Patents Assigned to Warner-Lambert Company
  • Center-filled chewing gum containing a deliverable form of calcium
    Patent number: 7244455
    Abstract: A centerfill chewing gum composition having a shell portion and a centerfill portion, the centerfill portion containing an effective amount of a calcium-containing compound suspended therein.
    Type: Grant
    Filed: January 16, 2002
    Date of Patent: July 17, 2007
    Assignee: Warner-Lambert Company
    Inventors: Jesse John Kiefer, Hector Olaya, Carolina Buitron Kellstein, Blake Henderson Glenn
  • PHARMACEUTICAL USES FOR ALPHA2DELTA LIGANDS
    Publication number: 20070161707
    Abstract: The invention relates to a method of treating central nervous system disorders and other disorders by administering an alpha2delta ligand such as, for example, a compound of the formula or a pharmaceutically acceptable salt thereof, wherein R1 is hydrogen or straight or branched lower alkyl, and n is an integer of from 4 to 6.
    Type: Application
    Filed: March 19, 2007
    Publication date: July 12, 2007
    Applicant: WARNER-LAMBERT COMPANY LLC
    Inventors: David Dooley, Charles Taylor, Andrew Thorpe, Fong Wang, David Wustrow
  • PHARMACEUTICAL USES FOR ALPHA2DELTA LIGANDS
    Publication number: 20070161706
    Abstract: The invention relates to a method of treating central nervous system disorders and other disorders by administering an alpha2delta ligand such as, for example, a compound of the formula or a pharmaceutically acceptable salt thereof, wherein R1 is hydrogen or straight or branched lower alkyl, and n is an integer of from 4 to 6.
    Type: Application
    Filed: March 19, 2007
    Publication date: July 12, 2007
    Applicant: WARNER-LAMBERT COMPANY LLC
    Inventors: David Dooley, Charles Taylor, Jr., Andrew Thorpe, Fong Wang, David Wustrow
  • Method for the screening of ??-1 subunit binding ligands
    Patent number: 7235363
    Abstract: A method for the screening of ligands which bind to soluble ?2?-1 subtype polypeptides.
    Type: Grant
    Filed: April 26, 2005
    Date of Patent: June 26, 2007
    Assignee: Warner-Lambert Company
    Inventors: François Bertelli, Jason Peter Brown, Visaka Udeni Karalliadde Dissanayake, Nirmala Suman-Chauhan, Nicolas Steven Gee
  • Process for the synthesis of 1,3-diols
    Patent number: 7232915
    Abstract: An improved process for the preparation of cis-1,3-diols is described where a beta hydroxy ketone is treated with a trialkylborane or dialkylalkoxyborane or a mixture of a trialkylborane and a dialkylalkoxyborane followed by recovery and reuse of the alkylborane species to convert additional beta hydroxy ketone to the cis-1,3-diol.
    Type: Grant
    Filed: April 29, 2005
    Date of Patent: June 19, 2007
    Assignee: Warner-Lambert Company
    Inventors: Robert Lee Bosch, Richard Joseph McCabe, Thomas Norman Nanninga, Robert Joseph Stahl
  • Composition for soluble films with a new hydrolyzed polysaccharide
    Patent number: 7229977
    Abstract: The invention is concerned with film-forming compositions containing hydrolysates of the exopolysaccharide YAS34 for the use in pharmaceutical, veterinary, food, cosmetic or other products like films for wrapping food, aspics or jellies, preferably for predosed formulations like soft or hard capsules.
    Type: Grant
    Filed: June 15, 2004
    Date of Patent: June 12, 2007
    Assignee: Warner-Lambert Company
    Inventors: Robert Anthony Scott, Dominique Cade, Xiongwei He
  • Ibuprofen containing hard shell capsules
    Patent number: 7229639
    Abstract: The present invention relates to pharmaceutically acceptable and stable compositions, which are preferably clear transparent, for liquid filling hard shell capsules, hard shell capsules containing these compositions, and a process for preparing these hard shell capsules and whereby the shells of said hard capsules are preferably clear transparent.
    Type: Grant
    Filed: March 7, 2003
    Date of Patent: June 12, 2007
    Assignee: Warner-Lambert Company
    Inventors: Emmanuelle Mireille Guillard, Nicolas Madit, Robert Anthony Scott
  • Synthesis of P-chiral bisphospholane ligands and their transition metal complexes for use as asymmetric hydrogenation catalysts
    Patent number: 7230135
    Abstract: P-chiral bisphospholane ligands and methods for their preparation are described. Use of metal/P-chiral bisphospholane complexes to catalyze asymmetric transformation reactions to provide high enantiomeric excesses of formed compounds is also described.
