Patents Assigned to Washington University
  • Publication number: 20230026377
    Abstract: A method for detecting minimal residual disease in a subject following a cancer surgery is disclosed. The method includes obtaining a sample from the subject. The sample includes a surgical drainage. The method also includes isolating an amount of tumor-associated genetic material from the sample, sequencing the amount of tumor-associated genetic material to detect and quantify at least one tumor-associated mutation or variant in the amount of tumor-associated genetic material, and providing the at least one quantity of the at least one tumor-associated mutation or variant to a practitioner.
    Type: Application
    Filed: December 17, 2020
    Publication date: January 26, 2023
    Applicant: Washington University
    Inventors: Jose Zevallos, Ricardo Ramirez
  • Patent number: 11561217
    Abstract: The invention relates to compounds and methods for restoring or preserving cholesterol efflux in a cell infected with Human Immunodeficiency Virus (HIV) by preventing or decreasing an interaction between Negative Regulatory Factor (Nef) protein and Calnexin protein, and methods for screening for such compounds.
    Type: Grant
    Filed: August 24, 2021
    Date of Patent: January 24, 2023
    Assignee: THE GEORGE WASHINGTON UNIVERSITY
    Inventors: Alexei Adzhubei, Michael Bukrinsky, Ruth Hunegnaw
  • Patent number: 11559559
    Abstract: The present invention relates, inter alia, to a method comprising administering to a subject having high output shock and undergoing treatment with a catecholamine at a dose equivalent to at least about 0.2 mcg/kg/min of norepinephrine a dose of angiotensin II which is effective to raise the blood pressure of the subject to a mean arterial pressure (MAP) of about 65 mm Hg or above, and which is effective to reduce the dose of the catecholamine required to maintain a MAP of about 65 mm Hg to the equivalent of about 0.05-0.2 mcg/kg/min norepinephrine or less, or to the equivalent of about 0.05 mcg/kg/min norepinephrine or less.
    Type: Grant
    Filed: July 20, 2021
    Date of Patent: January 24, 2023
    Assignee: The George Washington University, A Congressionally Chartered Not-For-Profit Corporation
    Inventor: Lakhmir S. Chawla
  • Patent number: 11559192
    Abstract: Systems and methods for visualizing ablated tissue are disclosed. In some embodiments, a system for imaging tissue comprising: a catheter having a distal end and a proximal end; an inflatable balloon disposed about the distal end of the catheter; and an optical housing extending from the distal end of the catheter into the balloon, the optical housing being configured to position inside the balloon a light source for illuminating a tissue outside the balloon and a camera for imaging the illuminated tissue.
    Type: Grant
    Filed: May 21, 2020
    Date of Patent: January 24, 2023
    Assignees: The George Washington University, 460Medical, Inc.
    Inventors: Omar Amirana, Kenneth C. Armstrong, Matthew W. Kay, Marco A. Mercader, Terrance J. Ransbury, Narine Sarvazyan
  • Patent number: 11559514
    Abstract: The present disclosure encompasses antibacterial compositions and methods of treating bacterial infections caused by resistant bacteria.
    Type: Grant
    Filed: October 29, 2019
    Date of Patent: January 24, 2023
    Assignees: Washington University, University of Notre Dame du Lac
    Inventors: Gautam Dantas, Patrick Gonzales, Kevin Forsberg, Mitchell Pesesky, Mayland Chang, Shahriar Mobashery
  • Patent number: 11559352
    Abstract: Ablation visualization and monitoring systems and methods are provided. In some embodiments, such methods comprise applying ablation energy to a tissue to form a lesion in the tissue, illuminating the tissue with a light to excite NADH in the tissue, wherein the tissue is illuminated in a radial direction, an axial direction, or both, monitoring a level of NADH fluorescence in the illuminated tissue to determine when the level of NADH fluorescence decreases from a base level in the beginning of the ablating to a predetermined lower level, and stopping ablation of the tissue when the level of NADH fluorescence reaches the predetermined lower level.
