Abstract: The current disclosure provides alternating current based systems and methods to develop chemical compounds, such as drug molecules using electrochemistry in organic synthesis.

Abstract: Disclosed herein is a lithium ion battery which operates stably at high temperatures. The battery disclosed herein has a chemical composition amenable to long-term operation at elevated temperatures and employs a lithium-based cathode, a silicon-based anode, and a piperidinium-based electrolyte solution.

Abstract: Injectable hydrogels in the form of crosslinked nano beads or particle in the size range 5 nm to 10 ?m, comprising PAMAM dendrimer with asymmetrical peripheral end groups such that one of the terminal groups is involved in formation of hydrogel and the other in involved in the conjugation of drugs or imaging agents are formed by reaction of the PAMAM dendrimer with asymmetrical end groups with linear, branched, hyperbranched or star shaped polymers with functionalized terminal groups. The PAMAM dendrimer with asymmetrical terminal groups consists of a Generation 2 and above PAMAM dendrimer with symmetrical end groups modified using the amino acids or their modified forms. The gel is formed as small crosslinked particles in the size range 25 nm to 10 ?m and is suitable for injectable delivery of hydrogel or ocular delivery for the purpose of therapeutic treatment and imaging.

Abstract: A system and method of determining blood pressure includes measuring heart sounds, separating the measured heart sounds into a first heart sound (S1) and a second heart sound (S2), mathematically characterizing S1 and S2, and determining a blood pressure based on the characterization.

Abstract: Compositions and methods for in vivo immunoimaging IL-12 as a marker of IL-12—producing activated antigen presenting cells (APCs) in a subject are provided according to aspects of the present disclosure which include: administering a labeled-antibody conjugate to a subject, wherein the labeled-antibody conjugate includes 1) an antibody or antibody fragment that specifically binds to IL-12, and 2) a detection label conjugated to the antibody or antibody fragment, wherein the detection label is a radionuclide tracer, fluorophore, or nanoparticle, and wherein the labeled-antibody conjugate specifically binds to IL-12; and detecting the presence of the labeled-antibody conjugate in the subject in vivo by imaging. According to embodiments of the present disclosure, the subject is human and the antibody or antibody fragment specifically binds to human IL-12.

Abstract: The present disclosure provides a method of solid-phase peptide synthesis from the N terminus to C terminus without detectable epimerization of the C-terminal amino acid. The method includes using derivatized amino acids comprising a diamino-aryl group.

Abstract: A system, method, and device that provides power to an electrical unit such as an Internet of Things (IoT) device that includes a transmitter that provides electrical power through electromagnetic waves, a receiver, an array that includes a plurality of metamaterial elements, such that the electrical power passes wirelessly from the transmitter to the array, and a controller that applies selective phase shifts to each of the plurality of metamaterial elements such that the electrical power is transmitted from the transmitter, reflected off the array, and is received in phase at the receiver that converts the electromagnetic waves to an electric current to power the device.

Abstract: A distributed sensing and control network includes a plurality of sensing/control nodes, each of the sensing/control nodes includes a sensor, a local controller, a local memory and a wireless transmitter/receiver. The local memory stores instructions for implementing a multiscale networking protocol for wireless transmissions. The multiscale networking protocol controls at least a first factor at a first timescale and at least a second factor at a second timescale, distinct from the first timescale. The at least a first factor includes an instantiated physical-ratio-K (PRK) interference model for wireless transmissions. The at least a second factor includes at least one of a channel assignment, a node transmission signal power control, a node transmission rate control, a real-time scheduling control, and a local signal map stored in the local memory.

Abstract: A system for characterization of a brain tissue sample includes a laser having an excitation fiber and a probe coupled to the excitation fiber for irradiating the brain tissue sample with light at an excitation wavelength. The probe further includes a plurality of return fibers for receiving light scattered from the brain tissue sample, wherein each return fiber includes a microfilter that permits light to pass for a different, spaced apart marker region. A Raman spectrometer is in communication with the plurality of return fibers, and a processor is in communication with the Raman spectrometer for analyzing Raman spectra within the marker regions to identify a tissue type of the brain tissue sample as one of normal white matter brain tissue, normal grey matter brain tissue, brain tumor tissue, infiltrating tumor tissue, and necrotic tissue.

