Abstract: A method of treating reperfusion injury in a tissue of a subject in need thereof. The method includes applying light, to the tissue, that inhibits electron transfer from cytochrome c to cytochrome c oxidase (CcO) to molecular oxygen to attenuate creation of reactive oxygen species. The light includes wavelengths in a first wavelength range of 730-770 nm and a second wavelength range of 930-970 nm.
Type:
Grant
Filed:
April 27, 2021
Date of Patent:
July 15, 2025
Assignee:
Wayne State University
Inventors:
Maik Huettemann, John Kamholz, Icksoo Lee, Karin Przyklenk, Lawrence Grossman, Thomas H. Sanderson
Abstract: Methods according to aspects of the disclosure, compositions and kits therefore, include at least one, two, or three sets of amplification primers and hydrolysis probes with at least two separate corresponding readouts per set. According to aspects of the present disclosure, the at least two hydrolysis probes and associated pair of primers of each set are directed to opposite strands of an amplification product of the set. According to aspects of the present disclosure, one of the two hydrolysis probes in each set is directed to a first strand of the amplification product and therefore has a sequence complementary to the first strand of the amplification product and the second of the two hydrolysis probes in the set is directed to the second strand of the amplification product and therefore has a sequence complementary to the second strand of the amplification product.
Abstract: Ventricular catheters and other embodiments are provided. The catheter for shunting fluid includes a tip end, a first portion, and a second portion. The first portion is between and in fluid communication with the tip end and the second portion. The first portion is configured to have a tapered shape. The first portion includes multiple rows of holes.
Type:
Application
Filed:
September 9, 2022
Publication date:
July 3, 2025
Applicant:
Wayne State University
Inventors:
Carolyn Harris, Ahmad Faryami, Adam Menkara, Daniel Viar
Abstract: Microbial type rhodopsins, such as the light-gated cation-selective membrane channel, channelrhodopsin-2 (Chop2/ChR2) or the ion pump halorhodopsin (HaloR) are expressed in retinal ganglion cells upon transduction using recombinant AAV vectors. Selective targeting of these transgenes for expression in discrete subcellular regions or sites is achieved by including a sorting motif in the vector that can target either the central area or surround (off-center) area of these cells. Nucleic acid molecules comprising nucleotide sequences encoding such rhodopsins and sorting motifs and their use in methods of differential expression of the transgene are disclosed. These compositions and methods provide significant improvements for restoring visual perception and various aspects of vision, particular in patients with retinal disease.
Abstract: Systems and methods (S/M) to detect stress in stem cells are described. The S/M, including modified stem cells, assays and high throughput screens, can be used to identify compounds or other potential stressors that can negatively affect development potential.
Abstract: Kits and methods to distinguish between false and true labor are provided. The kits and methods can utilize differences in abundance and/or differences in the rate of change in abundance of B7-H2, SORC2, TF, C1-Esterase Inhibitor, Ran, IMDH1 and/or PGAM1, as markers of true labor.
Type:
Grant
Filed:
January 16, 2024
Date of Patent:
April 29, 2025
Assignees:
Wayne State University, The United States of America, as Represented by the Secretary, Department of Health & Human Services
Inventors:
Adi L. Tarca, Piya Chaemsaithong, Tinnakorn Chaiworapongsa, Sonia S. Hassan, Roberto Romero
Abstract: Apparatuses, systems, and methods for Raman spectroscopy are described. In certain implementations, a spectrometer is provided. The spectrometer may include a plurality of optical elements, comprising an entrance aperture, a collimating element, a volume phase holographic grating, a focusing element, and a detector array. The plurality of optical elements are configured to transfer the light beam from the entrance aperture to the detector array with a high transfer efficiency over a preselected spectral band.
Type:
Grant
Filed:
May 18, 2023
Date of Patent:
April 22, 2025
Assignee:
Wayne State University
Inventors:
Gregory William Auner, Michelle Ann Brusatori, Changhe Huang
Abstract: Biomarkers tests which can be used to predict a positive or negative risk of preeclampsia are described. More specifically, a panel of biomarkers including MMP-7 and gpIIbIIIa, described. The test is useful to predict preeclampsia when a biological sample is obtained between the 16th and 22nd week of pregnancy. Prediction later in pregnancy can be achieved by a combination of Siglec-6, Activin A, ALCAM, and/or FCN2.
Type:
Grant
Filed:
October 6, 2023
Date of Patent:
April 8, 2025
Assignees:
Wayne State University, The United States of America, as Represented by the Secretary, Department of Health & Human Services
Inventors:
Adi L. Tarca, Piya Chaemsaithong, Tinnakorn Chaiworapongsa, Sonia S. Hassan, Roberto Romero
Abstract: Glucose-responsive zwitterionic polymer-insulin-saccharide compositions are provided according to aspects of the present disclosure which include a zwitterionic polymer, an insulin moiety, a saccharide moiety, and a saccharide binding molecule. Methods of use of glucose-responsive zwitterionic polymer-insulin-saccharide compositions according to aspects of the present disclosure include administration to human patients to alleviate conditions, such as diabetes, which are responsive to administration of insulin.