    Type: Grant
    Filed: May 21, 2020
    Date of Patent: January 24, 2023
    Assignees: The George Washington University, 460Medical, Inc.
    Inventors: Omar Amirana, Kenneth C. Armstrong, James Bowen, Cinnamon Larson, Marco A. Mercader, Terrance J. Ransbury, Narine Sarvazyan
  • Publication number: 20230014430
    Abstract: Among the various aspects of the present disclosure is the provision of methods and compositions for the generation of functionally mature beta cells having enhanced SIX2+ activity and therapeutic benefit and uses thereof. An aspect of the present disclosure provides for a method of generating SIX2-enhanced SC-? cells. In some embodiments, the method comprises providing a population of SC-? cells (or EP cells); providing a SIX2 positive regulator; and/or incubating the population of SC-? cells and the SIX2 positive regulator.
    Type: Application
    Filed: November 20, 2020
    Publication date: January 19, 2023
    Applicant: Washington University
    Inventors: Jeffrey Millman, Daniel Veronese Paniagua, Kristina Wernes, Leonardo Velazco-Cruz
  • Publication number: 20230020958
    Abstract: Methods for identifying MS in a subject based on an analysis of the strength of the immune-microbial homeostatic relationship based on the immune profile and the gut microbiome profile are described. In addition, methods of identifying MS patients likely to seek disease-modifying treatment within six months based on an analysis of the relative abundance of Barnesiella spp. based on the gut microbiome profile are described.
    Type: Application
    Filed: July 19, 2022
    Publication date: January 19, 2023
    Applicants: Washington University, University of Connecticut, THE JACKSON LABORATORY
    Inventors: Yanjiao Zhou, Laura Piccio
  • Publication number: 20230010794
    Abstract: Systems and methods for measuring a temperature using an optical whispering gallery mode (WGM) resonator are disclosed. The system includes a WGM resonator operatively coupled to a tunable laser source and a detector, as well as a computing device. The computing device is configured to transform a transmission spectrum from the detector into a measured barcode that includes a matrix of values indicative of at least one characteristic of the transmission spectrum. The computing device is further configured to transform the measured barcode into a temperature based on a relative collective shift of the measured barcode from a reference barcode selected from a predetermined library of reference barcodes.
    Type: Application
    Filed: July 7, 2022
    Publication date: January 12, 2023
    Applicant: Washington University
    Inventors: Lan Yang, Jie Liao
  • Patent number: 11548793
    Abstract: A process for gas-phase synthesis of titanium dioxide aerosol gels with controlled monomer size and crystalline phase using a diffusion flame aerosol reactor operated in a buoyancy-opposed configuration is disclosed. The process includes introducing a precursor stream into a diffusion flame aerosol reactor, introducing a fuel stream into the reactor, combusting the precursor stream and the fuel stream in a flame to form at least one nanoparticle, and operating the reactor in a down-fired buoyancy-opposed configuration to produce the aerosol gel.
    Type: Grant
    Filed: October 19, 2017
    Date of Patent: January 10, 2023
    Assignee: Washington University
    Inventors: Rajan K. Chakrabarty, Pai Liu
  • Patent number: 11542042
    Abstract: A matrix thruster that may be used to reposition and/or stabilize a CubeSAT satellite. The matrix thruster includes a conductive plate with an opening, a plurality of wires within the opening, a power supply electrically connected to the conductive plate or each of the plurality of wires via an inductor, and an electrical switch. The electrical switch creates a current change that creates an electric potential spike across the inductor. The electric potential spike across the inductor initiates an arc discharge between one of the wires and the conductive plate, which forms plasma that ejects cathode particles from the matrix thruster. Using multiple wires (e.g., four titanium wires) extends the lifetime of the thruster, as each wire restores an inter-electrode film needed for the other wires to continue generating plasma.
