Abstract: Isothiocyanate (ITC)-androgen receptor (AR) inhibitor conjugates for apoptosis induction in cancer cells are described. The conjugates can have electrophilicity blocked with an agent such as N-acetyl cysteine. When administered in combination with a glutathione (GSH)-depleting agent, the conjugates result in ferroptosis of cancer cells.
Abstract: Down-regulating autoimmune regulator (AIRE) function in B cells to produce antibodies is described. The antibodies can be class-switched, high affinity, and neutralizing, and have a high degree of somatic hypermutations, even in the framework region, as compared to antibodies produced in the absence of AIRE downregulation.
Abstract: The current disclosure provides alternating current based systems and methods to develop chemical compounds, such as drug molecules using electrochemistry in organic synthesis.
Abstract: Systems and methods for regulating fluid flow are provided. A valve for regulating fluid flow includes a tubing, a regulating element, and an actuator. The tubing is configured to allow fluid flow therethrough. The regulating element is arranged proximate to the tubing. The actuator is arranged proximate to the regulating element, and is configured to manipulate a parameter associated with the regulating element.
Type:
Application
Filed:
September 9, 2022
Publication date:
December 26, 2024
Applicant:
Wayne State University
Inventors:
Carolyn Harris, Ahmad Faryami, Adam Menkara, Daniel Viar
Abstract: A device may include a metallic substrate and a plurality of nanorod arrays arranged on the substrate. The nanorod arrays may be made of porous metallic nanostructures and may appear black in color.
Abstract: A system for an engine to determine in situ under specified conditions the auto-ignition quality of the fuel used in a compression ignition engine is provided. The system may include an ion current sensor. The ion current sensor may access an engine cylinder for obtaining ion current data. A control unit may be in communication with the ion current sensor for receiving the ion current data. The control unit being configured to determine the auto-ignition quality of the fuel based on features of the ion current data.
Type:
Grant
Filed:
April 29, 2020
Date of Patent:
November 26, 2024
Assignee:
Wayne State University
Inventors:
Naeim A. Henein, Prasad D. Raut, Omkar A. Atre, Joseph Stempnik
Abstract: A boost or DC-DC converter includes a first output and a second output, a first inductor having a first side and a second side, the first side of the first inductor being connectable in electrical communication with a first output of a power supply or DC voltage source, and a second inductor having a first side and a second side, the first side of the second inductor being connectable in electrical communication with the first output of the power supply, the first inductor being inversely coupled to the second inductor. The converter includes a first switch in communication with the second side of the first inductor and a second output of the power supply, and a second switch in communication with the second side of the second inductor and the second output of the power supply.
Abstract: This disclosure provides compositions, devices, systems, and methods that reduce the likelihood, amount, or level of cellular deposition (and associated blockage and/or failure) of implantable medical devices, such as central nervous system implants. Embodiments involve use of inhibitor(s) of one or more of TLR-4, TNF-?, IL-1?, or IL-6, for instance, to prevent, reduce, or reverse activation of astrocyte and/or glia cells, and/or to prevent, reduce, or reverse attachment of such cells to the surface of a medical device in contact with a biological fluid, such as cerebrospinal fluid.
Type:
Application
Filed:
September 9, 2022
Publication date:
November 14, 2024
Applicant:
Wayne State University
Inventors:
Carolyn Harris, Mira Zaranek, Fatemeh Khodadadei
Abstract: A line-scan Brillouin microscopy apparatus is configured to operate in a coaxial configuration. The line-scan Brillouin microscopy apparatus includes an illumination source that provides a P polarized illumination light beam for illuminating a sample. A first optical assembly provides the P polarized illumination light beam to the sample and collects initial Brillouin scattered light from the sample. The first optical assembly includes an optical component that converts the initial Brillouin scattered light to S polarized Brillouin scattered light. A second optical assembly is configured to receive the S polarized Brillouin scattered light from the first optical assembly. Characteristically, the second optical assembly is configured to induce a spectral dispersion. A detection unit is configured to detect a spatio-spectral pattern of the initial Brillouin scattered light. Advantageously, multiple points of the sample along P polarized illumination light beam are measured simultaneously.
Abstract: Isothiocyanate (ITC)-androgen receptor (AR) inhibitor conjugates for apoptosis induction in cancer cells are described. The conjugates can have electrophilicity blocked with an agent such as N-acetyl cysteine. When administered in combination with a glutathione (GSH)-depleting agent, the conjugates result in ferroptosis of cancer cells.
Abstract: An exemplary system includes an inverter coupled to a DC source, eight power switches and three DC-link capacitors that synthesize seven output voltage levels. In one example the inverter includes a four-level active neutral pointed clamped inverter (4L-ANCP) that includes six power switches of the eight power switches is operated at a switching frequency with a first voltage stress level, and a half-bridge that includes the other two of the eight power switches is coupled to the 4L-ANCP and operated at a fundamental frequency with a second voltage stress, the second voltage stress being higher than the first voltage stress level.
