Patents Assigned to Wayne State University
  • Publication number: 20230363836
    Abstract: Various systems, methods, and devices for identifying intraoperative bleeding are described. An example method includes identifying a first frame depicting a surgical scene; identifying a second frame depicting the surgical scene; identifying whether the second frame depicts bleeding by analyzing the first frame and the second frame; and outputting the second frame with an augmentation indicating whether bleeding is depicted in the second frame.
    Type: Application
    Filed: September 22, 2021
    Publication date: November 16, 2023
    Applicants: Wayne State University, RediMinds, Inc.
    Inventors: Abhilash K. Pandya, Mostafa Daneshgar Rahbar, Luke A. Reisner, Hao Ying, Mahendra Bhandari, Madhusudhan Reddiboina
  • Publication number: 20230348959
    Abstract: Methods discussed herein are directed to polymerase chain reaction (PCR) techniques, and more specifically quantitative-discrete PCR, wherein individual amplification reactions are performed on a per-payload basis among singly-captured and singly-isolated vesicles, for instance within individually sealed microwell reactors. These techniques enable post-process quality control measurements of per-vesicular manufacture loading efficiency and encapsulation efficiency of nucleic acid active ingredients in vesicular biologics, employing quantitative-discrete PCR techniques. By measuring variability of vesicular encapsulation of nucleic acids at a per-vesicular manufacture level of granularity, such techniques can enable collection of data that may be used to perform post-process formulation upon vesicular biologics, and to yield more homogenous formulations from both synthetic and biogenesis pathways.
    Type: Application
    Filed: April 27, 2023
    Publication date: November 2, 2023
    Applicant: Wayne State University
    Inventor: Thomas H. Linz
  • Patent number: 11801008
    Abstract: Methods and system are described for multi-modal, multi-parametric, non-invasive, and real-time assessment of cervical tissue through a multi-modal probe device for use within a vaginal canal and an associated imaging system to assess a risk of preterm delivery of an expectant mother. The multi-modal system may include ultrasound (US) imaging, viscoelastic (VE) imaging, and/or photoacoustic (PA) imaging of the cervical issue to determine cervical biomarker information indicative of parameters including, but not limited to, a collagen to water ratio such that a more water dominant ratio is indicative of a risk of preterm delivery.
    Type: Grant
    Filed: October 22, 2019
    Date of Patent: October 31, 2023
    Assignee: Wayne State University
    Inventors: Mohammad Mehrmohammadi, Sonia S. Hassan, Edgar Hernandez-Andrade, Yan Yan, Maryam Basij, Nardhy Gomez-Lopez
  • Publication number: 20230341415
    Abstract: Systems, kits, methods to diagnose sarcoidosis are described. In addition to diagnosing sarcoidosis, the systems and methods can distinguish sarcoidosis from tuberculosis and lung cancer.
    Type: Application
    Filed: October 13, 2022
    Publication date: October 26, 2023
    Applicant: Wayne State University
    Inventor: Lobelia Samavati
  • Publication number: 20230341414
    Abstract: Provided are systems and methods for assessing the presence or risk of obstetrical complications, particularly those related to an angiogenic and anti-angiogenic imbalance. Also provided are methods of treating an angiogenic and anti-angiogenic imbalance with water-soluble statins, such as pravastatin.
    Type: Application
    Filed: May 10, 2023
    Publication date: October 26, 2023
    Applicants: Wayne State University, The United States of America as Represented by the Secretary., Dept. of Health and Human Services
    Inventors: Tinnakorn Chaiworapongsa, Roberto Romero, Sonia S. Hassan
  • Patent number: 11782065
    Abstract: Biomarkers tests which can be used to predict a positive or negative risk of preeclampsia are described. More specifically, a panel of biomarkers including MMP-7 and gpIIbIIIa, described. The test is useful to predict preeclampsia when a biological sample is obtained between the 16th and 22nd week of pregnancy. Prediction later in pregnancy can be achieved by a combination of Siglec-6, Activin A, ALCAM, and/or FCN2.
    Type: Grant
    Filed: December 21, 2021
    Date of Patent: October 10, 2023
    Assignees: Wayne State University, The United States of America, as Represented by the Secretary, Department of Health & Human Services
    Inventors: Adi L. Tarca, Piya Chaemsaithong, Tinnakorn Chaiworapongsa, Sonia S. Hassan, Roberto Romero
  • Patent number: 11784227
    Abstract: A electronic device and a fabrication method is provided. The electronic device having a first electrode and a second electrode. A nano-gap is formed between first and second electrode. The first electrode, the second electrode and the gap may be located in the same layer of the device.
