Abstract: The present invention relates to antibodies and antigen-binding portions thereof that specifically bind to a M-CSF, preferably human M-CSF, and that function to inhibit a M-CSF. The invention also relates to human anti-M-CSF antibodies and antigen-binding portions thereof. The invention also relates to antibodies that are chimeric, bispecific, derivatized, single chain antibodies or portions of fusion proteins. The invention also relates to isolated heavy and light chain immunoglobulins derived from human anti-M-CSF antibodies and nucleic acid molecules encoding such immunoglobulins. The present invention also relates to methods of making human anti-M-CSF antibodies, compositions comprising these antibodies and methods of using the antibodies and compositions for diagnosis and treatment. The invention also provides gene therapy methods using nucleic acid molecules encoding the heavy and/or light immunoglobulin molecules that comprise the human anti-M-CSF antibodies.
Type:
Application
Filed:
March 13, 2006
Publication date:
July 13, 2006
Applicants:
Abgenix, Inc., Warner-Lambert Company LLC
Inventors:
Vahe Bedian, Madhav Devalaraja, Ian Foltz, Mary Haak-Frendscho, Sirid-Aimee Kellermann, Joseph Low, James Mobley
Abstract: The present invention provides indoles of Formula I: wherein R1 and R2 have any of the values defined therefor in the specification, and pharmaceutically acceptable salts thereof, that are useful as agents in the treatment of diseases and conditions, including inflammatory diseases, cardiovascular diseases, and cancers. Also provided are pharmaceutical compositions comprising one or more compounds of Formula I.
Type:
Grant
Filed:
June 3, 2004
Date of Patent:
July 11, 2006
Assignee:
Warner-Lambert Company LLC
Inventors:
Kimberly Suzanne Para, Charles John Stankovic, Melean Visnick
Abstract: The invention is directed to a new class of quinolin-zene and z-exc chromen compounds that have been derivatized at the 6-position with a urea or this urea moet, and to then use as androgen antagonists.
Type:
Grant
Filed:
February 10, 2004
Date of Patent:
July 11, 2006
Assignee:
Warner Lambert Company LLC
Inventors:
Daniel Y. Du, Martin James Procter, Matthew Colin Thor Fyfe, Vilasben Kanji Shah, Geoffrey Martyn Williams, Karen Lesley Schofield
Abstract: A process for preparing functionalized ?-butyrolactones 3 and various biologically active compounds using mucohalic acid 1 and halide 2 in the presence of indium is disclosed, wherein X, Y, R1, R2, and R3 may have any of the meanings defined herein
Abstract: Physiologically acceptable films, including edible films, are disclosed. The films include a water soluble film-forming polymer, such as pullulan, and a taste masked pharmaceutically active agent, such as dextromethorphan. The taste masking agent is preferably a sulfonated polymer ion exchange resin comprising polystyrene cross-linked with divinylbenzene, such as AMBERLITE. Methods for producing the films are also disclosed.
Type:
Grant
Filed:
March 23, 2000
Date of Patent:
June 27, 2006
Assignee:
Warner-Lambert Company LLC
Inventors:
William S. Bess, Neema Kulkarni, Suhas H. Ambike, Michael P. Ramsay
Abstract: Described is a method for determining the binding ability of a compound to bind to an ?2?2 subunit of a calcium channel comprising: providing an ?2?2 subunit of a calcium channel, contacting the subunit with the compound, and determining the binding ability of the compound to bind to the subunit.
Abstract: The present invention relates to sulfones that are useful in the treatment of chemokine-mediated disorders. In certain embodiments, the present invention concerns the compounds that are MCP-1 receptor antagonists.
Type:
Grant
Filed:
May 21, 2003
Date of Patent:
June 27, 2006
Assignee:
Warner-Lambert Company, LLC
Inventors:
Larry D. Bratton, Alexander J. Bridges, David T. Connor, Steven R. Miller, Yuntao Song, Kuai-Lin Sun, Bharat K. Trivedi, Paul C. Unangst
Abstract: The present invention is directed to a new class of 6-sulfonamido-quinolin-2-one and 6-sulfonamido-2-oxo-chromene derivatives to their use as androgen antagonists, and to relieve conditions associated with inappropriate activation of the androgen receptor.
Type:
Grant
Filed:
January 15, 2004
Date of Patent:
June 20, 2006
Assignee:
Warner Lambert Company LLC
Inventors:
Daniel Y. Du, Matthew Colin Thor Fyfe, Martin James Procter, Karen Lesley Schofield, Vilasben Kanji Shah, Geoffrey Martyn Williams
Abstract: The present invention is directed to a new class of 6-sulfonamido-quinolin-2-one and 6-sulfonamido-2-oxo-chromene derivatives to their use as androgen antagonists, and to relieve conditions associated with inappropriate activation of the androgen receptor.
Type:
Grant
Filed:
January 15, 2004
Date of Patent:
June 6, 2006
Assignee:
Warner Lambert Company LLC
Inventors:
Daniel Y. Du, Matthew Colin Thor Fyfe, Martin James Procter, Karen Lesley Schofield, Vilasben Kanji Shah, Geoffrey Martyn Williams
Abstract: A disposable teeth cleaning applicator device. An elongated tubular shaft member has an applicator tip member at one end and a toothpick device at the other end. A liquid dental material is positioned inside the tubular shaft member and, once released, is squeezed or allowed to flow into the applicator tip member and used to clean a person's teeth.
Abstract: This invention relates to novel cyclopropyl ?-amino acids derivatives of the formula wherein R1 through R4 are defined as in the specification, pharmaceutical compositions containing them and their use for the treatment of various central nervous system and other disorders. The cyclopropyl ?-amino acids derivatives of this invention exhibit activity as alpha2delta ligands (?2? ligands). Such compounds have affinity for the ?2? subunit of a calcium channel.
Type:
Grant
Filed:
January 16, 2004
Date of Patent:
April 18, 2006
Assignee:
Warner-Lambert Company, LLC
Inventors:
Jacob Bradley Schwarz, David Juergen Wustrow
Abstract: Physiologically acceptable films, including edible films, are disclosed. The films include a water soluble film-forming polymer such as pullulan. Edible films are disclosed that include pullulan and antimicrobially effective amounts of the essential oils thymol, methyl salicylate, eucalyptol and menthol. The edible films are effective at killing the plaque-producing germs that cause dental plaque, gingivitis and bad breath. The film can also contain pharmaceutically active agents. Methods for producing the films are also disclosed.
Type:
Grant
Filed:
April 18, 2001
Date of Patent:
April 11, 2006
Assignee:
Warner-Lambert Company LLC
Inventors:
Sau-Hung Spence Leung, Robert S. Leone, Lori D. Kumar, Neema Kulkarni, Albert F. Sorg
Abstract: The present invention is directed to ACE inhibitor-containing compositions stabilized by the presence of magnesium oxide. Preferably, the ACE inhibitor, quinapril, is protected from certain forms of degradation when prepared in a pharmaceutical composition consisting essentially of magnesium oxide as the stabilizing agent. The presence of magnesium oxide also lends itself to favorable processing conditions during the manufacture of ACE inhibitor-containing compositions, especially processing by wet granulation.
Type:
Grant
Filed:
April 22, 2002
Date of Patent:
March 21, 2006
Assignee:
Warner-Lambert Company, LLC
Inventors:
Jane Ellen Daniel, Michael Ray Harris, Gerard Clifford Hokanson, Jay Weiss