Patents Assigned to Wayne State University
  • Publication number: 20210017602
    Abstract: Systems and methods to diagnose sarcoidosis are described. In addition to diagnosing sarcoidosis, the systems and methods can distinguish sarcoidosis from tuberculosis. Further disclosed is a cDNA library and methods of its use for reliably identifying sarcoidosis markers.
    Type: Application
    Filed: August 3, 2020
    Publication date: January 21, 2021
    Applicants: Wayne State University, Henry Ford Health System
    Inventors: Lobelia Samavati, Harvinder S. Talwar, Rita Rosati, Felix Fernandez-Madrid, Jia Li
  • Patent number: 10890556
    Abstract: Materials and methods for generating nanowires are described. Krogmann salt potassium tetracyanoplatinate sesquihydrate (K(def)TCP) nanowires are synthesized as interconnects on metal lithographic patterns in which the K(def)TCP nanowires grow across the metal lines. The chemical sensing capability of the K(def)TCP chips is demonstrated by impedance measurements.
    Type: Grant
    Filed: November 9, 2017
    Date of Patent: January 12, 2021
    Assignee: WAYNE STATE UNIVERSITY
    Inventor: Guangzhao Mao
  • Patent number: 10874669
    Abstract: A compound having formula IA is useful for treating a neurodegenerative disease: or a pharmaceutically acceptable salt or ester thereof, where R0, R1, R2, R7, R8 are delineated substituents; A1 is a C6-12 aryl group, C5-12 heteroaryl group, substituted 3-hydroxypyridin-4(1H)-one, with i hydrogen atoms replaced with R7 and j hydrogen atoms replaced with R8; p is an integer from 1 to 6; X1, Y1 are each independently CH or N; M is absent or a divalent linking moiety in which Z is repeated m times; m is an integer from 0 to 5; i, j are each independently 0, 1, 2, or 3; and o is 0, 1, 2, 3, or 4.
    Type: Grant
    Filed: September 7, 2018
    Date of Patent: December 29, 2020
    Assignee: WAYNE STATE UNIVERSITY
    Inventor: Aloke K. Dutta
  • Patent number: 10857210
    Abstract: Compositions and methods to promote wound healing are described. The compositions and methods up-regulate X-box binding protein 1 (XBP1) and/or inositol-requiring enzyme-1 (IRE-1). In various embodiments, the compositions and methods can be used to promote wound healing in diabetic subjects.
    Type: Grant
    Filed: July 6, 2016
    Date of Patent: December 8, 2020
    Assignee: Wayne State University
    Inventors: Kezhong Zhang, Jiemei Wang
  • Publication number: 20200368313
    Abstract: Lipid-based drug delivery vehicles (including liposomal nanoparticles) are described which include antibiotic(s) for the FIG. 5 treatment of infections, such as Methicillin-Resistant Staphylococcus (S.) aureus (MRSA) infections and Methicillin-Susceptible S. aureus (MSSA) infections. These drug delivery vehicles have high drug-loading, do not accumulate in the liver, and can optionally include one or more targeting ligands.
    Type: Application
    Filed: December 28, 2018
    Publication date: November 26, 2020
    Applicant: Wayne State University
    Inventors: Arun K. Iyer, Samaresh Sau, Michael Rybak, Ketki Bhise, Razie Kebriaei
  • Publication number: 20200367750
    Abstract: A system for monitoring an ablation procedure in a target tissue includes a first light source for delivering light to the target tissue to generate photoacoustic signals and a second light source for delivering light to the target tissue for ablation therapy. The system further includes a beam mixer for receiving light from the first and second light sources to create a combined light beam. An ablation catheter including a single optical fiber receives the combined light beam from the beam mixer, wherein the combined light beam is emitted from a tip of the ablation catheter to perform simultaneous ablation therapy and photoacoustic monitoring of the ablation procedure in the target tissue in real time.
    Type: Application
    Filed: February 1, 2019
    Publication date: November 26, 2020
    Applicants: HENRY FORD HEALTH SYSTEM, WAYNE STATE UNIVERSITY
    Inventors: Mohammad MEHRMOHAMMADI, Loay KABBANI, Nicole A. KENNEDY, Yan YAN
  • Patent number: 10844012
    Abstract: Disclosed herein are antibacterial compounds, pharmaceutical compositions including the antibacterial compounds, and methods of treating bacterial infections using the compounds and compositions.
