Abstract: Various systems, methods, and devices for identifying intraoperative bleeding are described. An example method includes identifying a first frame depicting a surgical scene; identifying a second frame depicting the surgical scene; identifying whether the second frame depicts bleeding by analyzing the first frame and the second frame; and outputting the second frame with an augmentation indicating whether bleeding is depicted in the second frame.

Abstract: Methods discussed herein are directed to polymerase chain reaction (PCR) techniques, and more specifically quantitative-discrete PCR, wherein individual amplification reactions are performed on a per-payload basis among singly-captured and singly-isolated vesicles, for instance within individually sealed microwell reactors. These techniques enable post-process quality control measurements of per-vesicular manufacture loading efficiency and encapsulation efficiency of nucleic acid active ingredients in vesicular biologics, employing quantitative-discrete PCR techniques. By measuring variability of vesicular encapsulation of nucleic acids at a per-vesicular manufacture level of granularity, such techniques can enable collection of data that may be used to perform post-process formulation upon vesicular biologics, and to yield more homogenous formulations from both synthetic and biogenesis pathways.

Abstract: Methods and system are described for multi-modal, multi-parametric, non-invasive, and real-time assessment of cervical tissue through a multi-modal probe device for use within a vaginal canal and an associated imaging system to assess a risk of preterm delivery of an expectant mother. The multi-modal system may include ultrasound (US) imaging, viscoelastic (VE) imaging, and/or photoacoustic (PA) imaging of the cervical issue to determine cervical biomarker information indicative of parameters including, but not limited to, a collagen to water ratio such that a more water dominant ratio is indicative of a risk of preterm delivery.

Abstract: Systems, kits, methods to diagnose sarcoidosis are described. In addition to diagnosing sarcoidosis, the systems and methods can distinguish sarcoidosis from tuberculosis and lung cancer.

Abstract: Provided are systems and methods for assessing the presence or risk of obstetrical complications, particularly those related to an angiogenic and anti-angiogenic imbalance. Also provided are methods of treating an angiogenic and anti-angiogenic imbalance with water-soluble statins, such as pravastatin.

Abstract: Biomarkers tests which can be used to predict a positive or negative risk of preeclampsia are described. More specifically, a panel of biomarkers including MMP-7 and gpIIbIIIa, described. The test is useful to predict preeclampsia when a biological sample is obtained between the 16th and 22nd week of pregnancy. Prediction later in pregnancy can be achieved by a combination of Siglec-6, Activin A, ALCAM, and/or FCN2.

Abstract: A electronic device and a fabrication method is provided. The electronic device having a first electrode and a second electrode. A nano-gap is formed between first and second electrode. The first electrode, the second electrode and the gap may be located in the same layer of the device.

Abstract: The invention provides nucleic acids and nucleic acid expression vectors containing optimized mGluR6 promoters for expression of transgenes in the retina. The compositions and methods of the invention are useful for expression of gene products to preserve, improve, or restore phototransduction or vision.

Abstract: Described herein are systems using injectionless gel electrophoresis (GE), such as thermal GE (TGE), to selectively separate, concentrate, quantify, and/or otherwise analyze target analytes. Inline preconcentration and separation are demonstrated to resolve analytes, exemplified by resolving double-stranded miRNA-probe hybrids from excess single-stranded probes and analyzing multiple conformations of a protein. Microfluidic devices having a tapered channel are described, which improve detection sensitivity and separation resolution. The described separation strategy and microfluidic device designs establish injectionless gel electrophoresis as a simple, low-cost analysis method, for instance for analyzing clinical and pharmaceutical samples, including for miRNA, protein, and other biomolecular analyses.

Abstract: A detection layer (416) for a radiation detector (400) includes a porous silicon membrane (418). The porous silicon membrane includes silicon (419) with a first side (430) and a second opposing side (432), a plurality of pores (420) extending entirely through the silicon from the first side to the second opposing side, each including shared walls (426), at least one protrusion of silicon (424) protruding out and extending from the first side a distance (504, 604, 704). The porous silicon membrane further includes a plurality of radiation sensitive quantum dots (422) in the pores and a quantum dot layer disposed on the first side and having a surface (434) and a thickness (506, 606, 706), wherein the thickness is greater than the distance.

