Patents Assigned to Warner-Lambert Company LLC
  • Tetrazole and oxadiazolone substituted ?-amino acid derivatives
    Patent number: 7250433
    Abstract: This invention relates to novel tetrazole and oxadiazalone ?-amino acids derivatives of the formula wherein G is wherein R1 through R4 are defined as in the specification, pharmaceutical compositions containing them and their use for the treatment of various central nervous system and other disorders. The cyclopropyl ?-amino acids derivatives of this invention exhibit activity as alpha2delta ligands (?2? ligands). Such compounds have affinity for the ?2? subunit of a calcium channel.
    Type: Grant
    Filed: March 8, 2004
    Date of Patent: July 31, 2007
    Assignee: Warner Lambert Company LLC
    Inventors: Nancy Sue Barta, Norman Lloyd Colbry, Raymond Hudack, Jr., Kristin Knapp Lin, Jacob Bradley Schwarz, Andrew John Thorpe, David Juergen Wustrow, Zhijian Zhu
  • Compounds that modulate PPAR activity and methods of preparation
    Patent number: 7244763
    Abstract: This invention relates to compounds that alter PPAR activity. The invention also relates to pharmaceutically acceptable salts of the compounds, pharmaceutically acceptable compositions comprising the compounds or their salts, and methods of using them as therapeutic agents for treating or preventing dyslipidemia, hypercholesterolemia, obesity, hyperglycemia, atherosclerosis, hypertriglyceridemia and hyperinsulinemia in a mammal. The present invention also relates to methods for making the disclosed compounds.
    Type: Grant
    Filed: February 6, 2004
    Date of Patent: July 17, 2007
    Assignee: Warner Lambert Company LLC
    Inventors: Larry D. Bratton, Xue-Min Cheng, Noe Erasga, Gary F. Filzen, Andrew G. Geyer, Chitase Lee, Bharat K. Trivedi, Paul C. Unangst
  • PHARMACEUTICAL USES FOR ALPHA2DELTA LIGANDS
    Publication number: 20070161706
    Abstract: The invention relates to a method of treating central nervous system disorders and other disorders by administering an alpha2delta ligand such as, for example, a compound of the formula or a pharmaceutically acceptable salt thereof, wherein R1 is hydrogen or straight or branched lower alkyl, and n is an integer of from 4 to 6.
    Type: Application
    Filed: March 19, 2007
    Publication date: July 12, 2007
    Applicant: WARNER-LAMBERT COMPANY LLC
    Inventors: David Dooley, Charles Taylor, Jr., Andrew Thorpe, Fong Wang, David Wustrow
  • PHARMACEUTICAL USES FOR ALPHA2DELTA LIGANDS
    Publication number: 20070161707
    Abstract: The invention relates to a method of treating central nervous system disorders and other disorders by administering an alpha2delta ligand such as, for example, a compound of the formula or a pharmaceutically acceptable salt thereof, wherein R1 is hydrogen or straight or branched lower alkyl, and n is an integer of from 4 to 6.
    Type: Application
    Filed: March 19, 2007
    Publication date: July 12, 2007
    Applicant: WARNER-LAMBERT COMPANY LLC
    Inventors: David Dooley, Charles Taylor, Andrew Thorpe, Fong Wang, David Wustrow
  • Synthesis of P-chiral bisphospholane ligands and their transition metal complexes for use as asymmetric hydrogenation catalysts
    Patent number: 7230135
    Abstract: P-chiral bisphospholane ligands and methods for their preparation are described. Use of metal/P-chiral bisphospholane complexes to catalyze asymmetric transformation reactions to provide high enantiomeric excesses of formed compounds is also described.
    Type: Grant
    Filed: May 10, 2004
    Date of Patent: June 12, 2007
    Assignee: Warner Lambert Company LLC
    Inventors: Garrett Stewart Hoge, II, Om Prakash Goel
  • Spirotricyclic derivatives and their use as phosphodiesterase-7 inhibitors
    Patent number: 7214676
    Abstract: The invention provides compounds which are PDE7 inhibitors, having the following formula (I), (II) and (III) in which X1, X2, X3, X4, X, Y, Z, A and Z1 are as defined in the description, methods for preparing them and their use for the treatment of disorders for which therapy by a PDE7 inhibitor is relevant.
