Abstract: Methods and systems for distributing electrical energy to tissue which minimize Joule heating, thermal effects, and/or thermal damage, without sacrificing efficacy of treatment, are described. The methods and systems are particularly suitable to electrical energy-based therapies employing multiple electrodes, such as arrays of electrodes.

Abstract: A number of different sealed interfaces for power modules are described. In one example, a sealed interface includes a printed circuit board including a contact pad for power conduction to a bus bar of the printed circuit board, a semiconductor module including at least one power transistor, a terminal pin electrically coupled to the power module, and a housing for the power module. The housing includes an open terminal aperture that extends through the housing. The printed circuit board is seated upon the open terminal aperture, to close and seal the open terminal aperture, with the contact pad positioned within the open terminal aperture. The terminal pin contacts the contact pad of the printed circuit board within the open terminal aperture, and the open terminal aperture comprises a transitional feature to abate electric field intensity around an interface between the open terminal aperture and the printed circuit board.

Abstract: The present invention provides systems, methods, and devices for electroporation-based therapies (EBTs). Embodiments provide patient-specific treatment protocols derived by the numerical modeling of 3D reconstructions of target tissue from images taken of the tissue, and optionally accounting for one or more of physical constraints or dynamic tissue properties. The present invention further relates to systems, methods, and devices for delivering bipolar electric pulses for irreversible electroporation exhibiting reduced or no damage to tissue typically associated with an EBT-induced excessive charge delivered to the tissue.

Abstract: In one aspect, the disclosure relates to multi-material fibers capable of distributedly measuring temperature and pressure in which the methods comprise a thermal drawing step, and the methods of fabricating the disclosed fibers. The fibers can be utilized in methods of temperature and pressure mapping or sensing comprising electrical reflectometry for interrogation. Further disclosed are devices comprising a disclosed fiber with the multi-point detection capability with simple one-end connection. Also disclosed are articles, e.g., smart clothing, wound dressing, robotic skin and other industrial products, comprising a disclosed fiber or a fabric comprising a disclosed fiber. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present disclosure.

Abstract: Described herein are methods and systems of performing immunotherapy on a subject and/or determining if a subject will be responsive to ablation immunotherapy.

Abstract: This disclosure provides a diode including a semiconductor region having at least one two-dimensional carrier channel of a first conductivity type. The diode also includes a plurality of sidewalls exposed in the semiconductor region defining at least one trench extending through the at least one two-dimensional carrier channel and a material of a second conductivity type, the second conductivity type being the other of the n-type and the p-type conductivity, disposed on the plurality of sidewalls and in contact with the at least one two-dimensional carrier channel. The diode also includes an anode material in contact with at least a portion of the semiconductor region and in contact with at least a portion of the material of the second conductivity type, and a cathode material in contact with the at least one two-dimensional carrier channel.

Abstract: Techniques, systems, and devices are described for providing a computational frame for estimating high-dimensional stochastic behaviors. In one exemplary aspect, a method for performing numerical estimation includes receiving a set of measurements of a stochastic behavior. The set of correlated measurements follows a non-standard probability distribution and is non-linearly correlated. Also, a non-linear relationship exists between a set of system variables that describes the stochastic behavior and a corresponding set of measurements. The method includes determining, based on the set of measurements, a numerical model of the stochastic behavior. The numerical model comprises a feature space comprising non-correlated features corresponding to the stochastic behavior. The non-correlated features have a dimensionality of M and the set of measurements has a dimensionality of N, M being smaller than N.

Abstract: Semicrystalline polyethylene-2,2?-bifuran-5,5?-dicarboxylate (PEBF) homopolyester or copolyester with up to 5 mole percent isophthalate or up to 2.7 mole percent terephthalate, based on the diacid component, or up to 2.5 mole percent 1,4-cyclohexanedimethanol (CHDM), based on the diol component, prepared by esterifying or transesterifying the diacid and the diol components with a catalyst including about 10 to about 50 ppm wt metal, and polycondensation, wherein the bifuran polyester has an intrinsic viscosity of at least 0.4 g/dL and a semicrystalline melting peak (Tm) with ?Hf equal to or greater than 5 J/g on the second heating ramp.

Abstract: Described herein are systems and methods to enable generation of high-quality summaries of documents that have questions and answers. To help summarize such documents, parsing methods are disclosed that account for different document formats. Methods are disclosed to anonymize personal and identifying information present in the documents. An ontology is defined to categorize dialog acts for the questions and answers present. Classifiers are disclosed based on this ontology. Methods are also disclosed to transform a question-answer pair to a canonical form. Based on the dialog acts for the question and answer combination, transformation methods were developed that build upon each of traditional NLP, and deep learning, techniques.

