Patents Assigned to Wake Forest University
  • Devices and methods for treating spinal cord tissue
    Patent number: 8834520
    Abstract: The present invention provides devices and methods that treat damaged spinal cord tissue, such as spinal tissue damaged by disease, infection, or trauma, which may lead to the presence of swelling, compression, and compromised blood flow secondary to interstitial edema.
    Type: Grant
    Filed: October 9, 2008
    Date of Patent: September 16, 2014
    Assignee: Wake Forest University
    Inventors: Louis C. Argenta, David L. Carroll, Nicole H. Levi, Jie Liu, Michael J. Morykwas, Stephen Tatter, William D. Wagner
  • METHOD OF TREATING BRAIN TUMORS
    Publication number: 20140255471
    Abstract: Provided herein are methods useful for treating a brain tumor in a subject in need thereof, comprising administering to said subject an active agent comprising poly-FdUMP or a pharmaceutically acceptable salt thereof. Also provided are compositions comprising poly-FdUMP and one or more additional active agents useful for treating a brain tumor.
    Type: Application
    Filed: March 10, 2014
    Publication date: September 11, 2014
    Applicant: Wake Forest University Health Sciences
    Inventors: William H. Gmeiner, Waldemar Debinski
  • Methods and Devices for Improving Cognitive Function
    Publication number: 20140249445
    Abstract: The present invention provides methods and devices for improving cognitive function. In some embodiments, cognitive function is improved by detecting neuronal activity in the CA3 region of a patient's hippocampus and stimulating the CA3 region of the patient's hippocampus responsive to the neuronal activity detected.
    Type: Application
    Filed: March 4, 2014
    Publication date: September 4, 2014
    Applicant: Wake Forest University Health Sciences
    Inventors: Sam Deadwyler, Robert E. Hampson, Mark R. Witcher, Daniel E. Couture, Gautam Popli, Stephen Tatter, Thomas L. Ellis
  • Systemic Gene Replacement Therapy for Treatment of X-Linked MyoTubular Myopathy (XLMTM)
    Publication number: 20140249211
    Abstract: The present invention provides compositions and methods for treating a myopathy. In certain embodiments, the invention provides compositions and methods for treating, improving muscle function, and prolonging survival in a subject with X-linked myotubular myopathy (XLMTM). The present invention provides a method comprising systemic administration of a composition that induces the increased expression of myotubularin in the muscle of a subject. The invention provides sustained regional and global increases in muscle function.
    Type: Application
    Filed: February 28, 2014
    Publication date: September 4, 2014
    Applicants: Wake Forest University Health Sciences, President and Fellows of Harvard College, Genethon
    Inventors: Martin K. Childers, Alan H. Beggs, Anna Maria Buj-Bello
  • METHOD FOR DIAGNOSING RENAL DISEASES OR PREDISPOSITIONS
    Publication number: 20140243215
    Abstract: The invention provides a method of diagnosing a disease or a predisposition to contract a disease by assaying for mutations of uromodulin (UMOD) within a test subject or patient. The presence of a mutation in the UMOD supports a diagnosis of a disease or a predisposition to contract a disease within the patient.
    Type: Application
    Filed: May 5, 2014
    Publication date: August 28, 2014
    Applicants: University of Pittsburgh - Of the Commonwealth System of Higher Education, Wake Forest University
    Inventors: Thomas C. Hart, Patricia Suzanne Hart, Michael Gorry, Anthony J. Bleyer
  • BIOSCAFFOLDS FOR FORMATION OF MOTOR ENDPLATES AND OTHER SPECIALIZED TISSUE STRUCTURES
    Publication number: 20140234388
    Abstract: Provided herein are scaffolds and methods useful to promote the formation of functional clusters on a tissue, for example, motor endplates (MEPs) or a component thereof on skeletal muscle cells or tissue, as well as the use of scaffolds so produced for repairing a tissue injury or defect.
    Type: Application
    Filed: September 28, 2012
    Publication date: August 21, 2014
    Applicant: Wake Forest University Health Sciences
    Inventors: George J. Christ, Justin M. Saul, John B Scott, Benjamin T. Corona, Benjamin S. Harrison, Catherine Ward
  • COMPOSITE COMPOSITIONS AND APPLICATIONS THEREOF
    Publication number: 20140228840
    Abstract: In one aspect, composite compositions are described herein. In some embodiments, a composite composition comprises an embolic agent and a plurality of nanoparticles dispersed in the embolic agent, wherein a portion of the nanoparticles are individually dispersed in the embolic agent.
