Patents Assigned to Wake Forest University Health Sciences
  • Reprogramming Mesenchymal Stromal Cells Into Hematopoietic Cells
    Publication number: 20160130554
    Abstract: Method for reprogramming of stromal cells into hematopoietic cells are provided. Also provided are mesenchymal stromal cells that can be reprogrammed into hematopoietic cells. In addition, hematopoietic cells reprogrammed from mesenchymal stromal cells are provided. Reprogramming stromal cells into hematopoietic cells is effected through a vector encoding a transcription factor that controls hematopoietic cell differentiation. Methods of treating subjects having diminished hematopoietic cell populations are provided as well.
    Type: Application
    Filed: November 4, 2015
    Publication date: May 12, 2016
    Applicant: Wake Forest University Health Sciences
    Inventors: Maria Graca N.D. Almeida-Porada, Christopher D. Porada, Colin E. Bishop
  • Ureter to ileal conduit anastomosis using magnetic compression and related delivery devices and methods
    Patent number: 9332990
    Abstract: Magnetic compression anastomosis can be carried out by placing cooperating magnets, one in the ileal conduit and one in the ureter, to lock together and form the anastomosis. The magnets may be placed to form a side-to-side anastomosis. At least one of the magnets can include radioactive material. Catheters may be used to place the magnets, and the catheters may have at least one deflatable or retractable tissue spacer.
    Type: Grant
    Filed: December 22, 2011
    Date of Patent: May 10, 2016
    Assignee: WAKE FOREST UNIVERSITY HEALTH SCIENCES
    Inventor: Jay Anthony Requarth
  • Inkjet printing of tissues and cells
    Patent number: 9301925
    Abstract: Provided herein is an apparatus for printing cells which includes an electrospinning device and an inkjet printing device operatively associated therewith. Methods of making a biodegradable scaffold having cells seeded therein are also provided. Methods of forming microparticles containing one or more cells encapsulated by a substrate are also provided, as are methods of forming an array of said microparticles.
    Type: Grant
    Filed: March 11, 2015
    Date of Patent: April 5, 2016
    Assignee: Wake Forest University Health Sciences
    Inventors: Tao Xu, James J. Yoo, Anthony Atala
  • Methods of detecting ovarian cancer
    Patent number: 9297814
    Abstract: Methods of screening human female subject for a risk of ovarian cancer are described. High levels of calcium in serum are shown to be significantly positively associated with the risk of ovarian cancer and can advantageously be used to triage women into risk categories for more intensive testing. Also included are preoperative methods of determining if an adnexal mass is likely to be malignant or benign.
    Type: Grant
    Filed: January 6, 2014
    Date of Patent: March 29, 2016
    Assignees: WISCONSIN ALUMNI RESEARCH FOUDATION, WAKE FOREST UNIVERSITY HEALTH SCIENCES
    Inventors: Halcyon Gerald Skinner, Gary G. Schwartz
  • IL-13 receptor binding peptides
    Patent number: 9296785
    Abstract: A targeting peptide that specifically binds to an IL13 receptor (e.g., wherein said targeting peptide is not an IL13 fragment) is described. The targeting peptide is optionally conjugated to at least one effector molecule. In some embodiments, the peptide specifically binds to the IL13R?2 protein.
    Type: Grant
    Filed: April 16, 2010
    Date of Patent: March 29, 2016
    Assignee: Wake Forest University Health Sciences
    Inventors: Waldemar Debinski, Hetal Pandya, Denise Gibo
  • Apparatus and method for cardiac tissue modulation by topical application of vacuum to minimize cell death and damage
    Patent number: 9289193
    Abstract: A method and apparatus are provided for treating cardiac tissue to modulate ischemic heart tissue with topical sub-atmospheric pressure to minimize cell death and damage.
    Type: Grant
    Filed: July 16, 2009
    Date of Patent: March 22, 2016
    Assignee: Wake Forest University Health Sciences
    Inventors: Louis C. Argenta, David L. Carroll, James E. Jordan, Nicole H. Levi, Jie Liu, Michael J. Morykwas, William D. Wagner
  • Molecular signature of cancer
    Patent number: 9290558
    Abstract: The present invention provides compounds, compositions, and methods for detecting, diagnosing and treating cancers such as glioblastoma multiforme.
