Patents Assigned to Wyeth
  • Process for preparing 3-[2-(4-benzamidopiperid-1-yl)ethyl]indole
    Patent number: 4140691
    Abstract: The invention provides a process for preparing indole derivatives in which a compound containing an indole ring linked to an acylamido piperidine ring by a carbonyl alkylene group between the nitrogen of the piperidine and the 3-position of the indole is reduced with alkali-metal borohydride in special solvents so that the carbonyl group is reduced to a CH.sub.2 group.
    Type: Grant
    Filed: March 8, 1977
    Date of Patent: February 20, 1979
    Assignee: John Wyeth & Brother, Ltd.
    Inventors: George O. Weston, Susan E. Murfitt
  • Thiazole compositions
    Patent number: 4134984
    Abstract: The invention relates to the use of thiazoles in the treatment of ulcers and/or hypersecretion in mammals. The invention also provides in a preferred aspect a pharmaceutical composition for use in the treatment of ulcers or hypersecretion comprising a compound of formula I ##STR1## where R.sup.1 is hydrogen, alkyl of 1-6 carbon atoms, or phenyl, R is hydrogen, n-alkyl of 1-4 carbon atoms (which may be substituted by chlorine), or cyclopropyl, R.sup.3 is hydrogen or COR.sup.4 where R.sup.4 is as defined for R and R and R.sup.4 may be the same or different and a pharmaceutically acceptable carrier.
    Type: Grant
    Filed: November 10, 1976
    Date of Patent: January 16, 1979
    Assignee: John Wyeth & Brother Limited
    Inventor: Roger Crossley
  • Pharmaceutical compositions containing 4-amido-thiazoles
    Patent number: 4132798
    Abstract: The invention relates to pharmaceutical compositions for use in treating ulcers or hypersecretion comprising a compound of formula I ##STR1## wherein R is hydrogen, alkyl of 1 to 6 carbon atoms, or COR.sup.3 where R.sup.3 is hydrogen, alkyl of 1 to 5 carbon atoms, alkenyl of 2 to 5 carbon atoms, alkynyl of 2 to 5 carbon atoms or cycloalkyl of 3 to 5 carbon atoms; R.sup.1 is hydrogen or alkyl of 1 to 6 carbon atoms, R.sup.2 is alkyl of 1 to 6 carbon atoms or phenyl optionally substituted by halogen, alkyl of 1 to 6 carbon atoms or alkoxy of 1 to 6 carbon atoms, and R.sup.3 is as defined above, and a pharmaceutically acceptable carrier.
    Type: Grant
    Filed: March 16, 1978
    Date of Patent: January 2, 1979
    Assignee: John Wyeth & Brother Ltd.
    Inventor: Roger Crossley
  • Hypotensive sulphonamidopiperidyl indoles
    Patent number: 4131680
    Abstract: This invention relates to compounds having the general formula: ##STR1## WHEREIN W represents a phenyl or indolyl radical, either of which radicals may be unsubstituted or substituted by halogen, lower alkyl, lower alkoxy or hydroxy. A represents a lower alkylene radical, an oxo lower alkylene radical or a hydroxy lower alkylene radical; R represents a phenyl radical optionally substituted by halogen, lower alkyl, lower alkoxy or hydroxy, a cycloalkyl radical of 5 to 7 carbon atoms or a lower alkyl radical; R.sup.1 represents hydrogen or a lower alkyl radical or a pharmaceutically acceptable acid addition or quaternary ammonium salt thereof; which possess hypotensive activity.
    Type: Grant
    Filed: September 23, 1976
    Date of Patent: December 26, 1978
    Assignee: John Wyeth & Brother Ltd.
    Inventors: John L. Archibald, John L. Jackson
  • Thiazole derivatives to treat inflammation
    Patent number: 4127663
    Abstract: 4-(p-Chlorophenyl)-2-phenyl-5-thiazoleacetic acid and its pharmaceutically acceptable salts are useful as topical anti-inflammatory agents. The compounds can be administered in association with a pharmaceutically acceptable topical carrier.
    Type: Grant
    Filed: May 31, 1977
    Date of Patent: November 28, 1978
    Assignee: John Wyeth & Brother Limited
    Inventor: John F. Cavalla
  • Thiazoline derivatives
    Patent number: 4127660
    Abstract: New thiazolotriazines having the formula ##STR1## (where R.sup.1 is aryl and R.sup.2 is ar(lower)alkyl, lower alkyl or lower alkenyl) and their pharmaceutically acceptable acid addition salts are described. The corresponding thiazolotriazinium compounds comprising a cation having the formula ##STR2## (where R.sup.1 and R.sup.2 are as explained above and R.sup.3 is ar(lower)alkyl, lower alkyl or lower alkenyl) and a pharmaceutically acceptable anion are also described. The compounds are indicated for use as anti-ulcer agents.
