Patents Assigned to Wayne State University
  • Patent number: 12651740
    Abstract: A lithium-ion battery may include a lithium-free cathode, a lithiated anode, and a separator/electrolyte between the lithium-free cathode and the lithiated anode. The lithium-free cathode may include FeOF and MnO2. The FeOF may be in the form of nanorods, and the MnO2 may be in the form of monolayer nanosheets. The FeOF nanorods may be sandwiched or wrapped by the monolayer MnO2 nanosheets.
    Type: Grant
    Filed: March 5, 2021
    Date of Patent: June 9, 2026
    Assignee: Wayne State University
    Inventors: Da Deng, Venkata Rohit Punyapu
  • Publication number: 20260152303
    Abstract: A smart landing platform system includes a flat and rigid platform for landing a drone and having a geometrical center, a center of gravity and a weight, a digital scale disposed beneath the platform for providing measurements of a weight distribution of the platform and the drone, and a control unit connected to the digital scale for instantaneous data collection and storing logic including a statistical inference algorithm based on a nonlinear least squares model to perform automated pre-flight safety check for the drone.
    Type: Application
    Filed: January 27, 2026
    Publication date: June 4, 2026
    Applicant: WAYNE STATE UNIVERSITY
    Inventors: Zhenyu ZHOU, Yanchao LIU
  • Patent number: 12636098
    Abstract: Various systems, methods, and devices for identifying intraoperative bleeding are described. An example method includes identifying a first frame depicting a surgical scene; identifying a second frame depicting the surgical scene; identifying whether the second frame depicts bleeding by analyzing the first frame and the second frame; and outputting the second frame with an augmentation indicating whether bleeding is depicted in the second frame.
    Type: Grant
    Filed: September 22, 2021
    Date of Patent: May 26, 2026
    Assignees: Wayne State University, RediMinds, Inc.
    Inventors: Abhilash K. Pandya, Mostafa Daneshgar Rahbar, Luke A. Reisner, Hao Ying, Mahendra Bhandari, Madhusudhan Reddiboina
  • Patent number: 12625288
    Abstract: A source emits a pulse to an object to generate a particle, and an imaging detector produces a light flash at an X/Y hit position of the particle. The detector outputs a waveform arising from the particle. An event-driven camera provides a signal from the detector that includes intensity and time-over-threshold signals related to the light flash, time-of-arrival information of the event, and the X and Y hit position of the particle. A photodiode determines a time origin of the pulse from the source. A timing circuit is coupled to the detector and to the photodiode, and determines time-of-flight (TOF) of the particle based on the waveform, and based on the time origin of the pulse. The 3D coordinates are generated based on the X/Y hit position synchronized with the TOF of the particle.
    Type: Grant
    Filed: February 8, 2022
    Date of Patent: May 12, 2026
    Assignee: Wayne State University
    Inventors: Wen Li, Suk Kyoung Lee, Gabriel Stewart, Duke Debrah
  • Patent number: 12616382
    Abstract: A wearable mechano-acoustic sensor for continuous cardiorespiratory monitoring, and methods of making and using the same. The sensor includes a diaphragm with a chamber and a channel connected to the chamber, a plurality of electrodes including at least an anode and a cathode extending into the channel, and a liquid electrolyte solution that fills the chamber and channel. When the diaphragm is attached to a user's chest, mechano-acoustic movement from the chest cause the diaphragm to move, pushing the electrolyte solution across the electrodes. A voltage is applied to the anode and an electrochemical current is determined by the flux from the anode to the cathode by the modulation of the electrolyte solution across the electrodes and cardiorespiratory signals are measured from the electrochemical currents.
    Type: Grant
    Filed: January 10, 2023
    Date of Patent: May 5, 2026
    Assignee: Wayne State University
    Inventors: Yong Xu, Zhiguo Zhao, Xiaoce Feng, Xiaoyu Chen
  • Patent number: 12611463
    Abstract: Only limited success has been previously achieved from cancer vaccines targeting unmodified tumor-associated self-antigens and new compositions and methods are needed. Immunogenic compositions and methods of use thereof are provided according to the present disclosure which include a protein effective to stimulate immune activity against a tumor-associated self-antigen, or a variant thereof which is a tumor-associated self-antigen.
    Type: Grant
    Filed: December 4, 2023
    Date of Patent: April 28, 2026
    Assignee: Wayne State University
    Inventors: Wei-Zen Wei, Richard F. Jones, Joyce Reyes, Heather Gibson
  • Publication number: 20260077168
    Abstract: Systems and methods for regulating fluid flow are provided. Specific examples are device or system (such as a catheter system) for regulating fluid flow including a tubing configured to allow fluid flow therethrough, an implantable valve, and an external actuating component. The implantable valve includes a regulating element arranged proximate to the tubing. In use, the actuating component (which may be external to the body of the subject or arranged inside the subject's body) is arranged proximate to the regulating element. The actuating component, which may be an external actuating component, is configured to manipulate a parameter associated with the regulating element.