    Type: Grant
    Filed: December 3, 2012
    Date of Patent: March 22, 2016
    Assignee: Wake Forest University Health Sciences
    Inventors: Waldemar Debinski, Jill Wykosky, Denise Mazess Herpai
  • outer-membrane protein antigens and methods of making and using the same
    Patent number: 9283268
    Abstract: An isolated protein or peptide selected from the group consisting of Bordetella colonization factor A (BcfA) protein and antigenic fragments thereof is described, along with an isolated nucleic acid encoding the same, antibodies that bind to the same, methods of producing an immune response in a mammalian subject in need thereof by administering the proteins, peptides or antibodies, and pharmaceutical compositions comprising the same.
    Type: Grant
    Filed: September 26, 2014
    Date of Patent: March 15, 2016
    Assignee: Wake Forest University Health Sciences
    Inventors: Rajendar K. Deora, Meenu Mishra, Neelima Sukumar
  • Multivalent aptamer complexes
    Patent number: 9284559
    Abstract: A compound of the formula A-B-C, is provided, wherein: A is a first nucleic acid that specifically binds to an extracellular surface protein expressed by a cell of interest, B is an alkyl linker; and C is a second nucleic acid that hybridizes to a complementary nucleic acid. In some embodiments, the first nucleic acid is an aptamer. In some embodiments, the nucleic acid comprises an active compound, particularly cytotoxic nucleotides such as poly-FdUMP. Compositions and methods of using such compounds for treating and/or detecting cancer are also described.
    Type: Grant
    Filed: April 13, 2010
    Date of Patent: March 15, 2016
    Assignee: Wake Forest University Health Sciences
    Inventor: William H. Gmeiner
  • Encapsulated cells for hormone replacement therapy
    Patent number: 9283251
    Abstract: A composition comprising microcapsules, the microcapsules containing both live mammalian ovarian granulosa cells and live mammalian ovarian theca cells, is described. In some embodiments, the granulosa cells and the theca cells are contained in separate microcapsules in the composition; in some embodiments, the granulosa cells and the theca cells are contained together in the same microcapsules in the composition The composition is can be used for estrogen, and optionally also progesterone, delivery, and hence is preferably free or essentially free of oocytes. Methods of using the same and pharmaceutical formulations containing the same are also described.
    Type: Grant
    Filed: February 21, 2012
    Date of Patent: March 15, 2016
    Assignee: Wake Forest University Health Sciences
    Inventors: Emmanuel Opara, James J. Yoo, Justin M. Saul, Sittadjody Sivanandane, Anthony Atala
  • Tethered and/or visually coded brachytherapy devices and related methods
    Patent number: 9272160
    Abstract: Bracytherapy devices include a respective tether attached to a proximal end portion of the strands. The tether can be color-coded to match a color associated with the corresponding strand.
    Type: Grant
    Filed: August 3, 2011
    Date of Patent: March 1, 2016
    Assignee: Wake Forest University Health Sciences
    Inventors: Andrew Karim Kader, Daniel B. Fried
  • Flagellin fusion proteins and use thereof to induce immune responses against
    Patent number: 9260509
    Abstract: The invention provides compositions and fusion proteins comprising a flagellin adjuvant and a Pseudomonas aeruginosa antigen. The invention further provides pharmaceutical formulations and methods for inducing an immune response against P. aeruginosa (e.g., to prevent and/or treat P. aeruginosa infection).
    Type: Grant
    Filed: June 25, 2015
    Date of Patent: February 16, 2016
    Assignee: Wake Forest University Health Sciences
    Inventors: Steven B. Mizel, Daniel J. Wozniak, Eric T. Weimer
  • ANTIBODIES AGAINST HUMAN AND CANINE IL-13RA2
    Publication number: 20160039938
    Abstract: Provided herein is an antibody (e.g., an isolated antibody) that specifically binds an epitope (e.g., linear epitope) within amino acids spanning the extracellular portion of human IL-13RA2. In some embodiments, the amino acids spanning the extracellular portion of human IL-13RA2 have at least 90% identity with the corresponding canine sequence of IL-13RA2. In some embodiments, the antibody specifically binds both human and canine IL-13RA2. In some embodiments, the antibody is a monoclonal antibody. In some embodiments, the antibody is a recombinant antibody. In some embodiments, the antibody is humanized. In some embodiments, the antibody is the monoclonal antibody produced by hybridoma 1E10B9 or a recombinant form thereof.
