Abstract: A method for the synthesis of alkyl ?-carboxy(hydroxyethyl) polysaccharides is described. The method includes methylating or ethylating a polysaccharide or providing a methylated or ethylated polysaccharide, hydroxyethylating the methylated or ethylated polysaccharide, and oxidizing the hydroxyethylated polysaccharide to form the ?-carboxy(hydroxyethyl) polysaccharide. A method for the synthesis of oxidized polysaccharides is also described. The method includes hydroxypropylating a polysaccharide and oxidizing the hydroxypropylated polysaccharides. A method for the production of a solid capable of forming a hydrogel is also described. The method includes combining a first solution comprising an oxidized oligo(hydroxypropyl) polysaccharide bearing one or more ketone groups with a second solution comprising an amine substituted polysaccharide to form a third solution, and removing solvent from the third solution to form the solid, or adding an additional solvent to the third solution to precipitate the solid.

Abstract: The present invention relates to the field of biomedical engineering and medical treatment of diseases and disorders. Methods, devices, and systems for in vivo treatment of cell proliferative disorders are provided. In embodiments, the methods comprise the delivery of high-frequency bursts of bipolar pulses to achieve the desired modality of cell death. More specifically, embodiments of the invention relate to a device and method for destroying aberrant cells, including tumor tissues, using high-frequency, bipolar electrical pulses having a burst width on the order of microseconds and duration of single polarity on the microsecond to nanosecond scale. In embodiments, the methods rely on conventional electroporation with adjuvant drugs or irreversible electroporation to cause cell death in treated tumors. The invention can be used to treat solid tumors, such as brain tumors.

Abstract: Methods, systems, and apparatus, including computer programs encoded on computer storage media, for training and deploying machine-learned communication over multi-input-multi-output (MIMO) channels.

Abstract: Described herein are expandable foaming molds. The foaming molds described herein permit mold boundaries to expand along with the expanding polymer and thereby conform to the foaming dynamics of the polymer material. By modifying the temperature and pressure applied to the mold devices described herein, the properties of the resulting foamed polymer can be fine-tuned for specific applications.

Abstract: The present invention relates to airfoils having surface treatments to reduce trailing edge noise. The surface treatment is designed to reduce trailing edge noise by modifying the boundary layer turbulence as it approaches the trailing edge. The surface treatment accomplishes its function by breaking up spanwise-oriented turbulence approaching the trailing edge, thereby reducing the spanwise correlation lengthscales; deflecting the boundary layer turbulence away from the edge; and/or creating spanwise vortices or instability waves to reduce the turbulence-edge interaction.

Abstract: Aspects of hybrid-current-mode switching-cycle control are described. In one embodiment, a peak current mode is selected to control a switching power cell. The switching power cell is in an arm of a phase leg of a modular multilevel converter. The phase leg includes an upper arm and a lower arm, and the switching power cell includes a capacitor and at least one switch. At least one switch control signal switches the switching power cell according to a peak current mode based on at least one arm current boundary crossing identified for the arm.

Abstract: Disclosed are various embodiments of a modular building structure including modular cartridges. In one example, a modular residential structure comprises a systems cartridge that is configured to provide a number of services for the modular residential structure. A spine cartridge is configured to be attached to a top of or a bottom of the systems cartridge. The spine cartridge comprises conduits for conveying the services from the systems cartridge to a number of access points. A planar wall can be configured to form a portion of the modular residential structure. The systems cartridge, the planar wall, and the spine cartridge can be prefabricated at an off-site location. The systems cartridge can be attached to the spine cartridge at an on-site location.

Abstract: Various embodiments of laminated planar bus structures that minimize electromagnetic interference (EMI) and parasitic inductance are described. In one embodiment, a laminated planar bus structure may include a plurality of stacked conductive layers and a plurality of stacked insulation layers. The plurality of stacked conductive layers may include positive and negative conductive layers, and conductive ground layers stacked as outer layers as to enclose vertically the positive and the negative conductive layers. In another embodiment, the laminated planar bus structure may include a middle ground layer stacked in between the positive and the negative conductive layers to provide additional reduction in electric field strength. A laminated planar bus structure that is integrated with other power electronics components is also presented.

Abstract: Fine coal is cleaned of its mineral matter impurities and dewatered by mixing the aqueous slurry containing both with a hydrophobic liquid, subjecting the mixture to a phase separation. The resulting hydrophobic liquid phase contains coal particles free of surface moisture and droplets of water stabilized by coal particles, while the aqueous phase contains the mineral matter. By separating the entrained water droplets from the coal particles mechanically, a clean coal product of substantially reduced mineral matter and moisture contents is obtained. The spent hydrophobic liquid is separated from the clean coal product and recycled. The process can also be used to separate one type of hydrophilic particles from another by selectively hydrophobizing one.

