Abstract: The disclosure describes prodrugs and derivatives of prostaglandins, carbonic anhydrase inhibitors, kinase inhibitors, beta-adrenergic receptor antagonists and other drugs, as well as controlled delivery formulations containing such prodrugs and derivatives, for the treatment of ocular disorders.

Abstract: A rechargeable electrochemical battery in the form of a single or multi-stranded wire assembly may be utilized as a power source for any number of implantable or non-implantable medical devices. As the wire form battery may be scaled to micro size, it may be utilized to power medical devices that were traditionally non-active devices, but which may be enhanced with active components. The wire form battery may be cut to size for a particular application which provides the same open circuit voltage regardless of how the wire is ultimately configured and the length of the wire utilized. Although the battery is in wire form, various arrangements of the components within the battery are also possible.

Abstract: This invention discloses methods and apparatus for forming Ophthalmic Lenses with Stabilizing Features, and more specifically, Ophthalmic Lenses that include an encapsulated Insert Device.

Abstract: An enhanced object detecting method and apparatus is presented. A plurality of successive frames is captured by a monocular camera and the image data of the captured frames are transformed with respect to a predetermined point of view. For instance, the images may be transformed in order to obtain a top-down view. Particular features such as lines are extracted from the transformed image data, and corresponding features of successive frames are matched. An angular change of corresponding features is determined and boundaries of an object are identified based on the angular change of the features.

Abstract: A light module for a motor vehicle comprises at least one light source capable of emitting light rays, a support bearing the light source, optical deflection elements arranged so as to deflect the light rays emitted by the light source to form a light beam projected at the output of the light module, and guiding elements for guiding the optical deflection elements in rotation about an axis of rotation, in order to shift the projected light beam transversely. According to the invention, the rotation guiding elements comprise a first guiding element borne by the support and configured to cooperate with a second guiding element borne by the optical deflection elements.

Abstract: Embodiments of the disclosure relate to retrofitting LED light bars into fluorescent tubular style lamp fixtures as well as integrating LED light bars into new lamp fixtures. In various embodiments a single light bar may be utilized with multiple style base ends to allow it to retrofit into a variety of existing fixtures. Some embodiments offer multiple mounting options on an LED light bar for existing lamp fixtures so that electrical utilities' rebate requirements can be met with a single LED light bar assembly.

Abstract: The invention relates to an outer lens for a luminous device, in particular for a motor vehicle. The outer lens include a main portion made of transparent plastic, at least two edges for fastening to a housing of the luminous device, an electrically conductive coating forming a defrosting and/or demisting electrical resistor, and at least two electrodes that are electrically connected to the conductive coating. The electrodes are located on the fastening edges and are overmolded by the transparent plastic. The invention also relates to a luminous device including the outer lens in question and a process for producing the outer lens.

Abstract: A light module for a motor vehicle comprises at least one light source capable of emitting light rays, a support bearing the source, an electrical power supply cable of the source, an optical deflection element arranged so as to deflect the light rays emitted by this source to form a projected light beam at the output of the light module, and a guiding device for guiding the optical deflection element in rotation about an axis of rotation, in order to transversely shift the projected light beam. According to the invention, the support comprises a first part, bearing the light source, and the second part, between which there is inserted at least a part of the guiding device, and the cable passes through the rotation guiding device to be connected to said light source.

Abstract: A lighting module for a motor vehicle including at least one light source designed to emit light rays, optical deviation elements mounted movably in rotation about a first axis of rotation and arranged so as to deviate the light rays to form a light beam, and an actuator designed to rotate the optical element. According to the invention, the module is also designed to be movable in rotation about a second of rotation.

Abstract: The present invention provides a pharmaceutical composition containing albumin-binding arginine deiminase (AAD) fusion protein for treating cancer or other arginine-dependent diseases. The AAD fusion protein can be purified from both soluble and insoluble fractions of crude proteins, binds to human serum albumin (HSA) or animal serum albumin and has its high activity with longer half life for efficient depletion of arginine in cancer cells. The specific activities of wild-type ADI and AAD fusion protein in the present invention are about 20 and about 19 U/mg (at physiological pH 7.4), respectively. The composition can be used alone or in combination with at least one chemotherapeutic agent to give a synergistic effect on cancer treatment and/or inhibiting metastasis. The AAD fusion protein can also be used as a component for detection and quantitative analysis of arginine in a testing kit for various samples including blood, food and analytical samples.