    Type: Grant
    Filed: May 10, 2004
    Date of Patent: June 12, 2007
    Assignee: Warner Lambert Company LLC
    Inventors: Garrett Stewart Hoge, II, Om Prakash Goel
  • Spirotricyclic derivatives and their use as phosphodiesterase-7 inhibitors
    Patent number: 7214676
    Abstract: The invention provides compounds which are PDE7 inhibitors, having the following formula (I), (II) and (III) in which X1, X2, X3, X4, X, Y, Z, A and Z1 are as defined in the description, methods for preparing them and their use for the treatment of disorders for which therapy by a PDE7 inhibitor is relevant.
    Type: Grant
    Filed: May 24, 2004
    Date of Patent: May 8, 2007
    Assignee: Warner-Lambert Company LLC
    Inventors: Patrick Bernardelli, Pierre Ducrot, Edwige Lorthiois, Febrice Vergne
  • Isophthalic acid derivatives as matrix metalloproteinase inhibitors
    Patent number: 7214712
    Abstract: Selective MMP-13 inhibitors are isophthalic acid derivatives of the formula wherein: R1, R2, and R3 independently are hydrogen, halo, hydroxy, C1–C6 alkyl, C1–C6 alkoxy, C2–C6 alkenyl, C2–C6 alkynyl, NO2, NR4R5, CN, or CF3; E is independently O or S; A and B independently are OR4 or NR4R5; each R4 and R5 independently are H, C1–C6 alkyl, C2–C6 alkenyl, C2–C6 alkynyl, (CH2)n aryl, (CH2)n cycloalkyl, (CH2)n heteroaryl, or R4 and R5 when taken together with the nitrogen to which they are attached complete a 3- to 8-membered ring, optionally containing a heteroatom selected from O, S, or NH, and optionally substituted or unsubstituted; n is 0 to 6; or a pharmaceutically acceptable salt thereof. The compounds are useful for treating diseases in a mammal that are mediated by MMP enzymes.
    Type: Grant
    Filed: September 29, 2005
    Date of Patent: May 8, 2007
    Assignee: Warner-Lambert Company
    Inventors: Nicole Chantel Barvian, David Thomas Connor, Richard Dennis Dyer, Adam Richard Johnson, William Chester Patt
  • 2-(pyridin-2-ylamino)-pyrido [2,3-d]pyrimidin-7-ones
    Patent number: 7208489
    Abstract: The present invention provides substituted 2-aminopyridines useful in treating cell proliferative disorders.
    Type: Grant
    Filed: January 28, 2005
    Date of Patent: April 24, 2007
    Assignee: Warner-Lambert Company
    Inventors: Mark Barvian, Richard John Booth, John Quin, III, Joseph Thomas Repine, Derek J. Sheehan, Peter Laurence Toogood, Scott Norman Vanderwel, Hairong Zhou
  • Benzoxazin-3-ones and derivatives thereof as therapeutic agents
    Patent number: 7205295
    Abstract: The present invention provides compounds of Formula I wherein W, Q, E, D, R6, R7, R8, Y, K, R9, R10, R12, G, and the double bond denoted “*” have any of the values defined therefore in the specification, and pharmaceutically acceptable salts thereof, that are useful as agents in the treatment of diseases and conditions, including inflammatory diseases, cardiovascular diseases, and cancers. Also provided are pharmaceutical compositions comprising one or more compounds of Formula I.
    Type: Grant
    Filed: December 8, 2003
    Date of Patent: April 17, 2007
    Assignee: Warner-Lambert Company LLC
    Inventors: Nicole Barvian, Christine Nylund Kolz, Kimberly Suzanne Para, William Chester Patt, Melean Visnick
  • Malonamic acids and derivatives thereof as thyroid receptor ligands
    Patent number: 7202275
    Abstract: The present invention relates to novel thyroid receptor ligands and, more particularly, relates to malonamic acids and derivatives thereof of Formula I, which are useful in the treatment of obesity, overweight condition, hyperlipidemia, glaucoma, cardiac arrhythmias, skin disorders, thyroid disease, hypothyroidism, thyroid cancer and related disorders and diseases such as diabetes mellitus, atherosclerosis, hypertension, coronary heart disease, congestive heart failure, hypercholesteremia, depression, osteoporosis and hair loss.
