Patents Assigned to Warner-Lambert Company
  • Urea and thiourea derivatives
    Patent number: 7074933
    Abstract: The invention is directed to a new class of quinolin-zene and z-exc chromen compounds that have been derivatized at the 6-position with a urea or this urea moet, and to then use as androgen antagonists.
    Type: Grant
    Filed: February 10, 2004
    Date of Patent: July 11, 2006
    Assignee: Warner Lambert Company LLC
    Inventors: Daniel Y. Du, Martin James Procter, Matthew Colin Thor Fyfe, Vilasben Kanji Shah, Geoffrey Martyn Williams, Karen Lesley Schofield
  • Process for preparing functionalized ?-butyrolactones from mucohalic acid
    Patent number: 7071339
    Abstract: A process for preparing functionalized ?-butyrolactones 3 and various biologically active compounds using mucohalic acid 1 and halide 2 in the presence of indium is disclosed, wherein X, Y, R1, R2, and R3 may have any of the meanings defined herein
    Type: Grant
    Filed: June 18, 2003
    Date of Patent: July 4, 2006
    Assignee: Warner Lambert Company LLC
    Inventors: Daniel Belmont, Ji Zhang
  • Fast dissolving orally consumable solid film containing a taste masking agent and pharmaceutically active agent at weight ratio of 1:3 to 3:1
    Patent number: 7067116
    Abstract: Physiologically acceptable films, including edible films, are disclosed. The films include a water soluble film-forming polymer, such as pullulan, and a taste masked pharmaceutically active agent, such as dextromethorphan. The taste masking agent is preferably a sulfonated polymer ion exchange resin comprising polystyrene cross-linked with divinylbenzene, such as AMBERLITE. Methods for producing the films are also disclosed.
    Type: Grant
    Filed: March 23, 2000
    Date of Patent: June 27, 2006
    Assignee: Warner-Lambert Company LLC
    Inventors: William S. Bess, Neema Kulkarni, Suhas H. Ambike, Michael P. Ramsay
  • Sulfamato hydroxamic acid metalloprotease inhibitor
    Patent number: 7067670
    Abstract: A sulfamato hydroxamic acid compound that inter alia inhibits matrix metalloprotease activity is disclosed as are a process for preparing the same, intermediate compounds useful in those syntheses, and a treatment process that comprises administering a contemplated sulfamato hydroxamic acid compound in a MMP enzyme-inhibiting effective amount to a host having a condition associated with pathological matrix metalloprotease activity.
    Type: Grant
    Filed: July 8, 2004
    Date of Patent: June 27, 2006
    Assignee: Warner Lambert Company
    Inventors: Terri L. Boehm, Deborah A. Mischke, Gary A. DeCrescenzo, Joseph G. Rico, Shashidhar N. Rao, Darren J. Kassab, Jeffery N. Carroll
  • Cell line for the expression of an ?2?2 calcium channel subunit and methods of use
    Patent number: 7067262
    Abstract: Described is a method for determining the binding ability of a compound to bind to an ?2?2 subunit of a calcium channel comprising: providing an ?2?2 subunit of a calcium channel, contacting the subunit with the compound, and determining the binding ability of the compound to bind to the subunit.
    Type: Grant
    Filed: May 8, 2001
    Date of Patent: June 27, 2006
    Assignee: Warner Lambert Company LLC
    Inventor: Ti-Zhi Su
  • MCP-1 receptor antagonists and methods of use thereof
    Patent number: 7067538
    Abstract: The present invention relates to sulfones that are useful in the treatment of chemokine-mediated disorders. In certain embodiments, the present invention concerns the compounds that are MCP-1 receptor antagonists.
    Type: Grant
    Filed: May 21, 2003
    Date of Patent: June 27, 2006
    Assignee: Warner-Lambert Company, LLC
    Inventors: Larry D. Bratton, Alexander J. Bridges, David T. Connor, Steven R. Miller, Yuntao Song, Kuai-Lin Sun, Bharat K. Trivedi, Paul C. Unangst
  • Amino acids with affinity for the ?-2-delta-protein
    Patent number: 7064147
    Abstract: This invention relates to certain ?-amino acids that bind to the alpha-2-delta (?2?) subunit of a calcium channel. These compounds and their pharmaceutically acceptable salts are useful in the treatment of a variety of psychiatric, pain and other disorders.