Abstract: A sensor that detects contact using compression of a compliant material sandwiched between an electromagnetic signal transmitter and a corresponding signal receiver. Potential applications include inexpensive, robust collision sensors integrated into mobile robot bumpers, and sensors on robot grippers to detect grasping of an object. Deformation of the compliant material in response to contact forces changes the distance between the transmitter and the receiver, affecting the electromagnetic field between them. Changes in this electromagnetic field provide information on the location and magnitude of the contact forces. A transmitter and receiver may form opposing surfaces of a capacitor; the measured capacitance changes as the distance between transmitter and receiver changes. Alternatively, the strength of a received signal may be monitored to detect changing distance between transmitter and receiver. Shielding and signal filtering may be used to mitigate the effects of electromagnetic noise.

Abstract: An intraocular lens system is presented that comprises an electro-active lens comprising multiple independently controllable zones or pixels, and a controller capable of being remotely programmed.

Abstract: An apparatus for controlled healing of ocular erosions is described. The apparatus comprising; an optical surface comprising an energizable controller capable of being programmed to transmit energy from an energy source onto/into an ocular surface, through the use of a current generator in electrical connection with energy emitting contacts capable of transmitting an electric field. The controller, current generator and energy emitting contacts are biocompatible or encapsulated by a conductive biocompatible layer to allow positioning of said apparatus in an ocular surface.

Abstract: This invention discloses a device comprising multiple functional layers formed on substrates, wherein at least one functional layer comprises an electrical energy source. In some embodiments, the present invention includes an insert for incorporation into ophthalmic lenses that has been formed by the stacking of multiple functionalized layers.

Abstract: The present invention relates generally to an ophthalmic device capable of monitoring neural frequencies and correlating the measured frequencies them to specific brain activity/functions. In some embodiments, profiles specific to the user of the ophthalmic device can be pre-programmed to tailor a brain activity/function profiles according to a user. Based on the determined brain activity/function from the correlation, a signal may be generated to provide feedback to the user. The signal may be transmitted to the user in one or more form. For example, the signal may be outputted to a wireless device in wireless communication with the ophthalmic device, and/or through an audible signal projected by an acoustic element, and/or a visual signal projected using a photon emitter, both which may be included in the ophthalmic device.

Abstract: A tray holder apparatus that includes a frame on which a coffee maker may rest and a compartment into which a tray may be slid. The tray that slides into the frame is adaptable for receiving and displaying single serving beverage packages. A portion of the frame rolls over a countertop while the remaining portion of the frame rolls over a base of the tray holder apparatus. The tray may be slid in and out of the frame while the frame remains stationary above the base or while the frame is slid out from the base.

Abstract: This invention provides for a device and methods of dispensing a precise predetermined volume of liquid of discrete drops, vapor, or mist while preventing contamination due to Pull Back and ensuring precision dispensing.

Abstract: Systems and methods for processing portable wavefront aberrometer data are disclosed. In one embodiment, a method includes receiving, from a mobile computing device, image data captured by a light detector of the mobile computing device, the image data corresponding to light reflected from an eye of a patient and passed through a portable wavefront aberrometer coupled to the mobile computing device. The method further includes processing the image data to compute a patient-specific parameter associated with the patient, and transmitting the patient-specific parameter to one or more of the mobile computing device or a computing device associated with a medical provider.

Abstract: The present invention provides a device for an energizable Ophthalmic Lens with an event coloration mechanism. The event coloration mechanism may color or change color based on some predefined event. For example, a predefined constituent or predefined condition of the tear fluid may be indicative of the predefined event, and the event coloration mechanisms may interact with the tear fluid, accordingly. The event coloration mechanism may provide the energizable functionality of the Ophthalmic Lens in some embodiments. In others, the event coloration mechanism may be passive but may interact and interface with the electrical components of the Ophthalmic Lens, such as, for example, those included within the Media Insert. Event coloration mechanisms may be combined with additional functionalities that may be included in an energizable Ophthalmic Lens.

Abstract: The invention relates to a method for assembling a first and a second part of a lighting device for a vehicle by mirror welding, including a step of supplying the parts wherein each part comprises, in the interface area thereof for contact with the other part, a weld bead intended to come into contact against the weld bead of the other part during the mirror welding, the weld bead of at least one of the parts is provided with a plurality of expander ribs (N) spread out along the weld bead, in such a way as to locally expand the width of the weld bead.