Patents Assigned to Wyeth
  • Hydroxyethyl starch—containing polypeptide compositions
    Patent number: 6982080
    Abstract: The invention provides compositions containing hydroxyethyl starch and polypeptides, including therapeutic polypeptides such as interleukin-11, that provide for enhanced stability of the polypeptide following storage at room temperature or elevated temperatures.
    Type: Grant
    Filed: March 17, 2003
    Date of Patent: January 3, 2006
    Assignees: Wyeth, The Regents of the University of Colorado
    Inventors: Nicholas W. Warne, Rebecca L. Koval, John Carpenter, Theodore W. Randolph, Suchart Chongpraset
  • Process for the synthesis of intermediates useful for the synthesis of tubulin inhibitors
    Publication number: 20050288486
    Abstract: The invention is a process for the preparation of compounds of the Formula I: where R1, R2, R3, R4 and R5 are defined in the specification, which are intermediates useful for the preparation of tubulin inhibitors which are useful in the treatment of cancer.
    Type: Application
    Filed: August 11, 2005
    Publication date: December 29, 2005
    Applicant: Wyeth Holdings Corporation
    Inventor: John Kendall
  • Preparation of 6-hydroxyequilenins
    Publication number: 20050288268
    Abstract: This invention relates to a process for the preparation of 6-hydroxyequilenins, which are useful as estrogenic agents.
    Type: Application
    Filed: August 22, 2005
    Publication date: December 29, 2005
    Applicant: Wyeth
    Inventors: Sreenivasulu Megati, Galina Vid, Arthur Mohan, Panolil Raveendranath, John Potoski
  • Glycopeptide antibiotics
    Publication number: 20050288221
    Abstract: The invention provides compounds of formula Wherein R1, R2, R3, R4, R5, R6a, R6b, R6c, R6d, R6e and R7 are defined in the specification. These compounds are useful as antibiotic agents.
    Type: Application
    Filed: April 27, 2005
    Publication date: December 29, 2005
    Applicant: Wyeth Holdings Corporation
    Inventors: Jason Lotvin, Mark Ruppen
  • Probe arrays for expression profiling of rat genes
    Publication number: 20050287570
    Abstract: The present invention provides probe arrays for expression profiling of rat genes. Each probe array comprises a plurality of probes, each of which is directed to a rat gene that encodes a sequence selected from SEQ ID NOs: 1-8,192. Suitable probes for the present invention include polynucleotides that can hybridize under stringent or nucleic acid array hybridization conditions to the RNA transcripts, or the complements thereof, of the corresponding rat genes. Suitable probes also include antibodies or other protein-binding molecules that can bind to the protein products of the corresponding rat genes. In one embodiment, a probe array of the present invention includes one or more probes, each of which is directed to a rat gene that encodes a sequence selected from SEQ ID NOs: 7622 and 8084-8124.
    Type: Application
    Filed: May 25, 2005
    Publication date: December 29, 2005
    Applicant: Wyeth
    Inventor: William Mounts
  • Injectable solid hyaluronic acid carriers for delivery of osteogenic proteins
    Publication number: 20050287135
    Abstract: An injectable or implantable rod-shaped formulation is disclosed for delivery of osteogenic proteins. The formulation comprises hyaluronic acid derivatives and osteogenic proteins, and optional excipients and active ingredients such as a bone resorption inhibitor. Methods of making injectable rod-shaped pharmaceutical compositions and methods of using the osteogenic compositions to treat osteoporotic and/or osteopenic bone are also disclosed.
    Type: Application
    Filed: May 12, 2003
    Publication date: December 29, 2005
    Applicant: Wyeth
    Inventors: Rebecca Li, Hyun Kim
  • Amino-5,5-diphenylimidazolone derivatives for the inhibition of beta-secretase
    Publication number: 20050282825
    Abstract: The present invention provides a compound of formula I and the use thereof for the therapeutic treatment, prevention or amelioration of a disease or disorder characterized by elevated ?-amyloid deposits or ?-amyloid levels in a patient.
    Type: Application
    Filed: June 15, 2005
    Publication date: December 22, 2005
    Applicant: Wyeth
    Inventors: Michael Malamas, James Erdei, Iwan Gunawan, Ping Zhou, Yinfa Yan, Dominick Quagliato
  • Diphenylimidazopyrimidine and -imidazole amines as inhibitors of beta-secretase
    Publication number: 20050282826
    Abstract: The present invention provides a compound of formula I and the use thereof for the therapeutic treatment, prevention or amelioration of a disease or disorder characterized by elevated ?-amyloid deposits or ?-amyloid levels in a patient.