    Type: Application
    Filed: March 15, 2023
    Publication date: March 19, 2026
    Applicant: Wayne State University
    Inventors: Carolyn Harris, Ahmad Faryami, Adam Menkara, Daniel Viar
  • Patent number: 12578421
    Abstract: A system for locating a sound source includes at least four emitter/receiver pairs, each emitter/receiver pair of the at least four emitter/receiver pairs including a laser emitter and a receiver external to an enclosed structure. The laser directs a laser beam onto a respective reflector surface location on an outer surface of the structure, the respective reflector surface location being caused to vibrate due to sound waves generated from a sound source at a sound source location within the enclosed structure. The receiver receives vibrational signals from the laser beam on the surface at the respective reflector surface location and converting the vibrational signals to acoustic signals. A processor coupled to the emitter/receiver pairs for utilizing the acoustic signals to determine a time difference of arrival of the sound waves to the respective reflector surface locations to determine the sound source location based on the time difference of arrivals.
    Type: Grant
    Filed: March 21, 2023
    Date of Patent: March 17, 2026
    Assignee: Wayne State University
    Inventors: Sean F. Wu, Antonio Figueroa Mombela, Yazhong Lu
  • Patent number: 12580220
    Abstract: A hybrid solid-state electrolyte layer for use in an electrochemical cell is provided. The hybrid solid-state electrolyte layer includes a polymeric material, a ceramic material, and an interfacial material adhering the polymeric material and the ceramic material. The interfacial material includes a branched copolymer that includes dopamine and a second monomer. The second monomer forms a polymeric moiety in the copolymer that is the same or similar to the polymeric material. In certain variations, the polymeric material defines a polymeric layer, the ceramic material defines a ceramic layer, and the interfacial material defines an interfacial layer that is disposed between the polymeric layer and the ceramic layer. In other variations, the polymeric material defines a polymeric matrix, the ceramic material defines a plurality of ceramic particles dispersed in the polymeric matrix, and the plurality of ceramic particles are coated with the interfacial material.
    Type: Grant
    Filed: August 26, 2022
    Date of Patent: March 17, 2026
    Assignees: GM GLOBAL TECHNOLOGY OPERATIONS LLC, WAYNE STATE UNIVERSITY
    Inventors: Fan Xu, Robert D. Schmidt, Mei Cai, Manuela Ferreira Borras, Yingxi Elaine Zhu
  • Patent number: 12571100
    Abstract: Methods for depositing molybdenum silicide films on a substrate are described. The substrate is exposed to a molybdenum- and silicon-containing precursor and a silane reactant to form the molybdenum silicide film. The exposures can be sequential or simultaneous. Inherent deposition selectivity of the process can be achieved through adjusting process parameters, particularly temperature or precursor dose, to produce more deposition on a metal material over a dielectric material.
    Type: Grant
    Filed: May 3, 2024
    Date of Patent: March 10, 2026
    Assignees: Applied Materials, Inc., Wayne State University
    Inventors: Thomas Joseph Knisley, Daniel Wei Ming Beh, Zachary J. Devereaux, Avgerinos V. Gelatos, Jeffrey W. Anthis, Charles H. Winter
  • Publication number: 20260062446
    Abstract: A compound having formula I that is useful for preparing an anabaenopeptin or derivatives thereof is provided: or a salt thereof and/or stereoisomers thereof and/or isotopic variations thereof, wherein: X1, X2, X3, and X4 are alkyl, aryl, hydroxyl, alkyl phenyl, alkyl phenol, and benzyl groups; and R1, R2, R3, R4, and R5 are H or C1-10 alkyl, wherein at least one of X1, X2, X3, and X4 is alkyl phenol, with the proviso that at least one of X1, X2, X3, and X4 are alkyl phenol.
    Type: Application
    Filed: August 27, 2025
    Publication date: March 5, 2026
    Applicant: WAYNE STATE UNIVERSITY
    Inventors: Jeremy Jacob KODANKO, Judy A. WESTRICK, Megan Lee QUANDT
  • Patent number: 12566228
    Abstract: Hyperpolarized target molecules and contrast agents comprising the same, methods of making the same, and methods of imaging using same are provided. In a further aspect, imaging performed using the hyperpolarized target molecules and contrast agent can enable real time monitoring and diagnosis of diseases including various cancers and metabolic disorders. The methods are cryogen-free and inexpensive and can be performed in a short time.
    Type: Grant
    Filed: July 26, 2022
    Date of Patent: March 3, 2026
    Assignees: North Carolina State University, Wayne State University, Board of Trustees of Southern Illinois University, NATIONAL INSTITUTES OF HEALTH NHLBI
    Inventors: Thomas Theis, Mustapha Abdulmojeed, Sören Lehmkuhl, Patrick TomHon, Iuliia Mandzhieva, Eduard Y. Chekmenev, Isaiah Adelabu, Mohammad Kabir, Shiraz Nantogma, Jessica Ettedgui, Rolf Eric Swenson, Boyd Goodson
  • Patent number: 12559268
    Abstract: A smart landing platform system includes a flat and rigid platform for landing a drone and having a geometrical center, a center of gravity and a weight, a digital scale disposed beneath the platform for providing measurements of a weight distribution of the platform and the drone, and a control unit connected to the digital scale for instantaneous data collection and storing logic including a statistical inference algorithm based on a nonlinear least squares model to perform automated pre-flight safety check for the drone.