    Type: Grant
    Filed: May 24, 2004
    Date of Patent: May 8, 2007
    Assignee: Warner-Lambert Company LLC
    Inventors: Patrick Bernardelli, Pierre Ducrot, Edwige Lorthiois, Febrice Vergne
  • Benzoxazin-3-ones and derivatives thereof as therapeutic agents
    Patent number: 7205295
    Abstract: The present invention provides compounds of Formula I wherein W, Q, E, D, R6, R7, R8, Y, K, R9, R10, R12, G, and the double bond denoted “*” have any of the values defined therefore in the specification, and pharmaceutically acceptable salts thereof, that are useful as agents in the treatment of diseases and conditions, including inflammatory diseases, cardiovascular diseases, and cancers. Also provided are pharmaceutical compositions comprising one or more compounds of Formula I.
    Type: Grant
    Filed: December 8, 2003
    Date of Patent: April 17, 2007
    Assignee: Warner-Lambert Company LLC
    Inventors: Nicole Barvian, Christine Nylund Kolz, Kimberly Suzanne Para, William Chester Patt, Melean Visnick
  • Malonamic acids and derivatives thereof as thyroid receptor ligands
    Patent number: 7202275
    Abstract: The present invention relates to novel thyroid receptor ligands and, more particularly, relates to malonamic acids and derivatives thereof of Formula I, which are useful in the treatment of obesity, overweight condition, hyperlipidemia, glaucoma, cardiac arrhythmias, skin disorders, thyroid disease, hypothyroidism, thyroid cancer and related disorders and diseases such as diabetes mellitus, atherosclerosis, hypertension, coronary heart disease, congestive heart failure, hypercholesteremia, depression, osteoporosis and hair loss.
    Type: Grant
    Filed: May 10, 2005
    Date of Patent: April 10, 2007
    Assignee: Warner Lambert Company LLC
    Inventors: Yuan-Ching P. Chiang, Gary E. Aspnes, Kimberly G. Estep
  • ANDROGEN MODULATORS
    Publication number: 20070072936
    Abstract: The present invention is directed to a new class of benzonitriles and to their use as androgen receptor modulators. Other aspects of the invention are directed to the use of these compounds to decrease excess sebum secretions and to stimulate hair growth.
    Type: Application
    Filed: November 7, 2006
    Publication date: March 29, 2007
    Applicant: WARNER-LAMBERT COMPANY LLC
    Inventors: Stephen Barrett, Victor Fedij, Lain-Yen Hu, Donna Iula, Bruce Lefker, Raj Raheja, Karen Sexton, Jennifer Van Camp
  • Process for the synthesis of 5-(4-fluorophenyl)-1-[2-((2R,4R)-4-hydroxy-6-oxo-tetrahydro-pyran-2-yl)-ethyl]-2-isopropyl-4-phenyl-1-pyrrole-3-carboxylic acid phenylamide
    Patent number: 7183408
    Abstract: An improved process for the preparation of 5-(4-fluorophenyl)-1-[2-((2R,4R)-4-hydroxy-6-oxo-tetrahydro-pyran-2-yl)-ethyl]-2-isopropyl-4-phenyl-1H-pyrrole-3-carboxylic acid phenylamide by a novel synthesis is described where methyl cyanoacetate is converted in eight operations or fewer to the desired product, as well as other valuable intermediates used in the process.
    Type: Grant
    Filed: April 19, 2005
    Date of Patent: February 27, 2007
    Assignee: Warner-Lambert Company, LLC
    Inventors: Donald Eugene Butler, Randall Lee DeJong, Jade Douglas Nelson, Michael Gerard Pamment, Timothy Lee Stuk
  • Amino acids with affinity for the ?2?-protein
    Patent number: 7179934
    Abstract: Certain ?-amino acids that bind to the alpha-2-delta (?2?) subunit of a calcium channel are disclosed. These compounds and their pharmaceutically acceptable salts are useful in the treatment of a variety of psychiatric, pain and other disorders. Also disclosed are methods of making the ?-amino acids.
