Patents Assigned to Washington University
-
Patent number: 12044220Abstract: A satellite propulsion system and methods of operating the same include a first ionization stage and a second acceleration stage. The first ionization stage has a plasma source configured to produce an arc discharge and emit a preliminary plasma. The plasma source includes an external magnetic field configured to magnetize the arc discharge. The second acceleration stage has an accelerator positioned in series with the plasma source. The accelerator is configured to accelerate the preliminary plasma out through the accelerator, thereby creating an accelerated plasma flow. The application of an activation threshold voltage to the accelerator results in a surge in system performance parameters.Type: GrantFiled: February 22, 2021Date of Patent: July 23, 2024Assignee: THE GEORGE WASHINGTON UNIVERSITYInventors: Michael Keidar, Denis Zolotukhin, Siva Ram Prasad Bandaru
-
Patent number: 12043832Abstract: Among the various aspects of the present disclosure is the provision of compositions and methods for selectively reducing pathogenic isoforms (e.g., DNAJB6) in a subject having a neuromuscular disorder. An aspect of the present disclosure provides for selectively reducing DNAJB6 in a subject having a neuromuscular disorder (e.g., limb-girdle muscular dystrophy D1 (LGMD-D1)) comprising administering an amount of a DNAJB6-targeting antisense oligonucleotide (ASO) sufficient to reduce the expression of DNAJB6 compared to the subject prior to being administered the DNAJB6-targeting ASO.Type: GrantFiled: September 16, 2022Date of Patent: July 23, 2024Assignee: Washington UniversityInventors: Andrew Findlay, Conrad Weihl
-
Publication number: 20240238338Abstract: Compositions and methods for the treatment, prevention, or reversal of a central nervous system (CNS) injury or disorder in a patient in need that include administering a therapeutically effective amount of meningeal immune cells are disclosed. Specifically, the meningeal immune cells comprise Ly6C+ monocytes. Further disclosed are wherein the meningeal immune cells are modified to include a drug or gene therapeutic compound, and wherein the modified meningeal immune cells are configured to deliver the drug or gene therapeutic compound to the CNS of the subject via the parenchyma or meningeal tissue of the subject.Type: ApplicationFiled: May 10, 2022Publication date: July 18, 2024Applicant: Washington UniversityInventor: Jonathan Kipnis
-
Patent number: 12039639Abstract: Systems and methods reconstruct an image of a subject or object by performing an iterative reconstruction method to produce a plurality of intermediate images and the image of the subject, and transforming at least one selected intermediate image from the plurality of intermediate images using a quasi-projection operator. The quasi-projection operator includes a deep-learning model configured to map the at least one selected intermediate image to at least one regularized intermediate image. In addition, systems and methods for training the deep-learning model using a training data set that includes a plurality of training images and a plurality of corresponding training object images is disclosed.Type: GrantFiled: June 27, 2022Date of Patent: July 16, 2024Assignee: Washington UniversityInventors: Mark Anastasio, Thomas Matthews, Brendan Kelly
-
Patent number: 12040897Abstract: A proactive fault-tolerant scheme which improves performance and energy efficiency for NoCs. The fault-tolerant scheme allows routers to switch among several different fault-tolerant operations. Each operation mode has different trade-offs among fault-tolerant capability, retransmission traffic, latency, and energy efficiency. Another example provides a proactive, dynamic control policy to balance and optimize the dynamic interactions and trade-offs. The example control policy uses example machine learning algorithm called reinforcement learning (RL). The example RL-based controller independently observes a set of NoC system parameters at runtime, and over time they evolve optimal per-router control policies. By automatically and optimally switching among the four fault-tolerant modes, the trained control policy results in minimizing system level network latency and maximizing energy efficiency while detecting and correcting errors.Type: GrantFiled: August 21, 2019Date of Patent: July 16, 2024Assignee: THE GEORGE WASHINGTON UNIVERSITYInventors: Ke Wang, Ahmed Louri
-
Patent number: 12037329Abstract: Among the various aspects of the present disclosure is the provision of SphK inhibitors and methods of making and using same. An aspect of the present disclosure provides for an SphK2 inhibiting agent, wherein the SphK2 inhibiting agent is a 1,2,3-triazole having SphK2 inhibiting activity and SphK2 selectivity.Type: GrantFiled: August 16, 2022Date of Patent: July 16, 2024Assignee: Washington UniversityInventors: Zhude Tu, Vijai Kumar Reddy Tangadanchu, Hao Jiang, Buck Rogers
