Patents Assigned to Washington University
  • Patent number: 11158845
    Abstract: The present disclosure relates to an improved process for the synthesis of nanomaterials and composites from Zintl phases. The nanomaterials and composites are useful, for example, as ion storage materials.
    Type: Grant
    Filed: October 4, 2017
    Date of Patent: October 26, 2021
    Assignee: The George Washington University
    Inventors: Michael J. Wagner, Nathan A. Banek
  • Patent number: 11149192
    Abstract: The present disclosure provides for a photoredox-responsive material, processes of making the photoredox-responsive material, and methods of use thereof.
    Type: Grant
    Filed: March 29, 2018
    Date of Patent: October 19, 2021
    Assignee: Washington University
    Inventors: Jonathan C. Barnes, Angelique F. Greene, Kevin Liles, Abigail Delawder
  • Patent number: 11149305
    Abstract: The present disclosure encompasses methods of error corrected sequencing (ECS) that enable detection of very rare mutations well below the error rate of convention next generation sequencing (NGS). Further, the methods disclosed herein enable multiplex targeting of genomic DNA.
    Type: Grant
    Filed: January 22, 2016
    Date of Patent: October 19, 2021
    Assignee: Washington University
    Inventors: Todd E. Druley, Andrew Young
  • Patent number: 11148119
    Abstract: Coated iron oxide (10) nanocrystal structures, superparamagnetic 10 nanoparticles, methods for synthesizing coated 10 nanocrystal structures, and methods for synthesizing superparamagnetic 10 nanoparticles are described herein. A coated 10 nanocrystal structure may comprise an iron oxide core, a manganese ferrite shell layer surrounding the core, and a bilayer coating surrounding the shell layer. The bilayer coating may include an inner oleic acid layer surrounding the shell layer and an outer layer surrounding the inner oleic acid layer.
    Type: Grant
    Filed: August 11, 2016
    Date of Patent: October 19, 2021
    Assignee: Washington University
    Inventors: John Fortner, Brandon J. Lafferty, Seung Lee, Wenlu Li
  • Patent number: 11141709
    Abstract: A sequencing capture array for identifying mutations in Multiple Myeloma is disclosed. Also disclosed are targeted next generation sequencing methods for identifying SNV, CNV, and translocation mutations in Multiple Myeloma tumor cells. A capture array representing fewer than 500 genes implicated in Multiple Myeloma can be used to analyze tumor mutations and create a personalized treatment plan for a Multiple Myeloma patient. Analytical methods are presented that allow tumor mutations to be elucidated with coverage at a sequencing depth of no more than 500×, or as low as 100×, with optimal efficiency achieved at a sequencing depth of about 300×.
    Type: Grant
    Filed: November 6, 2017
    Date of Patent: October 12, 2021
    Assignee: Washington University
    Inventors: Brian White, Irena Lanc, Robert Fulton, Daniel Auclair, Michael H. Tomasson
  • Patent number: 11141379
    Abstract: The present invention encompasses prodrug compositions, nanoparticles comprising one or more prodrugs, and methods of use thereof.
    Type: Grant
    Filed: December 27, 2018
    Date of Patent: October 12, 2021
    Assignee: Washington University
    Inventors: Gregory M. Lanza, Dipanjan Pan
  • Publication number: 20210311046
    Abstract: Among the various aspects of the present disclosure is the provision of a method of reducing interference (e.g., the Hook effect) in an immunoassay (e.g., a single-step homogeneous turbidometric or nephelometric immune assay).
    Type: Application
    Filed: April 7, 2021
    Publication date: October 7, 2021
    Applicant: Washington University
    Inventors: Mark A. Zaydman, Jonathan R. Brestoff Parker, Ann Marie Gronowski
  • Publication number: 20210313247
    Abstract: A heat exchanger for thermal management of an electronic device includes a liquid delivery layer thermally coupled to the electronic device and configured to receive a liquid from a source. The heat exchanger also includes an evaporation layer comprising hollow pillars configured to receive a continuous flow of the liquid from the liquid delivery layer and evaporate the continuous flow of the liquid from droplets maintained on the hollow pillars. Each hollow pillar has an evaporation surface and a pore configured to channel the continuous flow of the liquid through the hollow pillar to the evaporation surface. The evaporation surface being configured to maintain a droplet on the respective hollow pillar within a contact line. The evaporation surface has a wetting efficiency of at least about 95% and the contact line has a length of less than about 0.0314 mm.