Abstract: Described herein are systems and methods for modeling fluid flow. The systems may comprise a plurality of chambers, a plurality of sensors, a pump, a plurality of valves, and a flow limiting operator (FLO). The respective sensor of the plurality of sensors may be configured to sense a respective monitoring parameter associated with the respective chamber. The pump may be configured to move media to or from the respective chamber. The respective valve of the plurality of valves may be configured to control a fluid velocity of the media flowing through the respective chamber. The FLO may be electrically connected to the plurality of sensors, the pump, and the plurality of valves. The FLO may be configured to independently control the respective chamber by manipulating one or more controllable parameters associated with the respective chamber based on the respective monitoring parameter associated with the respective chamber.

Abstract: Various systems, methods, and devices for identifying instrument movements likely to cause intraoperative bleeding are described. An example method includes identifying a movement of an instrument; determining that the movement of the instrument exceeds a threshold; and dampening the movement of the instrument based on determining that the movement exceeds the threshold.

Abstract: Molybdenum-DAD precursors are described. Methods for depositing molybdenum-containing films on a substrate are described. The substrate is exposed to a molybdenum-DAD precursor and a reactant to form the molybdenum-containing film (e.g., elemental molybdenum, molybdenum oxide, molybdenum carbide, molybdenum silicide, molybdenum nitride). The exposures can be sequential or simultaneous.

Abstract: Apparatuses, systems, and methods for Raman spectroscopy are described. In certain implementations, a spectrometer is provided. The spectrometer may include a plurality of optical elements, comprising an entrance aperture, a collimating element, a volume phase holographic grating, a focusing element, and a detector array. The plurality of optical elements are configured to transfer the light beam from the entrance aperture to the detector array with a high transfer efficiency over a preselected spectral band.

Abstract: Dendrimer-based compositions and methods are provided, that are useful for administering pharmaceutical compositions to target cells and tissues for treatment of ocular diseases including macular degeneration, diabetic retinopathy, and retinitis pigmentosa.

Abstract: Provided are systems and methods for assessing the presence or risk of obstetrical complications, particularly those related to an angiogenic and anti-angiogenic imbalance. Also provided are methods of treating an angiogenic and anti-angiogenic imbalance with water-soluble statins, such as pravastatin.

Abstract: A method of generating protein-induced pluripotent stem cells by delivering bacterially expressed reprogramming proteins into nuclei of starting somatic cells using the QQ-protein transduction technique, repeating several cell reprogramming cycles for creating reprogrammed protein-induced pluripotent stem cells, moving the reprogrammed cells into a feeder-free medium for expansion, and expanding and passaging the reprogrammed cells in a whole dish for generating homogeneous piPS cells. Also provided are the piPCS cells formed using this method and uses thereof.

Abstract: An exemplary system may include an augmented reality device with a user interface, a processor and memory having a program communicatively connected to the processor. A transceiver may be communicatively connected to a practitioner device for real-time practitioner guidance. The system may include a plurality of sensors and a feedback device in communication with the processor. The system may display initial and updated guidance objects in a real-time environment of the user and in response to sensor outputs of the plurality of sensors. The feedback device may provide at least one of audio, visual, and tactile feedback in response to the sensors outputs. The system may condition the user to provide a desired reaction by guiding the real-time user reactions in the real-time environment using the feedback in response to the sensor outputs.

Abstract: Methods for in vivo immunoimaging including: (a) administering a labeled-antibody conjugate to a subject, wherein the labeled-antibody conjugate includes: an antibody that specifically recognizes and binds to IFN-?, and a detection label conjugated to the antibody, wherein the detection label is a radionuclide tracer or tluorophore; and (b) detecting the presence of the radiolabeled-antibody conjugate in the subject in vivo by imaging. Embodiments of the present disclosure are directed to labeled-antibody conjugates and therapeutic radionuclide-antibody conjugates.

Abstract: A ring oscillator includes a first set of at least three laddered inverter quantizer (LIQAF) circuits connected in stages that are in series, including a first LIQAF circuit and a last LIQAF circuit, and a feedback circuit from the last LIQAF circuit to the first LIQAF circuit having a logical NOT output compared to the first LIQAF circuit. A voltage input creates a pair of phase shifted waveforms in the first of the at least three LIQAF circuits that propagate sequentially through the stages of the at least three LIQAF circuits. Each stage has a pair of outputs to the next stage that are then phase shifted from the previous stage in the next stage.