Abstract: Increasingly, human subjects are taking biotin as a medical therapy or nutritional supplement. This practice causes difficulty in analysis of biological samples, such as blood samples, using biotin conjugate reagents since free biotin results in interference. Inventive antibodies, and antigen binding fragments thereof, which specifically bind to biotin of a biotin conjugate and which have a higher affinity for biotin of a biotin conjugate than for free biotin, are provided along with methods of their use.
Abstract: Metal complexes with nitrile ligands of the type MO2X2L2, where M is molybdenum or tungsten, X is a halogen, each L is independently an organonitrile ligand with the general formula NCR, where each R is independently a C2-C18 group. Metal complexes with dinitrile bidentate ligands of the type MO2X2L?, where L? is a dintrile ligand, and dinitrile bridging ligands of the type (MO2X2)2L?, where L? is a dinitrile bridging ligand connecting the two metal atoms. Methods of making and using the metal complexes are described.
Type:
Application
Filed:
May 9, 2023
Publication date:
September 12, 2024
Applicants:
Applied Materials, Inc., Wayne State University
Inventors:
Thomas Joseph Knisley, Bhaskar Jyoti Bhuyan, Mark Saly, Shalini Tripathi, Charles H. Winter, Zachary J. Devereaux
Abstract: Advancements in solid tumor (e.g., renal cell carcinoma) treatments and imaging are described. The advancements are based on nanoformulations that: (i) overcome deliverability issues associated with anti-cancer compounds; (ii) have increased targeted delivery to tumors, and hypoxic cores of tumors due to the presence of targeting ligands; (iii) have increased delivery to the hypoxic cores of tumors due to engineered shapes; (iv) provide synergistic treatment combinations; and/or (v) overcome cancer cell resistance to therapeutic treatments.
Type:
Grant
Filed:
December 28, 2018
Date of Patent:
September 10, 2024
Assignee:
WAYNE STATE UNIVERSITY
Inventors:
Samaresh Sau, Arun K. Iyer, Hashem Alsaab
Abstract: Halide ligand free rhenium complexes are described as well as methods for depositing rhenium-containing films. Some embodiments provide a rhenium complex with a general formula of O3ReO-M-R1R2R3, where M is a group IV element, R1 is selected from H, alkyl, alkenyl, alkynyl, an aromatic ring, or alkoxy, and R2 and R3 are each independently selected from H, alkyl, alkenyl, alkynyl, an aromatic ring, or alkoxy, or R2 and R3 join together to form a ring structure or an oxo group. Some embodiments provide a rhenium complex with a general formula of Re(NR?)3(NHR?), where R? and R? are independently selected from H, alkyl, alkenyl, alkynyl, or an aromatic ring.
Type:
Grant
Filed:
November 20, 2020
Date of Patent:
September 10, 2024
Assignees:
Applied Materials, Inc., Wayne State University
Inventors:
Thomas Knisley, Keenan N. Woods, Mark Saly, Charles H. Winter, Stefan Cwik
Abstract: Methods and compositions for treating a disorder of cardiac muscle and/or skeletal muscle in a subject according to aspects of the present disclosure. Treatment methods include administering a therapeutically effective dose of a C-terminal portion of troponin I capable of reducing sensitivity of cardiac muscle and/or skeletal muscle to Ca2+ without decreasing maximum force production. Assays for identification of compounds capable of reducing sensitivity of cardiac muscle and/or skeletal muscle to Ca2+ without decreasing maximum force production are further provided.
Abstract: Down-regulating autoimmune regulator (AIRE) function in B cells to produce antibodies is described. The antibodies can be class-switched, high affinity, and neutralizing, and have a high degree of somatic hypermutations, even in the framework region, as compared to antibodies produced in the absence of AIRE downregulation.
Abstract: A multimodal optical technique that can measure the mechanical, optical, and acoustical properties of the sample at microscopic resolution, which is based on the integration of a Brillouin microscope and a photoacoustic (PA) microscopy is provided. The multimodal technique not only can acquire co-registered Brillouin and PA signals of the sample but also allows us to utilize the sound speed measurements by PA to quantify the sample's refractive index, which is an essential property of the material and cannot be measured by either technique individually. We demonstrated the colocalization of Brillouin and time-resolved PA signals by measuring the interface of kerosene and 1% CuSO4 aqueous solution. In addition, we measured the refractive index of saline solutions with a precision of 0.003 and validated the result against published data. This multimodal modality could open new way for charactering biological cell and tissue in physiological and pathological conditions.
Abstract: A power source for a micro-device is provided. The power source may include a cup, a lid and electrolytes. The cup may be formed of a hard metal material and walls of the cup may define a cavity. An opening in the cup may provide access to the cavity and a surface of the cavity may be deposited with one of an anode or cathode material. The lid may be formed of a hard metal material, the lid may cooperate with the cup to fit into the opening closing off the cavity. The cavity may be coated with the other of the anode or cathode material. Electrolytes may be contained in the cavity.
Abstract: An exemplary process for forming a cured hybrid magnesium cement composition may include first combining a mixture of magnesium-containing material, a metal silicate inorganic polymer having a repeat unit of SiP2O7, and a salt having a non-metallic oxide anion, and then mixing the mixture with water.