    Type: Application
    Filed: August 23, 2019
    Publication date: October 7, 2021
    Applicant: Washington University
    Inventors: Damena AGONAFER, Binjian MA, Li SHAN, Patricia WEISENSEE, John Mark MEACHAM
  • Patent number: 11137784
    Abstract: A linear regulator operates in the manner of a linear voltage regulator, but with the functionality of a switching converter. This concept enables DC voltage up-conversion with no switching, more efficient step down of large voltage steps, and requires no expensive and bulky additional components. An optocoupler device transfers power between light emitting and photovoltaic devices.
    Type: Grant
    Filed: September 6, 2019
    Date of Patent: October 5, 2021
    Assignee: The George Washington University
    Inventor: Matthew Lumb
  • Patent number: 11135316
    Abstract: The present disclosure discloses methods and compositions for administering Cerenkov radiation-induced therapy (CRIT). In an aspect, the invention encompasses a composition comprising at least two radiation-sensitive molecules. In another aspect, the invention encompasses a composition comprising a radiation-sensitive molecule and a targeting agent. In still another aspect, the invention encompasses a method for administering Cerenkov radiation-induced therapy (CRIT) to a target tissue in a subject. The method comprises administering to the subject an effective amount of a composition B comprising at least one radiation-sensitive molecule and administering to the subject an amount of a Cerenkov radiation (CR)-emitting radionuclide effective to activate the radiation-sensitive molecule, thereby administering CRIT to the target tissue in the subject.
    Type: Grant
    Filed: February 2, 2015
    Date of Patent: October 5, 2021
    Assignee: Washington University
    Inventors: Samuel Achilefu, Nalinikanth Kotagiri
  • Patent number: 11137408
    Abstract: The present disclosure provided methods for determining the severity of glaucoma using the expression levels of GDF15. Determining the severity of glaucoma aids in treatment decisions.
    Type: Grant
    Filed: January 30, 2017
    Date of Patent: October 5, 2021
    Assignee: Washington University
    Inventors: Rajendra S. Apte, Jun Yoshino
  • Publication number: 20210299223
    Abstract: Disclosed herein are therapeutic uses for treating cancer in a subject in need thereof, comprising administering to the subject a population of chimeric antigen receptor (CAR)-bearing immune effector cells and an IL-7 protein (e.g., modified IL-7 protein).
    Type: Application
    Filed: July 30, 2019
    Publication date: September 30, 2021
    Applicants: WASHINGTON UNIVERSITY, NEOIMMUNETECH, INC.
    Inventors: John F. DIPERSIO, Matthew COOPER, Karl STASER, Jaehan PARK, Byung Ha LEE, Dong Hoon CHOI
  • Publication number: 20210299650
    Abstract: Anion exchange membranes (AEMs) for separators in electrochemical devices and methods for making same are disclosed herein. AEMs include chloromethylated SEBS triblock copolymer functionalized with TRIS cations and chloromethylated QPEK-C functionalized with TMA cations. Composite AEMs further include metal oxide fillers. Reinforced AEMs and reinforced composite AEMs further include a reinforcement material base.
    Type: Application
    Filed: July 30, 2019
    Publication date: September 30, 2021
    Applicant: Washington University
    Inventors: Zhongyang Wang, Shrihari Sankarasubramanian, Vijay K. Ramani, Yunzhu Zhang, Javier Parrondo
  • Publication number: 20210303760
    Abstract: System and methods for forming a micropillar array for an evaporative heat exchanger include selecting a preliminary shape for a micropillar, determining a droplet shape that is generated by the preliminary shape, and generating at least one curve that defines the droplet shape. The system and methods also include performing an evaporative simulation based on the curve and selecting a final micropillar shape based on the evaporative simulation. The system and methods further include fabricating an array of micropillars including at least one micropillar having the final micropillar shape.
