Abstract: Various embodiments for a continuum manipulator are described for use in robotic surgical systems or other desired applications. The continuum manipulator includes an extensible continuum manipulator (ECM) body comprising a plurality of subsegments serially connected to one another. Adjacent ones of the subsegments are coupled by rack-and-pinion transmission sets that are configured to propagate subsegment motion to downstream ones of the subsegments. A multi-chain flexible parallel mechanism is provided in each of the subsegments that is configured to generate a desired spatial bending and extension mobility for each of the subsegments.

Abstract: Provided herein are PEGylated liposomes, and methods of making and using thereof. The PEGylated liposomes comprise at least a cholesterol, a non-PEGylated neutral lipid, and a PEGylated lipid, wherein the average molecular weight of the PEG component in the PEGylated lipid is about 5000 Daltons or less. The PEGylated liposomes are stable and capable of delivery of an agent for the generation of an immune response, for example an agent for vaccine, therapeutic, or diagnostic uses. Compositions and methods related to making the PEGylated liposomes and using the PEGylated liposomes for stimulating an immune response are also provided.

Abstract: The present disclosure relates to compositions and methods related to modification of trichome density and transport of metabolite and their uses in plants, including tobacco and cannabis. The provided transcription factors enable the increase in trichome density in plants.

Abstract: A conveyance apparatus for conveying a mold into an injection molding machine includes a frame configured to form a supporting plane for supporting the mold, and an actuator configured to move the mold along the supporting plane between a first position inside the injection molding machine and a second position different from the first position, wherein the improvement to the conveyance apparatus includes the actuator being located below the supporting plane in a vertical direction; and a linking unit configured to link the mold and the actuator, wherein the linking unit is connectable to a side surface of the mold, wherein, in a state where the mold is at the second position, at least a part of the actuator is closer to the injection molding machine than the side surface of the mold in a conveying direction where the actuator moves the mold.

Abstract: Methods for treating coronavirus disease 2019 (COVID-19), the disease caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infections, are described. The methods include administration of combinations of agents, including combinations that include dupilumab. The methods can be used to treat subjects diagnosed with a SARS-CoV-2 infection, including those already hospitalized to treat COVID-19 and/or those also having lymphopenia, to reduce the severity of outcomes related to COVID-19, such as admittance to the intensive care unit (ICU), mechanical ventilation, and/or death, particularly over periods of time longer than a month or two months following the initial administration of the agents. Compositions for use in the treatment of COVID-19 are also described.

Abstract: Some devices, systems, and methods obtain training images; select a first reference image and a second reference image from the training images; generate a first set of aligned training images, wherein generating the first set of aligned training images includes aligning the training images to the first reference image; generate a first anomaly-detection model based on the first set of aligned training images; generate a second set of aligned training images, wherein generating the second set of aligned training images includes aligning the training images to the second reference image; and generate a second anomaly-detection model based on the second set of aligned training images.

Abstract: Various examples of systems and methods for a coupled inductor winding structure for common-mode noise reduction is described herein. The coupled inductor structure can include a magnetic core including a first leg, a second leg, and a center leg; and a planar winding structure. The planar winding structures can include a first inductor winding for a forward path of a first phase of a power converter; a second inductor winding for a forward path of a second phase of the power converter; a third and fourth inductor winding for a return path. The third inductor winding having at least one turn interleaved within the number of first leg turns of the first inductor winding and configured to achieve unity coupling. The fourth inductor winding having at least one turn interleaved within the number of second leg turns of the second inductor winding and configured to achieve unity coupling.

Abstract: An aspect of an embodiment or partial embodiment of the present invention (or combinations of various embodiments in whole or in part of the present invention) comprises, but not limited thereto, a method and system (and related computer program product) for continually assessing the risk of hypoglycemia for a patient and then determining what action to take based on that risk assessment. A further embodiment results in two outputs: (1) an attenuation factor to be applied to the insulin rate command sent to the pump (either via conventional therapy or via open or closed loop control) and/or (2) a red/yellow/green light hypoglycemia alarm providing to the patient an indication of the risk of hypoglycemia. The two outputs of the CPHS can be used in combination or individually.

Abstract: An aspect of an embodiment or partial embodiment of the present invention (or combinations of various embodiments in whole or in part of the present invention) comprises, but not limited thereto, a method and system (and related computer program product) for continually assessing the risk of hypoglycemia for a patient and then determining what action to take based on that risk assessment. A further embodiment results in two outputs: (1) an attenuation factor to be applied to the insulin rate command sent to the pump (either via conventional therapy or via open or closed loop control) and/or (2) a red/yellow/green light hypoglycemia alarm providing to the patient an indication of the risk of hypoglycemia. The two outputs of the CPHS can be used in combination or individually.

Abstract: An aspect of an embodiment or partial embodiment of the present invention (or combinations of various embodiments in whole or in part of the present invention) comprises, but not limited thereto, a method and system (and related computer program product) for continually assessing the risk of hypoglycemia for a patient and then determining what action to take based on that risk assessment. A further embodiment results in two outputs: (1) an attenuation factor to be applied to the insulin rate command sent to the pump (either via conventional therapy or via open or closed loop control) and/or (2) a red/yellow/green light hypoglycemia alarm providing to the patient an indication of the risk of hypoglycemia. The two outputs of the CPHS can be used in combination or individually.