Abstract: The invention provides compositions and kits including at least one nucleic acid or polypeptide molecule encoding for a mutant CoChop protein. Methods of the invention include administering a composition comprising a mutant CoChop to a subject to preserve, improve, or restore phototransduction. Preferably, the compositions and methods of the invention are provided to a subject having impaired vision, thereby restoring vision to normal levels.
Type:
Grant
Filed:
May 19, 2021
Date of Patent:
February 25, 2025
Assignee:
Wayne State University
Inventors:
Zhuo-Hua Pan, Tushar Ganjawala, Qi Lu, Gary Abrams
Abstract: Advancements in solid tumor (e.g., renal cell carcinoma) treatments and imaging are described. The advancements are based on nanoformulations that: (i) overcome deliverability issues associated with anti-cancer compounds; (ii) have increased targeted delivery to tumors, and hypoxic cores of tumors due to the presence of targeting ligands; (iii) have increased delivery to the hypoxic cores of tumors due to engineered shapes; (iv) provide synergistic treatment combinations; and/or (v) overcome cancer cell resistance to therapeutic treatments.
Type:
Application
Filed:
July 22, 2024
Publication date:
February 13, 2025
Applicant:
Wayne State University
Inventors:
Samaresh Sau, Arun K. Iyer, Hashem Alsaab
Abstract: Isothiocyanate (ITC)-androgen receptor (AR) inhibitor conjugates for apoptosis induction in cancer cells are described. The conjugates can have electrophilicity blocked with an agent such as N-acetyl cysteine. When administered in combination with a glutathione (GSH)-depleting agent, the conjugates result in ferroptosis of cancer cells.
Abstract: Down-regulating autoimmune regulator (AIRE) function in B cells to produce antibodies is described. The antibodies can be class-switched, high affinity, and neutralizing, and have a high degree of somatic hypermutations, even in the framework region, as compared to antibodies produced in the absence of AIRE downregulation.
Abstract: The current disclosure provides alternating current based systems and methods to develop chemical compounds, such as drug molecules using electrochemistry in organic synthesis.
Abstract: Systems and methods for regulating fluid flow are provided. A valve for regulating fluid flow includes a tubing, a regulating element, and an actuator. The tubing is configured to allow fluid flow therethrough. The regulating element is arranged proximate to the tubing. The actuator is arranged proximate to the regulating element, and is configured to manipulate a parameter associated with the regulating element.
Type:
Application
Filed:
September 9, 2022
Publication date:
December 26, 2024
Applicant:
Wayne State University
Inventors:
Carolyn Harris, Ahmad Faryami, Adam Menkara, Daniel Viar
Abstract: A device may include a metallic substrate and a plurality of nanorod arrays arranged on the substrate. The nanorod arrays may be made of porous metallic nanostructures and may appear black in color.
Abstract: A system for an engine to determine in situ under specified conditions the auto-ignition quality of the fuel used in a compression ignition engine is provided. The system may include an ion current sensor. The ion current sensor may access an engine cylinder for obtaining ion current data. A control unit may be in communication with the ion current sensor for receiving the ion current data. The control unit being configured to determine the auto-ignition quality of the fuel based on features of the ion current data.
Type:
Grant
Filed:
April 29, 2020
Date of Patent:
November 26, 2024
Assignee:
Wayne State University
Inventors:
Naeim A. Henein, Prasad D. Raut, Omkar A. Atre, Joseph Stempnik
Abstract: A boost or DC-DC converter includes a first output and a second output, a first inductor having a first side and a second side, the first side of the first inductor being connectable in electrical communication with a first output of a power supply or DC voltage source, and a second inductor having a first side and a second side, the first side of the second inductor being connectable in electrical communication with the first output of the power supply, the first inductor being inversely coupled to the second inductor. The converter includes a first switch in communication with the second side of the first inductor and a second output of the power supply, and a second switch in communication with the second side of the second inductor and the second output of the power supply.
Abstract: This disclosure provides compositions, devices, systems, and methods that reduce the likelihood, amount, or level of cellular deposition (and associated blockage and/or failure) of implantable medical devices, such as central nervous system implants. Embodiments involve use of inhibitor(s) of one or more of TLR-4, TNF-?, IL-1?, or IL-6, for instance, to prevent, reduce, or reverse activation of astrocyte and/or glia cells, and/or to prevent, reduce, or reverse attachment of such cells to the surface of a medical device in contact with a biological fluid, such as cerebrospinal fluid.
Type:
Application
Filed:
September 9, 2022
Publication date:
November 14, 2024
Applicant:
Wayne State University
Inventors:
Carolyn Harris, Mira Zaranek, Fatemeh Khodadadei
Abstract: Isothiocyanate (ITC)-androgen receptor (AR) inhibitor conjugates for apoptosis induction in cancer cells are described. The conjugates can have electrophilicity blocked with an agent such as N-acetyl cysteine. When administered in combination with a glutathione (GSH)-depleting agent, the conjugates result in ferroptosis of cancer cells.