    Type: Grant
    Filed: September 29, 2022
    Date of Patent: February 24, 2026
    Assignee: Wayne State University
    Inventors: Zhenyu Zhou, Yanchao Liu
  • Patent number: 12551434
    Abstract: Compositions and methods for oral and/or mucosal administration of a biologically active agent are provided according to aspects of the present disclosure which include: a plurality of particles, wherein each particle has an exterior surface, the exterior surface defining a particle interior, the exterior surface having at least one type of zwitterionic polymer and/or zwitterionic copolymer disposed thereon and/or extending therefrom; and a biologically active agent disposed on the exterior surface and/or in the particle interior, wherein the biologically active agent is or includes a protein, peptide, or dietary supplement. According to particular aspects, compositions and methods for oral and/or mucosal administration of an anti diabetes biological agent, such as insulin and/or an insulin analog.
    Type: Grant
    Filed: May 20, 2021
    Date of Patent: February 17, 2026
    Assignee: Wayne State University
    Inventor: Zhiqiang Cao
  • Patent number: 12551527
    Abstract: Lipid-based drug delivery vehicles (including liposomal nanoparticles) are described which include antibiotic(s) for the treatment of infections, such as Methicillin-Resistant Staphylococcus (S.) aureus (MRSA) infections and Methicillin-Susceptible S. aureus (MSSA) infections. These drug delivery vehicles have high drug-loading, do not accumulate in the liver, and can optionally include one or more targeting ligands.
    Type: Grant
    Filed: December 28, 2018
    Date of Patent: February 17, 2026
    Assignee: Wayne State University
    Inventors: Arun K. Iyer, Samaresh Sau, Michael Rybak, Ketki Bhise, Razie Kebriaei
  • Patent number: 12545998
    Abstract: Methods for depositing rhenium-containing thin films on a substrate are described. The substrate is exposed to a rhenium precursor and a reducing agent to form the rhenium-containing film (e.g., metallic rhenium, rhenium nitride). The exposures can be sequential or simultaneous.
    Type: Grant
    Filed: May 14, 2020
    Date of Patent: February 10, 2026
    Assignees: Applied Materials, Inc., Wayne State University
    Inventors: Thomas Knisley, Keenan N. Woods, Mark Saly, Stefan Cwik, Charles H. Winter
  • Publication number: 20260014137
    Abstract: A compound having chemical structural formula I: where R1 is selected from the group consisting of: an alkyl group, a heteroalkyl group, an aryl group, a heteroaryl group, an alkenyl group, a heteroalkenyl group, an alkynyl group, a heteroalkynyl group, a cycloalkyl group, a hetercycloalkyl group, an alkylcycloalkyl group, a heteroalkyl cycloalkyl group, an aralkyl group, a heteroaralkyl group, an alkoxy group, a polar group, an ester and a charged group; a pharmaceutically acceptable hydrolysable, or enzymatically cleavable, prodrug form thereof, and/or a pharmaceutically acceptable salt thereof; where R4? is H or an alkoxy group; where both R5 and R3? are OH, and where one or both OH groups is modified as a pharmaceutically acceptable hydrolysable, or enzymatically cleavable, prodrug form thereof, wherein the prodrug form thereof comprises an ester selected from: an amino acid ester, a phosphate ester, and a sulfonate ester.
    Type: Application
    Filed: September 23, 2025
    Publication date: January 15, 2026
    Applicant: Wayne State University
    Inventor: Manohar Ratnam
  • Patent number: 12525639
    Abstract: A method of stabilizing a garnet-type solid-state electrolyte (SSE) includes obtaining pellets of SSE, removing surface impurities of the SSE, and depositing a passivation layer onto the SSE after the surface impurities are removed, the passivation layer including two of boron, carbon, and nitrogen.
    Type: Grant
    Filed: February 23, 2022
    Date of Patent: January 13, 2026
    Assignee: Wayne State University
    Inventors: Leela Mohana Reddy Arava, Sathish Rajendran, Jeffry Kelber, Aparna Pilli
  • Patent number: 12509734
    Abstract: Systems and methods to assess the health of various microbiomes and to identity species therein are disclosed. Described assessments and identifications can inform treatment decisions if a microbiome is determined to have a less than optimal balance of bacterial species within it; the presence of one or more negative species; and/or the absence of one or more positive species.
    Type: Grant
    Filed: October 19, 2021
    Date of Patent: December 30, 2025
    Assignee: Wayne State University
    Inventors: Robert A. Akins, Jack D. Sobel
  • Publication number: 20250387513
    Abstract: The present invention provides recombinant AAV particles comprising an opsin transgene for therapy of retinal diseases, and related compositions and methods.
    Type: Application
    Filed: August 15, 2025
    Publication date: December 25, 2025
    Applicants: Ray Therapeutics, Inc., Wayne State University
    Inventors: Peter Francis, Zhuo-Hua Pan, Paul Bresge, Gary Abrams, Qi Lu