Patents Assigned to Wyeth
  • 4-(2,4-dichloro-5-methoxyphenyl)amino-6-methoxy-7-{[5-substituted -amino)methyl]-3-furyl}-3-quinolinecarbonitriles as kinase inhibitors
    Publication number: 20060035930
    Abstract: This invention relates to compounds having the structure of Formula I wherein R1, R2, R3, and R4 are described herein.
    Type: Application
    Filed: August 11, 2005
    Publication date: February 16, 2006
    Applicant: Wyeth
    Inventors: Diane Boschelli, Jay Afragola, Asaf Alimardanov, Biqi Wu
  • USE OF AGENTS THAT MODULATE THE INTERACTION BETWEEN PD-1 AND ITS LIGANDS IN THE DOWNMODULATION OF IMMUNE RESPONSES
    Publication number: 20060034826
    Abstract: Disclosed are methods for downmodulating an immune response comprising contacting all immune cell with an agent that modulates the interaction between PD-1 and a PD-1 ligand (e.g., soluble forms of PD-1 or PD-1 ligand or antibodies to PD-1), to thereby modulate the immune response.
    Type: Application
    Filed: April 2, 2002
    Publication date: February 16, 2006
    Applicant: Wyeth
    Inventors: Beatriz Carreno, John Leonard
  • Methods and vaccines for providing in ovo protection against turkey rhinotracheitis
    Publication number: 20060034868
    Abstract: Methods and compositions for protecting avian hosts (e.g., turkeys and/or chickens) from turkey rhinotracheitis virus and/or TRT or SHS respiratory distress utilize in ovo administration of live, avirulent strains of TRTV at appropriate dosage levels on a per egg basis to provide an effective and efficient vaccination having acceptable safety and efficacy features, and additionally provides higher titers in vaccinated birds than conventionally administered vaccines.
    Type: Application
    Filed: October 17, 2005
    Publication date: February 16, 2006
    Applicant: Wyeth
    Inventor: Frans Davelaar
  • Selection of poultry strains through extra-intestinal sporozoites
    Patent number: 6998126
    Abstract: A method for obtaining an immunogenic strain useful for producing a vaccine against Coccidiosis comprises the cycle of infecting at least one first group of specific pathogen-free donor birds with oocysts from an Eimeria species. Blood is then collected from these donor birds, and is then used to infect a second group of specific pathogen-free birds. Oocysts are collected from the second group of birds. These oocysts are then multiplicated to complete the cycle. The cycle is then repeated using the multiplicated oocysts. After a total of about three cycles, a final antigen may be harvested and utilized as a source to generate oocysts for a vaccine.
    Type: Grant
    Filed: February 21, 2003
    Date of Patent: February 14, 2006
    Assignee: Wyeth
    Inventor: Frans Gerrit Davelaar
  • 1-Heterocyclylalkyl-3-sulfonylindole or -indazole derivatives as 5-hydroxytryptamine-6 ligands
    Publication number: 20060030593
    Abstract: The present invention provides a compound of formula I and the use thereof for the treatment of a central nervous system disorder related to or affected by the 5-HT6 receptor.
    Type: Application
    Filed: September 29, 2005
    Publication date: February 9, 2006
    Applicant: Wyeth
    Inventors: Ronald Bernotas, Steven Lenicek
  • Antineoplastic combinations
    Publication number: 20060030547
    Abstract: This invention provides the use of a combination of CCI-779 and an antineoplastic alkylating agent in the treatment of neoplasms.
    Type: Application
    Filed: October 12, 2005
    Publication date: February 9, 2006
    Applicant: Wyeth
    Inventors: Gary Dukart, James Gibbons
  • Indazoles useful in treating cardiovascular diseases
    Publication number: 20060030612
    Abstract: This invention provides compounds of Formula (I) or (Ia): that are useful in the treatment or inhibition of LXR mediated diseases.
    Type: Application
    Filed: August 1, 2005
    Publication date: February 9, 2006
    Applicant: Wyeth
    Inventors: Robert Steffan, Edward Matelan, Stephen Bowen, John Ullrich, Jay Wrobel, Edouard Zamaratski, Lars Kruger, Annabel Hedemyr, Aiping Cheng, Tomas Hansson, Rayomand Unwalla, Christopher Miller, Patrik Rhonnstad
  • Crystalline polymorph of pipindoxifene hydrochloride monohydrate
    Publication number: 20060030711
    Abstract: The present invention is directed to a crystalline polymorph of pipindoxifene hydrochloride monohydrate, compositions containing the same, preparations thereof, and uses thereof.
    Type: Application
    Filed: August 4, 2005
    Publication date: February 9, 2006
    Applicant: Wyeth
    Inventors: Christopher Demerson, Gloria Cheal
  • Progesterone receptor modulators comprising pyrrole-oxindole derivatives and uses thereof
    Publication number: 20060030717
    Abstract: Pyrrole-oxindole derivatives useful as progesterone receptor antagonists, and methods for preparing the same, are provided. Pharmaceutical compositions containing these derivatives are described, as is the use thereof in contraception and hormone-related conditions.
    Type: Application
    Filed: July 6, 2005
    Publication date: February 9, 2006
    Applicant: Wyeth
    Inventors: Andrew Fensome, Casey McComas, Edward Melenski, Michael Marella, Jay Wrobel, Gary Grubb
  • Crystalline polymorph of pipindoxifene hydrochloride monohydrate
    Publication number: 20060030591
    Abstract: The present invention is directed to a crystalline polymorph of pipindoxifene hydrochloride monohydrate, compositions containing the same, preparations thereof, and uses thereof.