    Type: Application
    Filed: June 15, 2005
    Publication date: December 22, 2005
    Applicant: Wyeth
    Inventors: Michael Malamas, James Erdei, Iwan Gunawan, Keith Barnes, Matthew Johnson, Yu Hui
  • Method for excystation of sporocysts
    Publication number: 20050281893
    Abstract: A process to excystate protozoal sporocysts involves treatment of an infected tissue sample with a sodium hypochlorite solution to stimulate excystation of the sporocysts from the tissue. Thereafter, removal of the sodium hypochlorite solution and treatment of the sample with a cell culture media as the excystation fluid eliminates incubation and subsequent washing steps using expensive reagents. The excystation fluid contains substantially no chelating agents, proteins, enzymes or bile acids.
    Type: Application
    Filed: August 18, 2005
    Publication date: December 22, 2005
    Applicant: Wyeth
    Inventors: Neil Jennings, Kirsten Dinka
  • Cell surface molecules as markers and therapeutic agents against kidney cancers
    Publication number: 20050282168
    Abstract: Human cell surface molecules CD70 and CD203c are expressed at higher levels in kidney carcinomas, particularly renal cell carcinomas and clear cell renal cell carcinomas, yet are expressed at low levels in normal kidney and other diseased kidney tissue, and at low levels in other tissues. CD70 and CD203c show specificity towards kidney carcinomas, particularly renal cell carcinomas and clear cell renal cell carcinomas and thus can be used as diagnostic markers and therapeutic targets for these diseases. In addition, antibodies or small molecules against these molecules could be used in treatments towards these diseases.
    Type: Application
    Filed: September 29, 2003
    Publication date: December 22, 2005
    Applicant: Wyeth
    Inventors: Wei Liu, Maryann Whitley, Donna Slonim, Steven Howes
  • Processes for preparing gonadotropin releasing hormone receptor antagonists
    Publication number: 20050282820
    Abstract: The present invention relates to methods of making Gonadotropin Releasing Hormone (“GnRH”) (also known as Leutinizing Hormone Releasing Hormone) receptor antagonists.
    Type: Application
    Filed: June 16, 2005
    Publication date: December 22, 2005
    Applicant: Wyeth
    Inventors: Alexander Gontcharov, Gulnaz Khafizova, John Potoski, Donna Huryn
  • Hydroxy cyclohexenyl phenyl carboxamides tocolytic oxytocin receptor antagonists
    Patent number: 6977254
    Abstract: The present invention provides substituted 10,11-Dihydro-5H-benzo[e]-pyrrolo[1,2-a][1,4]diazepine and 9,10-Dihydro-4H-3a,5,9-triaza-benzo[f]azulene compounds as well as methods and pharmaceutical compositions utilizing these compounds for the treatment and/or prevention and/or suppression of disorders which may be remedied or alleviated by oxytocin antagonist activity, including prevention and/or suppression of preterm labor, suppression labor at term prior to caesarean deliver, and for the treatment of dysmenorrhea. These compounds are also useful in enhancing fertility rates, enhancing survival rates and synchronizing estrus in farm animals.
    Type: Grant
    Filed: April 10, 2002
    Date of Patent: December 20, 2005
    Assignee: Wyeth
    Inventors: Amedeo Arturo Failli, William Jennings Sanders, Eugene John Trybulski
  • Processes for the preparation of 2-cyano-3-naphthalene-1-yl-acrylic acid alkyl or benzyl esters
    Publication number: 20050277784
    Abstract: The present invention provides processes for the preparation of compounds of Formula III that are useful in the preparation of pharmaceuticals for the treatment of inflammatory diseases.