    Type: Application
    Filed: September 28, 2012
    Publication date: August 14, 2014
    Applicant: Wake Forest University
    Inventors: Joel L. Berry, David L. Carroll, Pierre H. Rolland
  • INKJET PRINTING OF TISSUES AND CELLS
    Publication number: 20140199276
    Abstract: Provided herein is an apparatus for printing cells which includes an electrospinning device and an inkjet printing device operatively associated therewith. Methods of making a biodegradable scaffold having cells seeded therein are also provided. Methods of forming microparticles containing one or more cells encapsulated by a substrate are also provided, as are methods of forming an array of said microparticles.
    Type: Application
    Filed: February 20, 2014
    Publication date: July 17, 2014
    Applicant: Wake Forest University Health Sciences
    Inventors: Tao Xu, James J. Yoo, Anthony Atala, Dennis Dice
  • Scintillators and applications thereof
    Patent number: 8779365
    Abstract: Scintillators of various constructions and methods of making and using the same are provided. In some embodiments, a scintillator comprises at least one radiation absorption region and at least one spatially discrete radiative exciton recombination region.
    Type: Grant
    Filed: April 19, 2011
    Date of Patent: July 15, 2014
    Assignee: Wake Forest University
    Inventor: Richard T Williams
  • Fiber photovoltaic devices and applications thereof
    Patent number: 8772629
    Abstract: The present invention relates to organic optoelectronic devices and, in particular, to organic photovoltaic devices having a fiber structure. In one embodiment, a photovoltaic device comprises a first electrode comprising an indium tin oxide fiber, at least one photosensitive organic layer surrounding the first electrode and electrically connected to the first electrode, and a second electrode surrounding the organic layer and electrically connected to the organic layer.
    Type: Grant
    Filed: May 1, 2007
    Date of Patent: July 8, 2014
    Assignees: Wake Forest University, Arrowhead Center, Inc.
    Inventors: Seamus A. Curran, David L. Carroll, James Lee Dewald, Sr.
  • Device and method for treating central nervous system pathology
    Patent number: 8764794
    Abstract: The present invention relates generally to a device and method for treating tissues of the central nervous system and more particularly, but not exclusively, to a device and method for treating the brain tissue.
    Type: Grant
    Filed: September 18, 2012
    Date of Patent: July 1, 2014
    Assignee: Wake Forest University Health Sciences
    Inventors: Louis C Argenta, David L Carroll, Nicole H Levi, Michael J Morykwas, Stephen B Tatter, William D Wagner, Jie Liu
  • Method for diagnosing renal diseases or predispositions
    Patent number: 8759001
    Abstract: The invention provides a method of diagnosing a disease or a predisposition to contract a disease by assaying for mutations of uromodulin (UMOD) within a test subject or patient. The presence of a mutation in the UMOD supports a diagnosis of a disease or a predisposition to contract a disease within the patient.
    Type: Grant
    Filed: July 26, 2010
    Date of Patent: June 24, 2014
    Assignees: University of Pittsburgh—Of the Commonwealth System of Higher Education, Wake Forest University
    Inventors: Thomas C. Hart, Patricia Suzanne Hart, Michael Gorry, Anthony J. Bleyer
  • NON-PRESSURE TRANSDUCING FLUSHABLE CATHETER
    Publication number: 20140163530
    Abstract: The present invention provides catheters whose lumen may be cleared of obstructions without transducing pressure changes to the patient compartment in which its proximal end is placed. In an illustrative embodiment, the lumen is cleared by a flush fluid supplied from or to a secondary lumen, with the patient compartment isolated with a gate mechanism. In another illustrative embodiment, the lumen is cleared by a progressively expanding balloon therein.
    Type: Application
    Filed: November 27, 2013
    Publication date: June 12, 2014
    Applicant: Wake Forest University Health Sciences
    Inventor: Mark B. Frenkel
  • APPARATUS AND METHOD FOR WOUND TREATMENT EMPLOYING PERIODIC SUB-ATMOSPHERIC PRESSURE
    Publication number: 20140155790
    Abstract: A tissue treatment apparatus and method are provided for treating tissue by the application of the time-varying sub-atmospheric pressure. The apparatus includes a cover adapted to cover a wound and adapted to maintain sub-atmospheric pressure the site of the wound. The apparatus further includes a source of suction configured to generate a time-varying sub-atmospheric pressure having a periodic waveform comprising a gradual change in pressure. The suction source cooperates with the cover to supply the time-varying sub-atmospheric pressure under the cover to the wound. The time-varying sub-atmospheric pressure may vary between a first pressure value below the inherent tissue tension of the wound tissue and a second pressure value above the inherent tissue tension of the wound tissue.
