Patents Assigned to Wayne State University
  • Patent number: 11404917
    Abstract: A system, method, and device that provides power to an electrical unit such as an Internet of Things (IoT) device that includes a transmitter that provides electrical power through electromagnetic waves, a receiver, an array that includes a plurality of metamaterial elements, such that the electrical power passes wirelessly from the transmitter to the array, and a controller that applies selective phase shifts to each of the plurality of metamaterial elements such that the electrical power is transmitted from the transmitter, reflected off the array, and is received in phase at the receiver that converts the electromagnetic waves to an electric current to power the device.
    Type: Grant
    Filed: July 27, 2021
    Date of Patent: August 2, 2022
    Assignee: Wayne State University
    Inventors: Dimitrios Sounas, Zahra Katbay, Mohammed Ismail Elnaggar
  • Patent number: 11388736
    Abstract: A distributed sensing and control network includes a plurality of sensing/control nodes, each of the sensing/control nodes includes a sensor, a local controller, a local memory and a wireless transmitter/receiver. The local memory stores instructions for implementing a multiscale networking protocol for wireless transmissions. The multiscale networking protocol controls at least a first factor at a first timescale and at least a second factor at a second timescale, distinct from the first timescale. The at least a first factor includes an instantiated physical-ratio-K (PRK) interference model for wireless transmissions. The at least a second factor includes at least one of a channel assignment, a node transmission signal power control, a node transmission rate control, a real-time scheduling control, and a local signal map stored in the local memory.
    Type: Grant
    Filed: July 17, 2020
    Date of Patent: July 12, 2022
    Assignee: Wayne State University
    Inventor: Hongwei Zhang
  • Patent number: 11375897
    Abstract: A system for characterization of a brain tissue sample includes a laser having an excitation fiber and a probe coupled to the excitation fiber for irradiating the brain tissue sample with light at an excitation wavelength. The probe further includes a plurality of return fibers for receiving light scattered from the brain tissue sample, wherein each return fiber includes a microfilter that permits light to pass for a different, spaced apart marker region. A Raman spectrometer is in communication with the plurality of return fibers, and a processor is in communication with the Raman spectrometer for analyzing Raman spectra within the marker regions to identify a tissue type of the brain tissue sample as one of normal white matter brain tissue, normal grey matter brain tissue, brain tumor tissue, infiltrating tumor tissue, and necrotic tissue.
    Type: Grant
    Filed: April 20, 2018
    Date of Patent: July 5, 2022
    Assignees: Henry Ford Health System, Wayne State University
    Inventors: Gregory William Auner, Michelle Brusatori, Steven N. Kalkanis, Lisa Scarpace
  • Patent number: 11377454
    Abstract: The present disclosure is in the field of processes for the generation of thin inorganic films on substrates, in particular atomic layer deposition processes. Described herein is a process for preparing metal-containing films including: (a) depositing a metal-containing compound from the gaseous state onto a solid substrate, and (b) bringing the solid substrate with the deposited metal-containing compound in contact with a compound of general formula (I) wherein Z is a C2-C4 alkylene group, and R is hydrogen, an alkyl group, an alkenyl group, an aryl group, or a silyl group.
    Type: Grant
    Filed: April 10, 2019
    Date of Patent: July 5, 2022
    Assignees: BASF SE, Wayne State University
    Inventors: Charles Hartger Winter, Kyle Blakeney, Lukas Mayr, David Dominique Schweinfurth, Sabine Weiguny, Daniel Waldmann
  • Publication number: 20220202701
    Abstract: The present disclosure describes compositions and methods to promote wound healing. The compositions and methods include an interleukin-1 beta (IL-1?) receptor antagonist (IL-1Ra), such as anakinra. The IL-1Ra can be administered topically to a chronic wound including a diabetic ulcer.
    Type: Application
    Filed: March 15, 2022
    Publication date: June 30, 2022
    Applicant: Wayne State University
    Inventor: Fu-Shin X. Yu
  • Patent number: 11348964
    Abstract: An imaging module (114) of an imaging system comprises a porous silicon membrane (116) with a first side (208), a contact side (210) opposite the first side, columns of silicon (212) configured to extend from the first side to the contact side, and columnar holes (214, 502) interlaced with the columns of silicon and configured to extend from the first side to the contact side. The imaging module further includes quantum dots (118) in the columnar holes. The imaging module further includes a metal pad (120) electrically coupled to the columns of silicon of the porous silicon membrane. The quantum dots in the columnar holes are electrically insulated from the metal pad. The imaging module further includes a substrate (122) with an electrically conductive pad (204) in electrical communication with the metal pad that defines a pixel.