    Type: Grant
    Filed: October 9, 2018
    Date of Patent: October 10, 2023
    Assignee: Wayne State University
    Inventors: Leela Mohana Reddy Arava, Nirul Masurkar
  • Publication number: 20230310657
    Abstract: The invention provides nucleic acids and nucleic acid expression vectors containing optimized mGluR6 promoters for expression of transgenes in the retina. The compositions and methods of the invention are useful for expression of gene products to preserve, improve, or restore phototransduction or vision.
    Type: Application
    Filed: January 11, 2023
    Publication date: October 5, 2023
    Applicant: Wayne State University
    Inventors: Zhuo-Hua Pan, Qi Lu, Tushar H. Ganjawala, JrGang Cheng
  • Publication number: 20230314370
    Abstract: Described herein are systems using injectionless gel electrophoresis (GE), such as thermal GE (TGE), to selectively separate, concentrate, quantify, and/or otherwise analyze target analytes. Inline preconcentration and separation are demonstrated to resolve analytes, exemplified by resolving double-stranded miRNA-probe hybrids from excess single-stranded probes and analyzing multiple conformations of a protein. Microfluidic devices having a tapered channel are described, which improve detection sensitivity and separation resolution. The described separation strategy and microfluidic device designs establish injectionless gel electrophoresis as a simple, low-cost analysis method, for instance for analyzing clinical and pharmaceutical samples, including for miRNA, protein, and other biomolecular analyses.
    Type: Application
    Filed: February 7, 2023
    Publication date: October 5, 2023
    Applicant: Wayne State University
    Inventors: Thomas H. Linz, Mario A. Cornejo
  • Patent number: 11749706
    Abstract: A detection layer (416) for a radiation detector (400) includes a porous silicon membrane (418). The porous silicon membrane includes silicon (419) with a first side (430) and a second opposing side (432), a plurality of pores (420) extending entirely through the silicon from the first side to the second opposing side, each including shared walls (426), at least one protrusion of silicon (424) protruding out and extending from the first side a distance (504, 604, 704). The porous silicon membrane further includes a plurality of radiation sensitive quantum dots (422) in the pores and a quantum dot layer disposed on the first side and having a surface (434) and a thickness (506, 606, 706), wherein the thickness is greater than the distance.
    Type: Grant
    Filed: March 16, 2020
    Date of Patent: September 5, 2023
    Assignees: KONINKLIJKE PHILIPS N.V., WAYNE STATE UNIVERSITY
    Inventors: Marc Anthony Chappo, Stephanie Lee Brock
  • Publication number: 20230274055
    Abstract: Described herein are systems and methods for modeling fluid flow. The systems may comprise a plurality of chambers, a plurality of sensors, a pump, a plurality of valves, and a flow limiting operator (FLO). The respective sensor of the plurality of sensors may be configured to sense a respective monitoring parameter associated with the respective chamber. The pump may be configured to move media to or from the respective chamber. The respective valve of the plurality of valves may be configured to control a fluid velocity of the media flowing through the respective chamber. The FLO may be electrically connected to the plurality of sensors, the pump, and the plurality of valves. The FLO may be configured to independently control the respective chamber by manipulating one or more controllable parameters associated with the respective chamber based on the respective monitoring parameter associated with the respective chamber.
    Type: Application
    Filed: July 16, 2021
    Publication date: August 31, 2023
    Applicant: Wayne State University
    Inventors: Jeffrey Horbatiuk, Carolyn Harris, Lubna Alazzawi, Ahmad Faryami
  • Publication number: 20230263587
    Abstract: Various systems, methods, and devices for identifying instrument movements likely to cause intraoperative bleeding are described. An example method includes identifying a movement of an instrument; determining that the movement of the instrument exceeds a threshold; and dampening the movement of the instrument based on determining that the movement exceeds the threshold.
    Type: Application
    Filed: September 22, 2021
    Publication date: August 24, 2023
    Applicant: Wayne State University
    Inventors: Abhilash K. Pandya, Mostafa Daneshgar Rahbar, Luke A. Reisner, Hao Ying
  • Publication number: 20230235451
    Abstract: Molybdenum-DAD precursors are described. Methods for depositing molybdenum-containing films on a substrate are described. The substrate is exposed to a molybdenum-DAD precursor and a reactant to form the molybdenum-containing film (e.g., elemental molybdenum, molybdenum oxide, molybdenum carbide, molybdenum silicide, molybdenum nitride). The exposures can be sequential or simultaneous.
    Type: Application
    Filed: January 24, 2023
    Publication date: July 27, 2023
    Applicants: Applied Materials, Inc., Wayne State University
    Inventors: Thomas Joseph Knisley, Martha Serna Villacis, Mark Saly, Lakmal C. Kalutarage, Charles H. Winter, Matthew Bertram Edward Griffiths, Shalini Tripathi
  • Patent number: 11698304
    Abstract: Apparatuses, systems, and methods for Raman spectroscopy are described. In certain implementations, a spectrometer is provided. The spectrometer may include a plurality of optical elements, comprising an entrance aperture, a collimating element, a volume phase holographic grating, a focusing element, and a detector array. The plurality of optical elements are configured to transfer the light beam from the entrance aperture to the detector array with a high transfer efficiency over a preselected spectral band.
