Patents Assigned to Wyeth
  • [1,4]Diazocino[7,8,1-hi]indole derivatives as antipsychotic and antiobesity agents
    Patent number: 7012089
    Abstract: Compounds of formula (I) or pharmaceutically acceptable salts thereof are provided: where R1 through R7 are defined herein. The compounds of formula (I) are 5HT2c agonists or partial agonists, and are useful for treating a variety of disorders.
    Type: Grant
    Filed: April 24, 2003
    Date of Patent: March 14, 2006
    Assignee: Wyeth
    Inventors: Hong Gao, Gary P. Stack, Annmarie L. Sabb
  • Method for producing monoclonal antibodies
    Patent number: 7011974
    Abstract: An improved method for the production of monoclonal antibodies is disclosed.
    Type: Grant
    Filed: September 17, 2002
    Date of Patent: March 14, 2006
    Assignee: Wyeth
    Inventors: Clive R. Wood, Randal J. Kaufman
  • Thiazolo-naphthyl acids
    Publication number: 20060052420
    Abstract: The present invention relates to thiazolo-naphthyl acids of the formula and methods of using them to modulate PAI-1 expression and to treat PAI-1 related disorders.
    Type: Application
    Filed: August 22, 2005
    Publication date: March 9, 2006
    Applicant: WYETH
    Inventor: Thomas Commons
  • Oxazolo-naphthyl acids
    Publication number: 20060052348
    Abstract: The present invention relates to oxazolo-naphthyl acids of the formula and methods of using them to modulate PAI-1 expression and to treat PAI-1 related disorders.
    Type: Application
    Filed: August 22, 2005
    Publication date: March 9, 2006
    Applicant: WYETH
    Inventors: Thomas Commons, Richard Woodworth
  • Pyrrolo-naphthyl acids and methods for using them
    Publication number: 20060052349
    Abstract: The present invention relates to pyrrolo-naphthyl compounds of the formula and methods of using them to modulate PAI-1 expression and to treat PAI-1 related disorders.
    Type: Application
    Filed: August 22, 2005
    Publication date: March 9, 2006
    Applicant: WYETH
    Inventors: Thomas Commons, Douglas Jenkins
  • 6H-[1]benzopyrano[4,3-b]quinolines and their use as estrogenic agents
    Publication number: 20060052410
    Abstract: This invention provides 6H-[1]benzopyrano[4,3-b]quinoline compounds having the formula I: The invention further provides compositions including the compounds, methods for the use of the compounds, and methods of preparation of the compounds.
    Type: Application
    Filed: September 6, 2005
    Publication date: March 9, 2006
    Applicant: Wyeth
    Inventor: An Vu
  • 2,3,5-substituted biphenyls useful in the treatment of insulin resistance and hyperglycemia
    Patent number: 7008636
    Abstract: This invention provides compounds of Formula I having the structure or a pharmaceutically acceptable salt thereof, which are useful in treating metabolic disorders related to insulin resistance or hyperglycemia.
    Type: Grant
    Filed: May 11, 2004
    Date of Patent: March 7, 2006
    Assignee: Wyeth
    Inventors: John A. Butera, Craig E. Caufield, Russell F. Graceffa, Alexander Greenfield, Eric G. Gundersen, Lisa Marie Havran, Alan H. Katz, Joseph R. Lennox, Scott C. Mayer, Robert E. McDevitt
  • Heterocyclic compounds which inhibit leukocyte adhesion mediated by ?integrins
    Patent number: 7008949
    Abstract: Disclosed are compounds which bind ?4 integrins, where the ?4 integrin is preferably VLA-4. Certain of these compounds also inhibit leukocyte adhesion and, in particular, leukocyte adhesion mediated by ?4 integrins, where the ?4 integrin is preferably VLA-4. Such compounds are useful in the treatment of inflammatory diseases in a mammalian patient, e.g., human, such as asthma, Alzheimer's disease, atherosclerosis, AIDS dementia, diabetes, inflammatory bowel disease, rheumatoid arthritis, tissue transplantation, tumor metastasis and myocardial ischemia. The compounds can also be administered for the treatment of inflammatory brain diseases such as multiple sclerosis.
