Abstract: Active compounds include compounds of Formula I and Formula II are described: along with compositions containing the same and methods of use thereof.
Type:
Application
Filed:
February 28, 2014
Publication date:
October 30, 2014
Applicant:
Wake Forest University Health Sciences
Inventors:
Freddie R. Salsbury, JR., Karin D. Scarpinato, S. Bruce King
Abstract: A method of screening for increased risk of fatal prostate cancer in a subject comprises providing a blood sample collected from the subject, and then detecting the presence or absence of an increased level of serum calcium in the sample. An increased level of serum calcium indicates the subject is at increased risk of fatal prostate cancer.
Abstract: Evaluating tissue characteristics including identification of injured tissue or alteration of the ratios of native tissue components such as shifting the amounts of normal myocytes and fibrotic tissue in the heart, identifying increases in the amount of extracellular components or fluid (like edema or extracellular matrix proteins), or detecting infiltration of tumor cells or mediators of inflammation into the tissue of interest in a patient, such as a human being, is provided by obtaining a first image of tissue including a region of interest from a first acquisition, and obtaining a second image of the tissue including the region of interest during a second, subsequent acquisition. The subsequent acquisition may be obtained after a period of time to determine if injury has occurred during that period of time. Such a comparison may include comparison of mean, average characteristics, histogram shape, such as skew and kurtosis, or distribution of intensities within the histogram.
Type:
Grant
Filed:
August 7, 2013
Date of Patent:
October 28, 2014
Assignee:
Wake Forest University Health Sciences
Inventors:
William Gregory Hundley, Craig A. Hamilton, Kimberly Lane, Tim Morgan, Frank Torti
Abstract: Cardiac information of a patient is displayed by obtaining a plurality of MRI cine loops of the heart of the patient at a plurality of heart rates, the plurality of cine loops including both wall motion cine loops and at least one perfusion cine loops and simultaneously displaying both the wall motion cine loops and the at least one perfusion cine loop.
Type:
Grant
Filed:
September 13, 2012
Date of Patent:
October 28, 2014
Assignee:
Wake Forest University Health Sciences
Inventors:
Craig A. Hamilton, William Gregory Hundley
Abstract: The present invention provides compounds of Formula I: wherein: R1 is a label (e.g., a detectable group and an anti-tumor agent); L is present or absent and when present is a linking group; and x represents an integer from 1 to 10; or a pharmaceutically acceptable salt thereof. The compounds are useful for, among other things, identifying cysteine sulfenic acids in proteins and monitoring oxidative damage in proteins and cells. Adduct formation can be detected using analytical methods such as electrospray ionization mass spectrometry and fluorescence.
Type:
Grant
Filed:
June 18, 2013
Date of Patent:
September 23, 2014
Assignee:
Wake Forest University Health Sciences
Inventors:
Leslie B. Poole, S. Bruce King, Jacquelyn S. Fetrow
Abstract: Differentiation and stability of neural stem cells can be enhanced by in vitro or in vivo culturing with one or more extracellular matrix (ECM) compositions, such as collagen I, IV, laminin and/or a heparan sulfate proteoglycan. In one aspect of the invention, adult mammalian enteric neuronal progenitor cells can be induced to differentiate on various substrates derived from components or combinations of neural ECM compositions. Collagen I and IV supported neuronal differentiation and extensive glial differentiation individually and in combination. Addition of laminin or heparan sulfate to collagen substrates unexpectedly improved neuronal differentiation, increasing neuron number, branching of neuronal processes, and initiation of neuronal network formation. In another aspect, neuronal subtype differentiation was affected by varying ECM compositions in hydrogels overlaid on intestinal smooth muscle sheets.
Abstract: Methods, systems, computer programs, circuits and workstations are configured to generate at least one two-dimensional weighted CBF territory map of color-coded source artery locations using an automated vascular segmentation process to identify source locations using mutual connectivity in both image and label space.
Abstract: Provided herein are methods useful for treating a brain tumor in a subject in need thereof, comprising administering to said subject an active agent comprising poly-FdUMP or a pharmaceutically acceptable salt thereof. Also provided are compositions comprising poly-FdUMP and one or more additional active agents useful for treating a brain tumor.
Abstract: The present invention provides compositions and methods for treating a myopathy. In certain embodiments, the invention provides compositions and methods for treating, improving muscle function, and prolonging survival in a subject with X-linked myotubular myopathy (XLMTM). The present invention provides a method comprising systemic administration of a composition that induces the increased expression of myotubularin in the muscle of a subject. The invention provides sustained regional and global increases in muscle function.
Type:
Application
Filed:
February 28, 2014
Publication date:
September 4, 2014
Applicants:
Wake Forest University Health Sciences, President and Fellows of Harvard College, Genethon
Inventors:
Martin K. Childers, Alan H. Beggs, Anna Maria Buj-Bello
Abstract: The present invention provides methods and devices for improving cognitive function. In some embodiments, cognitive function is improved by detecting neuronal activity in the CA3 region of a patient's hippocampus and stimulating the CA3 region of the patient's hippocampus responsive to the neuronal activity detected.