    Type: Grant
    Filed: May 27, 2020
    Date of Patent: November 24, 2020
    Assignee: Wayne State University
    Inventors: Fazlul H. Sarkar, Subhash Padhye, Bernhard Max Biersack, Hossein Salimnia
  • Publication number: 20200362458
    Abstract: Methods for depositing rhenium-containing thin films on a substrate are described. The substrate is exposed to a rhenium precursor and a reducing agent to form the rhenium-containing film (e.g., metallic rhenium, rhenium nitride). The exposures can be sequential or simultaneous.
    Type: Application
    Filed: May 14, 2020
    Publication date: November 19, 2020
    Applicants: Applied Materials, Inc., Wayne State University
    Inventors: Thomas Knisley, Keenan N. Woods, Mark Saly, Stefan Cwik, Charles H. Winter
  • Patent number: 10839707
    Abstract: An exemplary system may include an augmented reality device with a user interface, a processor and memory having a program communicatively connected to the processor. A transceiver may be communicatively connected to a practitioner device for real-time practitioner guidance. The system may include a plurality of sensors and a feedback device in communication with the processor. The system may display initial and updated guidance objects in a real-time environment of the user and in response to sensor outputs of the plurality of sensors. The feedback device may provide at least one of audio, visual, and tactile feedback in response to the sensors outputs. The system may condition the user to provide a desired reaction by guiding the real-time user reactions in the real-time environment using the feedback in response to the sensor outputs.
    Type: Grant
    Filed: September 8, 2016
    Date of Patent: November 17, 2020
    Assignee: Wayne State University
    Inventor: Arash Javanbakht
  • Patent number: 10828379
    Abstract: A method of magnetic resonance imaging a target tissue in a subject includes a step of administering a first Eu2+-containing complex to the subject. The first Eu2+-containing complex has a reduction potential that is more negative than a reduction potential for a selected compound present in the target tissue. A first set of images of the target tissue in the subject is then taken by T1-weighted magnetic resonance imaging.
    Type: Grant
    Filed: March 11, 2016
    Date of Patent: November 10, 2020
    Assignee: WAYNE STATE UNIVERSITY
    Inventor: Matthew J. Allen
  • Publication number: 20200347463
    Abstract: Systems and methods (S/M) to detect stress in stem cells are described. The S/M, including modified stem cells, assays and high throughput screens, can be used to identify compounds or other potential stressors that can negatively affect development potential.
    Type: Application
    Filed: May 27, 2020
    Publication date: November 5, 2020
    Applicant: Wayne State University
    Inventors: Daniel A. Rappolee, Elizabeth Puscheck
  • Publication number: 20200338211
    Abstract: Advancements in solid tumor (e.g., renal cell carcinoma) treatments and imaging are described. The advancements are based on nanoformulations that: (i) overcome deliverability issues associated with anti-cancer compounds; (ii) have increased targeted delivery to tumors, and hypoxic cores of tumors due to the presence of targeting ligands; (iii) have increased delivery to the hypoxic cores of tumors due to engineered shapes; (iv) provide synergistic treatment combinations; and/or (v) overcome cancer cell resistance to therapeutic treatments.
    Type: Application
    Filed: December 28, 2018
    Publication date: October 29, 2020
    Applicant: Wayne State University
    Inventors: Samaresh Sau, Arun K. Iyer, Hashem Alsaab
  • Patent number: 10815916
    Abstract: A system and method is provided for the use of the ion current signal characteristics for onboard cycle-by-cycle, cylinder-by-cylinder measurement. The system may also control the engine operating parameters based on a predicted NOx emission level, CO emission level, CO2 emission level, O2 emission level, unburned hydrocarbon (HC) emission level, cylinder pressure, or a cylinder temperature measurement according to characteristics of the ion current signal.
    Type: Grant
    Filed: August 17, 2018
    Date of Patent: October 27, 2020
    Assignee: Wayne State University
    Inventors: Tamer H. Badawy, Fadi A. Estefanous, Naeim A. Henein
  • Patent number: 10808239
    Abstract: Methods of isolating DNA of a fetus of an ongoing pregnancy are provided according to the present invention which include obtaining a maternal endocervical sample containing maternal cells and fetal extravillous trophoblast cells from a pregnant subject; isolating fetal extravillous trophoblast cells from the maternal endocervical sample, producing isolated fetal extravillous trophoblast cells contaminated with maternal DNA; lysing the isolated fetal extravillous trophoblast cells; isolating fetal nuclei from the lysed fetal extravillous trophoblast cells, producing isolated fetal nuclei, thereby removing at least a portion of the contaminating maternal DNA; and purifying genomic DNA from the isolated fetal nuclei, producing purified fetal genomic DNA. The purified fetal genomic DNA can be assayed to determine a characteristic of a genomic DNA sequence of the purified fetal genomic DNA, thereby determining a characteristic of DNA of a fetus of an ongoing pregnancy.