    Type: Grant
    Filed: September 15, 2020
    Date of Patent: January 3, 2023
    Assignee: The George Washington University
    Inventors: Keir Daniels, Zachary Switzer, Dimitris Kiaoulias, Michael Keidar
  • Patent number: 11542495
    Abstract: A sample containing particles having high-molecular-weight (HMW) DNA is entrapped in a gel matrix, and the gel matrix is exposed to a lysis reagent configured to release the HMW DNA from the particles. The HMW DNA may be purified by subjecting the gel matrix to an electrophoretic field that removes the HMW DNA from the particles, lysis reagents, and/or other sample constituents, from the gel matrix such that the HMW DNA remains. The gel matrix may be subjected with DNA cleavase reagents configured to cleave at specific DNA sequences within the HMW DNA to liberate defined segments of the DNA as fragments of reduced size. The gel matrix may also be subjected to an electrophoretic field, which moves and separates the DNA fragments from uncleaved DNA of the HMW DNA, which remains substantially immobile. The electrophoretically separated DNA fragments may be isolated from the gel matrix.
    Type: Grant
    Filed: November 21, 2016
    Date of Patent: January 3, 2023
    Assignees: Sage Science, Inc., Washington University
    Inventors: Robi David Mitra, Jeffrey Milbrandt, Ezra Solomon Abrams, Todd J. Barbera, T. Christian Boles
  • Patent number: 11543483
    Abstract: Methods, computer-readable storage devices, and systems are described for reducing movement of a patient undergoing a magnetic resonance imaging (MRI) scan by aligning MRI data, the method implemented on a Framewise Integrated Real-time MRI Monitoring (“FIRMM”) computing device including at least one processor in communication with at least one memory device. Aspects of the method comprise receiving a data frame from the MRI system, aligning the received data frame to a preceding data frame, calculating motion of a body part between the received data frame and the preceding data frame, calculating total frame displacement, and excluding data frames with a cutoff above a pre-identified threshold of the total frame displacement.
    Type: Grant
    Filed: October 20, 2021
    Date of Patent: January 3, 2023
    Assignees: Washington University, Oregon Health & Science University
    Inventors: Nico Dosenbach, Jonathan Koller, Andrew Van, Abraham Snyder, Amy Mirro, Damien Fair, Eric Earl, Rachel Klein, Oscar Miranda Dominguez, Anders Perrone
  • Patent number: 11534423
    Abstract: Among the various aspects of the present disclosure is the provision of methods and compositions for improving exercise endurance, performance, or tolerance using an S1P inhibiting agent.
    Type: Grant
    Filed: January 2, 2020
    Date of Patent: December 27, 2022
    Assignee: Washington University
    Inventors: Rita Brookheart, Brian Finck
  • Publication number: 20220401468
    Abstract: A method of treating an RNA virus infection in a subject in need that includes administering a therapeutically effective amount of a heparanase inhibitor. The RNA virus includes SARS-CoV-1, SARS-CoV-2, HTLV-1, HIV-1, and any combination thereof. The heparanase inhibitor includes heparin, a heparin mimetic, or any combination thereof. In some aspects, the heparanase inhibitor is Roneparstat. In some aspects, the administration of the therapeutically effective amount of the heparanase inhibitor results in the inhibition of infection by the RNA virus and associated inflammatory cytokine production.
    Type: Application
    Filed: June 15, 2022
    Publication date: December 22, 2022
    Applicant: Washington University
    Inventors: Katherine Weilbaecher, Jingyu Xiang
  • Patent number: 11529108
    Abstract: A positron emission tomography (PET) technique that can enhance the image resolution and system sensitivity of a clinical PET/CT scanner for imaging a whole body or a target region of a subject is provided. The system includes a detector array and a detector panel. The detector array includes an array of gamma ray detectors defining a field of view of a scanner and configured to detect at least one coincidence event. The detector panel includes an array of gamma ray detectors having a higher intrinsic spatial resolution than the detector array and positioned in closer proximity to a patient table than the detector array. The detector panel is positioned outside the field of view defined by the detector array during at least a portion of scanning by the PET system. The detector panel is configured to detect at least one coincidence event in cooperation with the detector array.