    Type: Application
    Filed: March 14, 2014
    Publication date: February 11, 2016
    Applicant: Wake Forest University Health Sciences
    Inventors: Waldemar Debinski, Denise Mazess Herpai
  • Methods of measuring amount of cholesteryl ester in a blood sample
    Patent number: 9222948
    Abstract: A method of measuring an amount of at least one cholesteryl ester in a blood sample is carried out by combining a blood sample with a salt and an alcohol to provide a dilute sample; introducing the dilute sample into a mass spectrometer; and then measuring the amount of the at least one cholesteryl ester in the dilute sample by mass spectrometry, to thereby measure the amount of at least one cholesteryl ester in the blood sample, is described.
    Type: Grant
    Filed: May 30, 2012
    Date of Patent: December 29, 2015
    Assignee: Wake Forest University Health Sciences
    Inventors: Lawrence L. Rudel, Chadwick D. Miller, Michael J. Thomas
  • Keratin compositions for treatment of bone deficiency or injury
    Patent number: 9220754
    Abstract: A bone graft composition is described, with one or more of: (a) keratose; (b) kerateine; (c) optionally, particulate filler; (d) optionally, an antibiotic; and (e) water or saline. The composition may be provided in sterile form in a container, and optionally lyophilized. Methods of treating a bone deficiency or fracture making use of such compositions are also described.
    Type: Grant
    Filed: May 16, 2013
    Date of Patent: December 29, 2015
    Assignee: Wake Forest University Health Sciences
    Inventors: Mark E. Van Dyke, Thaleia Teli
  • Vascular territory segmentation using mutual clustering information from image space and label space
    Patent number: 9196037
    Abstract: Methods, systems, computer programs, circuits and workstations are configured to generate at least one two-dimensional weighted CBF territory map of color-coded source artery locations using an automated vascular segmentation process to identify source locations using mutual connectivity in both image and label space.
    Type: Grant
    Filed: March 5, 2014
    Date of Patent: November 24, 2015
    Assignee: Wake Forest University Health Sciences
    Inventor: Youngkyoo Jung
  • Electrospun cell matrices
    Patent number: 9163331
    Abstract: The invention is directed to compositions and methods for preparing electrospun matrices comprising at least one natural biological material component and at least one synthetic polymer material. The natural component makes the matrices highly biocompatible while the molecular weight polymer component can impart additional strength mechanical strength to the scaffold and/or improve ease of manufacture by increasing viscosity and spinning characteristics of the solution during electrospining.
    Type: Grant
    Filed: November 18, 2009
    Date of Patent: October 20, 2015
    Assignee: Wake Forest University Health Sciences
    Inventors: Anthony Atala, James Yoo, Grace Lim, Richard Czerw, Shay Soker, Joel Stitzel
  • One-card presbyopia treatment laser systems and related methods
    Patent number: 9155659
    Abstract: Methods and systems for correcting presbyopia using a surgical excimer laser include activating the laser once and transmitting a pre-defined three dimensional ablation profile to treat presbyopia based on the single activating step.
    Type: Grant
    Filed: October 19, 2011
    Date of Patent: October 13, 2015
    Assignee: Wake Forest University Health Sciences
    Inventors: Keith Andrew Walter, Evan Scott Luxon, Christopher Bligh Komanski
  • Coatings and biomedical implants formed from keratin biomaterials
    Patent number: 9149566
    Abstract: Methods are provided to produce optimal fractionations of charged keratins that have superior biomedical activity. Also provided are medical implants coated with these keratin preparations. Further provided are methods of treating blood coagulation in a patient in need thereof.
    Type: Grant
    Filed: February 15, 2007
    Date of Patent: October 6, 2015
    Assignee: Wake Forest University Health Sciences
    Inventor: Mark E. Van Dyke
  • NOVEL NANOFIBER-BASED GRAFT FOR HEART VALVE REPLACEMENT AND METHODS OF USING THE SAME
    Publication number: 20150272729
    Abstract: Nanofiber-based biomaterials containing fibroin for wound repair and tissue replacement and, more particularly, heart valve replacement.
    Type: Application
    Filed: October 25, 2013
    Publication date: October 1, 2015
    Applicant: WAKE FOREST UNIVERSITY HEALTH SCIENCES
    Inventors: William D. Wagner, Levi-Polyachenko Nicole, Rui Wang, Louis C. Argenta, Michael J. Morykwas