Patents Assigned to Washington University
  • Patent number: 11911999
    Abstract: Fluorescence-based techniques are the cornerstone of modern biomedical optics with applications ranging from bioimaging at various scales (organelle to organism) to detection and quantification of a wide variety of biological species of interest. However, feeble fluorescence signal remains a persistent challenge in meeting the ever-increasing demand to image, detect and quantify biological species of low abundance. Disclosed herein are simple and universal methods based on a flexible and conformal elastomeric film adsorbed with plasmonic nanostructures, referred to as “plasmonic skin” or “plasmonic patch”, that provide large and uniform enhancement of fluorescence on a variety of surfaces, through an “add-on-top” process.
    Type: Grant
    Filed: May 6, 2022
    Date of Patent: February 27, 2024
    Assignee: Washington University
    Inventors: Srikanth Singamaneni, Jingyi Luan, Jeremiah Morrissey, Evan Kharasch
  • Patent number: 11914034
    Abstract: A diffuse optical tomography (DOT) system for generating a functional image of a lesion region of a subject is described. The DOT system includes a source subsystem configured to generate optical waves, a probe coupled to the source subsystem and configured to emit the optical waves generated by the source subsystem toward the lesion region and to detect optical waves reflected by the lesion region, a detection subsystem configured to convert the optical waves detected by the probe to digital signals, and a computing device including a processor and a memory. The memory includes instructions that program the processor to receive the digital signals sent from the detection subsystem and perform reconstruction using a depth-regularized reconstruction algorithm combined with a semi-automated interactive convolutional neural network (CNN) for depth-dependent reconstruction of absorption distribution.
    Type: Grant
    Filed: September 10, 2020
    Date of Patent: February 27, 2024
    Assignee: Washington University
    Inventors: Quing Zhu, Shiqi Xu
  • Patent number: 11903935
    Abstract: The present disclosure provides compounds useful as inhibitors of SARM1 NADase activity, compositions thereof, and methods of using the same. The present disclosure provides compounds useful for treating a neurodegenerative or neurological disease or disorder, compositions thereof, and methods of using the same.
    Type: Grant
    Filed: October 22, 2021
    Date of Patent: February 20, 2024
    Assignees: Washington University, Disarm Therapeutics, Inc.
    Inventors: Jeffrey Milbrandt, Kow Essuman, Yo Sasaki, Aaron Diantonio, Xianrong Mao, Rajesh Devraj, Raul Eduardo Krauss, Robert Owen Hughes
  • Publication number: 20240050219
    Abstract: Devices and methods for joining a first and second tissue in a patient are disclosed that include a base with a plurality of recurved tines oriented to a tine axis and extending from a first surface of the base. The tines provide unidirectional traction of the first tissue along the tine axis toward the first surface. The first tissue is secured to the first surface of the device at the plurality of recurved tines and the second tissue is secured to the device at a second surface opposite the first surface to join the first and second tissues.
    Type: Application
    Filed: October 5, 2020
    Publication date: February 15, 2024
    Applicants: Washington University, Columbia University
    Inventors: Guy Genin, Ethan Hoppe, Dong Hwan Yoon, Stavros Thomopoulos, Iden Kurtaliaj, Liana Tedesco, David Kovacevic, Victor Birman, Lester Smith, Leesa Galatz, William Levine
  • Publication number: 20240050435
    Abstract: The present disclosure provides methods of treating cancer in a subject including administering a therapeutic composition comprising an ATR inhibitor and a hypomethylating agent. Methods of inducing DNA replication stress or cell death in a cancer cell are also provided. The combination of an ATR inhibitor and hypomethylating agent is particularly useful for treating TP53-mutated cancers, such as acute myeloid leukemia (AML) or myelodysplastic syndrome (MDS).
    Type: Application
    Filed: August 2, 2023
    Publication date: February 15, 2024
    Applicant: Washington University
    Inventor: Daniel Link
  • Publication number: 20240050471
    Abstract: The present disclosure provides for methods of activating an immune cell in a subject by administering to the subject a CYR61 activating agent, as well as methods of treating ocular neovascularization in a subject by administering a CYR61 activating agent to an immune cell to form a treated immune cell and administering the treated immune cell to the subject.
