Patents Assigned to Washington University
  • Publication number: 20190150822
    Abstract: Methods and systems for diagnosing a condition of a central nervous system are provided. A method includes providing a DBSI-MRI data set obtained from the central nervous system of the subject, and transforming the DBSI-MRI data set to obtain at least one DBSI biomarker value. The method further includes comparing each DBSI biomarker value to at least one corresponding threshold value from a diagnostic database to obtain a relation between each DBSI biomarker value and the at least one corresponding threshold value, and diagnosing the condition according to at least one diagnostic rule, wherein each diagnostic rule defines a candidate condition in terms of the relations between the at least one DBSI biomarker value and the at least one corresponding threshold value.
    Type: Application
    Filed: April 28, 2017
    Publication date: May 23, 2019
    Applicant: Washington University
    Inventors: Yong Wang, Qing Wang, Tammie Benzinger
  • Publication number: 20190145961
    Abstract: Compositions and methods are provided for modifying diagnosing and treating inflammatory disease. The methods and compositions can be used to ameliorate the effects of a deficiency in the LAP pathway for clearing dead cells. Thus, methods are further provided for modulating dead cell clearance using an effective amount of a pharmaceutical composition that targets the LAP pathway. Accordingly, pharmaceutical compositions that target the LAP pathway re provided herein. The methods and compositions described herein can be used to treat inflammatory disease, such as systemic lupus erythematosus (SLE).
    Type: Application
    Filed: April 20, 2017
    Publication date: May 16, 2019
    Applicants: Washington University, St. Jude Children's Research Hospital
    Inventors: Herbert W. Virgin, Douglas R. Green, Jennifer Martinez
  • Patent number: 10289448
    Abstract: A traffic management mechanism can employ a two-tiered approach for managing background traffic based on prioritizing tasks by remaining time flexibility then scheduling prioritized tasks using linear programming.
    Type: Grant
    Filed: September 6, 2016
    Date of Patent: May 14, 2019
    Assignees: AT&T Intellectual Property I, L.P., George Washington University
    Inventors: Moo-Ryong Ra, Rajesh Krishna Panta, Tian Lan, Shijing Li
  • Publication number: 20190137398
    Abstract: Bio-photonic devices or target cells and cell cultures including bio-photonic devices and target cells are provided. Methods of preparing cell cultures including bio-photonic devices and target cells are also provided. Methods of analyzing the electrophysiology of target cells using the cell cultures are provided. Systems for analyzing the electrophysiology of target cells are also provided.
    Type: Application
    Filed: May 2, 2017
    Publication date: May 9, 2019
    Applicant: The George Washington University
    Inventors: Emilia ENTCHEVA, Aleksandra KLIMAS
  • Publication number: 20190134060
    Abstract: The present disclosure provides compositions comprising 25-hydroxycholesterol, derivatives and prodrugs thereof, and methods of use thereof. Specifically, disclosed herein are methods of decreasing neuronal cell death.
    Type: Application
    Filed: April 25, 2017
    Publication date: May 9, 2019
    Applicant: Washington University
    Inventors: Steve Mennerick, Amanda Ann Taylor, Min-Yu Sun, Charles F. Zorumski
  • Publication number: 20190134233
    Abstract: Among the various aspects of the present disclosure is the provision of compositions and methods for imaging and treating subjects with amyloidosis or multiple myeloma with or without amyloidosis.
    Type: Application
    Filed: November 6, 2018
    Publication date: May 9, 2019
    Applicant: Washington University
    Inventor: Vijay Sharma
  • Patent number: 10278583
    Abstract: A method for rapid computation of three-dimensional displacement and Lagrange strain in a high resolution filed of phase data obtained with Displacement Encoding with Stimulated Echoes (DENSE) in magnetic resonance images of the myocardium. The method includes semi-automated segmentation of a region of a heart, phase unwrapping the images in three dimensions, and a custom radial point interpolation method (RPIM). The RPIM is a meshfree numerical analysis method that uses radial basis functions and polynomial functions to calculate the Lagrange strain of DENSE displacement data acquired from the myocardium.
    Type: Grant
    Filed: October 22, 2015
    Date of Patent: May 7, 2019
    Assignee: Washington University
    Inventors: Julia Kar, Michael K. Pasque, Brian P. Cupps
  • Publication number: 20190127515
    Abstract: Kits, recyclable covalently crosslinked polymer networks and composites, and related methods of making and recycling are described.