    Type: Grant
    Filed: March 27, 2003
    Date of Patent: June 20, 2006
    Assignee: Warner-Lambert Company
    Inventors: Nancy Sue Barta, Jacob Bradley Schwarz, Andrew John Thorpe, David Juergen Wustrow
  • Androgen receptor antagonists
    Patent number: 7064207
    Abstract: The present invention is directed to a new class of 6-sulfonamido-quinolin-2-one and 6-sulfonamido-2-oxo-chromene derivatives to their use as androgen antagonists, and to relieve conditions associated with inappropriate activation of the androgen receptor.
    Type: Grant
    Filed: January 15, 2004
    Date of Patent: June 20, 2006
    Assignee: Warner Lambert Company LLC
    Inventors: Daniel Y. Du, Matthew Colin Thor Fyfe, Martin James Procter, Karen Lesley Schofield, Vilasben Kanji Shah, Geoffrey Martyn Williams
  • Polymorphic form of N-[(R)-2,3-dihydroxy-propoxy]-3,4-difluoro-2-(2-fluoro-4-iodophenylamino)-benzamide
    Patent number: 7060856
    Abstract: This invention provides a novel polymorphic form of N-[(R)-2,3-dihydroxy-propoxy]-3,4-difluoro-2-(2-fluoro-4-iodo-phenylamino)-benzamide, as well a pharmaceutical compositions and therapeutic methods utilizing the polymorphic form.
    Type: Grant
    Filed: October 20, 2004
    Date of Patent: June 13, 2006
    Assignee: Warner-Lambert Company
    Inventors: Dainius Macikenas, Thomas Nanninga
  • Androgen receptor antagonists
    Patent number: 7057048
    Abstract: The present invention is directed to a new class of 6-sulfonamido-quinolin-2-one and 6-sulfonamido-2-oxo-chromene derivatives to their use as androgen antagonists, and to relieve conditions associated with inappropriate activation of the androgen receptor.
    Type: Grant
    Filed: January 15, 2004
    Date of Patent: June 6, 2006
    Assignee: Warner Lambert Company LLC
    Inventors: Daniel Y. Du, Matthew Colin Thor Fyfe, Martin James Procter, Karen Lesley Schofield, Vilasben Kanji Shah, Geoffrey Martyn Williams
  • Pyrido[2,3-d]pyrimidine-2,7-diamine kinase inhibitors
    Patent number: 7053070
    Abstract: Disclosed are compounds of the formula wherein R2, R5, R6, R7, and R8 are as defined herein. These compounds and their pharmaceutical compositions are useful for treating cell proliferative disorders, such as cancer and restenosis. These compounds are potent inhibitors of cdks and growth factor-mediated kinases.
    Type: Grant
    Filed: January 23, 2001
    Date of Patent: May 30, 2006
    Assignee: Warner-Lambert Company
    Inventors: Richard John Booth, Ellen Myra Dobrusin, Vara Prasad Venkata Nagendra Josyula, Dennis Joseph Mc Namara, Peter Laurence Toogood
  • Applicator for cleaning teeth
    Patent number: 7044671
    Abstract: A disposable teeth cleaning applicator device. An elongated tubular shaft member has an applicator tip member at one end and a toothpick device at the other end. A liquid dental material is positioned inside the tubular shaft member and, once released, is squeezed or allowed to flow into the applicator tip member and used to clean a person's teeth.
    Type: Grant
    Filed: September 26, 2003
    Date of Patent: May 16, 2006
    Assignee: Warner-Lambert Company LLC
    Inventors: Rita Parikh, Arthur Fox, Diane Lorello
  • Polyvinyl alcohol compositions
    Patent number: 7045184
    Abstract: The invention concerns polyvinyl alcohol (PVA) compositions for the use in pharmaceutical, veterinary, food, cosmetic or other products like films for wrapping food, aspics or jellies, preferably for predosed formulations like soft or hard capsules. Compared with hard gelatine capsules (HGC) capsule films consisting of PVA have extremely low water vapour permeability and much lower water content.