    Type: Application
    Filed: June 9, 2005
    Publication date: December 15, 2005
    Applicant: Wyeth
    Inventors: Weiguo Liu, John Considine, Zhixian Ding, John Potoski
  • Truncated ADAMTS molecules
    Publication number: 20050277175
    Abstract: The invention provides truncated biologically active ADAMTS polypeptides, particularly those with hyalectenase activity, and more particularly those with aggrecanase activity, that exhibit greater stability and homogeneity and higher expression yields than their full-length counterparts. The invention also provides nucleic acid molecules encoding such truncated biologically active ADAMTS polypeptides and methods for producing the truncated biologically active ADAMTS polypeptides. In addition, the invention provides methods for identifying compounds capable of modulating biologically active ADAMTS polypeptides, particularly those compounds that inhibit aggrecanase activity.
    Type: Application
    Filed: April 18, 2005
    Publication date: December 15, 2005
    Applicant: WYETH
    Inventors: Edward LaVallie, Lisa Collins-Racie, Christopher Corcoran, Natalie Twine, Michael Agostino
  • Processes for the preparation of 2-cyano-3-naphthalene-1-yl-3-phenyl-propionic acid alkyl or benzyl esters
    Publication number: 20050277783
    Abstract: The present invention provides processes for the preparation of compounds of Formula I, which are useful in the preparation of pharmaceuticals for the treatment of inflammatory diseases. The compounds of Formula I are also useful as pharmaceuticals.
    Type: Application
    Filed: June 9, 2005
    Publication date: December 15, 2005
    Applicant: Wyeth
    Inventors: Weiguo Liu, John Considine, Zhixian Ding, John Potoski
  • Coupling process for generating reactive boron-containing derivatives of N-substituted pyrrole-2-carbonitriles to produce biaryls
    Publication number: 20050272702
    Abstract: A convenient preparation of boron-containing compounds, borate salts, pyrrolecarbonitrile boron-containing compounds, N-substituted-pyrrole-2-carbonitrile boron-containing compounds, and derivatives thereof is provided. The present invention also provides for the use of these boron-containing compounds and derivatives thereof in coupling reactions to provide bi-aryl compounds.
    Type: Application
    Filed: April 25, 2005
    Publication date: December 8, 2005
    Applicant: Wyeth
    Inventors: Bogdan Wilk, Arkadiy Rubezhov, Jean Helom
  • Method for preparing hydroxamic acids
    Publication number: 20050272928
    Abstract: Processes for using a compound of formula III: to make compounds of formulae I and II: and processes for making the compound of formula III, where R1-5 and J are as defined herein.
    Type: Application
    Filed: June 7, 2005
    Publication date: December 8, 2005
    Applicant: Wyeth
    Inventors: Ting-Zhong Wang, Lalitha Krishnan, Joseph Zeldis, Jeremy Levin, Jean Schmid, Mellard Jennings, Huan-Qiu Li, Zhixin Wen
  • Enzymatic process for deacetylation of a phenoxy-alkynyl acetate to the corresponding alcohol
    Publication number: 20050272725
    Abstract: A process for preparing the compound of formula II by reacting the compound of formula I with an enzyme that can hydrolyze the ester bond: where * indicates a chiral center, R1 and R2 each independently represent H, C1-C6alkyl, —CN or —CCH, and R3 and R4 each independently represent H or C1-C6alkyl.
    Type: Application
    Filed: June 7, 2005
    Publication date: December 8, 2005
    Applicant: Wyeth
    Inventors: Ramesh Matur, Mark Ruppen
  • Naphthyl benzoxazoles and benzisoxazoles as estrogenic agents
    Publication number: 20050272786
    Abstract: This invention provides estrogen receptor modulators of formula 1, having the structure wherein, A is wherein R1, R2, R3, and R4, and X as defined in the specification, or a pharmaceutically acceptable salt thereof.
    Type: Application
    Filed: March 30, 2005
    Publication date: December 8, 2005
    Applicant: Wyeth
    Inventors: Michael Malamas, Iwan Gunawan, Heather Harris, James Keith, Leo Albert
  • Sugar coatings and methods therefor
    Publication number: 20050271724
    Abstract: Compositions particularly useful as coatings for solid dosage forms of therapeutic agents are provided, as are solid dosage forms comprising such coatings, processes for preparing such solid dosage forms, and the products of those processes. The coating compositions generally provide excellent strength and resistance to cracking, even when applied to flexible/swellable tablet cores such as hydrogel-type cores. The compositions also exhibit excellent odor-blocking characteristics.
    Type: Application
    Filed: June 7, 2005
    Publication date: December 8, 2005
    Applicant: Wyeth
    Inventors: John Clark, John Michelucci, Deborah Sherman