    Type: Application
    Filed: November 18, 2013
    Publication date: June 5, 2014
    Applicant: Wake Forest University Health Sciences
    Inventors: Louis C. Argenta, Michael J. Morykwas, Lawrence X. Webb
  • Compositions, methods, and kits for identifying candidate molecules from encoded chemical libraries
    Patent number: 8741558
    Abstract: The subject matter relates to relates to a one-bead-one-sequence composition, a library of tagged chemicals comprising a plurality of one-bead-one-sequence compositions, a method for identifying a candidate molecule from a library of tagged chemicals, and a composition produced by a process, all as described herein.
    Type: Grant
    Filed: February 4, 2010
    Date of Patent: June 3, 2014
    Assignee: Wake Forest University
    Inventors: Martin Guthold, Jed C. Macosko
  • Non-viral delivery of compounds to mitochondria
    Patent number: 8735341
    Abstract: A conjugate comprises: (a) a mitochondrial membrane-permeant peptide; (b) an active agent or compound of interest such as a detectable group or mitochondrial protein or peptide; and (c) a mitochondrial targeting sequence linking said mitochondrial membrane-permeant peptide and said active mitochondrial protein or peptide. The targeting sequence is one which is cleaved within the mitochondrial matrix, and not cleaved within the cellular cytoplasm, of a target cell into which said compound is delivered. Methods of use of such compounds are also described.
    Type: Grant
    Filed: April 8, 2011
    Date of Patent: May 27, 2014
    Assignee: Wake Forest University
    Inventor: R. Mark Payne
  • MEDICAL TOOLS FOR SMALL INCISION EYE SURGERY
    Publication number: 20140142587
    Abstract: Systems, devices and methods for performing small incision DLEK include providing a corneal transplantation donor tissue graft; then forming the tissue graft into an implantable configuration using the flexible substrate. Related medical kits and tools for forming a compact or rolled donor tissue graft are also described.
    Type: Application
    Filed: January 23, 2014
    Publication date: May 22, 2014
    Applicant: Wake Forest University Health Sciences
    Inventors: Keith Andrew Walter, Kurt Weber
  • Production of tissue engineered digits and limbs
    Patent number: 8728463
    Abstract: The invention pertains to methods of producing artificial composite tissue constructs that permit coordinated motion. Biocompatable structural matrices having sufficient rigidity to provide structural support for cartilage-forming cells and bone-forming cells are used. Biocompatable flexible matrices seeded with muscle cells are joined to the structural matrices to produce artificial composite tissue constructs that are capable of coordinated motion.
    Type: Grant
    Filed: March 10, 2006
    Date of Patent: May 20, 2014
    Assignee: Wake Forest University Health Science
    Inventors: Anthony Atala, James Yoo, Grace Lim, Sang Jin Lee
  • SYSTEMS AND APPARATUS FOR INDICATING RISK OF CORONARY STENOSIS
    Publication number: 20140134654
    Abstract: A computer-based method for determining a prediction of risk and/or an indication of extent of coronary stenosis in a human subject, comprises the steps of: (a) inputting the level of at least one cholesteryl ester measured in a blood sample collected from said subject; and then (b) inputting the age and gender of said subject; and then (c) generating in said computer from said cholesteryl ester level input, said age input and said gender input a prediction of risk and/or an indication of extent of coronary stenosis blood sample by mass spectrometry.
    Type: Application
    Filed: May 30, 2012
    Publication date: May 15, 2014
    Applicant: Wake Forest University Health Sciences
    Inventors: Lawrence L. Rudel, Chadwick D. Miller, Michael J. Thomas
  • ENCAPSULATED CELLS FOR HORMONE REPLACEMENT THERAPY
    Publication number: 20140127308
    Abstract: A composition comprising microcapsules, the microcapsules containing both live mammalian ovarian granulosa cells and live mammalian ovarian theca cells, is described. In some embodiments, the granulosa cells and the theca cells are contained in separate microcapsules in the composition; in some embodiments, the granulosa cells and the theca cells are contained together in the same microcapsules in the composition The composition is can be used for estrogen, and optionally also progesterone, delivery, and hence is preferably free or essentially free of oocytes. Methods of using the same and pharmaceutical formulations containing the same are also described.
    Type: Application
    Filed: February 21, 2012
    Publication date: May 8, 2014
    Applicant: Wake Forest University Health Sciences
    Inventors: Emmanuel Opara, James J. Yoo, Justin M. Saul, Sittadjody Sivanandane, Anthony Atala