    Type: Grant
    Filed: April 23, 2001
    Date of Patent: May 16, 2006
    Assignee: Warner-Lambert Company
    Inventors: Robert A. Scott, Dominque Cadé, Xiongwei He
  • Pectin film compositions
    Patent number: 7041315
    Abstract: The invention concerns, film-forming compositions containing pectin, at least one additional film-forming polymer and a setting system for use in pharmaceutical, veterinary, food, cosmetic or other products like films for wrapping food, aspics or jellies, preferably for predosed formulations like soft or hard capsules, as well as aqueous solutions of the composition for the manufacturing of said products.
    Type: Grant
    Filed: August 21, 2001
    Date of Patent: May 9, 2006
    Assignee: Warner Lambert Company
    Inventors: Robert Anthony Scott, Dominique Cade, Xiongwei He
  • Novel method for the stereoselective synthesis of cyclic amino acids
    Publication number: 20060084825
    Abstract: The instant invention is a route to stereospecific 3-substituted 5-membered ring isomers of Formula (A). The final products are useful as agents in the treatment of epilepsy, faintness attacks, hypokinesia, cranial disorders, neurodegenerative disorders, depression, anxiety, panic, pain, neuropathological disorders, gastrointestinal disorders such as irritable bowel syndrome (IBS), inflammation especially arthritis, sleep disorders, premenstrual syndrome, and hot flashes. The invention provides novel routes to synthesize stereoselectively analogs of gabapentin (Neurontin™) of Formulas (I), (II), (III), and (IV) wherein R is C1-C10 alkyl or C3 -C10 cycloalkyl and pharmaceutically acceptable salts thereof.
    Type: Application
    Filed: October 19, 2004
    Publication date: April 20, 2006
    Applicant: Warner-Lambert Company
    Inventors: Justin Bryans, David Blakemore, Sophie Williams
  • Cycloproply ?-amino acid derivatives
    Patent number: 7030267
    Abstract: This invention relates to novel cyclopropyl ?-amino acids derivatives of the formula wherein R1 through R4 are defined as in the specification, pharmaceutical compositions containing them and their use for the treatment of various central nervous system and other disorders. The cyclopropyl ?-amino acids derivatives of this invention exhibit activity as alpha2delta ligands (?2? ligands). Such compounds have affinity for the ?2? subunit of a calcium channel.
    Type: Grant
    Filed: January 16, 2004
    Date of Patent: April 18, 2006
    Assignee: Warner-Lambert Company, LLC
    Inventors: Jacob Bradley Schwarz, David Juergen Wustrow
  • Method for treating chronic pain using MEK inhibitors
    Patent number: 7030119
    Abstract: The invention features a method for treating chronic pain using a compound of formula (I).
    Type: Grant
    Filed: July 5, 2000
    Date of Patent: April 18, 2006
    Assignee: Warner-Lambert Company
    Inventors: Stephen Douglas Barrett, Alexander James Bridges, Haile Tecle, Alistair Dixon, Kevin Lee, Robert Pinnock
  • Spray dispenser
    Patent number: D519377
    Type: Grant
    Filed: August 16, 2004
    Date of Patent: April 25, 2006
    Assignee: Warner-Lambert Company LLC
    Inventor: Bradford S. Grant
  • Spray dispenser
    Patent number: D519841
    Type: Grant
    Filed: August 16, 2004
    Date of Patent: May 2, 2006
    Assignee: Warner-Lambert Company LLC
    Inventor: Bradford S. Grant
  • Spray dispenser
    Patent number: D523342
    Type: Grant
    Filed: August 16, 2004
    Date of Patent: June 20, 2006
    Assignee: Warner-Lambert Company LLC
    Inventor: Bradford S. Grant