Patents Assigned to Wake Forest University Health Sciences
  • MEDICAL DEVICES INCORPORATING COLLAGEN INHIBITORS
    Publication number: 20140128416
    Abstract: Provided herein are implantable or insertable biomedical devices comprising a substrate and a collagen inhibitor on or in said substrate, and methods of treatment using the same. In some embodiments, the device is a urethral, ureteral, or nephroureteral catheter or stent. In some embodiments, the device is an absorbable esophageal or tracheal stent. Wound closure devices are also provided herein, including a substrate and a collagen inhibitor on or in the substrate. Also provided are surgical packings, including a substrate and a collagen inhibitor on or in the substrate. A barrier material for preventing adhesions in a subject is further provided, including a preformed or in situ formable barrier substrate and a collagen inhibitor on or in the substrate. Kits comprising the coated substrates are also provided.
    Type: Application
    Filed: January 13, 2014
    Publication date: May 8, 2014
    Applicant: Wake Forest University Health Sciences
    Inventors: Christopher A. Sullivan, Steve J. Hodges, Anthony Atala, James J. Yoo
  • ENDOTHELIAL SCAFFOLDS
    Publication number: 20140099290
    Abstract: Provided herein is an endothelial scaffold comprising, consisting of, or consisting essentially of decellularized corneal stroma. In some embodiments, the scaffold has cultured endothelial cells seeded thereon. Methods of treating a patient in need of corneal endothelial transplant are also provided, including implanting the scaffold as described herein onto a cornea of the patient (e.g., by deep keratectomy).
    Type: Application
    Filed: December 11, 2013
    Publication date: April 10, 2014
    Applicant: Wake Forest University Health Sciences
    Inventors: Shay Soker, J. Koudy Williams, Patrick Laber, Margaret Greven, Keith A. Walter
  • Inkjet printing of tissues and cells
    Patent number: 8691274
    Abstract: Provided herein is an apparatus for printing cells which includes an electrospinning device and an inkjet printing device operatively associated therewith. Methods of making a biodegradable scaffold having cells seeded therein are also provided. Methods of forming microparticles containing one or more cells encapsulated by a substrate are also provided, as are methods of forming an array of said microparticles.
    Type: Grant
    Filed: February 13, 2009
    Date of Patent: April 8, 2014
    Assignee: Wake Forest University Health Sciences
    Inventors: Tao Xu, James J. Yoo, Anthony Atala, Dennis Dice
  • Virtual endoscopy with improved image segmentation and lesion detection
    Patent number: 8682045
    Abstract: A system, and computer implemented method are provided for interactively displaying three-dimensional structures. Three-dimensional volume data (34) is formed from a series of two-dimensional images (33) representing at least one physical property associated with the three-dimensional structure, such as a body organ having a lumen. A wire frame model of a selected region of interest is generated (38b). The wireframe model is then deformed or reshaped to more accurately represent the region of interest (40b). Vertices of the wire frame model may be grouped into regions having a characteristic indicating abnormal structure, such as a lesion. Finally, the deformed wire frame model may be rendered in an interactive three-dimensional display.
    Type: Grant
    Filed: June 29, 2010
    Date of Patent: March 25, 2014
    Assignee: Wake Forest University Health Sciences
    Inventors: David J. Vining, Gordon W. Hunt, David K. Ahn, David R. Stelts, Yaorong Ge, Paul F. Hemler, Tiffany W. Salido
  • Medical tools for facilitating keratoplasty and related methods
    Patent number: 8673002
    Abstract: Systems, devices and methods for performing small incision DLEK include providing a corneal transplantation donor tissue graft; then forming the tissue graft into an implantable configuration using the flexible substrate. Related medical kits and tools for forming a compact or rolled donor tissue graft are also described.
    Type: Grant
    Filed: May 23, 2013
    Date of Patent: March 18, 2014
    Assignee: Wake Forest University Health Science
    Inventors: Keith Andrew Walter, Kurt Weber
  • Medical devices incorporating collagen inhibitors
    Patent number: 8668703
    Abstract: Provided herein are implantable or insertable biomedical devices comprising a substrate and a collagen inhibitor on or in said substrate, and methods of treatment using the same. In some embodiments, the device is a urethral, ureteral, or nephroureteral catheter or stent. In some embodiments, the device is an absorbable esophageal or tracheal stent. Wound closure devices are also provided herein, including a substrate and a collagen inhibitor on or in the substrate. Also provided are surgical packings, including a substrate and a collagen inhibitor on or in the substrate. A barrier material for preventing adhesions in a subject is further provided, including a preformed or in situ formable barrier substrate and a collagen inhibitor on or in the substrate. Kits comprising the coated substrates are also provided.
