Abstract: This disclosure relates to methods of using nitrite to detoxify stroma-free hemoglobin based blood substitutes. In particular, methods are described for using a blood substitute comprised of about equimolar amounts of nitrite and hemoglobin (e.g., nitrite-metHb) to treat, prevent, or ameliorate diseases of the blood in a subject, or as a blood replacement in a subject.
Type:
Grant
Filed:
August 29, 2008
Date of Patent:
October 8, 2013
Assignees:
The United States of America as represented by the Secretary of the Department of Health and Human Services, University of Alabama at Birmingham, Wake Forest University
Inventors:
Mark T. Gladwin, Daniel B. Kim-Shapiro, Rakesh P. Patel, Jeffrey Kerby
Abstract: Provided herein are keratin compositions useful for treating ischemia and/or reperfusion injury, such as that associated with myocardial infarct, ischemic stroke, brain trauma such as traumatic brain injury, hypothermia, chronic wounds, and burns.
Type:
Grant
Filed:
March 8, 2011
Date of Patent:
October 1, 2013
Assignee:
Wake Forest University Health Sciences
Inventors:
Mark E. Van Dyke, Thomas L. Smith, Michael Callahan, Luke Burnett
Abstract: A bone graft composition is described, with one or more of: (a) keratose; (b) kerateine; (c) optionally, particulate filler; (d) optionally, an antibiotic; and (e) water or saline. The composition may be provided in sterile form in a container, and optionally lyophilized. Methods of treating a bone deficiency or fracture making use of such compositions are also described.
Abstract: Provided are methods and keratin compositions useful for modulation of cell differentiation, both in vitro and in vivo, for example, in cell therapy applications.
Abstract: The present invention comprises compounds, compositions and methods of use for sensitizing cancer cells, tumors, neoplasms, and malignancies to the effects of ionizing radiation used in the treatment of cancer. The invention further comprises a method of identifying novel radiosensitizing compounds.
Type:
Grant
Filed:
September 12, 2008
Date of Patent:
September 24, 2013
Assignees:
The Trustees of the University of Pennsylvania, Wake Forest University Health Sciences, University of the Sciences in Philadelphia
Inventors:
Constantinos Koumenis, Brian E. Lally, Steven Kridel, Gary D. Kao, Adeboye Adejare
Abstract: Evaluating tissue characteristics including identification of injured tissue or alteration of the ratios of native tissue components such as shifting the amounts of normal myocytes and fibrotic tissue in the heart, identifying increases in the amount of extracellular components or fluid (like edema or extracellular matrix proteins), or detecting infiltration of tumor cells or mediators of inflammation into the tissue of interest in a patient, such as a human being, is provided by obtaining a first image of tissue including a region of interest from a first acquisition, and obtaining a second image of the tissue including the region of interest during a second, subsequent acquisition. The subsequent acquisition may be obtained after a period of time to determine if injury has occurred during that period of time. Such a comparison may include comparison of mean, average characteristics, histogram shape, such as skew and kurtosis, or distribution of intensities within the histogram.
Type:
Grant
Filed:
January 24, 2008
Date of Patent:
September 10, 2013
Assignee:
Wake Forest University Health Sciences
Inventors:
William Gregory Hundley, Craig A. Hamilton, Kimberly Lane, Tim Morgan, Frank Torti
Abstract: Devices and methods for cataract surgery include a tip with a textured outer surface that is configured to gently scrape the capsule bag to allow aspiration of cortical tissue.
Abstract: Methods, systems, computer programs, circuits and workstations are configured to generate at least one two-dimensional color blood flow map that combines X and Y encoded primary and secondary peak data of 1-dimensional Inverse Fourier Transform images to visually indicate (i) anterior/posterior and right/left directional components of respective feeding arteries using defined colors and (ii) brightness to indicate an amount of blood flow associated with each voxel, with increased brightness associated with increased blood flow.
Abstract: A subdural drainage system includes (a) a subdural drainage device having an opening formed therethrough, said subdural drainage device having an upper portion, a body portion, and a lower portion; (b) a housing having an upper portion and lower portion, with said housing connected to said subdural drainage device; said housing movable between (i) a first configuration and (ii) a second configuration; and (c) a stylet positioned inside said housing, said stylet having an upper portion and a lower portion and configured such that said stylet is moved between (i) a withdrawn position with said stylet withdrawn from a portion of said subdural evacuation port device, and (ii) an extended position with said stylet extending through said subdural drainage device such that blockages are disrupted in the subdural drainage device when said housing is moved between said first and second housing configurations; and (d) an external drain opening formed on either said subdural drainage device or said housing.
Abstract: The present invention relates to compositions and methods for treating cancer and, in particular, to composition and methods comprising nanostructures. In one embodiment, the present invention provides a composition comprising a mixture, the mixture comprising at least one nanoparticle and at least one chemotherapeutic.