    Type: Grant
    Filed: May 27, 2003
    Date of Patent: March 7, 2006
    Assignees: Elan Pharmaceuticals, Inc., Wyeth
    Inventors: Andrei W. Konradi, Christopher M. Semko, Ying-zi Xu, Frank Stappenbeck, Brian P. Stupi, Jenifer L. Smith, Michael A. Pleiss, Eugene D. Thorsett
  • Antidepressant azaheterocyclylmethyl derivatives of 2,3-dihydro-1,4-Dioxino[2,3-f]quinoxaline
    Patent number: 7008944
    Abstract: Compounds of the formula: are useful for the treatment of depression and other diseases such as obsessive compulsive disorder, panic attacks, generalized anxiety disorder, social anxiety disorder, sexual dysfunction, eating disorders, obesity, addictive disorders caused by ethanol or cocaine abuse and related illnesses.
    Type: Grant
    Filed: July 14, 2003
    Date of Patent: March 7, 2006
    Assignee: Wyeth
    Inventors: Jonathan L. Gross, Gary P. Stack
  • Neisseria meningitdis inner core lipo-oligosaccharide epitopes, multivalent conjugates thereof and immunogenic compositions thereof
    Publication number: 20060047106
    Abstract: The present invention is directed to novel Neisseria meningitidis lipo-oligosaccharide inner core molecules, conjugates thereof and immunogenic compositions thereof. In particular embodiments, the invention relates to multivalent immunogenic compositions comprising five distinct Neisseria meningitidis inner core lipo-oligosaccharide epitope groups, wherein the multivalent compositions induce cross-reactive immune responses against Neisseria meningitidis lipo-oligosaccharide immunotypes.
    Type: Application
    Filed: August 26, 2005
    Publication date: March 2, 2006
    Applicant: Wyeth
    Inventors: Viliam Pavliak, Mario Monteiro, Maria Fortuna-Nevin
  • Prodrug substituted benzoxazoles as estrogenic agents
    Publication number: 20060046968
    Abstract: This invention provides estrogen receptor modulators of formula I, having the structure wherein Q, Q2, R1, R2, R2a, R3, R3a, and X as defined in the specification, or a pharmaceutically acceptable salt thereof.
    Type: Application
    Filed: August 24, 2005
    Publication date: March 2, 2006
    Applicant: Wyeth
    Inventors: Sayed Elmarakby, Ping Cai, Appavu Chandrasekaran, Mark Ruppen, Rasmy Talaat
  • Method of treating estrogen receptor positive carcinoma with 17 ?-dihydroequilin
    Patent number: 7005429
    Abstract: This invention provides a method of treating estrogen receptor positive carcinoma in a mammal in need thereof which comprises administering an antineoplastic amount of 17(?-dihydroequilin or a mammalian metabolic conjugate thereof orally, parenterally, transdermally, topically, rectally, intravaginally, intranasally, or intrabronchially. As such, the compounds of this invention are useful in treating estrogen receptor positive carcinomas such as carcinomas of the breast, uterus, ovary, fallopian tube, cervix, vagina, liver, pituitary, central nervous system, hypothalamus, bone, skin, kidney, urethra, prostate, and the like.
    Type: Grant
    Filed: September 26, 2001
    Date of Patent: February 28, 2006
    Assignee: Wyeth
    Inventors: Michael S. Dey, Frederick J. Bex, Alan Corbin
  • ?-amyloid peptide-binding proteins and polynucleotides encoding the same
    Patent number: 7005295
    Abstract: Novel proteins which bind human ?-amyloid peptide, polynucleotides which encode these proteins, and methods for producing these proteins are provided. Diagnostic, therapeutic, and screening methods employing the polynucleotides and polypeptides of the present invention are also provided.
