Abstract: A high temperature carbon monoxide sensor for in-situ combustion monitoring is provided having a yttrium-stabilized zirconia interface based emf-measuring electrochemical sensor and a nickel oxide (NiO) first sensing electrode for targeting carbon monoxide gas at a temperature range from between about 1000 degrees Centigrade to about 1200 degrees Centigrade. A method of measuring carbon monoxide using this sensor is provided.

Abstract: The present disclosure relates to novel and improved methods of analyzing proteins, peptides and polypeptides by mass spectrometry using ion-ion reactions. More specifically the disclosure relates to improved methods for implementing the m/z selective arresting of ion-ion reactions within the ion-ion reaction cell of a mass spectrometer system during a period where ion-ion reactions are performed.

Abstract: Provided are methods for treating cancers and/or tumors in subjects. In some embodiments, the methods include administering to a subject an effective amount of a ceramide nanoliposome (CNL), wherein the CNL has a lipid bilayer that includes one or more C2-C24 ceramides and encapsulates one or more anti-cancer and/or anti-tumor agents. Also provided are methods for treating cancers and/or tumors associated with receptor tyrosine kinase or nuclear receptor activities, methods for treating Prostate Cancer, methods for inhibiting growth of EGFR-dependent cancers and/or tumors, methods for inhibiting growth of androgen receptor negative cells, method for reducing or eliminating androgen receptor negative cells from subject, CNLs that encapsulate one or more anti-cancer and/or anti-tumor agents, wherein the CNLs include a lipid bilayer that has one or more C2-C24 ceramides, and pharmaceutical compositions that include the disclosed CNLs.

Abstract: Systems and methods are provided for evaluating pain for a user. A first pain-relevant parameter representing the user is monitored at an in-vivo sensing device over a defined period to produce a time series for the first pain-relevant parameter. A value for a second pain-relevant parameter for the user is obtained at first and second times in the defined period from the user via a portable computing device to provide respective first and second values for the second pain-relevant parameter. A value is assigned to the user via a predictive model according to the time series for the first pain-relevant parameter, the first value for the second pain-relevant parameter, and the second value for the second pain-relevant parameter.

Abstract: A method for an injection molding system including an injection molding machine that includes a supporting member for movably supporting the mold at a molding operation position and a conveyance apparatus that includes a supporting member for supporting the mold and that extends from the conveyance apparatus into the injection molding machine includes performing an injection molding process with a first mold at the molding operation position, unloading the first mold from the molding operation position, loading a second mold to the molding operation position, and opening the second mold at the molding operation position while at least a part of the first mold is on a section of the supporting member of the conveying apparatus extending into injection molding machine.

Abstract: A composition for restoring or increasing tissue perfusion is provided. The composition includes polyethylene glycol polymers (PEG) with a molecular weight of 18,000-100,000 Da at a concentration of 5-20% by weight; PEG with a molecular weight of 1,000-10,000 Da at a concentration of 1-30% by weight; and water, wherein said PEG with a molecular weight of 18,000-100,000 Da and said PEG with a molecular weight of 1,000-10,000 Da are dissolved or dispersed in said water.

Abstract: A system for generating a hypoglycemia risk signal associated with exercise-induced Hypoglycemia. The system can include a processor configured to obtain a blood glucose signal (BGstart), a ratio of absolute insulin on board over total daily insulin signal (IOBabs/TDI), and an initial glycemic slope signal (S0); generate a hypoglycemia risk signal based on a hypoglycemia prediction algorithm that determines the probability of a user being hypoglycemic during or after exercise based on the obtained BGstart, IOBabs/TDI and S0.

Abstract: An integrated circuit memory device can include a plurality of banks of memory, each of the banks of memory including a first pair of sub-arrays comprising first and second sub-arrays, the first pair of sub-arrays configured to store data in memory cells of the first pair of sub-arrays, a first row buffer memory circuit located in the integrated circuit memory device adjacent to the first pair of sub-arrays and configured to store first row data received from the first pair of sub-arrays and configured to transfer the row data into and/or out of the first row buffer memory circuit, and a first sub-array level processor circuit in the integrated circuit memory device adjacent to the first pair of sub-arrays and operatively coupled to the first row data, wherein the first sub-array level processor circuit is configured to perform column oriented processing a sparse matrix kernel stored, at least in-part, in the first pair of sub-arrays, with input vector values stored, at least in part, in the first pair of sub

Abstract: An automated and quantitative facial weakness screening framework that utilizes a Bi-LSTM network to model the temporal dynamics among the shape and appearance features. The technique is beneficial to assist the paramedics or other users to identify the facial weakness in the field or, more importantly, whenever expertise in neurology is not available either for emergency patient triage (e.g., pre-hospital stroke care) or chronic disease management (e.g., Bell's palsy rehabilitation screen), leading to increased coverage and earlier treatment. The technique provides visualizable and interpretable results to increase its transparency and interpretability. The technique provides for inexpensive solutions that can be used in areas underserved by non-neurologists to more readily identify neurological deficits such as facial weakness in the field or other environment.

Abstract: A device and related method that provides, but is not limited thereto, a two-phase heat transfer device with unique combination of enhanced evaporation and increased cooling capacity. An advantage associated with the device and method includes, but is not limited thereto, increased cooling capacity per unit area, controlled and optimized evaporation, prevention of boiling, and prevention of drying of the evaporator. An aspect associated with an approach may include, but is not limited thereto, using anon-wetting coating or structure to keep working fluid away from the spaces between elongated members of an evaporator and using a wetting coating or structure to form thin films of working fluid around the distal region of the elongated members. For example it can be used to cool a computer chip, a skin of a hypersonic flying object, parabolic solar collector, turbine or engine blade, or any other heat source that requires high heat flux.

