Abstract: The present invention is a system to continuously monitor, in real-time, the small molecules being dialyzed during hemodialysis treatment using Raman spectroscopy and press control algorithms. By monitoring the treatment, the amount of water needed per dialysis treatment is drastically reduced by optimizing analyte saturation and removal of wastes. This will significantly conserve water and reduce the cost of dialysis treatments, possibly reducing the amount of time necessary for dialysis treatment, improving quality of life for patients during and after treatment, and reducing the costs of building new treatment centers as well as operating costs.

Abstract: Described here are blocky PEEK copolymers and corresponding synthesis methods. It was surprisingly found that synthesis of blocky PEEK copolymers in a non-solvent environment with respect to PEEK produced blocky PEEK copolymers with high degrees of functionalization and crystallinity. The blocky PEEK copolymers had an increased blocky structure, relative to corresponding PEEK copolymer synthesized with other known methods. Moreover, membranes formed from the blocky PEEK polymers are particularly desirable in fuel cell applications. For example, the membranes formed from the blocky PEEK polymers had surprisingly large ion conductivities as well as significantly improved chemical and thermal resistance, at least in part, to the improved functionalization and crystallinity.

Abstract: Described herein are methods of performing immunotherapy on a subject and/or determining if a subject will be responsive to ablation immunotherapy.

Abstract: Disclosed are a vehicle anti-collision forewarning method, an in-vehicle computer device and a vehicle anti-collision forewarning system.

Abstract: An articulated multi-link robotic tail (MLRT) system is provided comprising a rigid housing, an actuation unit coupled to the rigid housing, and an MLRT having a proximal end that is coupled to the rigid housing and a distal end opposite the proximal end. The MLRT comprises N segments, where N is a positive integer that is greater than or equal to one. Each segment comprises i links, where i is a positive integer that is greater than or equal to two. Each link is mechanically coupled to an actuator of the actuation unit and capable of being actuated by the actuator to which it is mechanically coupled to adjust a pitch, yaw and roll of the MLRT. The articulated MLRT system is well suited for being integrated with a mobile robot to assist in stabilizing and maneuvering the mobile robot.

Abstract: Various examples of a high frequency, inductor and transformer core loss characterization and measurement method and system for arbitrary waveforms are disclosed herein. A system and method for determining core loss of a magnetic core can include generating a waveform to excite a first test circuit which comprises an excitation circuit, a circuit under test (CUT) comprising the magnetic core, and an inductance circuit having an inductor connected in parallel to the CUT. The method includes measuring a first current, when the first test circuit is excited. The method includes disconnecting the CUT from the first test circuit to form a second test circuit. The method includes generating the waveform to excite the second test circuit, and measuring a second current, when the second test circuit is excited. The power loss for the magnetic core is calculated based on an input voltage and the first and second measured current.

Abstract: Aspects of bidirectional architectures with partial energy processing in resonant direct current (DC)-to-DC converters are described. In one embodiment, an alternating circuit (AC)-to-DC circuit generates an AC voltage from a DC voltage. A voltage of the AC voltage is transformed into a majority AC voltage of a majority power path and at least one minority AC voltage of the minority power paths. The majority AC voltage is rectified into a majority DC voltage and a minority AC voltage is rectified into a minority DC voltage. The majority power path and the minority power path are combined as a combined DC voltage.

Abstract: Provided herein are nicotine polymer-stabilized nanoparticles, formulations thereof, and vaccines. Also provided herein are methods of treating and/or preventing nicotine addiction in a subject in need thereof.

Abstract: Systems and methods are provided for modeling and for providing a graphical representation of tissue heating and electric field distributions for medical treatment devices that apply electrical treatment energy through one or a plurality of electrodes. In embodiments, methods comprise: providing one or more parameters of a treatment protocol for delivering one or more electrical pulses to tissue through a plurality of electrodes; modeling electric and heat distribution in the tissue based on the parameters; and displaying a graphical representation of the modeled electric and heat distribution. In another embodiment, a treatment planning module is adapted to generate an estimated target ablation zone based on a combination of one or more parameters for an irreversible electroporation protocol and one or more tissue-specific conductivity parameters.

Abstract: The present invention provides systems, methods, and devices for electroporation-based therapies (EBTs). Embodiments provide patient-specific treatment protocols derived by the numerical modeling of 3D reconstructions of target tissue from images taken of the tissue, and optionally accounting for one or more of physical constraints or dynamic tissue properties. The present invention further relates to systems, methods, and devices for delivering bipolar electric pulses for irreversible electroporation exhibiting reduced or no damage to tissue typically associated with an EBT-induced excessive charge delivered to the tissue.

Abstract: A variety of high electron mobility transistor structures are provided having charge compensation regions that can extend below the gate electrode through the barrier layer and at least partially through the III-V semiconductor layer. The charge compensation regions include a p-type semiconductor or oxide. In some aspects, the charge compensation regions extend vertically through said barrier layer into said channel layer, wherein said charge-compensation regions are doped with p-type dopants and are placed aside the 2DEG channel and do not overlap vertically with the 2DEG channel. In some aspects, at least a portion of the charge compensation regions extend from below the gate electrode to make Ohmic contact with the source electrode. In some aspects, by extending the charge compensation regions from below the gate electrode and closer to the source and drain electrodes, the HEFTs can demonstrate avalanche characteristics.

