpA in vaccine compositions and as diagnostic targets
    Patent number: 9945851
    Abstract: Anaplasma Marginale surface protein OmpA and homologous genes from Anaplasmatacaea family members are used in compositions suitable for vaccines to treat or prevent infections caused by tick-born bacteria of the Anaplasmatacaea family. OmpA proteins or peptide fragments may be used in combination with other Anaplasmatacaea surface proteins to elicit an immune response. Furthermore, antibodies to OmpA proteins can be used in diagnostic methods to determine whether an individual has contracted an Anaplasmatacaea infection.
    Type: Grant
    Filed: March 30, 2017
    Date of Patent: April 17, 2018
    Assignee: Virginia Commonwealth University
    Inventor: Jason A. Carlyon
  • Device for control of difficult to compress hemorrhage
    Patent number: 9931125
    Abstract: Bleeding from blood vessels located in difficult-to-compress regions of the body (especially the abdomen, pelvic or groin region) is controlled by the use of a portable, small-footprint belt-like device that contains multiple inflatable bladders. The inflatable bladders are selectively positioned and inflated over exsanguinating blood vessels, thereby exerting pressure to stop the bleeding. The device may also be used to provide perfusion support in low flow disease states such as hemorrhagic shock and cardiac arrest.
    Type: Grant
    Filed: February 26, 2016
    Date of Patent: April 3, 2018
    Assignee: Virginia Commonwealth University
    Inventors: Kevin Ward, Mark Licata
  • Identification and quantification of multiple nucleic acid targets in complex mixtures
    Patent number: 9926589
    Abstract: A complex mixture is analyzed for multiple nucleic acid sequences (e.g., DNA or RNA sequences) simultaneously by target specific multiplex amplification followed by single molecule detection of amplicons by Atomic Force Microscopy (AFM). The presence or absence of target nucleic acids can be determined from the presence or absence of specific amplicons for those nucleic acids. In addition, quantification of target nucleic acids in the complex mixture is achieved by determination of the numbers of amplicons.
    Type: Grant
    Filed: September 11, 2014
    Date of Patent: March 27, 2018
    Assignee: VIRGINIA COMMONWEALTH UNIVERSITY
    Inventors: Jason Reed, Andrey Mikheykin
  • Rapid localization platform for location based applications in self-organized networking systems
    Patent number: 9906431
    Abstract: Time-critical Location Based Service (LBS) applications in mobile ad hoc networks (MANETs) require fast localization. An On-Demand Fast Localization (ODFL) start from multi-coordinate systems, and the position transformation is integrated with LBS application information transmissions. The framework of ODFL turns two pipe-lined procedures into two semi-concurrent procedures by employing coordinate system transformation on a per hop basis, which consists of three components: (1) Local Coordinate System (LCS) construction; (2) embedded information selection; and (3) position transformation.
    Type: Grant
    Filed: May 17, 2016
    Date of Patent: February 27, 2018
    Assignee: VIRGINIA COMMONWEALTH UNIVERSITY
    Inventor: Wei Cheng
  • 2-substituted-5-hydroxy-4H-chromen-4-ones as novel ligands for the serotonin receptor 2B (5-HT2B)
    Patent number: 9884836
    Abstract: A family of compounds which function as selective ligands for the serotonin receptor 2B (5-HT2B) is identified. Some of the compounds are synthetic non-natural ligands which have a relatively strong interaction with 5-HT2B compared to naturally occurring compounds (some of which are identified for the first time herein as ligands for 5-HT2B). Because the compounds, both naturally occurring and synthetically produced, function as ligands for 5-HT2B they will have application in, for example, the treatment and/or prevention of nervous system disorders such as Alzheimer's disease.
    Type: Grant
    Filed: January 22, 2015
    Date of Patent: February 6, 2018
    Assignee: Virginia Commonwealth University
    Inventors: Dwight A. Williams, Yan Zhang
  • Sulfated and unsulfated flavonoid oligomers as cancer therapeutics
    Patent number: 9850221
    Abstract: Sulfated and unsulfated flavonoid oligomers as inhibitors of cancer stem cells (CSCs) are provided. In particular, sulfated flavonoid dimers are shown to selectively inhibit CSCs growth and self-renewal both in vitro and in vivo.
    Type: Grant
    Filed: November 7, 2014
    Date of Patent: December 26, 2017
    Assignee: VIRGINIA COMMONWEALTH UNIVERSITY
    Inventors: Umesh R. Desai, Rajesh Karuturi, Bhaumik B. Patel, Nirmita J. Patel
  • Hemostasis of wound having high pressure blood flow using kaolin and bentonite
    Patent number: 9821084
    Abstract: Compositions comprising clay minerals and methods for their use in promoting hemostasis are provided. The compositions comprise clay minerals such as bentonite, and facilitate blood clotting when applied to a hemorrhaging wound. Electrospun or electrosprayed materials (e.g. bandages, micron beads, etc.) which include clay minerals, and methods for the treatment of acute hemorrhage, are also provided.