Abstract: Methods, systems, and apparatus, including computer programs encoded on computer storage media, for training and deploying machine-learned communication over multi-input-multi-output (MIMO) channels.

Abstract: In one aspect, the disclosure relates to a multifunctional fiber-reinforced polymer (FRP) composite jacket system configured to improve the safety of a container at least partially enclosed within the FRP composite jacket system. This can be accomplished by increasing the container's overall puncture resistance and thermal resistance which, in part, corresponds to a performance increase in terms of strength, energy absorption, and other efficiencies compared to traditional protective jacketing methods and materials. In a further aspect, this system can be applied to in-service tank cars as an in situ retrofit. Alternatively, it can be applied to newly manufactured tank cars as a design improvement over traditional approaches to existing outer jackets of tank cars. This abstract is intended as a scanning tool for purposes of searching in the art and is not intended to be limiting of the present disclosure.

Abstract: An injection molding system includes an injection molding apparatus configured to perform injection molding with a mold, a conveyor apparatus configured to move the mold along a supporting plane; and a cable carrier configured to cover a cable connected to the mold, wherein a shape of the cable carrier changes for guiding the cable based on a movement of the mold by the conveyor apparatus, and wherein at least one of a first end of the cable carrier or a second end of the cable carrier are located below the supporting plane in a direction perpendicular to the supporting plane.

Abstract: In some aspects, described herein are methods of additive manufacturing in which one or more corrugated layers are incorporated into the three-dimensional (3D) object. Also provided herein are 3D objects that can include one or more corrugated layers.

Abstract: A flexible system for utilizing data from different monitoring techniques and capable of providing assistance to patients with diabetes at several scalable levels, ranging from advice about long-term trends and prognosis to real-time automated closed-loop control (artificial pancreas). These scalable monitoring and treatment strategies are delivered by a unified system called the Diabetes Assistant (DiAs) platform. The system provides a foundation for implementation of various monitoring, advisory, and automated diabetes treatment algorithms or methods. The DiAs recommendations are tailored to the specifics of an individual patient, and to the patient risk assessment at any given moment.

Abstract: In various aspects, the present disclosure provides polynucleotides encoding a fusion protein, as well as vectors, cells, and compositions comprising the same. In embodiments, the fusion protein includes an insulin signal peptide and an MDA-7/IL-24 protein. Methods of using the polynucleotides, vectors, cells, and compositions, such as in the treatment or prevention of cancer, are also provided.

Abstract: An insulin delivery supervisor (IDS) with a safety analysis and supervision function that can reside between the insulin request and the insulin delivery and can intercept any excessive insulin requests before the insulin was delivered. The IDS can be implemented in any system based on insulin pump or pen and will work with either SMBG or CGM modes of blood glucose monitoring.

Abstract: Provided are methods and compositions for treating and/or preventing C. difficile infections, particularly recurring C. difficile infections. The compositions for use in treating and/or preventing C. difficile infections include in some embodiments at least one agent that inhibits an alpha 2 adrenergic receptor, and the presently disclosed methods include administering at least one such composition to a subject in need thereof, optionally in combination with other therapeutically active agents including but not limited to an enhancer of an IL-13 biological activity, optionally an IL-13 peptide or a fragment or homolog thereof; an interleukin-13 receptor subunit alpha-2 (IL-13Ra2) inhibitor; an enhancer of an Interleukin-33 (IL-33) biological activity, optionally an IL-33 polypeptide or a biologically active fragment or homolog thereof; or any combination thereof.

Abstract: Compositions and methods for regenerating pancreatic islet viability and/or cell proliferation in vitro, ex vivo, and/or in vivo; and/or for regenerating glucose-stimulated insulin secretion; and/or for regenerating viability and/or cell proliferation of a transplanted pancreatic islets; and/or for preventing and/or inhibiting rejection of a transplanted islets; and/or for pancreatic islet transplantation; and/or for treating a symptom of a condition, disorder, or disease associated with abnormal insulin responsiveness to glucose are provided. In some embodiments, the compositions include a peptide and/or a pharmaceutically acceptable salt thereof, and/or a biologically active fragment, analog, or derivative thereof, wherein the peptide, the pharmaceutically acceptable salt thereof, and/or the biologically active fragment, analog, or derivative thereof has an amino acid sequence of any of SEQ ID NOs: 1-60, or any combination thereof.

Abstract: Provided are methods for treating viral infections in subject in need thereof. In some embodiments, the method include administering to the subject a composition that has an effective amount of an agent that selectively interferes with host protease function to inhibit fusion-ready viral fragment generation, optionally S2 in case of SARS-CoV2 or GP160 or GP120 in case of HIV, and/or to destabilize a full-length viral fusion protein, optionally SARS-CoV-2 spike. Also provided are compositions that include an effective amount of an agent that selectively interferes with host protease function to inhibit fusion-ready viral fragment generation, optionally S2 in case of SARS-CoV2 or GP160 or GP120 in case of HIV, and/or to destabilize a full-length viral fusion protein, optionally SARS-CoV-2 spike, which compositions can optionally be employed in the disclosed methods.