    Type: Application
    Filed: August 4, 2005
    Publication date: February 9, 2006
    Applicant: Wyeth
    Inventors: Christopher Demerson, Gloria Cheal
  • Progesterone receptor modulators comprising pyrrole-oxindole derivatives and uses thereof
    Publication number: 20060030615
    Abstract: Pyrrole-oxindole derivatives useful as progesterone receptor antagonists are provided. Pharmaceutical compositions containing these derivatives are described, as is the use thereof in contraception and hormone-related conditions.
    Type: Application
    Filed: July 6, 2005
    Publication date: February 9, 2006
    Applicant: Wyeth
    Inventors: Andrew Fensome, Casey McComas, Edward Melenski, Michael Marella, Jay Wrobel
  • Processing for preparing monoprotected diols from symmetric diols
    Patent number: 6995001
    Abstract: This invention provides a two-step enzymatic process for the synthesis of monoprotected diols from symmetric diols.
    Type: Grant
    Filed: September 26, 2003
    Date of Patent: February 7, 2006
    Assignee: Wyeth Holdings Corporation
    Inventors: Jianxin Gu, Mark Edward Ruppen
  • 1-heterocyclylalkyl-3-sulfonyl-indole or -indazole derivatives as 5-hydroxytryptamine-6 ligands
    Patent number: 6995176
    Abstract: The present invention provides a compound of formula I and the use thereof for the treatment of a central nervous system disorder related to or affected by the 5-HT6 receptor.
    Type: Grant
    Filed: July 17, 2003
    Date of Patent: February 7, 2006
    Assignee: Wyeth
    Inventors: Ronald Charles Bernotas, Steven Edward Lenicek
  • Novel human estrogen receptor beta
    Publication number: 20060025580
    Abstract: The present invention provides isolated nucleic acids encoding full-length human estrogen receptor-? (hER?), which comprises 530 amino acids. The invention also provides isolated hER? polypeptides and hER?-reactive antibodies, including those that specifically recognize amino acids 1-45 of hER?. The invention also encompasses methods for identifying hER?-interactive compounds, including agonists, antagonists, and co-activators.
    Type: Application
    Filed: December 30, 2004
    Publication date: February 2, 2006
    Applicant: Wyeth
    Inventors: Ramesh Bhat, Ruth Henderson, Chulai Hsiao, Sotirios Karathanasis
  • Processes for preparing 6-alkyl-5-arylsulfonyl-dihydrophenanthridines
    Publication number: 20060025436
    Abstract: Synthetic methods are provided for production of compounds of the formula: where R1, R2, R3, R4, R5, R6, R7, R8, R9, R10, R11, R12, R13 and R14 are as defined in the specification.
    Type: Application
    Filed: June 17, 2005
    Publication date: February 2, 2006
    Applicant: Wyeth
    Inventors: Brian Ridgway, William Moore, Mark Ashwell, William Solvibile, Amy Lee, Molly Hoke, Madelene Antane, Amedeo Failli
  • Method for treating nervous system disorders and conditions
    Publication number: 20060019966
    Abstract: The present invention is directed to selective dopamine reuptake inhibitors, including (?)-1-(3,4-dichlorophenyl)-3-azabicyclo[3.1.0]hexane, (?)-1-(4-methylphenyl)-3-azabicyclo[3.1.0]hexane, and 1-[2-[bis(4-fluorophenyl)methoxy]ethyl]-4-(3-phenylpropyl)piperazine, and methods of their use for treating certain nervous system disorders and conditions, including, inter alia, vasomotor symptoms (VMS), chronic pain, and Shy Drager syndrome.
    Type: Application
    Filed: July 21, 2005
    Publication date: January 26, 2006
    Applicant: Wyeth
    Inventors: Darlene Deecher, Magid Abou-Gharbia
  • Method for treating nervous system disorders and conditions
    Publication number: 20060020015
    Abstract: The present invention is directed to racemic 1-(3,4-dichlorophenyl)-3-azabicyclo[3.1.0]hexane, (+)-1-(3,4-dichlorophenyl)-3-azabicyclo[3.1.0]hexane, racemic 1-(4-methylphenyl)-3-azabicyclo[3.1.0]hexane, and (+)-1-(4-methylphenyl)-3-azabicyclo[3.1.0]hexane, and methods of their use for treating certain nervous system disorders and conditions, including, inter alia, vasomotor symptoms (VMS) and chronic pain.
    Type: Application
    Filed: July 21, 2005
    Publication date: January 26, 2006
    Applicant: Wyeth
    Inventors: Magid Abou-Gharbia, Arthur Cohn, Darlene Deecher
  • Gonadotropin releasing hormone receptor antagonists
    Publication number: 20060019965
    Abstract: The present invention relates to Gonadotropin Releasing Hormone (“GnRH”) (also known as Leutinizing Hormone Releasing Hormone) receptor antagonists.
    Type: Application
    Filed: June 16, 2005
    Publication date: January 26, 2006
    Applicant: Wyeth
    Inventors: Lloyd Garrick, Daniel Green, Diane Hauze, Kenneth Kees, Joseph Lundquist, Charles Mann, John Mehlmann, Jeffrey Pelletier, John Rogers, Jay Wrobel
  • Cytosolic phospholipase A2-beta enzymes
    Publication number: 20060019363
    Abstract: The invention provides a novel calcium-independent cytosolic phospholipase A2-Beta enzyme, polynucleotides encoding such enzyme and methods for screening unknown compounds for anti-inflammatory activity mediated by the arachidonic acid cascade.
    Type: Application
    Filed: November 24, 2004
    Publication date: January 26, 2006
    Applicant: Wyeth
    Inventors: Ronald Kriz, Chuanzheng Song
  • Tablet dispenser
    Patent number: D513977
    Type: Grant
    Filed: October 10, 2003
    Date of Patent: January 31, 2006
    Assignee: Wyeth
    Inventors: Mark A. Nichols, David G. Honan