Abstract: Among the various aspects of the present disclosure is the provision of detecting proteins associated with Alzheimer's disease (AD) or risk variant thereof; diagnosis, prognosis, and monitoring of disease progression; or monitoring treatment.

Abstract: Among the various aspects of the present disclosure is the provision of methods for producing radioisotopes and improving the specific activity of radioisotopes (e.g., Cu-64 chloride). As described herein, the method includes matching of the target material and the proton beam strike area or the proton beam strike shape, resulting in improved specific activity while reducing the amount of target material used.

Abstract: Among the various aspects of the present disclosure is the provision of method of inducing or providing a pH gradient in electrochemical or chemical systems. Briefly, the pH gradient is induced by use of coated particles or films with an ion exchange ionomer.

Abstract: Effective management of cloud computing service levels (e.g. availability, performance, security) and financial risk is dependent on the cloud service provider's (CSP's) capability and trustworthiness. The invention applies industry cloud service level agreements (SLAs) with statistical and machine learning models for assessing CSPs and cloud services, and predicting performance and compliance against service levels. Cloud SLAs (ISO/IEC, EC, ENISA), cloud security requirements and compliance (CSA CCM, CAIQ), along with CSP performance (SLAs, cloud services) are analyzed via Graph Theory analysis and MCDA AHP to calculate CSP trustworthiness levels. CSP trustworthiness levels are input with CSP SLA content, cloud service performance measurements and configuration parameters into machine learning Regression analysis models to predict CSP cloud service performance and cloud SLA compliance, and enable model analysis and comparison.

Abstract: The present disclosure describes a method for the treatment of pancreatic cancer includes administering an effective amount of an MK2 inhibiting agent. In other aspects, the method may include administering the effective amount of the MK2 inhibiting agent in combination with a chemotherapy composition. In additional aspects, a composition for the treatment of pancreatic cancer is disclosed that includes an effective amount of an MK2 inhibiting agent and an effective amount of a chemotherapy composition.

Abstract: A self-capacitance based remote power delivery device includes a power source, an energy harvesting device, and a substrate. The power source and the energy harvesting device are configured to be capacitively coupled to a self-capacitive body. The substrate is configured to be capacitively coupled to a portion of the self-capacitive body in contact with the substrate.

Abstract: The present disclosure relates to modulation of protein expression.

Abstract: Systems, devices and methods for determining an orientation and a rotational mobility of the single point emitter using a duo-spot point spread function (PSF) phase mask are disclosed. The duo-spot PSF phase mask includes at least three partitions, in which each partition includes a phase delay ramp aligned along one of two phase delay axes. Each phase delay ramp includes a gradient of phase delays. Each partition includes a subset of a total area of the phase mask and the two phase delay axes are oriented in different directions. The duo-spot PSF phase mask is configured to produce a duo-spot PSF that includes two light spots. The relative brightness of the two spots encodes an orientation and a rotational mobility of the single point emitter.

Abstract: The ability to rapidly identify symmetry and anti-symmetry is an essential attribute of intelligence. Symmetry perception is a central process in human vision and may be key to human 3D visualization. While previous work in understanding neuron symmetry perception has concentrated on the neuron as an integrator, the invention provides the coincidence detecting property of the spiking neuron can be used to reveal symmetry density in spatial data. A synchronized symmetry-identifying spiking artificial neural network enables layering and feedback in the network. The network of the invention can identify symmetry density between sets of data and present a digital logic implementation demonstrating an 8×8 leaky-integrate-and-fire symmetry detector in a field-programmable gate array. The efficiency of spiking neural networks can be harnessed to rapidly identify symmetry in spatial data with applications in image processing, 3D computer vision, and robotics.

Abstract: This invention relates, e.g., to a Myocyte-based Flow Assist Device (MFAD) for treating a subject in need of increased flow of a biological fluid, such as venous blood or lymph, comprising a sheath which comprises rhythmically contracting myocytes.

Abstract: A three-dimensional electrospun biomedical patch includes a first polymeric scaffold having a first structure of deposited electrospun fibers extending in a plurality of directions in three dimensions to facilitate cellular migration for a first period of time upon application of the biomedical patch to a tissue, wherein the first period of time is less than twelve months, and a second polymeric scaffold having a second structure of deposited electrospun fibers. The second structure of deposited electrospun fibers includes the plurality of deposited electrospun fibers configured to provide structural reinforcement for a second period of time upon application of the three-dimensional electrospun biomedical patch to the tissue wherein the second period of time is less than twelve months. The three-dimensional electrospun biomedical patch is sufficiently pliable and resistant to tearing to enable movement of the three-dimensional electrospun biomedical patch with the tissue.

Abstract: Among the various aspects of the present disclosure is the provision of methods and compositions for modulating the Natural Cyotoxicity Receptor 2 (NCR2).

Abstract: The present invention is related to a dual promoter lentiviral vector and methods of use for the treatment of diseases and disorders, specifically lysosomal storage disorders.

Abstract: Self-assembling compounds for the formation of ion channels in biological membranes include monoacylated benzo(crown-ether) (MAcBCE) compounds and monoalkylated benzo(crown-ether) (MAkBCE) compounds. Methods of preparing the MAcBCE and MAkBCE compounds and methods of forming an ion channel in a biological membrane are also disclosed.

Abstract: A computing device for use in a system for mapping brain activity of a subject includes a processor. The processor is programmed to select a plurality of measurements of brain activity that is representative of at least one parameter of a brain of the subject during a resting state. Moreover, the processor is programmed to compare at least one data point from each of the measurements with a corresponding data point from a previously acquired data set from at least one other subject. The processor is also programmed to produce at least one map for each of the measurements based on the comparison of the resting state data point and the corresponding previously acquired data point. The processor may also be programmed to categorize the brain activity in a plurality of networks in the brain based on the map.

Abstract: Among the various aspects of the present disclosure is the provision of methods for treating pathologic calcification or bone formation and methods of inhibiting KIF26B that include administering a therapeutically effective amount of a synthetic nucleic acid against KIF26B. Compositions comprising a small hairpin RNA (shRNA) against KIF26B are also provided.

Abstract: Systems, devices, and methods for producing an optimized phase mask for use in a single-molecule orientation localization microscopy (SMOLM) imaging system are disclosed.

Abstract: Isolated polypeptides having enhanced affinity for a PDGF receptor and/or a VEGF receptor are provided. Compositions comprising the polypeptides and methods of use thereof are also provided.

Abstract: A method of performing personalized neuromodulation on a subject is provided. The method includes acquiring functional magnetic resonance imaging (fMRI) data of a brain of the subject. The method also includes calculating functional connectivity of the brain between a voxel in a subcortical region of the brain and a voxel in a cortical region of the brain, based on the fMRI data. The method also includes identifying a target location in the brain to be targeted by neuromodulation based on the calculated functional connectivity.

Abstract: A passive heat switch device is disclosed that includes a casing defining a closed channel, as well as a passive thermal actuator and liquid slug positioned inside the closed channel. The closed channel includes a heat conducting region made of a heat conducting material and an insulating region made of an insulating material. The passive thermal actuator is thermally coupled to the heat conducting material of the heat conducting region and extends into the insulating region of the closed channel. The passive thermal actuator deforms when an actuator temperature falls within a switching temperature range. The liquid slug is positioned within the closed channel and contacts at least a portion of the passive thermal actuator and the closed channel and is configured to move along the closed channel between the insulating region and the thermally conductive region in response to deformation of the passive thermal actuator.