    Type: Grant
    Filed: November 30, 2007
    Date of Patent: March 11, 2014
    Assignee: Wake Forest University Health Sciences
    Inventors: Christopher A. Sullivan, Steve J. Hodges, Anthony Atala, James J. Yoo
  • Methods and Compositions for Correlating Genetic Markers with Prostate Cancer Risk
    Publication number: 20140057795
    Abstract: The present invention provides methods of assessing an individual subject's risk of developing prostate cancer, comprising: a) analyzing a nucleic acid sample obtained from the subject and determining a genotype for the subject at a plurality of biallelic polymorphic loci, wherein each of said plurality has an associated allele and an unassociated allele, wherein the genotype is selected from the group consisting of homozygous for the associated allele, heterozygous, and homozygous for the unassociated allele; and b) calculating a cumulative relative risk (CRR) for the subject based on the genotype determined in step (a). A CRR of greater than 1.00 identifies a subject as having an increased risk of developing prostate cancer and also can identify a subject who is a candidate for early PSA screening, prostate biopsy and/or chemoprevention.
    Type: Application
    Filed: September 2, 2011
    Publication date: February 27, 2014
    Applicant: Wake Forest University Health Sciences
    Inventors: Jianfeng Xu, Siqun Lilly Zheng, Jielin Sun, Andrew Karim Kader
  • Workstations with circuits for generating images of global injury
    Patent number: 8660327
    Abstract: Physician interactive workstations with global voxel distribution visualization may also include one or more of a 3-D color scale image of a population of voxel in target regions, organs or systems. The workstation may be configured to evaluate intensity or other measures of voxels of patient images associated with tissue for early detection of a global injury.
    Type: Grant
    Filed: December 9, 2011
    Date of Patent: February 25, 2014
    Assignee: Wake Forest University Health Sciences
    Inventors: William Gregory Hundley, Craig A. Hamilton, Ralph B. D'Agostino
  • CYCLOPROPYL DERIVATIVES AND METHODS OF USE
    Publication number: 20140045936
    Abstract: The disclosure relates to cyclopropyl derivatives and methods of use. In some embodiments, the disclosure relates to methods of managing medical disorders with pharmaceutical compositions disclosed herein administered to subject in need thereof. In certain embodiments, the disclosure relates to methods of managing mental disorders, mood disorders, pain, and fibromyalgia and related conditions with pharmaceutical compositions disclosed herein.
    Type: Application
    Filed: April 13, 2012
    Publication date: February 13, 2014
    Applicants: WAKE FOREST UNIVERSITY HEALTH SCIENCES, EMORY UNIVERSITY
    Inventors: Huw M. Davies, Spandan Chennamadhavuni, Thomas J. Martin, Steven R. Childrens
  • Compositions and methods for increasing production of recombinant gamma-carboxylated proteins
    Patent number: 8647868
    Abstract: Methods and cell lines for overexpressing functional gamma-carboxylated proteins are disclosed by way of genetically engineered cell lines which over-express VKORC1. Also disclosed is the antisense inhibition of expression of calumenin in conjunction with overexpression of VKORC1 which also increases expression of functional gamma-carboxylated proteins. Gamma-carboxylated proteins of interest may include blood coagulation factors such as human clotting factors IX and VII.
    Type: Grant
    Filed: December 4, 2006
    Date of Patent: February 11, 2014
    Assignee: Wake Forest University Health Sciences
    Inventor: Reidar Wallin
  • Method for increasing the volume of a blood substitute with an expander comprising basic alpha keratose
    Patent number: 8637231
    Abstract: A liquid plasma expander or resuscitation fluid composition for use in a subject in need thereof, comprising, consisting of, or consisting essentially of: (a) a keratin derivative (preferably alpha keratose, gamma keratose, or combinations thereof, and with basic alpha keratose preferred over acidic alpha keratose); and (b) an electrolyte solution, with the keratin derivative solubilized in the electrolyte solution to form a homogeneous liquid composition. Blood substitutes formed therefrom and methods of making and using the same are also described.
    Type: Grant
    Filed: August 11, 2011
    Date of Patent: January 28, 2014
    Assignee: Wake Forest University Health Sciences
    Inventor: Mark E. Van Dyke
  • Corneal endothelial scaffolds and methods of use
    Patent number: 8628572
    Abstract: Provided herein is an endothelial scaffold comprising, consisting of, or consisting essentially of decellularized corneal stroma. In some embodiments, the scaffold has cultured endothelial cells seeded thereon. Methods of treating a patient in need of corneal endothelial transplant are also provided, including implanting the scaffold as described herein onto a cornea of the patient (e.g., by deep keratectomy).