    Type: Application
    Filed: August 11, 2023
    Publication date: February 15, 2024
    Applicant: Washington University
    Inventors: Rajendra Apte, Joseph Lin, Philip Ruzycki
  • Patent number: 11897929
    Abstract: The present disclosure encompasses compositions and methods for targeted cytokine delivery. The compositions disclosed herein comprise a cytokine linked to an NKG2D ligand or PD1 ligand and may improve immunotherapy by limiting side effects associated with immunotherapy. The present disclosure also encompasses compositions and methods for recruiting cytotoxic lymphocytes to target cells using NKG2D receptor ligands or PD1 ligands. The compositions disclosed herein comprise a NKG2D receptor ligand and a targeting molecule and may improve immunotherapy by limiting side effects associated with immunotherapy.
    Type: Grant
    Filed: April 23, 2021
    Date of Patent: February 13, 2024
    Assignee: Washington University
    Inventors: Alexander Sasha Krupnick, Daved Henry Fremont, Eric Reed Lazear, John Westwick
  • Publication number: 20240043842
    Abstract: Methods are provided of reversing muscle loss and improving mitochondrial function via site-1 protease (S1P) inhibition. Further methods are provided for treating Duchenne muscular dystrophy and age-related muscle loss via site-1 protease (S1P) inhibition.
    Type: Application
    Filed: August 8, 2023
    Publication date: February 8, 2024
    Applicant: Washington University
    Inventor: Rita Brookheart
  • Publication number: 20240041859
    Abstract: Among the various aspects of the present disclosure is the provision of a method of treating or preventing kidney disease in a subject in need thereof. Another aspect of the present disclosure provides for a method of reducing a number of kidney cells having excess centrosomes or centrosome amplification (CA) or inhibiting centrosome clustering in a subject having or suspected of having a kidney disease associated with CA or increased centrosome clustering. In some embodiments, the method comprises administering to the subject a centrosome clustering inhibiting agent.
    Type: Application
    Filed: December 2, 2021
    Publication date: February 8, 2024
    Applicant: Washington University
    Inventors: Mohamed 'Moe' Mahjoub, Tao Cheng
  • Patent number: 11894590
    Abstract: Described herein is a novel electrode-decoupled redox flow battery, a novel reinforced electrode-decoupled redox flow battery, and methods of using same to store energy. Advantages of these novel electrode-decoupled redox flow batteries include long life, excellent rate capability, and stability.
    Type: Grant
    Filed: July 7, 2021
    Date of Patent: February 6, 2024
    Assignee: Washington University
    Inventors: Shrihari Sankarasubramanian, Vijay Ramani
  • Patent number: 11887686
    Abstract: Embodiments provide for predicting rowhammer attack vulnerability of one or more memory cells of a direct random access memory (DRAM) chip, the DRAM chip including a plurality of memory cells. An example method, determines, for each memory cell of a subset of memory cells of the plurality of memory cells, a leakage time t, a resistance of intrinsic leakage RL based at least in part on the leakage time t, an activation time of an adjacent aggressor row to flip a bit in the memory cell, a resistance of coupling leaking RSW based at least in part on the activation time, and a toggling count. The method identifies, based at least in part on one or more of the RSW, RL, or toggling count, whether the direct random memory access (DRAM) chip is vulnerable to a rowhammer attack.
    Type: Grant
    Filed: June 24, 2021
    Date of Patent: January 30, 2024
    Assignees: University of Florida Research Foundation, Incorporated, Washington University
    Inventors: Yier Jin, Yichen Jiang, Xuan Zhang, Huifeng Zhu, Xiaolong Guo
  • Patent number: 11887745
    Abstract: Among the various aspects of the present disclosure is the provision of methods for producing radioisotopes and improving the specific activity of radioisotopes (e.g., Cu-64 chloride). As described herein, the method includes matching of the target material and the proton beam strike area, resulting in improved specific activity while reducing the amount of target material used.
    Type: Grant
    Filed: October 5, 2022
    Date of Patent: January 30, 2024
    Assignee: Washington University
    Inventor: Gregory Gaehle
  • Patent number: 11884934
    Abstract: Among the various aspects of the present disclosure is the provision of methods, synthetic DC, and compositions for T cell activation. The present disclosure provides for synthetic dendritic cells (DCs), methods of generating synthetic dendritic cells (DCs), methods of generating T cell-encapsulated gelatin microspheres and microcapsules, methods of activating T cells using synthetic DCs, methods for expanding T cells against individualized antigen-specific mutational antigens using synthetic DCs, and methods of treating a chronic disease (e.g., HIV, HPV) or cancer using the synthetic DCs.