    Type: Grant
    Filed: November 27, 2019
    Date of Patent: December 20, 2022
    Assignee: Washington University
    Inventors: Yuan-Chuan Tai, Joseph O'Sullivan, Ke Li, Qiang Wang
  • Patent number: 11530245
    Abstract: Mussels strongly adhere to a variety of surfaces by secreting byssal threads that contain mussel foot proteins (Mfps). Recombinant production of Mfps presents an attractive route for preparing advanced adhesive materials. Using synthetic biology strategies, Mfp5 together with Mfp5 oligomers containing two or three consecutive, covalently-linked Mfp5 sequences (named Mfp52 and Mfp53) were synthesized. Positive correlations were found between Mfp5 molecular weight and underwater adhesive properties, including adhesion force, adhesion work, protein layer thickness, and recovery distance. Dopa-modified Mfp53 displayed a high adhesion force (201±36 nN ?m?1) and a high adhesion work (68±21 fJ ?m?1) for 200 s cure times, higher than previously reported Mfp-mimetic adhesives. Results disclosed herein highlight the power of synthetic biology in producing biocompatible and highly adhesive Mfp-based materials.
    Type: Grant
    Filed: August 28, 2019
    Date of Patent: December 20, 2022
    Assignee: Washington University
    Inventors: Fuzhong Zhang, Eugene Kim
  • Publication number: 20220395511
    Abstract: Among the various aspects of the present disclosure is the provision of OXTR chaperones and methods of use thereof. An aspect of the present disclosure provides for a method of increasing the display of oxytocin receptor (OXTR) on a plasma membrane in a cell of a subject comprising: administering an OXTR chaperone, wherein the OXTR chaperone increases OXTR on a cell surface. Another aspect of the present disclosure provides for a method of increasing or restoring oxytocin sensitivity in a subject comprising: administering an OXTR chaperone, wherein the OXTR chaperone increases OXTR on a cell surface. Yet another aspect of the present disclosure provides for a method of increasing the efficacy of oxytocin or synthetic oxytocin in a subject comprising: administering an OXTR chaperone, wherein the OXTR chaperone increases OXTR on a cell surface.
    Type: Application
    Filed: June 10, 2022
    Publication date: December 15, 2022
    Applicant: Washington University
    Inventors: Sarah England, Manasi Malik, Princess Imoukhuede, Yingye Fang
  • Publication number: 20220396597
    Abstract: N-methyl-d-aspartate receptors (NMDAR) and/or potentiating y-aminobutyric acid receptors (GABAAR) agents and uses thereof are described. Uses of these agents include methods of treating or preventing various psychiatric diseases, disorders, or conditions and methods of treating or preventing alcohol use disorder in a subject in need thereof.
    Type: Application
    Filed: October 16, 2020
    Publication date: December 15, 2022
    Applicant: Washington University
    Inventors: Douglas Covey, Steven Mennerick
  • Patent number: 11527891
    Abstract: Waveforms in power grids typically reveal a certain pattern with specific features and peculiarities driven by the system operating conditions, internal and external uncertainties, etc. This prompts an observation of different types of waveforms at the measurement points (substations). An innovative next-generation smart sensor technology includes a measurement unit embedded with sophisticated analytics for power grid online surveillance and situational awareness. The smart sensor brings additional levels of smartness into the existing phasor measurement units (PMUs) and intelligent electronic devices (IEDs). It unlocks the full potential of advanced signal processing and machine learning for online power grid monitoring in a distributed paradigm.
    Type: Grant
    Filed: November 30, 2019
    Date of Patent: December 13, 2022
    Assignee: The George Washington University
    Inventors: Payman Dehghanian, Shiyuan Wang