Abstract: Methods, systems, and apparatus, including computer programs encoded on computer storage media, for training and deploying machine-learning estimation networks in a communications system. One of the methods includes: processing first information with ground truth information to generate a first RF signal by altering the first information by channel impairment having at least one channel effect, using a receiver to process the first RF signal to generate second information, training a machine-learning estimation network based on a network architecture, the second information, and the ground truth information, receiving by the receiver a second RF signal transmitted through a communication channel including the at least one channel effect, inferring by the trained estimation network the receiver to estimate an offset of the second RF signal caused by the at least one channel effect, and correcting the offset of the RF signal with the estimated offset to obtain a recovered RF signal.

Abstract: The present invention is a system to continuously monitor, in real-time, the small molecules being dialyzed during hemodialysis treatment using Raman spectroscopy and press control algorithms. By monitoring the treatment, the amount of water needed per dialysis treatment is drastically reduced by optimizing analyte saturation and removal of wastes. This will significantly conserve water and reduce the cost of dialysis treatments, possibly reducing the amount of time necessary for dialysis treatment, improving quality of life for patients during and after treatment, and reducing the costs of building new treatment centers as well as operating costs.

Abstract: Described here are blocky PEEK copolymers and corresponding synthesis methods. It was surprisingly found that synthesis of blocky PEEK copolymers in a non-solvent environment with respect to PEEK produced blocky PEEK copolymers with high degrees of functionalization and crystallinity. The blocky PEEK copolymers had an increased blocky structure, relative to corresponding PEEK copolymer synthesized with other known methods. Moreover, membranes formed from the blocky PEEK polymers are particularly desirable in fuel cell applications. For example, the membranes formed from the blocky PEEK polymers had surprisingly large ion conductivities as well as significantly improved chemical and thermal resistance, at least in part, to the improved functionalization and crystallinity.

Abstract: Disclosed are a vehicle anti-collision forewarning method, an in-vehicle computer device and a vehicle anti-collision forewarning system.

Abstract: Described herein are methods of performing immunotherapy on a subject and/or determining if a subject will be responsive to ablation immunotherapy.

Abstract: An articulated multi-link robotic tail (MLRT) system is provided comprising a rigid housing, an actuation unit coupled to the rigid housing, and an MLRT having a proximal end that is coupled to the rigid housing and a distal end opposite the proximal end. The MLRT comprises N segments, where N is a positive integer that is greater than or equal to one. Each segment comprises i links, where i is a positive integer that is greater than or equal to two. Each link is mechanically coupled to an actuator of the actuation unit and capable of being actuated by the actuator to which it is mechanically coupled to adjust a pitch, yaw and roll of the MLRT. The articulated MLRT system is well suited for being integrated with a mobile robot to assist in stabilizing and maneuvering the mobile robot.

Abstract: Various examples of a high frequency, inductor and transformer core loss characterization and measurement method and system for arbitrary waveforms are disclosed herein. A system and method for determining core loss of a magnetic core can include generating a waveform to excite a first test circuit which comprises an excitation circuit, a circuit under test (CUT) comprising the magnetic core, and an inductance circuit having an inductor connected in parallel to the CUT. The method includes measuring a first current, when the first test circuit is excited. The method includes disconnecting the CUT from the first test circuit to form a second test circuit. The method includes generating the waveform to excite the second test circuit, and measuring a second current, when the second test circuit is excited. The power loss for the magnetic core is calculated based on an input voltage and the first and second measured current.

Abstract: Aspects of bidirectional architectures with partial energy processing in resonant direct current (DC)-to-DC converters are described. In one embodiment, an alternating circuit (AC)-to-DC circuit generates an AC voltage from a DC voltage. A voltage of the AC voltage is transformed into a majority AC voltage of a majority power path and at least one minority AC voltage of the minority power paths. The majority AC voltage is rectified into a majority DC voltage and a minority AC voltage is rectified into a minority DC voltage. The majority power path and the minority power path are combined as a combined DC voltage.

Abstract: Provided herein are nicotine polymer-stabilized nanoparticles, formulations thereof, and vaccines. Also provided herein are methods of treating and/or preventing nicotine addiction in a subject in need thereof.

Abstract: Systems and methods are provided for modeling and for providing a graphical representation of tissue heating and electric field distributions for medical treatment devices that apply electrical treatment energy through one or a plurality of electrodes. In embodiments, methods comprise: providing one or more parameters of a treatment protocol for delivering one or more electrical pulses to tissue through a plurality of electrodes; modeling electric and heat distribution in the tissue based on the parameters; and displaying a graphical representation of the modeled electric and heat distribution. In another embodiment, a treatment planning module is adapted to generate an estimated target ablation zone based on a combination of one or more parameters for an irreversible electroporation protocol and one or more tissue-specific conductivity parameters.

Abstract: The present invention provides systems, methods, and devices for electroporation-based therapies (EBTs). Embodiments provide patient-specific treatment protocols derived by the numerical modeling of 3D reconstructions of target tissue from images taken of the tissue, and optionally accounting for one or more of physical constraints or dynamic tissue properties. The present invention further relates to systems, methods, and devices for delivering bipolar electric pulses for irreversible electroporation exhibiting reduced or no damage to tissue typically associated with an EBT-induced excessive charge delivered to the tissue.