    Type: Grant
    Filed: May 10, 2005
    Date of Patent: April 10, 2007
    Assignee: Warner Lambert Company LLC
    Inventors: Yuan-Ching P. Chiang, Gary E. Aspnes, Kimberly G. Estep
  • ANDROGEN MODULATORS
    Publication number: 20070072936
    Abstract: The present invention is directed to a new class of benzonitriles and to their use as androgen receptor modulators. Other aspects of the invention are directed to the use of these compounds to decrease excess sebum secretions and to stimulate hair growth.
    Type: Application
    Filed: November 7, 2006
    Publication date: March 29, 2007
    Applicant: WARNER-LAMBERT COMPANY LLC
    Inventors: Stephen Barrett, Victor Fedij, Lain-Yen Hu, Donna Iula, Bruce Lefker, Raj Raheja, Karen Sexton, Jennifer Van Camp
  • Kinase inhibitors
    Patent number: 7196090
    Abstract: This invention provides phenyl-substituted pyrimidopyrimidines, dihydropyrimido-pyrimidines, pyridopyrimidines, naphthyridines, and pyridopyrazines of the general formula: that inhibit cyclin-dependent kinase and tyrosine kinase enzymes, methods and intermediate compounds for their synthesis, as well as pharmaceutical compositions and methods for their use in treating, inhibiting or preventing maladies associated with cell proliferative disorders, including angiogenesis, atherosclerosis, restenosis, and cancer.
    Type: Grant
    Filed: July 17, 2003
    Date of Patent: March 27, 2007
    Assignee: Warner-Lambert Company
    Inventors: Cleo J. Chivikas Connolly, Christopher James Deur, James Marino Hamby, Denton Wade Hoyer, Chris Limberakis, Jessica Elizabeth Reed, Mel Conrad Schroeder, Clarke Taylor
  • Method of treating noninflammatory cartilage damage
    Patent number: 7189747
    Abstract: The invention relates to a method of preventing or treating cartilage damage by administering a GABA analog such as, for example, a compound of Formula and pharmaceutically acceptable salts thereof, wherein R1 is hydrogen or straight or branched lower alkyl, and n is an integer of from 4 to 6.
    Type: Grant
    Filed: June 23, 2003
    Date of Patent: March 13, 2007
    Assignee: Warner-Lambert Company
    Inventors: Denis Schrier, Howard Glenn Welgus, David Juergen Wustrow
  • Process for the synthesis of 5-(4-fluorophenyl)-1-[2-((2R,4R)-4-hydroxy-6-oxo-tetrahydro-pyran-2-yl)-ethyl]-2-isopropyl-4-phenyl-1-pyrrole-3-carboxylic acid phenylamide
    Patent number: 7183408
    Abstract: An improved process for the preparation of 5-(4-fluorophenyl)-1-[2-((2R,4R)-4-hydroxy-6-oxo-tetrahydro-pyran-2-yl)-ethyl]-2-isopropyl-4-phenyl-1H-pyrrole-3-carboxylic acid phenylamide by a novel synthesis is described where methyl cyanoacetate is converted in eight operations or fewer to the desired product, as well as other valuable intermediates used in the process.
    Type: Grant
    Filed: April 19, 2005
    Date of Patent: February 27, 2007
    Assignee: Warner-Lambert Company, LLC
    Inventors: Donald Eugene Butler, Randall Lee DeJong, Jade Douglas Nelson, Michael Gerard Pamment, Timothy Lee Stuk
  • Pregnancy tester
    Patent number: D537168
    Type: Grant
    Filed: February 24, 2006
    Date of Patent: February 20, 2007
    Assignee: Warner-Lambert Company LLC
    Inventors: Jennifer E. Sigel, Ellen Tawil, Annette Young
  • Pregnancy tester
    Patent number: D537531
    Type: Grant
    Filed: February 24, 2006
    Date of Patent: February 27, 2007
    Assignee: Warner-Lambert Company LLC
    Inventors: Jennifer E. Sigel, Ellen Tawil, Annette Young
  • Applicator device
    Patent number: D543035
    Type: Grant
    Filed: November 8, 2005
    Date of Patent: May 22, 2007
    Assignee: Warner-Lambert Company LLC
    Inventor: Bradford Grant