    Type: Grant
    Filed: March 28, 2019
    Date of Patent: May 31, 2022
    Assignees: KONINKLIJKE PHILIPS N.V., WAYNE STATE UNIVERSITY
    Inventors: Marc Anthony Chappo, Stephanie Lee Brock
  • Patent number: 11332794
    Abstract: The use of genes or biomarkers to more accurately diagnose aggressive prostate cancer in men of African descent or European descent is provided. More specifically, the genes or biomarkers of the present invention can be used in diagnostic tests and methods to determine, qualify, and/or assess aggressive prostate cancer or status, for example, to diagnose or identify aggressive prostate cancer, in an individual, subject, or patient, such as men of African descent or men of European descent.
    Type: Grant
    Filed: January 19, 2017
    Date of Patent: May 17, 2022
    Assignee: Wayne State University
    Inventors: Isaac J. Powell, Aliccia Bollig-Fischer, Greg Dyson
  • Patent number: 11330993
    Abstract: An optical proximity sensor assembly includes an optical proximity sensor with an IR LED emitting light having an infrared wavelength, an IR photo detector sensitive to the infrared wavelength, an optical barrier blocking direct light rays from the LED to the IR photo detector and permitting reflected light rays to reach the at least one photo detector; and an electronic integrated circuit with an amplifier for amplifying a signal detected by the photo detector, an analog to digital converter, LED drivers, noise reduction and ambient light cancellation circuitry, and a digital interface for communication with a microcontroller. The optical proximity sensor is accommodated on a wearable carrier. A single sensor may include a plurality of identical or different LEDs, a plurality of photodiodes, or both. Also, several sensors may be placed on a person's skin along a vascular path to obtain data relating to blood flow and artery stiffness.
    Type: Grant
    Filed: February 25, 2019
    Date of Patent: May 17, 2022
    Assignee: Wayne State University
    Inventor: Amar S. Basu
  • Patent number: 11323947
    Abstract: A Distributed sensing and control network includes multiple sensing/control nodes, each of which includes a controller. Each sensing/control node determines signal transmission/receipt scheduling based on a physical-ratio-k-scheduling (PRKS) protocol stored within the controller.
    Type: Grant
    Filed: May 28, 2019
    Date of Patent: May 3, 2022
    Assignee: Wayne State University
    Inventors: Hongwei Zhang, Xiaohui Liu, Chuan Li
  • Patent number: 11319332
    Abstract: A process including bringing a solid substrate in contact with a compound of general formula (I), (II), (III), or (IV) in the gaseous state where A is NR2 or OR with R being an alkyl group, an alkenyl group, an aryl group, or a silyl group, E is NR or O, n is 0, 1 or 2, m is 0, 1 or 2, and R? is hydrogen, an alkyl group, an alkenyl group, an aryl group, or a silyl group.
    Type: Grant
    Filed: September 17, 2018
    Date of Patent: May 3, 2022
    Assignees: BASF SE, Wayne State University
    Inventors: David Dominique Schweinfurth, Lukas Mayr, Sinja Verena Klenk, Sabine Weiguny, Charles Hartger Winter, Kyle Blakeney, Nilanka Weerathunga Sirikkathuge, Tharindu Malawara Arachchige Nimanthaka Karunaratne
  • Patent number: 11313865
    Abstract: Methods for detecting a cardiac condition in a human subject are provided according to aspects of the present invention which include providing an immunological reagent characterized by specific binding to: an N-terminal fragment of human cardiac troponin T (HcTnT-N69) or a neoepitope of human cardiac troponin T generated by removal of HcTnT-N69 from HcTnT (HcTnT-neo); contacting the immunological reagent with a biological sample of the human subject under binding conditions; and detecting binding of the immunological reagent with HcTnT-N69 or HcTnT-neo, wherein detection of HcTnT-N69 or HcTnT-neo in the biological sample is indicative of a cardiac condition in the subject. Antibodies and antigen binding fragments thereof characterized by specific binding to HcTnT-N69 or HcTnT-neo, or a variant of either thereof, are provided according to aspects of the present invention.
    Type: Grant
    Filed: April 29, 2020
    Date of Patent: April 26, 2022
    Assignee: Wayne State University
    Inventor: Jian-Ping Jin
  • Publication number: 20220113316
    Abstract: Biomarkers tests which can be used to predict a positive or negative risk of preeclampsia are described. More specifically, a panel of biomarkers including MMP-7 and gpIIbIIIa, described. The test is useful to predict preeclampsia when a biological sample is obtained between the 16th and 22nd week of pregnancy. Prediction later in pregnancy can be achieved by a combination of Siglec-6, Activin A, ALCAM, and/or FCN2.
    Type: Application
    Filed: December 21, 2021
    Publication date: April 14, 2022
    Applicants: Wayne State University, The United States of America, as Represented by the Secretary, Department of Health & Human Services
    Inventors: Adi L. Tarca, Piya Chaemsaithong, Tinnakorn Chaiworapongsa, Sonia S. Hassan, Roberto Romero
  • Patent number: 11285147
    Abstract: A compound having formula I is useful for treating a neurodegenerative disease: or a pharmaceutically acceptable salt or ester thereof, wherein R1, R2, R3, R4, R5, R6, R7, R8 are each independently hydroxyl, C1-4 alkyl, C1-4 alkoxyl, C1-8 alkyl, C2-8 alkenyl, C2-8 alkynyl, C4-8, are specified substituents.
