Patents Assigned to Washington University
  • Publication number: 20200330026
    Abstract: A diffuse optical tomography (DOT) system for generating a functional image of a lesion region of a subject includes a source subsystem configured to generate optical waves, a probe coupled to the source subsystem and configured to emit the optical waves generated by the source subsystem toward the lesion region and to detect optical waves reflected by the lesion region, a detection subsystem configured to convert the optical waves detected by the probe to digital signals, and a computing device including a processor and a memory. The memory includes instructions that program the processor to receive the digital signals sent from the detection subsystem, calculate an initial estimate of the functional image by solving an inverse optimization problem with a shape-regularized Fast Iterative Shrinkage-Thresholding algorithm (FISTA), reconstruct the functional image iteratively using a Finite Difference Method (FDM) or a Finite Element Method (FEM), and display the functional image.
    Type: Application
    Filed: April 16, 2020
    Publication date: October 22, 2020
    Applicant: Washington University
    Inventors: Quing Zhu, Shiqi Xu
  • Patent number: 10807029
    Abstract: Disclosed herein are devices and methods of high throughput separation. A device comprises a reservoir for receiving a fluid in a flow direction and a transducer for generating a pressure field that is not perpendicular to the flow direction of the fluid through the reservoir. A method comprises receiving a fluid in a flow direction into a reservoir comprising an array of openings on at least one side of the channel or reservoir, generating a pressure field that is not perpendicular to the flow of the fluid through the reservoir, wherein at least one node and at least one antinode of the pressure field are within the reservoir, and separating the plurality of objects within the fluid, wherein at least a first object is retained within the reservoir and at least a second object is passed from the reservoir through the array of openings.
    Type: Grant
    Filed: March 15, 2017
    Date of Patent: October 20, 2020
    Assignee: WASHINGTON UNIVERSITY
    Inventors: John Mark Meacham, Michael Binkley, Andrei G. Fedorov, Fahrettin Levent Degertekin, Courtney Swadley
  • Patent number: 10806804
    Abstract: The present invention provides compounds that have motifs that target the compounds to cells that express integrins. In particular, the compounds have peptides with one or more RD motifs conjugated to an agent selected from an imaging agent and a targeting agent. The compounds may be used to detect, monitor and treat a variety of disorders mediated by integrins.
    Type: Grant
    Filed: May 5, 2016
    Date of Patent: October 20, 2020
    Assignee: Washington University
    Inventors: Samuel Achilefu, Kexian Liang, Rui Tang
  • Publication number: 20200323959
    Abstract: The present invention provides compositions and method for treating a subject having or suspected of having pulmonary dysfunction resulting from impaired alveolar macrophage (AM) development. The compositions comprise granulocyte-macrophage colony stimulating factor (GM-CSF) in formulations suitable for pulmonary airway administration.
    Type: Application
    Filed: April 9, 2020
    Publication date: October 15, 2020
    Applicant: Washington University
    Inventors: Sharon Celeste Morley, Elizabeth M. Todd
  • Publication number: 20200319200
    Abstract: Reagents and methods for the digital analysis of proteins or peptides are provided. Specifically provided herein are proteins for identifying the N-terminal amino acid or N-terminal phosphorylated amino acid of a polypeptide. Also, an enzyme for use in the cleavage step of the Edman degradation reaction and a method for using this enzyme are described.
    Type: Application
    Filed: June 22, 2020
    Publication date: October 8, 2020
    Applicant: Washington University
    Inventors: James J. Havranek, Benjamin Borgo
  • Publication number: 20200305416
    Abstract: Methods and systems for preparing and preserving biological samples are disclosed herein. A method comprises contacting a preserving agent with a biological sample to form a mixture, wherein the preserving agent is selected from at least one of a metal-organic framework (MOF) encapsulant or a precursor forming a MOF encapsulant, and wherein the biological sample comprises at least one target analyte. A system comprises a preserving agent selected from at least one of a metal-organic framework (MOF) encapsulant or a precursor forming a MOF encapsulant; and a substrate configured to receive a drop cast mixture of the preserving agent and a biological sample, wherein the biological sample comprises at least one target analyte.