Abstract: An image calibration method includes capturing and correcting a flood field image for background signal and effects of known image-panel features (dead/bad pixels). The corrected image is processed to separate frequencies characteristic of relative pixel sensitivities from frequencies characteristic of radiation energy fluence. The incident energy fluence has a known maximum in-field energy fluence gradient. A model that describes the incident energy fluence on a detector is generated or received. The corrected image may be modeled at frequencies at or below the maximum in-field energy fluence gradient. A pixel sensitivity matrix (PSM) is generated by adjusting the corrected image with the model of the incident energy fluence on the detector. For example, the corrected image signal may be divided by the model or the model may be subtracted from the corrected image. The PSM may be used to correct additional raw images captured by the detector.

Abstract: Systems, methods, and devices are described herein for identifying, monitoring, isolating, or selecting a cell having a predefined characteristic in a mixed population of cells utilizing a combination of any one or more of iDEP, a region of localized field enhancement, a variable frequency electric field, a wide bandwidth amplifier, and/or an imaging apparatus.

Abstract: The present disclosure relates to methods and devices for the separation of blood components including separation by rapid sedimentation, including in an automated fashion.

Abstract: An improved long-acting injectable depot suspension formulation of LB displaying progestational effects which overcomes the aggregation and physical instability of LB injectable depot products, and also provides a longer duration of action of at least 4 months. Potential uses of this formulation include but are not limited to contraception and treatment or prevention of progestin/progesterone-sensitive reproductive tract dysfunctions and disorders.

Abstract: An injection molding system includes an injection molding apparatus that performs injection molding with a die and a conveyor apparatus on one side of the injection molding apparatus that inserts the die into the injection molding apparatus, where the conveyor apparatus includes an actuator connectable to the die. The injection molding system also includes a die detection unit that detects the conveyed die, an actuator detection unit that detects a state of the actuator, and a controller that controls the conveyor apparatus to prohibit a conveying operation of the die based on detection results by the die detection unit and the actuator detection unit.

Abstract: Methods, systems, and apparatus, including computer programs encoded on computer storage media, for training and deploying machine-learned compact representations of radio frequency (RF) signals. One of the methods includes: determining a first RF signal to be compressed; using an encoder machine-learning network to process the first RF signal and generate a compressed signal; calculating a measure of compression in the compressed signal; using a decoder machine-learning network to process the compressed signal and generate a second RF signal that represents a reconstruction of the first RF signal; calculating a measure of distance between the second RF signal and the first RF signal; and updating at least one of the encoder machine-learning network or the decoder machine-learning network based on (i) the measure of distance between the second RF signal and the first RF signal, and (ii) the measure of compression in the compressed signal.

Abstract: Drying polar solvents which do not form hydrogen bonds with a wet gel or aerogel, or eutectics or solvent mixtures with the drying solvents, are utilized in a solvent exchange with wet gels used in the formation of aerogels. Preferably the drying solvents are non-polar solvents. The drying solvent or solvent mixtures results in profoundly less shrinkage, thereby allowing for the production of aerogels of preferred materials properties.

Abstract: In various aspects, top-down stereolithography apparatus and methods of use thereof are provided herein that allow for additive manufacturing of an article from a high-viscosity resin. The apparatus and methods can print resins having viscosities higher than conventional systems, e.g. viscosities up to about 100 Pa·s at the elevated temperature. The resin may have a room temperature viscosity of about 100 Pa·s, about 250 Pa·s, about 1000 Pa·s, or more. In some aspects, the resin is a solid at room temperature. The apparatus and methods do not rely upon solvents or other viscosity modifiers being added to the resin, and are capable of top-down additive manufacturing approaches which provide reduced stress on the printed article.

Abstract: A method for detachably attaching a linking unit, including an end with a hole and a slit, to a mold, the method comprising inserting a first attachment member connected to the mold through the hole; and inserting a second attachment member connected to the mold through the slit, wherein the linking unit is detached from the mold by moving the linking unit in a direction opposite to a direction in which the slit is formed in a state where the first attachment member is disconnected from the mold and the second attachment member remains connected to the mold.

Abstract: A method for producing an additively manufactured, graded composite transition joint (AM-GCTJ) includes preparing a grating or lattice pattern from a first alloy A; the grating or lattice pattern includes pores in the grating or lattice patterns. The grating pattern is built from a first end to a second end being denser on the first end than on second end, and gradually reduces density by increasing the pore size and/or reducing density of the grating or lattice pattern; adding a second alloy B powder to the second end of grating or lattice pattern. The second alloy B powder is filled towards the first end. A composite is formed of first alloy A and second alloy B powder in the AM-GCTJ. The composite is subjected to hot isostatic pressing (HIP) to densify the composite. The second alloy B is graduated from the first end to the second end O of AM-GCTJ.