-
Publication number: 20240228448Abstract: The present disclosure generally relates to compounds and compositions for use in imaging agents, methods of use for monitoring and/or treating conditions or diseases related to sphingosine-1-phosphate (S1P) signaling, and processes for preparing these compositions and compounds.Type: ApplicationFiled: March 31, 2022Publication date: July 11, 2024Applicant: Washington UniversityInventors: Zhude Tu, Lin Qiu, Jiwei Gu, Yanbo Yu, Robert Gropler
-
Publication number: 20240226342Abstract: The present disclosure provides compositions and methods for reactive oxygen species imaging agents. Compositions include a reactive oxygen species (ROS) imaging agent according to any one of Formulas (I-VI)a and (I-VII)b. Methods of detecting ROS in a subject include administering to the subject an effective amount of a composition comprising a reactive oxygen species (ROS) imaging agent according to any one of Formulas (I-VI)a and (I-VII)b, and exposing the subject to an imaging modality such as PET or CT. Administering the composition comprising the ROS imaging agent results in penetration of the ROS imaging agent into a membrane, oxidation of the ROS imaging 10 agent by ROS, and trapping of the ROS imaging agent in a cell membrane and intracellular compartments.Type: ApplicationFiled: December 5, 2023Publication date: July 11, 2024Applicant: Washington UniversityInventors: Vijay Sharma, Lakshminarayana Satham, Jothilingam Sivapackiam
-
Patent number: 12029832Abstract: A cardiac patch for treatment of a mammalian heart including perfusable vessels embedded integratedly between two layers of anisotropically oriented myocardial fibers. The cardiac patch is made using a dual 3D bioprinting technique using stereolithography to form an anisotropic construct and extrusion printing to form perfusion vessels. A nutrient and oxygen containing media can be provided within the perfusion vessels for growth of cells in the cardiac patch. The technique permits larger patches to be made for the treatment of cardiac damage in both small and large mammalian hearts.Type: GrantFiled: April 10, 2020Date of Patent: July 9, 2024Assignee: The George Washington UniversityInventors: Haitao Cui, Lijie Grace Zhang, Yimin Huang
-
Patent number: 12030020Abstract: A photothermal distillation membrane including a polydopamine (PDA) coated, polyvinylidene fluoride (PVDF) membrane is disclosed, as well as a process for synthesizing same. A photothermal aerogel membrane including a polydopamine (PDA)-containing bacterial nanocellulose (BNC) is also disclosed, as well as a process for synthesizing same.Type: GrantFiled: June 7, 2023Date of Patent: July 9, 2024Assignee: Washington UniversityInventors: Young-Shin Jun, Srikanth Singamaneni, Xuanhao Wu, Qisheng Jiang
-
Publication number: 20240218222Abstract: Hybrid proteins are described that include an amino acid sequence with at least two zipper-forming protein sequences and at least one flexible sequence from a spider silk protein sequence, in which each of the at least one flexible sequences is positioned between each pair of the at least two zipper-forming protein sequences to form a repeated sequence. The amino acid sequence also includes at least one mussel foot protein sequence positioned at a C-terminus or an N-terminus of the alternating repeated sequence. Also described are adhesive hydrogels and methods of forming the adhesive hydrogels using the hybrid proteins described herein.Type: ApplicationFiled: August 25, 2021Publication date: July 4, 2024Applicant: Washington UniversityInventors: Fuzhong Zhang, Eugene Kim
-
Patent number: 12024493Abstract: The present disclosure provides compounds represented by Formula I: and pharmaceutically acceptable salts, solvates, e.g., hydrates, and prodrugs thereof, wherein X and n are as defined as set forth in the specification. The present disclosure also provides compounds of Formula I for use to treat diseases and conditions, e.g., cancer, wherein inhibition of HDAC provides a benefit.Type: GrantFiled: February 1, 2022Date of Patent: July 2, 2024Assignees: The George Washington University, A Congressionally Chartered Not-for-Profit Corporation, The Board of Trustees of the University of IllinoisInventors: Alejandro Villagra, Alan P. Kozikowski, Sida Shen
-
Patent number: 12024707Abstract: Among the various aspects of the present disclosure is the provision of a methods and compositions for modulating lncRNAs and methods of treatment based on lncRNA expression.Type: GrantFiled: January 26, 2021Date of Patent: July 2, 2024Assignee: Washington UniversityInventors: Christopher Maher, Jessica Silva-Fisher, Ryan Fields