    Type: Application
    Filed: April 20, 2018
    Publication date: October 1, 2020
    Applicant: Washington University
    Inventors: Srikanth SINGAMANENI, Congzhou WANG, Jeremiah J. MORRISSEY, Evan D. KHARASCH
  • Patent number: 10786156
    Abstract: A system includes a wearable head apparatus and an electronic console. The head apparatus is configured to receive resultant light from the head of a subject. The electronic console includes a fiber array, a detector, and a computing device. The fiber array includes a plurality of fibers configured to transport resultant light received by the head apparatus. The detector includes a plurality of super-pixels each defined by a plurality of pixels of an array of pixels. Each super-pixel is associated with a fiber. Each super-pixel is configured to generate a plurality of detection signals in response to detected resultant light from its associated fiber. The computing device receives the detection signals from each of the plurality of super-pixels. The computing device generates a high density-diffuse optical tomography (HD-DOT) image signal of the brain activity of the subject based on the detection signals from the super-pixels.
    Type: Grant
    Filed: October 16, 2015
    Date of Patent: September 29, 2020
    Assignee: Washington University
    Inventors: Joseph P. Culver, Karla Bergonzi, Adam Eggebrecht, Silvina Ferradal
  • Patent number: 10779762
    Abstract: Disclosed are systems, biomarkers, and methods for the diagnosis of Alzheimer's Disease.
    Type: Grant
    Filed: October 19, 2016
    Date of Patent: September 22, 2020
    Assignee: Washington University
    Inventors: Dmitriy Yablonskiy, Yue Zhao
  • Patent number: 10781427
    Abstract: The present invention relates to recombinant adenoviruses and vectors thereof. In particular, the adenoviruses are novel simian adenoviruses having a low seroprevalence and high immunogenicity relative to other adenoviruses and vectors thereof. The invention also provides methods for production of the adenoviruses and for the treatment of diseases by administering the adenoviral vector(s) to a subject (e.g., a human).
    Type: Grant
    Filed: October 12, 2018
    Date of Patent: September 22, 2020
    Assignees: Beth Israel Deaconess Medical Center, Inc., Washington University
    Inventors: Dan H. Barouch, Herbert Virgin, IV, Peter Abbink
  • Patent number: 10782289
    Abstract: A micro-resonator and fiber taper based sensing system, which uses mode splitting or frequency shift methods and polarization measurements for particle sensing.
    Type: Grant
    Filed: November 2, 2017
    Date of Patent: September 22, 2020
    Assignee: Washington University
    Inventors: Sahin Kaya Ozdemir, Lan Yang
  • Patent number: 10773060
    Abstract: A method of using a catheter assembly for inserting in a fluid filled space in a body includes providing a main body having a first end portion and a second end portion. The first end portion is positioned within the fluid filled space. The second end portion is adjusted to extend outwardly from the fluid filled space when the first end portion is positioned within the fluid filled space. A catheter tip is connected to the second end portion of the main body. The catheter tip includes a housing having a cavity defined therein and a rotating element positioned within the fluid filled space. The rotating element is rotated within the cavity of the housing to impart movement of the first end portion of the main body within the fluid filled space.
    Type: Grant
    Filed: November 30, 2015
    Date of Patent: September 15, 2020
    Assignee: Washington University
    Inventors: Eric Leuthardt, Guy Genin, Matthew Smyth, David Limbrick, Daniel Moran, Lihong Wang, Aaron McLaughlin, Manish Shah, Alexander Yang, Samuel Stone, Devon Haydon, Michael Winek, Richard Marcus
  • Publication number: 20200284866
    Abstract: Among the various aspects of the present disclosure is the provision of methods and systems for real-time 3D MRI that combines dynamic keyhole data sharing with super-resolution imaging methods to improve real-time 3D MR images in the presence of motion.
    Type: Application
    Filed: March 9, 2020
    Publication date: September 10, 2020
    Applicant: Washington University
    Inventors: Taeho Kim, Chunjoo Park
  • Publication number: 20200287411
    Abstract: A hybrid-powered sensing device is disclosed that includes a power source coupled to a sensing module via an RF-triggered load switching module.
    Type: Application
    Filed: March 5, 2020
    Publication date: September 10, 2020
    Applicant: Washington University
    Inventors: Shantanu Chakrabartty, Kenji Aono, Sri Harsha Kondapalli, Owen Pochettino
  • Publication number: 20200282051
    Abstract: The present invention provides methods for treating pruritus in a subject in need thereof comprising administering a therapeutically effective amount of a JAK inhibitor. Also provided are methods of intranasal administration of JAK inhibitors for use in treating pruritus.