    Type: Application
    Filed: October 26, 2018
    Publication date: May 2, 2019
    Applicant: Western Washington University
    Inventors: John Misasi, Scott Lew
  • Patent number: 10273468
    Abstract: The present disclosure provides compositions and methods for treating bacterial infections in a subject. The methods comprise administering a compound that binds a FAD-dependent flavoenzyme and a tetracycline, analog, derivative, or pharmaceutically acceptable salt thereof.
    Type: Grant
    Filed: June 26, 2017
    Date of Patent: April 30, 2019
    Assignee: Washington University
    Inventors: Niraj Tolia, Gautam Dantas, Timothy Wencewicz, Jooyoung Park, Andrew Gasparrini, Kevin Forsberg, Joseph Vogel, Margaret Ruth Reck, Chanez Tiffany Symister, Jana L. Markley
  • Patent number: 10273260
    Abstract: The present invention encompasses compounds and methods for treating urinary tract infections.
    Type: Grant
    Filed: December 8, 2016
    Date of Patent: April 30, 2019
    Assignee: WASHINGTON UNIVERSITY
    Inventors: James W. Janetka, Zhenfu Han, Scott Hultgren, Jerome S. Pinkner, Corinne Cusumano
  • Patent number: 10273474
    Abstract: Disclosed herein are methods for reducing expression of Tau mRNA and protein in an animal with Tau antisense compounds. Also disclosed are methods for modulating splicing of Tau mRNA in an animal with Tau antisense compounds. Such methods are useful to treat, prevent, or ameliorate neurodegenerative diseases in an individual in need thereof. Examples of neurodegenerative diseases that can be treated, prevented, and ameliorated with the administration Tau antisense oligonucleotides include Alzheimer's Disease, Fronto-temporal Dementia (FTD), FTDP-17, Progressive Supranuclear Palsy, Chronic Traumatic Encephalopathy, Epilepsy, and Dravet's Syndrome.
    Type: Grant
    Filed: March 14, 2013
    Date of Patent: April 30, 2019
    Assignees: WASHINGTON UNIVERSITY, ISIS PHARMACEUTICALS, INC.
    Inventors: Timothy M. Miller, Sarah Devos, C. Frank Bennett, Frank Rigo
  • Patent number: 10272056
    Abstract: The present application relates to methods of treating a subject with a disease or disorder associated with a mitochondrial deficit, comprising: determining at least one of a type or degree of the mitochondrial deficit in the subject; and administering an amount of a butyrate compound to the subject based at least partially on the determining step so as to promote Adenosine triphosphate (ATP) production in the subject as well as to methods of screening for compounds that restore cellular mitochondrial activity.
    Type: Grant
    Filed: April 1, 2016
    Date of Patent: April 30, 2019
    Assignee: The George Washington University, A Congressionally Chartered Not-for-Profit Corporation
    Inventors: Anne Chiaramello, Martine Uittenbogaard
  • Patent number: 10265543
    Abstract: A treatment planning system for generating patient-specific treatment. The system including one or more processors programmed to receive a radiation treatment plan (RTP) for irradiating a target over the course of one or more treatment fractions, said RTP including a planned dose distribution to be delivered to the target, receive motion data for at least one of the treatment fractions of the RTP, receive temporal delivery metric data for at least one of the treatment fractions of the RTP, calculate a motion-compensated dose distribution for the target using the motion data and the temporal delivery metric data to adjust the planned dose distribution based on the received motion data and temporal delivery metric data, and compare the motion-compensated dose distribution to the planned dose distribution.
    Type: Grant
    Filed: November 30, 2012
    Date of Patent: April 23, 2019
    Assignees: KONINKLIJKE PHILIPS N.V., WASHINGTON UNIVERSITY
    Inventors: Shyam Bharat, Mingyao Zhu, Parag Jitendra Parikh, Karl Antonin Bzdusek
  • Publication number: 20190115714
    Abstract: A photonic molecule laser is described that includes a photonic molecule waveguide coupled to a photonic molecule seeding source configured to deliver a plurality of photonic molecules. The photonic molecule waveguide includes a second dopant maintained at a population inverted state with an energy level transition corresponding to a second frequency that is an N-fold multiple of a first frequency and amplifies the number of photonic molecules via stimulated emission. The photonic molecule seeding source includes a waveguide with a first dopant maintained at a population inverted state with an energy level transition corresponding to the first frequency. A pump source is coupled to the waveguide configured to deliver a first frequency laser pulse with pulse coherence time less than the photonic molecules correlation time. Each photonic molecule includes a threshold bound state of N first frequency photons, and each photonic molecule has the second frequency.