Abstract: The present disclosure is in the field of processes for the generation of thin inorganic films on substrates, in particular atomic layer deposition processes. Described herein is a process for preparing metal-containing films including: (a) depositing a metal-containing compound from the gaseous state onto a solid substrate, and (b) bringing the solid substrate with the deposited metal-containing compound in contact with a compound of general formula (I) wherein Z is a C2-C4 alkylene group, and R is hydrogen, an alkyl group, an alkenyl group, an aryl group, or a silyl group.

Abstract: The present disclosure describes compositions and methods to promote wound healing. The compositions and methods include an interleukin-1 beta (IL-1?) receptor antagonist (IL-1Ra), such as anakinra. The IL-1Ra can be administered topically to a chronic wound including a diabetic ulcer.

Abstract: The use of genes or biomarkers to more accurately diagnose aggressive prostate cancer in men of African descent or European descent is provided. More specifically, the genes or biomarkers of the present invention can be used in diagnostic tests and methods to determine, qualify, and/or assess aggressive prostate cancer or status, for example, to diagnose or identify aggressive prostate cancer, in an individual, subject, or patient, such as men of African descent or men of European descent.

Abstract: An optical proximity sensor assembly includes an optical proximity sensor with an IR LED emitting light having an infrared wavelength, an IR photo detector sensitive to the infrared wavelength, an optical barrier blocking direct light rays from the LED to the IR photo detector and permitting reflected light rays to reach the at least one photo detector; and an electronic integrated circuit with an amplifier for amplifying a signal detected by the photo detector, an analog to digital converter, LED drivers, noise reduction and ambient light cancellation circuitry, and a digital interface for communication with a microcontroller. The optical proximity sensor is accommodated on a wearable carrier. A single sensor may include a plurality of identical or different LEDs, a plurality of photodiodes, or both. Also, several sensors may be placed on a person's skin along a vascular path to obtain data relating to blood flow and artery stiffness.

Abstract: A Distributed sensing and control network includes multiple sensing/control nodes, each of which includes a controller. Each sensing/control node determines signal transmission/receipt scheduling based on a physical-ratio-k-scheduling (PRKS) protocol stored within the controller.

Abstract: A process including bringing a solid substrate in contact with a compound of general formula (I), (II), (III), or (IV) in the gaseous state where A is NR2 or OR with R being an alkyl group, an alkenyl group, an aryl group, or a silyl group, E is NR or O, n is 0, 1 or 2, m is 0, 1 or 2, and R? is hydrogen, an alkyl group, an alkenyl group, an aryl group, or a silyl group.

Abstract: Methods for detecting a cardiac condition in a human subject are provided according to aspects of the present invention which include providing an immunological reagent characterized by specific binding to: an N-terminal fragment of human cardiac troponin T (HcTnT-N69) or a neoepitope of human cardiac troponin T generated by removal of HcTnT-N69 from HcTnT (HcTnT-neo); contacting the immunological reagent with a biological sample of the human subject under binding conditions; and detecting binding of the immunological reagent with HcTnT-N69 or HcTnT-neo, wherein detection of HcTnT-N69 or HcTnT-neo in the biological sample is indicative of a cardiac condition in the subject. Antibodies and antigen binding fragments thereof characterized by specific binding to HcTnT-N69 or HcTnT-neo, or a variant of either thereof, are provided according to aspects of the present invention.

Abstract: Biomarkers tests which can be used to predict a positive or negative risk of preeclampsia are described. More specifically, a panel of biomarkers including MMP-7 and gpIIbIIIa, described. The test is useful to predict preeclampsia when a biological sample is obtained between the 16th and 22nd week of pregnancy. Prediction later in pregnancy can be achieved by a combination of Siglec-6, Activin A, ALCAM, and/or FCN2.

Abstract: A compound having formula I is useful for treating a neurodegenerative disease: or a pharmaceutically acceptable salt or ester thereof, wherein R1, R2, R3, R4, R5, R6, R7, R8 are each independently hydroxyl, C1-4 alkyl, C1-4 alkoxyl, C1-8 alkyl, C2-8 alkenyl, C2-8 alkynyl, C4-8, are specified substituents.

Abstract: Kits and methods to distinguish between false and true labor are provided. The kits and methods can utilize differences in abundance and/or differences in the rate of change in abundance of B7-H2, SORC2, TF, C1-Esterase Inhibitor, Ran, IMDH1 and/or PGAM1, as markers of true labor.

Abstract: Systems and methods to assess the health of various microbiomes and to identity species therein are disclosed. Described assessments and identifications can inform treatment decisions if a microbiome is determined to have a less than optimal balance of bacterial species within it; the presence of one or more negative species; and/or the absence of one or more positive species.