-
Patent number: 12023489Abstract: A system for stimulating tissue generally comprises a resorbable implant. The resorbable implant includes a substrate, at least one contact, and a transceiver, wherein the substrate, the at least one contact, and the transceiver are resorbable. The system also includes a controller configured to communicate with the transceiver of the resorbable implant and a power supply connected to the controller. The controller delivers power to the resorbable implant from the power supply. The resorbable implant delivers electrical stimulation to tissue when the resorbable implant receives power.Type: GrantFiled: October 21, 2021Date of Patent: July 2, 2024Assignees: Washington University, Northwestern UniversityInventors: Wilson Z. Ray, Matthew R. MacEwan, Zohny S. Zohny, John A. Rogers
-
Publication number: 20240207617Abstract: Among the various aspects of the present disclosure is the provision for systems and methods for individualized targeting of deep brain stimulation (DBS). In addition, methods for monitoring the treatment of a subject using a DBS system are described.Type: ApplicationFiled: December 1, 2023Publication date: June 27, 2024Applicants: Washington University, The Regents of the University of Michigan, Emory UniversityInventors: Peter Brunner, Markus Adamek, Jon Willie, Eric Leuthardt, Enrico Opri, Svjetlana Miocinovic
-
Patent number: 12017075Abstract: A system for stimulating a sympathetic chain includes an electrode assembly that is configured to attach to a bone in proximity to a targeted portion of the sympathetic chain. The electrode assembly includes a cathode and an anode. The system also includes a power supply connected to the electrode assembly and configured to deliver power to the electrode assembly. The electrode assembly generates an electrical field between the cathode and the anode when power is delivered to the electrode assembly. The electrical field reaches the targeted portion of the sympathetic chain to provide electrical stimulation to the targeted portion of the sympathetic chain.Type: GrantFiled: March 9, 2022Date of Patent: June 25, 2024Assignee: Washington UniversityInventors: Eric Leuthardt, Daniel Moran, Matthew MacEwan, Amy Moore, Paige Cloonan, Yidan Qin, Christopher Zhang, Ashwin Kamath, Wilson Ray
-
Patent number: 12016701Abstract: Provided herein are methods for imaging and diagnosing at least one disorder in a patient utilizing diffusion basis spectrum imaging MRI with extended isotropic spectrum (DBSI-EIS). The methods may be used as a tool to image and diagnose heterogeneities within tumors. As a result, different tumor types can be detected, distinguished from one another, and individually quantified without the need to inject exogenous contrast agents.Type: GrantFiled: August 30, 2017Date of Patent: June 25, 2024Assignee: Washington UniversityInventors: Yong Wang, Gloria Guzman, Qing Wang, Tammie Benzinger
-
Patent number: 12016935Abstract: Among the various aspects of the present disclosure is the provision of compositions of imaging agents and methods for use in detecting, monitoring, and evaluating CCR2 associated diseases, disorders, and conditions.Type: GrantFiled: August 25, 2020Date of Patent: June 25, 2024Assignee: Washington UniversityInventors: Yongjian Liu, Robert Gropler, Steven Brody, Daniel Kreisel
-
Publication number: 20240201199Abstract: Reagents and methods for the digital analysis of proteins or peptides are provided. Specifically provided herein are proteins for identifying the N-terminal amino acid or N-terminal phosphorylated amino acid of a polypeptide. Also, an enzyme for use in the cleavage step of the Edman degradation reaction and a method for using this enzyme are described.Type: ApplicationFiled: November 30, 2023Publication date: June 20, 2024Applicant: Washington UniversityInventors: James J. Havranek, Benjamin Borgo
-
Patent number: 12013292Abstract: A sensor system for detecting events includes an array of memory devices and a read-out interface. Each memory device includes a floating-gate with a sensing interface, the sensing interface having an energy barrier configured to leak electrons at a predetermined electron leakage rate through Fowler-Nordheim (F-N) tunneling. An an input to the sensing interface is configured to alter a geometry of the energy barrier to change the electron leakage rate. The read-out interface is communicatively coupled to at least one memory device, and is configured to retrieve data stored on the at least one memory device for analysis.Type: GrantFiled: May 20, 2021Date of Patent: June 18, 2024Assignee: Washington UniversityInventors: Shantanu Chakrabartty, Liang Zhou