Type:
Application
Filed:
March 4, 2014
Publication date:
September 4, 2014
Applicant:
Wake Forest University Health Sciences
Inventors:
Sam Deadwyler, Robert E. Hampson, Mark R. Witcher, Daniel E. Couture, Gautam Popli, Stephen Tatter, Thomas L. Ellis
Abstract: The invention is directed to methods and compositions for obtaining uniform sized muscle fiber fragments for transplantation. These muscle fiber fragments are able to reconstitute into long fibers that are oriented along native muscle. The implanted muscle cells integrate with native vascular and neural network, as confirmed by histology and immunohistochemistry. This invention is particularly advantageous because autologous muscle can be harvested from a donor site, processed and injected into target sites in the operating room. The fragmented muscle fibers can be readily integrated within the host.
Abstract: Provided herein are scaffolds and methods useful to promote the formation of functional clusters on a tissue, for example, motor endplates (MEPs) or a component thereof on skeletal muscle cells or tissue, as well as the use of scaffolds so produced for repairing a tissue injury or defect.
Type:
Application
Filed:
September 28, 2012
Publication date:
August 21, 2014
Applicant:
Wake Forest University Health Sciences
Inventors:
George J. Christ, Justin M. Saul, John B Scott, Benjamin T. Corona, Benjamin S. Harrison, Catherine Ward
Abstract: Provided herein is an apparatus for printing cells which includes an electrospinning device and an inkjet printing device operatively associated therewith. Methods of making a biodegradable scaffold having cells seeded therein are also provided. Methods of forming microparticles containing one or more cells encapsulated by a substrate are also provided, as are methods of forming an array of said microparticles.
Type:
Application
Filed:
February 20, 2014
Publication date:
July 17, 2014
Applicant:
Wake Forest University Health Sciences
Inventors:
Tao Xu, James J. Yoo, Anthony Atala, Dennis Dice
Abstract: The present invention relates generally to a device and method for treating tissues of the central nervous system and more particularly, but not exclusively, to a device and method for treating the brain tissue.
Type:
Grant
Filed:
September 18, 2012
Date of Patent:
July 1, 2014
Assignee:
Wake Forest University Health Sciences
Inventors:
Louis C Argenta, David L Carroll, Nicole H Levi, Michael J Morykwas, Stephen B Tatter, William D Wagner, Jie Liu
Abstract: The present invention provides catheters whose lumen may be cleared of obstructions without transducing pressure changes to the patient compartment in which its proximal end is placed. In an illustrative embodiment, the lumen is cleared by a flush fluid supplied from or to a secondary lumen, with the patient compartment isolated with a gate mechanism. In another illustrative embodiment, the lumen is cleared by a progressively expanding balloon therein.
Abstract: A tissue treatment apparatus and method are provided for treating tissue by the application of the time-varying sub-atmospheric pressure. The apparatus includes a cover adapted to cover a wound and adapted to maintain sub-atmospheric pressure the site of the wound. The apparatus further includes a source of suction configured to generate a time-varying sub-atmospheric pressure having a periodic waveform comprising a gradual change in pressure. The suction source cooperates with the cover to supply the time-varying sub-atmospheric pressure under the cover to the wound. The time-varying sub-atmospheric pressure may vary between a first pressure value below the inherent tissue tension of the wound tissue and a second pressure value above the inherent tissue tension of the wound tissue.
Type:
Application
Filed:
November 18, 2013
Publication date:
June 5, 2014
Applicant:
Wake Forest University Health Sciences
Inventors:
Louis C. Argenta, Michael J. Morykwas, Lawrence X. Webb
Abstract: Systems, devices and methods for performing small incision DLEK include providing a corneal transplantation donor tissue graft; then forming the tissue graft into an implantable configuration using the flexible substrate. Related medical kits and tools for forming a compact or rolled donor tissue graft are also described.
Abstract: The invention pertains to methods of producing artificial composite tissue constructs that permit coordinated motion. Biocompatable structural matrices having sufficient rigidity to provide structural support for cartilage-forming cells and bone-forming cells are used. Biocompatable flexible matrices seeded with muscle cells are joined to the structural matrices to produce artificial composite tissue constructs that are capable of coordinated motion.
Type:
Grant
Filed:
March 10, 2006
Date of Patent:
May 20, 2014
Assignee:
Wake Forest University Health Science
Inventors:
Anthony Atala, James Yoo, Grace Lim, Sang Jin Lee
Abstract: A computer-based method for determining a prediction of risk and/or an indication of extent of coronary stenosis in a human subject, comprises the steps of: (a) inputting the level of at least one cholesteryl ester measured in a blood sample collected from said subject; and then (b) inputting the age and gender of said subject; and then (c) generating in said computer from said cholesteryl ester level input, said age input and said gender input a prediction of risk and/or an indication of extent of coronary stenosis blood sample by mass spectrometry.
Type:
Application
Filed:
May 30, 2012
Publication date:
May 15, 2014
Applicant:
Wake Forest University Health Sciences
Inventors:
Lawrence L. Rudel, Chadwick D. Miller, Michael J. Thomas
Abstract: A composition comprising microcapsules, the microcapsules containing both live mammalian ovarian granulosa cells and live mammalian ovarian theca cells, is described. In some embodiments, the granulosa cells and the theca cells are contained in separate microcapsules in the composition; in some embodiments, the granulosa cells and the theca cells are contained together in the same microcapsules in the composition The composition is can be used for estrogen, and optionally also progesterone, delivery, and hence is preferably free or essentially free of oocytes. Methods of using the same and pharmaceutical formulations containing the same are also described.
Type:
Application
Filed:
February 21, 2012
Publication date:
May 8, 2014
Applicant:
Wake Forest University Health Sciences
Inventors:
Emmanuel Opara, James J. Yoo, Justin M. Saul, Sittadjody Sivanandane, Anthony Atala