    Type: Grant
    Filed: June 10, 2010
    Date of Patent: November 21, 2017
    Assignee: Virginia Commonwealth University
    Inventors: Robert F. Diegelmann, Kevin R. Ward, Marcus E. Carr, Gary Lee Bowlin
  • Immune modulator for immunotherapy and vaccine formulation
    Patent number: 9822154
    Abstract: A recombinant Flagrp170 protein and pharmaceutical compositions comprising a Flagrp170 protein and related molecules encoding same, and cells presenting such a protein are provided. The Flagrp170 protein comprises an NF-KB-activating domain of Flagellin and an ATP-binding domain truncated Grp170. The pharmaceutical compositions of the invention can be used for the treatment or prevention of cancer or infectious disease.
    Type: Grant
    Filed: December 14, 2013
    Date of Patent: November 21, 2017
    Assignees: VIRGINIA COMMONWEALTH UNIVERSITY, HEALTH RESEARCH, INC.
    Inventors: Xiang-Yang Wang, Xiaofei Yu, John R. Subjeck
  • USE OF HEMOGLOBIN EFFECTORS TO INCREASE THE BIOAVAILABILITY OF THERAPEUTIC GASES
    Publication number: 20170326086
    Abstract: Methods which increase the bioavailability of beneficial gases in the circulatory system are provided. The methods involve administering agents that changes the binding affinity of a medicinal gas such as NO, CO, H2S, N2O, SO, SO2 and O2 for IIb and/or hemoglobin based oxygen carriers (HBOCs). The change results in increased release of gases carried by Hb and HBOCs. As a result, the concentration of the gases in circulation is raised, and they are more available to exert their beneficial effects, e.g. in the treatment of disease or conditions caused by low levels of the gases. The methods are optionally used together with administration of medicinal gases and/or administration of HBOCs and/or other non-HBOC gas carriers such as PFC, and as (or in conjunction with) diagnostic methods.
    Type: Application
    Filed: June 21, 2017
    Publication date: November 16, 2017
    Applicant: VIRGINIA COMMONWEALTH UNIVERSITY
    Inventors: Martin SAFO, Kevin R. WARD
  • IN SITU-FORMING OF DENDRIMER HYDROGELS USING MICHAEL-ADDITION REACTION
    Publication number: 20170313828
    Abstract: A method of forming a dendrimer hydrogel, the method comprising providing one or more amine end-functioned polyamidoamine (PAMAM) as a first reactant; providing one or more small molecule, polymer, hyperbranched molecule, or dendrimer as a second reactant, wherein the second reactant comprises one or more acrylate groups; and reacting the first reactant with the second reactant by way of conjugate addition. Compositions obtained thereby and uses thereof are also provided.
    Type: Application
    Filed: May 2, 2017
    Publication date: November 2, 2017
    Applicant: Virginia Commonwealth University
    Inventors: Juan Wang, Hu Yang
  • Sulfated beta-O4 low molecular weight lignins
    Patent number: 9777123
    Abstract: Low molecular weight sulfated beta-O4 lignin (SbO4L) are potent inhibitors of coagulation with high selectivity.
    Type: Grant
    Filed: May 29, 2014
    Date of Patent: October 3, 2017
    Assignee: Virginia Commonwealth University
    Inventors: Umesh R. Desai, Jay Thakkar, Akul Mehta
  • Non-rare earth magnetic nanoparticles
    Patent number: 9773594
    Abstract: Continuous flow synthetic methods are used to make single phase magnetic metal alloy nanoparticles that do not contain rare earth metals. Soft and hard magnets made from the magnetic nanoparticles are used for a variety of purposes, e.g. in electric motors, communication devices, etc.
    Type: Grant
    Filed: January 4, 2013
    Date of Patent: September 26, 2017
    Assignee: VIRGINIA COMMONWEALTH UNIVERSITY
    Inventors: Everett E. Carpenter, Zachary J. Huba, Kyler J. Carroll, Ahmed Farghaly, Shiv N. Khanna, Meichun Qian, Massimo Bertino
  • Photoactive silk protein and fabrication of silk protein structures using photolithography
    Patent number: 9771400
    Abstract: A natural protein, specifically silk fibroin or sericin, is chemically modified such that it can be rendered photoactive, but which otherwise has similar structure and attributes as silk fibroin or sericin. This chemically modified silk conjugate can be patterned using radiant energy to produce patterned silk materials which may be used for a wide variety of applications such as making micro and nanoparticles of different shapes and functionalities for drug delivery, creating new forms of intricate 3D scaffolds for tissue engineering, and forming substrates for flexible bio-electronics.