    Type: Grant
    Filed: September 6, 2019
    Date of Patent: March 29, 2022
    Assignee: Wayne State University
    Inventor: Aloke K. Dutta
  • Publication number: 20220065867
    Abstract: Kits and methods to distinguish between false and true labor are provided. The kits and methods can utilize differences in abundance and/or differences in the rate of change in abundance of B7-H2, SORC2, TF, C1-Esterase Inhibitor, Ran, IMDH1 and/or PGAM1, as markers of true labor.
    Type: Application
    Filed: November 12, 2021
    Publication date: March 3, 2022
    Applicants: Wayne State University, The United States of America, as Represented by the Secretary, Department of Health & Human Service
    Inventors: Adi L. Tarca, Piya Chaemsaithong, Tinnakorn Chaiworapongsa, Sonia S. Hassan, Roberto Romero
  • Publication number: 20220049290
    Abstract: Systems and methods to assess the health of various microbiomes and to identity species therein are disclosed. Described assessments and identifications can inform treatment decisions if a microbiome is determined to have a less than optimal balance of bacterial species within it; the presence of one or more negative species; and/or the absence of one or more positive species.
    Type: Application
    Filed: October 19, 2021
    Publication date: February 17, 2022
    Applicant: Wayne State University
    Inventors: Robert A. Akins, Jack D. Sobel
  • Patent number: 11243213
    Abstract: Biomarkers tests which can be used to predict a positive or negative risk of preeclampsia are described. More specifically, a panel of biomarkers including MMP-7 and gpIIbIIIa, described. The test is useful to predict preeclampsia when a biological sample is obtained between the 16th and 22nd week of pregnancy. Prediction later in pregnancy can be achieved by a combination of Siglec-6, Activin A, ALCAM, and/or FCN2.
    Type: Grant
    Filed: November 7, 2016
    Date of Patent: February 8, 2022
    Assignees: Wayne State University, The United States of America as Represented by the Secretary, Department of Health and Human Services
    Inventors: Adi L. Tarca, Piya Chaemsaithong, Tinnakorn Chaiworapongsa, Sonia S. Hassan, Roberto Romero
  • Patent number: 11236379
    Abstract: A Raman spectroscopy based system and method for examination and interrogation provides a method for rapid and cost effective screening of various protein-based compounds such as bacteria, virus, drugs, and tissue abnormalities. A hand-held spectroscope includes a laser and optical train for generating a Raman-shifting sample signal, signal processing and identification algorithms for signal conditioning and target detection with combinations of ultra-high resolution micro-filters and an imaging detector array to provide specific analysis of target spectral peaks within discrete spectral bands associated with a target pathogen.
    Type: Grant
    Filed: February 25, 2019
    Date of Patent: February 1, 2022
    Assignees: Seraph Biosciences, Inc., Wayne State University
    Inventors: Gregory William Auner, Charles Shanley, Michelle Brusatori, Tara Twomey, David Sant
  • Publication number: 20210393788
    Abstract: IgA-based Fc-folate conjugates as a treatment for cancer are provided. The conjugates utilize only the Fc portion of IgA to target its receptor on neutrophils (Fc?R1) to elicit antibody-dependent cellular-cytotoxicity (ADCC).
    Type: Application
    Filed: September 3, 2021
    Publication date: December 23, 2021
    Applicant: Wayne State University
    Inventor: Cecilia Speyer
  • Patent number: 11204354
    Abstract: Kits and methods to distinguish between false and true labor are provided. The kits and methods can utilize differences in abundance and/or differences in the rate of change in abundance of B7-H2, SORC2, TF, C1-Esterase Inhibitor, Ran, IMD-H1 and/or PGAM1, as markers of true labor.
    Type: Grant
    Filed: November 7, 2016
    Date of Patent: December 21, 2021
    Assignees: Wayne State University, The United States of America, as Represented by the Secretary, Dept. of Health and Human Services
    Inventors: Adi L. Tarca, Piya Chaemsaithong, Tinnakorn Chaiworapongsa, Sonia S. Hassan, Roberto Romero
  • Patent number: 11185599
    Abstract: An MRI contrast composition includes a liposome and a europium metal complex disposed within the liposome. The europium metal complex includes a europium metal ion and a multi-dentate ligand selected from the group consisting of cryptands and thiacryptands and one or more counter-ions that balances a charge of the europium metal ion and the multi-dentate ligand, the europium metal ion being switchable between a 2÷ and 3÷ oxidation state. The contrast composition advantageously provides an oxidation-responsive dual-mode contrast agent because it would enhance either T1-weighted images or CEST images depending on the oxidation state of Eu.
    Type: Grant
    Filed: June 25, 2019
    Date of Patent: November 30, 2021
    Assignee: Wayne State University
    Inventor: Matthew J. Allen