    Type: Grant
    Filed: September 24, 2004
    Date of Patent: February 20, 2007
    Assignee: Warner-Lambert Company LLC
    Inventors: Peter Garth Blazecka, Joseph Richard Bozelak, Norman Lloyd Colbry, Timothy Thomas Curran, Annise Paige Goodman, Kevin E. Henegar, Garrett Hoge, Paul D. Johnson, Augustine Tobi Osuma, Mark Stephen Plummer, Jacob Bradley Schwarz, Derek Clinton Vrieze, Ji Zhang
  • Hetero biaryl derivatives as matrix metalloproteinase inhibitors
    Patent number: 7179822
    Abstract: This invention provides compounds defined by Formula I and pharmaceutically acceptable salts thereof, and pharmaceutical compositions comprising a compound of Formula I, or a pharmaceutically acceptable salt thereof, together with a pharmaceutically acceptable carrier, diluent, or excipient. The invention also provides methods of treating osteo- and rheumatoid arthritis.
    Type: Grant
    Filed: August 5, 2003
    Date of Patent: February 20, 2007
    Assignees: Warner-Lambert Company, Warner-Lambert Company LLC
    Inventors: Amy Mae Bunker, Mark Anthony Morris, Patrick Michael O'Brien, Michael William Wilson
  • Method and system for periodontal charting
    Patent number: 7168954
    Abstract: Methods and systems for graphically depicting gum tissue and teeth for illustrating gingival health and plaque reduction. The relative risk as one type of statistical methods for comparing two treatments of different therapeutic agents for gingivitis and plaque are displayed. The upper and lower sets of teeth are represented in rows or groups of teeth separated by rows of boxes which depict the result of various treatments by various therapeutic agents.
    Type: Grant
    Filed: November 21, 2003
    Date of Patent: January 30, 2007
    Assignee: Warner-Lambert Company LLC
    Inventors: Christine A. Charles, Mei-Miau Wu, John F. Coelho
  • Applicator device
    Patent number: D536528
    Type: Grant
    Filed: April 24, 2006
    Date of Patent: February 13, 2007
    Assignee: Warner-Lambert Company LLC
    Inventor: Bradford Grant
  • Pregnancy tester
    Patent number: D537167
    Type: Grant
    Filed: February 24, 2006
    Date of Patent: February 20, 2007
    Assignee: Warner-Lambert Company LLC
    Inventors: Jennifer E. Sigel, Ellen Tawil, Annette Young
  • Pregnancy tester
    Patent number: D537168
    Type: Grant
    Filed: February 24, 2006
    Date of Patent: February 20, 2007
    Assignee: Warner-Lambert Company LLC
    Inventors: Jennifer E. Sigel, Ellen Tawil, Annette Young
  • Pregnancy tester
    Patent number: D537169
    Type: Grant
    Filed: February 24, 2006
    Date of Patent: February 20, 2007
    Assignee: Warner-Lambert Company LLC
    Inventors: Jennifer E. Sigel, Ellen Tawil, Annette Young
  • Pregnancy tester
    Patent number: D537531
    Type: Grant
    Filed: February 24, 2006
    Date of Patent: February 27, 2007
    Assignee: Warner-Lambert Company LLC
    Inventors: Jennifer E. Sigel, Ellen Tawil, Annette Young
  • Applicator device
    Patent number: D543035
    Type: Grant
    Filed: November 8, 2005
    Date of Patent: May 22, 2007
    Assignee: Warner-Lambert Company LLC
    Inventor: Bradford Grant
  • Bottle
    Patent number: D549100
    Type: Grant
    Filed: July 30, 2003
    Date of Patent: August 21, 2007
    Assignee: Warner-Lambert Company LLC
    Inventors: Cristina E. Bonaldes, Charles D. Denton, Heath A. Doty, Bryan Holmes, Marc Hunter, Victoria Noble, Randal D. Porter, Kim Sines, John E. Smethers, Russell Wright