    Type: Application
    Filed: March 16, 2021
    Publication date: September 30, 2021
    Applicant: Washington University
    Inventor: Damena Agonafer
  • Publication number: 20210300433
    Abstract: An image classification system defends against physically realizable attacks. A training dataset of input images is retrieved and an adversarial image is generated based on one of the input images that is selected. The adversarial image is created by occluding a portion of the selected image by superimposing a predetermined shape (e.g., a rectangle) containing noise on the selected image. A defense against occlusion attacks (DOA) classifier is trained using the training dataset and the adversarial image. The DOA classifier is utilized to classify captured images of items (e.g., street signs) that may have been attacked (e.g., sticker placement, vandalism).
    Type: Application
    Filed: March 26, 2021
    Publication date: September 30, 2021
    Applicant: Washington University
    Inventors: Yevgeniy Vorobeychik, Tong Wu, Liang Tong
  • Patent number: 11131619
    Abstract: A system and method for engineering loss in a physical system by steering parameters of the physical system to the vicinity of an exceptional point is disclosed. In the vicinity of an exceptional point, localization of the fields helps to enhance any linear or nonlinear processes. As examples loss-induced transparency in the intracavity field intensities of coupled resonators, loss-induced suppression and enhancement of thermal nonlinearity in coupled resonators and loss-induced suppression and revival of Raman lasing in whispering-gallery-microcavities are demonstrated.
    Type: Grant
    Filed: May 16, 2018
    Date of Patent: September 28, 2021
    Assignee: Washington University
    Inventors: Sahin Kaya Ozdemir, Lan Yang, Bo Peng
  • Patent number: 11131661
    Abstract: The invention relates to compounds and methods for restoring or preserving cholesterol efflux in a cell infected with Human Immunodeficiency Virus (HIV) by preventing or decreasing an interaction between Negative Regulatory Factor (Nef) protein and Calnexin protein, and methods for screening for such compounds.
    Type: Grant
    Filed: April 6, 2020
    Date of Patent: September 28, 2021
    Assignee: THE GEORGE WASHINGTON UNIVERSITY, A CONGRESSIONALLY CHARTERED NOT-FOR-PROFIT CORPORATION
    Inventors: Alexei Adzhubei, Michael Bukrinsky, Ruth Hunegnaw
  • Patent number: 11129871
    Abstract: Among the various aspects of the present disclosure is the provision of methods and compositions to treat or prevent an endoplasmic reticulum (ER) stress-mediated kidney disease in a subject, the method comprising administering to the subject a pharmaceutical composition comprising a therapeutically effective amount of an ER calcium channel stabilizing agent or an ER stress modulating agent (e.g., mesencephalic astrocyte-derived neurotrophic factor (MANF), compound K201).
    Type: Grant
    Filed: June 19, 2019
    Date of Patent: September 28, 2021
    Assignee: Washington University
    Inventors: Ying Chen, Fumihiko Urano, Yeawon Kim, Sun-Ji Park
  • Patent number: 11129816
    Abstract: Described is a composition that includes: (i) a drug against tuberculosis inhibiting the cytochrome b subunit of the bc1 complex, said cytochrome b subunit being encoded by the gene qcrB, in Mycobacterium tuberculosis, or a pharmaceutically acceptable salt thereof, and (ii) a compound of Formula II, or a pharmaceutically acceptable salt thereof.
    Type: Grant
    Filed: October 5, 2018
    Date of Patent: September 28, 2021
    Assignees: Quretech Bio AB, Washington University in St. Louis
    Inventors: Christina Leigh Stallings, Gregory Alexander Harrison, Fredrik Almqvist, Souvik Sarkar
  • Patent number: 11130780
    Abstract: The present invention generally relates to compounds that are useful for inhibiting one or more of hepatocyte growth factor activator, matriptase, hepsin, Factor Xa, or thrombin. The present invention also relates to various methods of using the inhibitor compounds including treating a malignancy, a pre-malignant condition, or cancer by administering an effective amount of the inhibitor to a subject in need thereof.
    Type: Grant
    Filed: March 2, 2016
    Date of Patent: September 28, 2021
    Assignee: Washington University
    Inventors: James W. Janetka, Zhenfu Han, Peter Harris, Partha Karmakar