    Type: Grant
    Filed: June 25, 2019
    Date of Patent: July 11, 2023
    Assignee: Wayne State University
    Inventors: Gregory William Auner, Michelle Ann Brusatori, Changhe Huang
  • Patent number: 11684569
    Abstract: Dendrimer-based compositions and methods are provided, that are useful for administering pharmaceutical compositions to target cells and tissues for treatment of ocular diseases including macular degeneration, diabetic retinopathy, and retinitis pigmentosa.
    Type: Grant
    Filed: August 21, 2020
    Date of Patent: June 27, 2023
    Assignee: WAYNE STATE UNIVERSITY
    Inventors: Kannan Rangaramanujam, Raymond Iezzi, Bharath Raja Guru, Sujatha Kannan
  • Patent number: 11686735
    Abstract: Provided are systems and methods for assessing the presence or risk of obstetrical complications, particularly those related to an angiogenic and anti-angiogenic imbalance. Also provided are methods of treating an angiogenic and anti-angiogenic imbalance with water-soluble statins, such as pravastatin.
    Type: Grant
    Filed: April 17, 2019
    Date of Patent: June 27, 2023
    Assignees: WAYNE STATE UNIVERSITY, THE UNITED STATES OF AMERICA AS REPRESENTED BY THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES
    Inventors: Tinnakorn Chaiworapongsa, Roberto Romero, Sonia S. Hassan
  • Patent number: 11685903
    Abstract: A method of generating protein-induced pluripotent stem cells by delivering bacterially expressed reprogramming proteins into nuclei of starting somatic cells using the QQ-protein transduction technique, repeating several cell reprogramming cycles for creating reprogrammed protein-induced pluripotent stem cells, moving the reprogrammed cells into a feeder-free medium for expansion, and expanding and passaging the reprogrammed cells in a whole dish for generating homogeneous piPS cells. Also provided are the piPCS cells formed using this method and uses thereof.
    Type: Grant
    Filed: April 15, 2020
    Date of Patent: June 27, 2023
    Assignee: Wayne State University
    Inventors: Jianjun Wang, Qianqian Li
  • Patent number: 11682315
    Abstract: An exemplary system may include an augmented reality device with a user interface, a processor and memory having a program communicatively connected to the processor. A transceiver may be communicatively connected to a practitioner device for real-time practitioner guidance. The system may include a plurality of sensors and a feedback device in communication with the processor. The system may display initial and updated guidance objects in a real-time environment of the user and in response to sensor outputs of the plurality of sensors. The feedback device may provide at least one of audio, visual, and tactile feedback in response to the sensors outputs. The system may condition the user to provide a desired reaction by guiding the real-time user reactions in the real-time environment using the feedback in response to the sensor outputs.
    Type: Grant
    Filed: March 16, 2021
    Date of Patent: June 20, 2023
    Assignee: Wayne State University
    Inventor: Arash Javanbakht
  • Patent number: 11672877
    Abstract: Methods for in vivo immunoimaging including: (a) administering a labeled-antibody conjugate to a subject, wherein the labeled-antibody conjugate includes: an antibody that specifically recognizes and binds to IFN-?, and a detection label conjugated to the antibody, wherein the detection label is a radionuclide tracer or tluorophore; and (b) detecting the presence of the radiolabeled-antibody conjugate in the subject in vivo by imaging. Embodiments of the present disclosure are directed to labeled-antibody conjugates and therapeutic radionuclide-antibody conjugates.
    Type: Grant
    Filed: August 23, 2018
    Date of Patent: June 13, 2023
    Assignee: Wayne State University
    Inventors: Nerissa Viola, Heather Gibson
  • Patent number: 11664787
    Abstract: A ring oscillator includes a first set of at least three laddered inverter quantizer (LIQAF) circuits connected in stages that are in series, including a first LIQAF circuit and a last LIQAF circuit, and a feedback circuit from the last LIQAF circuit to the first LIQAF circuit having a logical NOT output compared to the first LIQAF circuit. A voltage input creates a pair of phase shifted waveforms in the first of the at least three LIQAF circuits that propagate sequentially through the stages of the at least three LIQAF circuits. Each stage has a pair of outputs to the next stage that are then phase shifted from the previous stage in the next stage.
    Type: Grant
    Filed: March 4, 2022
    Date of Patent: May 30, 2023
    Assignee: Wayne State University
    Inventors: Mohammad Alhawari, Melvin D. Edwards, II