    Type: Grant
    Filed: April 6, 2017
    Date of Patent: October 20, 2020
    Assignee: Wayne State University
    Inventors: Sascha Drewlo, D. Randall Armant
  • Patent number: 10802030
    Abstract: Provided are systems and methods to identify subjects at risk for preterm labor and/or preterm birth. The systems and methods utilize biomarkers. Also provided are systems and methods for decreasing the risk of preterm labor by administering a treatment following a positive risk identification.
    Type: Grant
    Filed: April 20, 2018
    Date of Patent: October 13, 2020
    Assignees: Wayne State University, The United States of America as Represented by the Secretary, Department of Health and Human Service
    Inventors: Adi L. Tarca, Offer Erez, Tinnakorn Chaiworapongsa, Sonia S. Hassan, Roberto Romero
  • Patent number: 10799522
    Abstract: Compositions and methods for detection and assessment of galectins are provided by the present invention, including labeled compositions, pharmaceutical composition including a labeled composition for galectin detection and a pharmaceutically acceptable carrier, method of aiding in diagnosis and/or treatment of a condition characterized by upregulation of one or more galectins in a subject in need thereof and precursor compositions for synthesis of chemical compositions, including but not limited to labeled compositions for detection and assessment of galectins.
    Type: Grant
    Filed: July 27, 2016
    Date of Patent: October 13, 2020
    Assignee: Wayne State University
    Inventors: Juri G. Gelovani, Nashaat Turkman, Vadim Popov, Robin Bonomi, Aleksandr Shavrin, Philip Alther, Andrei Borisov
  • Patent number: 10781489
    Abstract: Systems and methods to diagnose sarcoidosis are described. In addition to diagnosing sarcoidosis, the systems and methods can distinguish sarcoidosis from tuberculosis. Further disclosed is a cDNA library and methods of its use for reliably identifying sarcoidosis markers.
    Type: Grant
    Filed: March 4, 2016
    Date of Patent: September 22, 2020
    Assignees: WAYNE STATE UNIVERSITY, HENRY FORD HEALTH SYSTEM
    Inventors: Lobelia Samavati, Harvinder S. Talwar, Rita Rosati, Felix Fernandez-Madrid, Jia Li
  • Patent number: 10782302
    Abstract: Polypeptide marker antigens for detecting the presence of autoantibody biomarkers associated with ovarian cancer recurrence, each of the polypeptide marker antigens binding specifically to at least one autoantibody marker. An antibody binding assay for detecting the presence of autoantibody biomarkers associated with ovarian cancer recurrence, and methods for performing the assay. Methods for determining ovarian cancer recurrence in an ovarian cancer patient. A method for isolating antibodies specific for ovarian cancer by their affinity to the polypeptide marker antigens, and antibodies isolated by that method.
    Type: Grant
    Filed: October 17, 2017
    Date of Patent: September 22, 2020
    Assignee: Wayne State University
    Inventors: Michael Tainsky, Madhumita Chatterjee, Gregory Dyson, Nancy Levin
  • Patent number: 10774773
    Abstract: A system and method to enable electronically controlled internal combustion engines to self-adjust parameters and operate properly on different fuels that have wide ranges of physical and chemical properties. Input from a sensor is utilized that gives a signal indicative of the combustion process. The ECU processes the signal and readjusts the engine operating parameters to achieve its operating goals.
    Type: Grant
    Filed: January 26, 2012
    Date of Patent: September 15, 2020
    Assignee: WAYNE STATE UNIVERSITY
    Inventors: Naeim A. Henein, Tamer H. Badawy
  • Publication number: 20200281946
    Abstract: Treatments and diagnostics for treatment efficacy against solid and liquid cancers are described. The treatments utilize a combination therapy of Galeterone and a proteasome inhibitor. The diagnostics can measure androgen receptor (AR) cleavage products including AR-variant 7 (AR-V7) cleavage products, Poly (ADP-ribose) polymerase (PARP) cleavage products, and/or Spectrin ?2 cleavage products or inhibition of DUB activities from a blood sample to monitor treatment efficacy for castration-resistant prostate cancer (CRPC) or multiple myeloma (MM).
    Type: Application
    Filed: May 5, 2020
    Publication date: September 10, 2020
    Applicant: Wayne State University
    Inventors: Qingping Dou, Huanjie Yang, Elisabeth I. Heath