    Type: Grant
    Filed: January 31, 2014
    Date of Patent: September 26, 2017
    Assignee: VIRGINIA COMMONWEALTH UNIVERSITY
    Inventors: Nicholas E. Kurland, Vamsi K. Yadavalli
  • Production of graphene and nanoparticle catalysts supported on graphene using laser radiation
    Patent number: 9768355
    Abstract: Methods and apparatuses to produce graphene and nanoparticle catalysts supported on graphene without the use of reducing agents, and with the concomitant production of heat, are provided. The methods and apparatuses employ radiant energy to reduce (deoxygenate) graphite oxide (GO) to graphene, or to reduce a mixture of GO plus one or more metals to produce nanoparticle catalysts supported on graphene. Methods and systems to generate and utilize heat that is produced by irradiating GO, graphene and their metal and semiconductor nanocomposites with visible, infrared and/or ultraviolet radiation, e.g. using sunlight, lasers, etc. are also provided.
    Type: Grant
    Filed: December 10, 2010
    Date of Patent: September 19, 2017
    Assignee: Virginia Commonwealth University
    Inventors: M. Samy El-Shall, Victor Abdelsayed, Saud I. Al-Resayes, Zeid Abdullah M. Alothman
  • Allosteric hemoglobin modifiers with nitric oxide releasing moiety
    Patent number: 9765017
    Abstract: Allosteric hemoglobin (Hb) modifiers of hemoglobin which contain nitric oxide (NO) moieties allowing for the release of NO in vivo. The compounds retain the oxygen delivery capability of the allosteric hemoglobin modifier to bind Hb and enhance Hb's ability to deliver oxygen to cells and tissues, and also release NO from the NO moiety. Methods of delivering oxygen and/or NO to cells and tissues are also provided.
    Type: Grant
    Filed: December 22, 2014
    Date of Patent: September 19, 2017
    Assignee: VIRGINIA COMMONWEALTH UNIVERSITY
    Inventors: Martin K. Safo, Richmond Danso-Danquah, Mohini Ghatge, Jurgen Venitz, Martin Mangino, Kevin R. Ward
  • Inflammation therapy
    Patent number: 9763894
    Abstract: A method is provided for treating a patient in need of therapy for central nervous system inflammation comprising administering to that patient a therapeutically effective amount of a cannabinoid agonist having efficacy at the CB2 receptor but having substantially no efficacy at the CB1 receptor at that amount.
    Type: Grant
    Filed: December 5, 2007
    Date of Patent: September 19, 2017
    Assignees: Virginia Commonwealth University, Organix, Inc., Temple University
    Inventors: Billy R. Martin, Mohamad Imad Damaj, Martin W. Adler, Ronald F. Tuma, Ming Zhang, Anu Mahadevan, Raj K. Razdan
  • Allosteric modulators of factor XIa as anticoagulant agents
    Patent number: 9758459
    Abstract: Compounds which allosterically modulate and/or inhibit factor XIa activity are provided, as are methods of their use. These compounds include i) sulfated gallolyl glucosides, ii) sulfated quinazolinones, and iii) sulfated inositol analogs. The compounds used as anticoagulant agents.
    Type: Grant
    Filed: November 12, 2013
    Date of Patent: September 12, 2017
    Assignee: Virginia Commonwealth University
    Inventors: Umesh R. Desai, Rajesh Karuturi, Akul Mehta, Rami A. Al-Horani
  • Hybrid compounds of curcumin and melatonin as neuroprotectants for neurodegenerative disorders
    Patent number: 9738605
    Abstract: Hybrid compounds of curcumin and melatonin as neuroprotectants are provided. The hybrid compounds are useful for the treatment and/or prevention of Alzheimer's disease (AD), as well as other neurodegenerative diseases. The hybrid compounds exhibited superior and potent neuroprotection in an AD model.
    Type: Grant
    Filed: November 7, 2014
    Date of Patent: August 22, 2017
    Assignee: Virginia Commonwealth University
    Inventor: Shijun Zhang
  • Hands free breastfeeding aid
    Patent number: D797944
    Type: Grant
    Filed: December 16, 2015
    Date of Patent: September 19, 2017
    Assignee: VIRGINIA COMMONWEALTH UNIVERSITY
    Inventors: Kristie Bonovitch, Sharon Brinkley, Gauri Gulati, Lisa Rettig