    Type: Grant
    Filed: July 20, 2018
    Date of Patent: January 30, 2024
    Assignee: Washington University
    Inventors: Eynav Klechevsky, Amit Pathak, Bapi Sarker
  • Publication number: 20240026345
    Abstract: Among the various aspects of the present disclosure is the provision of compositions for single-cell reporter assays and methods of use thereof. Also provided are methods of determining individual activities of a plurality of nucleic acid regulatory elements, identifying a regulatory element having cell type-specific activity, or determining variance in activity of a plurality of nucleic acid regulatory elements.
    Type: Application
    Filed: November 10, 2022
    Publication date: January 25, 2024
    Applicant: Washington University
    Inventors: Barak Cohen, Siqi Zhao
  • Publication number: 20240024869
    Abstract: A micro-bioelectrochemical cell (?-BEC) device is disclosed that includes from 4 to 96 microfluidically connected chambers, in which each chamber encloses a volume of about 1 ?L to 2 ?L. A working electrode, reference electrode, and counting electrode contacts each volume. The ?-BEC device includes a support layer coated with a working electrode layer, a microfluidics layer containing a plurality of wells, and an electrical layer containing the reference and counter electrodes. Methods of using the ?-BEC device to perform bioelectrochemical measurements of cells are also disclosed.
    Type: Application
    Filed: September 28, 2023
    Publication date: January 25, 2024
    Applicant: Washington University
    Inventors: John Meacham, Arpita Bose
  • Patent number: 11878188
    Abstract: Devices, systems, and methods for enhancing MRI image quality and tracking accuracy in MR-guided treatment systems are described.
    Type: Grant
    Filed: May 3, 2022
    Date of Patent: January 23, 2024
    Assignee: Washington University
    Inventors: H. Michael Gach, Austen Curcuru, Taeho Kim, Umberto Villa
  • Publication number: 20240020842
    Abstract: Among the various aspects of the present disclosure are the provision of an image alignment and registration system and a breast cancer risk prediction system.
    Type: Application
    Filed: July 18, 2023
    Publication date: January 18, 2024
    Applicant: Washington University
    Inventors: Graham Colditz, Shu Jiang
  • Publication number: 20240009222
    Abstract: Disclosed are methods and compositions related to methods of treating, ameliorating, mitigating, slowing, arresting, preventing or reversing various diseases and conditions, including age-related obesity, age-related increases in blood lipid levels, age-related decreases in insulin sensitivity, age-related decreases in memory function, and age-related changes in eye function such as macular degeneration. The methods comprise administering nicotinamide mononucleotide (NMN) to a subject. In some embodiments, the administration can be oral administration. Also disclosed are pharmaceutical compositions comprising NMN.
    Type: Application
    Filed: September 21, 2023
    Publication date: January 11, 2024
    Applicant: Washington University
    Inventors: Shin-ichiro Imai, Rajendra Apte
  • Patent number: 11867627
    Abstract: A compact diffuse optical tomography system for generating a functional image of a lesion region is provided. The system includes a source subsystem, a probe, a detection subsystem, and a computing device. The source subsystem includes laser diodes and a laser diode driver board. The probe is configured to emit the optical waves generated by the source subsystem toward the lesion region and detect optical waves reflected by the lesion region. The detection subsystem includes a miniaturized detection board and a miniaturized data acquisition board. The miniaturized detection board includes a photomultiplier tube configured to convert the optical waves detected by the probe to electrical signals. The miniaturized data acquisition board is configured to convert electrical signals outputted by the miniaturized detection board to digital signals. The computing device is configured to receive the digital signals, reconstruct the functional image, and display the functional image.
    Type: Grant
    Filed: October 11, 2019
    Date of Patent: January 9, 2024
    Assignees: Washington University, The University of Connecticut
    Inventors: Quing Zhu, Hamed Vavadi, Atahar Mostafa
  • Patent number: 11864865
    Abstract: A wearable device for high-density-diffuse optical tomography includes a plurality of source modules that include source housings containing a light source. The device also includes a plurality of detector modules that include detector housings, a photodiodes, transimpedance amplifiers operatively coupled to the photodiodes, and analog to digital converters operatively coupled to the transimpedance amplifier. Each detector housing contains at least one of the photodiode, the analog to digital converter, and the transimpedance amplifier. Each source and detector housing is configurable to contact a subject's scalp and deliver or receive light from the scalp at one position. The wearable device also includes a control circuit operatively coupled to the plurality of source modules and to the plurality of detector modules to operate the source and detector modules in a coordinated manner to acquire a plurality of diffuse optical tomography measurements.
    Type: Grant
    Filed: February 26, 2019
    Date of Patent: January 9, 2024
    Assignee: Washington University
    Inventors: Joseph Culver, Edward Richter, Adam T. Eggebrecht