    Type: Application
    Filed: February 16, 2017
    Publication date: September 10, 2020
    Applicant: Washington University
    Inventor: Brian Kim
  • Publication number: 20200282396
    Abstract: A micro-bioelectrochemical cell (?-BEC) device is disclosed that includes from 4 to 96 microfluidically connected of chambers, in which each chamber encloses a volume of about 1 ?L to 2 ?L. A working electrode, reference electrode, and counting electrode contacts each volume. The ?-BEC device includes a support layer coated with a working electrode layer, a microfluidics layer containing a plurality of wells, and an electrical layer containing the reference and counter electrodes. Methods of using the ?-BEC device to perform bioelectrochemical measurements of cells are also disclosed.
    Type: Application
    Filed: January 29, 2020
    Publication date: September 10, 2020
    Applicant: Washington University
    Inventors: John Meacham, Arpita Bose
  • Patent number: 10765722
    Abstract: The present invention relates, inter alia, to a method comprising administering to a subject having high output shock and undergoing treatment with a catecholamine at a dose equivalent to at least about 0.2 mcg/kg/min of norepinephrine a dose of angiotensin II which is effective to raise the blood pressure of the subject to a mean arterial pressure (MAP) of about 65 mm Hg or above, and which is effective to reduce the dose of the catecholamine required to maintain a MAP of about 65 mm Hg to the equivalent of about 0.05-0.2 mcg/kg/min norepinephrine or less, or to the equivalent of about 0.05 mcg/kg/min norepinephrine or less.
    Type: Grant
    Filed: September 19, 2018
    Date of Patent: September 8, 2020
    Assignee: The George Washington University a Congressionally Chartered Not-for-Profit Corporation
    Inventor: Lakhmir S. Chawla
  • Patent number: 10769236
    Abstract: Battery models using robust fail-safe iteration free approach for solving Differential Algebraic Equations, and associated systems and methods are disclosed. In one embodiment, a method includes generating a model of the rechargeable battery; determining one or more initial conditions for one or more algebraic variables of the model using a solver; holding differential variables of the model static by a switch function while determining the one or more initial conditions; applying the initial conditions to the model by the switch function; and determining one or more parameters for the rechargeable battery by solving the algebraic and differential equations.
    Type: Grant
    Filed: July 20, 2016
    Date of Patent: September 8, 2020
    Assignees: University of Washington, Washington University
    Inventors: Dayaram Sonawane, Manan Pathak, Venkat Subramanian, Matthew Lawder
  • Patent number: 10767861
    Abstract: A boiler system having a series of boilers. Each boiler includes a shell having an upstream end, a downstream end, and a hollow interior. The boilers also have an oxidizer inlet entering the hollow interior adjacent the upstream end of the shell and a fuel nozzle positioned adjacent the upstream end of the shell for introducing fuel into the hollow interior of the shell. Each boiler includes a flue duct connected to the shell adjacent the downstream end for transporting flue gas from the hollow interior. Oxygen is delivered to the oxidizer inlet of the first boiler in the series. Flue gas from the immediately preceding boiler in the series is delivered through the oxidizer inlet of each boiler subsequent to the first boiler in the series.
    Type: Grant
    Filed: February 27, 2018
    Date of Patent: September 8, 2020
    Assignee: Washington University
    Inventors: Richard L. Axelbaum, Benjamin M. Kumfer, Fei Xia, Akshay Gopan, Bhupesh Dhungel
  • Patent number: 10761419
    Abstract: Systems and methods for use in tri-spot point spread function imaging are provided that include a phase mask. The phase mask includes three partitions that each include a subset of the total area that is asymmetrical to other partitions. Each partition includes a phase delay ramp aligned along a phase delay axis, and includes a gradient of phase delays. Each phase delay axis is oriented in a different direction with respect to each other. Included is a source that outputs an excitation beam into a sample containing at least one light emitter that emits a radiation pattern when illuminated. Included is at least one sensor arranged to capture at least one image of the radiation pattern and a phase mask positioned between the at least one emitter and the at least one sensor. The phase mask is configured to produce a tri-spot point spread function.
    Type: Grant
    Filed: April 17, 2018
    Date of Patent: September 1, 2020
    Assignee: Washington University
    Inventors: Oumeng Zhang, Matthew D. Lew
  • Patent number: 10758627
    Abstract: A pharmaceutical composition comprising a peptide-polynucleotide complex, and methods of use thereof.
    Type: Grant
    Filed: July 1, 2016
    Date of Patent: September 1, 2020
    Assignee: Washington University
    Inventors: Samuel A. Wickline, Kirk Hou