    Type: Grant
    Filed: January 31, 2001
    Date of Patent: February 28, 2006
    Assignee: Wyeth
    Inventors: Bradley A. Ozenberger, Jonathan A. Bard, Eileen M. Kajkowski, Jack S. Jacobsen, Stephen G. Walker, Heidi Sofia
  • Rapamycin polymorphs and uses thereof
    Publication number: 20060040971
    Abstract: The present invention provides rapamycin polymorph Form II. This invention also provides processes for preparing rapamycin polymorph Form II and pharmaceutical compositions including rapamycin polymorph Form II.
    Type: Application
    Filed: August 18, 2005
    Publication date: February 23, 2006
    Applicant: Wyeth
    Inventors: Tianmin Zhu, Mahdi Fawzi
  • Process for the synthesis C-2, C-3 substituted N-alkylated indoles useful as CPLA2 inhibitors
    Publication number: 20060041005
    Abstract: The present invention provides method for making a compound of formula 1: comprising the steps of reacting compounds of formulas 2 and 3: to produce a compound of formula 4: wherein R1, R2, R3, R4 and R5 are defined as described herein. The compound of formula 4 is then converted to the compound of formula 1. The invention further comprises compounds of formulas 3 and 4 and methods for making compounds of formulas 3 and 4.
    Type: Application
    Filed: August 18, 2005
    Publication date: February 23, 2006
    Applicant: Wyeth
    Inventors: Ronald Michalak, Mahmut Levent, Frederick Vyverberg, Ara Boyajian, Panolil Raveendranath, Michel Cantin, Alan Stockton, Michael Winkley, Mousumi Ghosh, Christoph Dehnhardt, Charles Guinosso
  • Formate salt of O-desmethyl-venlafaxine
    Patent number: 7001920
    Abstract: A novel salt of O-desmethylvenlafaxine, O-desmethylvenlafaxine formate, is provided. Pharmaceutical compositions, dosage forms and methods of use are also provided.
    Type: Grant
    Filed: June 9, 2003
    Date of Patent: February 21, 2006
    Assignee: Wyeth
    Inventors: Anthony Francis Hadfield, Michael William Winkley
  • Antineoplastic combinations
    Publication number: 20060035904
    Abstract: This invention provides the use of a combination of an mTOR inhibitor and an antimetabolite antineoplastic agent in the treatment of neoplasms.
    Type: Application
    Filed: September 29, 2005
    Publication date: February 16, 2006
    Applicant: Wyeth
    Inventors: Jurgen Frisch, James Gibbons, Gary Dukart
  • Tanaproget derivatives, metabolites,and uses thereof
    Publication number: 20060035843
    Abstract: A method of generating synthetic metabolites of tanaproget derivatives thereof is provided. These compounds and methods of using these derivatives for detecting tanaproget metabolites in samples are provided.
    Type: Application
    Filed: August 11, 2005
    Publication date: February 16, 2006
    Applicant: Wyeth
    Inventors: Li Shen, Kelly Keating, Oliver McConnell, William DeMaio, Appavu Chandrasekaran
  • CCI-779 derivatives and methods of making same
    Publication number: 20060036091
    Abstract: A method of generating synthetic metabolites of CCI-779 is provided. Five novel CCI-779 derivatives are described, as are methods of using these derivatives for detecting CCI-779 metabolites in samples.
    Type: Application
    Filed: August 9, 2005
    Publication date: February 16, 2006
    Applicant: Wyeth
    Inventors: Ping Cai, Mark Ruppen, Russ Tsao
  • Scalloped cap
    Patent number: D515422
    Type: Grant
    Filed: December 17, 2003
    Date of Patent: February 21, 2006
    Assignee: Wyeth
    Inventor: Gerald J. Forte