    Type: Grant
    Filed: February 25, 2010
    Date of Patent: January 14, 2014
    Assignee: Wake Forest University Health Sciences
    Inventors: Shay Soker, J. Koudy Williams, Patrick Laber, Margaret Greven, Keith A. Walter
  • DELIVERY SYSTEM
    Publication number: 20140012225
    Abstract: Provided herein is a delivery system, including: (a) an optical sensor configured to detect data to create a map of a patient bodily surface; and (b) a dispenser operatively associated with the optical sensor and configured to deliver compositions (optionally including cells) to the patient bodily surface based upon the data or map. Methods of forming a tissue on a patient bodily surface of a patient in need thereof are also provided, as are methods, systems and computer program products useful for processing patient bodily surface data.
    Type: Application
    Filed: September 6, 2013
    Publication date: January 9, 2014
    Applicant: Wake Forest University Health Sciences
    Inventors: James J. Yoo, Anthony Atala, Kyle W. Binder, Mohammad Z. Albanna, Weixin Zhao, Dennis Dice, Tao Xu
  • KERATIN BIOMATERIALS FOR TREATMENT OF ISCHEMIA
    Publication number: 20130344056
    Abstract: Provided herein are keratin compositions useful for treating ischemia and/or reperfusion injury, such as that associated with myocardial infarct, ischemic stroke, brain trauma such as traumatic brain injury, hypothermia, chronic wounds, and burns.
    Type: Application
    Filed: August 27, 2013
    Publication date: December 26, 2013
    Applicant: Wake Forest University Health Sciences
    Inventors: Mark E. Van Dyke, Thomas L. Smith, Michael Callahan, Luke Burnett
  • Tissue-Specific Extracellular Matrix With or Without Tissue Protein Components for Cell Culture
    Publication number: 20130288375
    Abstract: The present invention relates to compositions and methods for mimicking an in vivo environment for culturing cells in vitro. The in vivo mimicking environment is based on the generation of a tissue-specific extracellular matrix wherein the matrix provides a substrate for which the cultured cell originated from. The tissue-specific extracellular matrix can further comprise a component of a whole tissue-specific homogenate.
    Type: Application
    Filed: November 4, 2011
    Publication date: October 31, 2013
    Applicant: Wake Forest University Health Sciences
    Inventors: Yuanyuan Zhang, Shay Soker, Anthony Atala
  • C-nitroso-derived nitroxyl donors
    Patent number: 8569536
    Abstract: Active compounds of Formula I are described: wherein: R1 and R2 are each independently C1-C4 alkyl; or R1 and R2 together form a C2-C7 alkylene chain; and Z is a non-steroidal anti-inflammatory drug (NSAID); along with pharmaceutically acceptable salts and prodrug thereof, and methods of using the same.
    Type: Grant
    Filed: August 20, 2012
    Date of Patent: October 29, 2013
    Assignee: Wake Forest University Health Sciences
    Inventor: S. Bruce King
  • Metabolic Downregulation for Cell Survival
    Publication number: 20130281400
    Abstract: The present provides a system and method of maintaining and/or increasing cell viability by downregulating cellular metabolic rate under hypoxic conditions. The present invention also relates to a system and method of prolonging the survival of implanted cells that are under hypoxic condition until host neovascularization is achieved.
    Type: Application
    Filed: November 10, 2011
    Publication date: October 24, 2013
    Applicant: Wake Forest University Health Sciences
    Inventors: James J. Yoo, Sang Jin Lee, Jaehyun Kim, Anthony Atala
  • Keratin biomaterials for treatment of ischemia
    Patent number: 8545893
    Abstract: Provided herein are keratin compositions useful for treating ischemia and/or reperfusion injury, such as that associated with myocardial infarct, ischemic stroke, brain trauma such as traumatic brain injury, hypothermia, chronic wounds, and burns.
    Type: Grant
    Filed: March 8, 2011
    Date of Patent: October 1, 2013
    Assignee: Wake Forest University Health Sciences
    Inventors: Mark E. Van Dyke, Thomas L. Smith, Michael Callahan, Luke Burnett
  • STEM CELL DIFFERENTIATION USING KERATIN BIOMATERIALS
    Publication number: 20130251690
    Abstract: Provided are methods and keratin compositions useful for modulation of cell differentiation, both in vitro and in vivo, for example, in cell therapy applications.
    Type: Application
    Filed: May 16, 2013
    Publication date: September 26, 2013
    Applicant: Wake Forest University Health Sciences
    Inventors: Mark E. Van Dyke, Thaleia Teli
  • KERATIN COMPOSITIONS FOR TREATMENT OF BONE DEFICIENCY OR INJURY
    Publication number: 20130251689
    Abstract: A bone graft composition is described, with one or more of: (a) keratose; (b) kerateine; (c) optionally, particulate filler; (d) optionally, an antibiotic; and (e) water or saline. The composition may be provided in sterile form in a container, and optionally lyophilized. Methods of treating a bone deficiency or fracture making use of such compositions are also described.
    Type: Application
    Filed: May 16, 2013
    Publication date: September 26, 2013
    Applicant: Wake Forest University Health Sciences
    Inventors: Mark E. Van Dyke, Thaleia Teli