Type:
Grant
Filed:
March 13, 2008
Date of Patent:
August 6, 2013
Assignees:
Wake Forest University, Wake Forest University Health Sciences
Inventors:
David Loren Carroll, John H. Stewart, IV, Nicole H. Levi
Abstract: Methods of cardiac diagnostics of a patient are provided that include administering a stress test to the patient, acquiring a plurality of MRI cine loops of the heart of the patient at a plurality of heart rates, adjusting the plurality of MRI cine loops based on a heart rate associated with respective ones of the MRI cines so as to compensate for differences in heart rate and evaluating the compensated MRI cine loops so as to assess a state of coronary physiology of the patient. Furthermore, the administration of the stress test may be adjusted based on the evaluated compensated MRI cine loops. Also, the evaluation of the compensated MRI cine loops may determine a presence or absence of coronary artery disease based on the compensated cine loops.
Type:
Grant
Filed:
July 29, 2003
Date of Patent:
July 23, 2013
Assignee:
Wake Forest University Health Sciences
Inventors:
Craig A. Hamilton, William Gregory Hundley
Abstract: The invention is directed to methods for preparing artificial blood vessels by preconditioning a matrix seeded with endothelial cells to fluid flow conditions that mimic blood flow.
Abstract: A method of treating cancer in a subject in need thereof comprises administering said subject reserpine, yohimbine, an analog thereof, or a pharmaceutically acceptable salt or prodrug thereof, in an amount effective to treat the cancer. Compounds and compositions useful for carrying out the method are also described.
Type:
Grant
Filed:
February 24, 2010
Date of Patent:
July 16, 2013
Assignee:
Wake Forest University Health Sciences
Inventors:
Freddie R. Salsbury, Jr., Karin D. Scarpinato, S. Bruce King
Abstract: The present invention provides a method of synthesizing compounds of Formula I: wherein: R1 is a label (e.g., a detectable groups; an anti-tumor agents); L is present or absent and when present is a linking group; and x represents an integer from 1 to 10; or a pharmaceutically acceptable salt thereof. the compounds are useful for, among other things, identifying cysteine sulfenic acids in proteins and monitoring oxidative damage in proteins and cells.
Type:
Grant
Filed:
August 23, 2010
Date of Patent:
July 16, 2013
Assignee:
Wake Forest University Health Sciences
Inventors:
Leslie B. Poole, S. Bruce King, Jacquelyn S. Fetrow
Abstract: The present invention relates to lighting technologies and, in particular, to solid state lighting technologies. In one embodiment, the present invention provides a lighting apparatus comprising a first electrode, a radiation transmissive second electrode, and a composite layer disposed between the first and second electrode, the composite layer comprising at least one electric field concentrator and at least one phosphor disposed in a radiation transmissive dielectric material.
Type:
Grant
Filed:
November 1, 2007
Date of Patent:
July 2, 2013
Assignee:
Wake Forest University
Inventors:
David Loren Carroll, Manoj A. G. Namboothiry
Abstract: A compound comprising, in combination: a cell surface binding ligand or internalizing factor, such as an IL-13R?2 binding ligand; at least one effector molecule (e.g., one, two, three or more effector molecules); optionally but preferably, a cytosol localization element covalently coupled between said binding ligand and said at least one effector molecule; and a subcellular compartment localization signal element covalently coupled between said binding ligand and said at least one effector molecule (and preferably with said cytosol localization element between said binding ligand and said subcellular compartment localization signal element). Methods of using such compounds and formulations containing the same are also described.
Abstract: Systems, devices and methods for performing small incision DLEK include providing a corneal transplantation donor tissue graft; then forming the tissue graft into an implantable configuration using the flexible substrate. Related medical kits and tools for forming a compact or rolled donor tissue graft are also described.
Abstract: An external fixation assembly includes a plurality of hollow pins that are inserted into a patient's bone. Each pin has an interior bore and a plurality of apertures extending through the pin wall from the bore. The pin may be coupled to a source of vacuum pressure operable to create reduced pressure in the tissue surrounding the pin. A cover is placed around the pin and sealed to provide a fluid-tight enclosure that maintains reduced pressure around the pin. A method for applying external fixation using the fixator pins described above includes the steps of inserting each pin through a skin opening, positioning the pin apertures near selected tissue, covering the skin opening with a sealed enclosure, connecting the pins to a source of vacuum pressure, and activating the source of vacuum pressure to create reduced pressure in the patient's tissue at or near the bone.
Type:
Grant
Filed:
April 26, 2011
Date of Patent:
June 4, 2013
Assignee:
Wake Forest University Health Sciences
Inventors:
Lawrence X. Webb, Louis C. Argenta, Michael J. Morykwas
Abstract: The present invention provides compounds, compositions, and methods for detecting, diagnosing and treating cancers such as glioblastoma multiforme.
Abstract: Renal screening systems include a circuit configured to electronically analyze MRI image data of a subject to evaluate renal function and generate a renal-risk report for a plurality of different therapeutic agents based on renal responses to test doses of each of the agents.