    Type: Application
    Filed: October 12, 2018
    Publication date: April 18, 2019
    Applicant: WASHINGTON UNIVERSITY
    Inventors: Jung-Tsung Shen, Lihong Wang
  • Patent number: 10258289
    Abstract: A computing device for use in a system for mapping brain activity of a subject includes a processor. The processor is programmed to select a plurality of measurements of brain activity that is representative of at least one parameter of a brain of the subject during a resting state. Moreover, the processor is programmed to compare at least one data point from each of the measurements with a corresponding data point from a previously acquired data set from at least one other subject. The processor is also programmed to produce at least one map for each of the measurements based on the comparison of the resting state data point and the corresponding previously acquired data point. The processor may also be programmed to categorize the brain activity in a plurality of networks in the brain based on the map.
    Type: Grant
    Filed: September 20, 2018
    Date of Patent: April 16, 2019
    Assignee: Washington University
    Inventors: Eric Leuthardt, Nicholas Szrama, Carl Hacker, Tim Laumann, Maurizio Corbetta, Abraham Z. Snyder
  • Patent number: 10258638
    Abstract: Disclosed are methods and compositions related to methods of treating, ameliorating, mitigating, slowing, arresting, preventing or reversing various diseases and conditions, including age-related obesity, age-related increases in blood lipid levels, age-related decreases in insulin sensitivity, age-related decreases in memory function, and age-related changes in eye function such as macular degeneration. The methods comprise administering nicotinamide mononucleotide (NMN) to a subject. In some embodiments, the administration can be oral administration. Also disclosed are pharmaceutical compositions comprising NMN.
    Type: Grant
    Filed: October 13, 2017
    Date of Patent: April 16, 2019
    Assignee: Washington University
    Inventor: Shin-ichiro Imai
  • Patent number: 10258426
    Abstract: Systems and methods for virtual reality or augmented reality (VR/AR) visualization of 3D medical images using a VR/AR visualization system are disclosed. The VR/AR visualization system includes a computing device operatively coupled to a VR/AR device, and the VR/AR device includes a holographic display and at least one sensor. The holographic display is configured to display a holographic image to an operator. The computing device is configured to receive at least one stored 3D image of a subject's anatomy and at least one real-time 3D position of at least one surgical instrument. The computing device is further configured to register the at least one real-time 3D position of the at least one surgical instrument to correspond to the at least one 3D image of the subject's anatomy, and to generate the holographic image comprising the at least one real-time position of the at least one surgical instrument overlaid on the at least one 3D image of the subject's anatomy.
    Type: Grant
    Filed: March 12, 2018
    Date of Patent: April 16, 2019
    Assignee: Washington University
    Inventors: Jonathan Silva, Jennifer Silva
  • Patent number: 10259884
    Abstract: The present invention is directed towards isolated antibodies that bind to GRP78.
    Type: Grant
    Filed: June 20, 2017
    Date of Patent: April 16, 2019
    Assignees: Washington University, Vanderbilt University
    Inventors: Dennis E. Hallahan, Heping Yan
  • Patent number: 10256600
    Abstract: The Hybrid Photonic Plasmonic Interconnect (HyPPI) combines both low loss photonic signal propagation and passive routing with ultra-compact plasmonic devices. These optical interconnects therefore uniquely combine fast operational data-bandwidths (in hundreds of Gbps) for light manipulation with low optical attenuation losses by hybridizing low loss photonics with strong light-matter-interaction plasmonics to create, modulate, switch and detect light efficiently at the same time. Initial implementations were considered for on-chip photonic integration, but also promising for free space or fiber-based systems. In general two technical options exist, which distinguished by the method the electric-optic conversion is executed: the extrinsic modulation method consists of an continuous wave source such as an LED or laser operating at steady power output, and signal encoding is done via an electro-optic modulator downstream of the source in the interconnect.
    Type: Grant
    Filed: June 27, 2016
    Date of Patent: April 9, 2019
    Assignee: The George Washington University
    Inventors: Shuai Sun, Volker J. Sorger, Tarek El-Ghazawi, Vikram K. Narayana, Abdel-Hameed A. Badawy
  • Publication number: 20190101550
    Abstract: The present disclosure provides the use of two very long chain ceramides for determining the risk of cardiovascular disease.
    Type: Application
    Filed: December 16, 2015
    Publication date: April 4, 2019
    Applicants: WASHINGTON UNIVERSITY, TRUSTEES OF BOSTON UNIVERSITY
    Inventors: Jean E. SCHAFFER, Daniel S. ORY, Linda PETERSON, Vasan S. RAMACHANDRAN, Venessa XANTHAKIS