Abstract: A method is provided for creating a porous coating on a surface of a substrate by electrodeposition. The substrate is a part of the cathode. An anode is also provided. A coating is deposited or disposed on the surface by applying a voltage that creates a plurality of porous structures on the surface to be coated. Continuing to apply a voltage creates additional porosity and causes portions of the attached porous structures to detach. A covering layer is created by applying a voltage that creates a thin layer that covers the attached porous structures and the detached portions which binds the porous structures and detached portions together.

Abstract: In some aspects, described herein are methods of additive manufacturing in which one or more corrugated layers are incorporated into the three-dimensional (3D) object. Also provided herein are 3D objects that can include one or more corrugated layers.

Abstract: The disclosure provides compounds of Formula (I-A) and (I-B) and the pharmaceutically acceptable salts thereof. The variables, R, R2, R3, X1, X2, X3, Y1, Y, and Z are defined herein. Certain compounds of Formula (I-A) and (I-B) act as selective mitochondrial protonophore uncouplers that do not affect plasma membrane potential. These compounds are useful for treating or decreasing the risk of conditions responsive to mitochondrial uncoupling, such as cancer, obesity, type II diabetes, fatty liver disease, insulin resistance, Parkinson's disease, ischemia reperfusion injury, heart failure, non-alcoholic fatty liver disease (NALFD), and non-alcoholic steatohepatitis (NASH), Because mitochondrial uncouplers decrease the production of reactive oxygen species (ROS), which are known to contribute to age-related cell damage, the compounds are useful for increasing lifespan. Compounds and salts of Formulae (I-A) and (I-B) are also useful for regulating glucose homeostasis or insulin action in a patient.

Abstract: A swimming pool cleaner includes a chassis that supports a motor and a camera that is associated with the chassis and configured to identify at least one object. A controller is in communication with the camera and is configured to control movement of the pool cleaner based on output from the camera.

Abstract: One or more processors control processing of radio frequency (RF) signals using a machine-learning network. The one or more processors receive as input, to a radio communications apparatus, a first representation of an RF signal, which is processed using one or more radio stages, providing a second representation of the RF signal. Observations about, and metrics of, the second representation of the RF signal are obtained. Past observations and metrics are accessed from storage. Using the observations, metrics and past observations and metrics, parameters of a machine-learning network, which implements policies to process RF signals, are adjusted by controlling the radio stages. In response to the adjustments, actions performed by one or more controllers of the radio stages are updated. A representation of a subsequent input RF signal is processed using the radio stages that are controlled based on actions including the updated one or more actions.

Abstract: Described herein are low sodium formulations. In some embodiments, the low sodium formulations can contain an effective concentration of sodium and an effective concentration of calcium. The low sodium formulations can be provided as combination kit that can include, in some embodiments, a low sodium formulation and a defibrillation device. Also described herein are methods of administering the low sodium formulation to a subject in need thereof and performing cardiac resuscitation and/or defibrillation on the subject in need thereof.

Abstract: Novel crystalline porous materials known as metal-organic frameworks (MOFs) and methods for their synthesis are provided herein. The MOFs include a M6(?3-OH)8(OH)8(?2,?2-(O2C)2cyclam)8 cluster, and a metal atom coordinated to the one or more cyclam of the cluster, wherein M is Zr or Hf, and the metal atom is any one of Cu, Ni, Cr, Ru, Co, and Gd. The MOFs can be used as an adsorbent, alone or in a medium with other components, of CO2. The MOFs can also be used as a catalyst for the transformation of CO2 and epoxides to cyclic carbonates. The MOFs can also be used in the electrochemical catalytic reduction of CO2. The MOFs can also be used for photocatalytic CO2 reduction for the production of carbon-based fossil fuels. The MOFs can also be used for light-induced nitric oxide (NO) release. The MOFs can also be used as magnetic resonance imaging (MRI) agents.

Abstract: Provided herein are 3D printing systems including, but not limited to, 3D printing systems that can, in some aspects, be configured to print multi-materials and/or 3D structures having micro-scale features. In some aspects, the 3D printing system can include a jethead, wherein the jethead can include a body portion, one or more printing material dispensers that are each coupled to one or more feedstock material reservoirs and the body portion, and at least one cleaning unit configured to clean a printed object, a printing platform, a component of an x axis cartridge, or any combination thereof. Also provided herein are scanning projection optical micro-sterolithography systems that can be configured to allow for printing micro-scale features in large scale 3D objects.

Abstract: In various aspects, a polymer resin is provided for vat or ultraviolet-assisted direct ink writing (UV-DIW) photopolymerization. The resin can include a polyamic acid salt formed from the addition of a photocrosslinkable amine to a polyamic acid. The resin can include a photoinitiator suitable for initiating crosslinking of the photocrosslinkable amine when exposed to a light source of a suitable wavelength and intensity. The polyamic acid can be formed, for instance, by the addition of a diamine to a suitable dianhydride. Methods of additive manufacturing using the resins are also provided.