Abstract: Provided herein are devices, systems, and methods for monitoring lesion or treated area in a tissue during focal ablation or cell membrane disruption therapy.

Abstract: Aspects of direct current (DC)-DC converters with an integrated matrix transformer and multiphase current doubler rectifiers are described. In some examples, a DC-DC converter can include a matrix transformer that has multiple magnetically integrated transformer components that are magnetically integrated using transformer components that share a top plate and a bottom plate. A multiphase current doubler rectifier can include multiple synchronous rectifiers corresponding to the plurality of transformer components of the matrix transformer.

Abstract: A medical system for ablating a tissue site with real-time monitoring during an electroporation treatment procedure. A pulse generator generates a pre-treatment (PT) test signal prior to the treatment procedure and intra-treatment (IT) test signals during the treatment procedure. A treatment control module determines impedance values from the PT test signal and IT test signals and determines a progress of electroporation and an end point of treatment in real-time based on the determined impedance values while the treatment progresses.

Abstract: The present invention concerns a novel leg mechanism for quadrupedal locomotion. This design engages a linkage to couple assembly that only requires a single degree of actuation. The topological arrangement of the system produces a foot trajectory that is well-suited for dynamic gaits including trot-running, bounding, and galloping.

Abstract: The present disclosure relates to the intelligent distribution of data for robotic, autonomous, and similar systems. To reduce the impact of multi-agent coordination on networked systems embodiments are disclosed that include the use of action-based constraints which yield constrained-action POMDP (CA-POMDP) models, and probabilistic constraint satisfaction for the resulting infinite-horizon finite state controllers. To enable constraint analysis over an infinite horizon, an unconstrained policy is first represented as a finite state controller (FSC). A combination of a Markov chain Monte Carlo (MCMC) routine and a discrete optimization routine can be performed on the finite state controller to improve probabilistic constraint satisfaction of the finite state controller, while minimizing impact to a value function.

Abstract: Methods, systems, and apparatus, including computer programs encoded on computer storage media, for training and deploying machine-learned communication over multi-input-multi-output (MIMO) channels.

Abstract: The present disclosure concerns a Gas-Assisted Microbubble Extraction (GAME) system with an innovative dispersion module that can be used to efficiently separate and purify base metals and rare earth elements from various sources. The GAME system utilizes a three phase system of a gas phase, an organic phase, and an aqueous phase to efficiently extract low concentration metals from a solution.

Abstract: Various examples of an integrated parallel matrix transformer and inductor are disclosed herein. In one aspect, the transformer includes a first magnetic core having a first set of pillars of a first transformer and a second set of pillars of a second transformer and a second magnetic core having a first and second inductor pillar. The first and second magnetic cores can be separate or integrated into one core. The transformer also includes a planar winding structure. The planar winding structure may include a primary winding and a plurality of secondary windings. The primary winding can be configured to equally divide a primary current. The primary winding can extend a number of turns to conduct half of the primary current around the first inductor pillar and the first set of pillars and to conduct half of the primary current around the second inductor pillar and the second set of pillars.

Abstract: Described here are blocky PEEK copolymers and corresponding synthesis methods. It was surprisingly found that synthesis of blocky PEEK copolymers in a non-solvent environment with respect to PEEK produced blocky PEEK copolymers with high degrees of functionalization and crystallinity. The blocky PEEK copolymers had an increased blocky structure, relative to corresponding PEEK copolymer synthesized with other known methods. Moreover, membranes formed from the blocky PEEK polymers are particularly desirable in fuel cell applications. For example, the membranes formed from the blocky PEEK polymers had surprisingly large ion conductivities as well as significantly improved chemical and thermal resistance, at least in part, to the improved functionalization and crystallinity.

Abstract: A method of thermodynamic assessment of flow through a turbomachine having a compressor, comprising: receiving sensor readings from a plurality of acoustic sensors located about an intake for the turbomachine upstream of the compressor; and receiving pressure and stagnation temperature readings for the flow into the intake. A static temperature is determined for the flow into the intake and an average velocity of the flow over a flow area of the intake upstream of the compressor using the acoustic sensor readings. A mass flow rate of the flow through the intake is determined using the average velocity of the flow and the stagnation pressure.

Abstract: The present invention relates to poly(amide imide) (PAI) precursor polymers which can for example be used in Vat photopolymerization processes like lithographic processes for the photofabrication of three-dimensional (3D) articles. The invention further relates to polymer compositions including these poly(amide imide) (PAI) precursor polymers. Still further, the invention relates to vat photopolymerization methods to form three-dimensional (3D) objects that incorporate the aforementioned polymer compositions.