    Type: Grant
    Filed: December 16, 1977
    Date of Patent: November 28, 1978
    Assignee: John Wyeth & Brother Limited
    Inventor: John T. A. Boyle
  • Fused ring indole derivatives and antidepressant compositions containing them
    Patent number: 4126683
    Abstract: The invention concerns novel fused ring indole derivatives of the formula ##STR1## and the pharmaceutically acceptable acid addition and quaternary ammonium salts thereof, wherein n represents 1 or 2 and R.sup.1 represents hydrogen, hydroxyl, lower alkyl, lower alkoxy, trifluoromethyl, halogen, amino or mono- or di-(lower)alkylamino. The compounds are useful as anti-depressant agents.
    Type: Grant
    Filed: June 8, 1977
    Date of Patent: November 21, 1978
    Assignee: John Wyeth & Brother Limited
    Inventors: Alan C. White, Robert F. Sugden
  • Piperidine derivatives
    Patent number: 4105666
    Abstract: (Aroylamino)-1-(aroyloxyalkyl)piperidines having the formula ##STR1## WHERE Ar.sup.1 and Ar.sup.2 are aryl (including heteroaryl) groups and n is from 2 to 6, and their pharmaceutically acceptable acid addition salts are described. The piperidine derivatives show hypotensive activity.
    Type: Grant
    Filed: July 13, 1977
    Date of Patent: August 8, 1978
    Assignee: John Wyeth & Brother Limited
    Inventor: Terence J. Ward
  • 1-Aminoalkylpiperidine derivatives
    Patent number: 4105771
    Abstract: This invention relates to compounds having the formula ##STR1## and the pharmaceutically acceptable acid addition and quaternary ammonium salts thereof, wherein R represents phenyl or phenyl substituted by halogen, lower alkyl, hydroxy, trifluoromethyl or lower alkoxy; n represents 0 or 1 and m represents 2 or 3 with the proviso that n plus m equals 3; and R.sup.1 represents phenyl, thienyl, pyridyl, furyl, indolyl or phenyl substituted by halogen, lower alkyl, lower alkoxy, trifluoromethyl or hydroxy, which exhibit antihypertensive activity in warm blooded animals.
    Type: Grant
    Filed: June 9, 1977
    Date of Patent: August 8, 1978
    Assignee: John Wyeth & Brother Limited
    Inventors: John L. Archibald, Terence J. Wart
  • 4-Amido-2-alkoxy thiazoles and composition
    Patent number: 4105773
    Abstract: The invention provides a compound of formula I, ##STR1## wherein R is hydrogen, alkyl of 1-6 carbon atoms, or COR.sup.3 where R.sup.3 is hydrogen, alkyl of 1-5 carbon atoms, alkenyl of 2 to 5 carbon atoms, alkynyl of 2 to 5 carbon atoms, or cycloalkyl of 3 to 5 carbon atoms, R.sup.1 is hydrogen or alkyl of 1-6 carbon atoms, R.sup.2 is alkyl of 1-6 carbon atoms and R.sup.3 is as above defined.The compounds are intended for use in the treatment of ulcers or hypersecretion in mammals.
    Type: Grant
    Filed: May 23, 1977
    Date of Patent: August 8, 1978
    Assignee: John Wyeth & Brother Limited
    Inventors: Roger Crossley, David G. Hill
  • 1,3-Diaryl-pyrazol-4-acrylic acid and derivatives
    Patent number: 4095025
    Abstract: The invention concerns diarylpyrazole lower alkanoic acids and derivatives which are pharmacologically efficacious as anti-inflammatory agents. The said compounds can be represented by the formula ##STR1## in which one of D, E, F and G represents hydrogen, one is a lower aliphatic acid radical or derivative thereof and the remaining two of D, E, F and G are aryl or heteroaryl radicals.
    Type: Grant
    Filed: November 30, 1971
    Date of Patent: June 13, 1978
    Assignee: John Wyeth & Brother Limited
    Inventor: Robert Anthony Newberry
  • Preparation of quinoline derivatives
    Patent number: 4092317
    Abstract: A new process for preparing 5-oxo-tetrahydroquinolines comprises condensing a compound of formula II with a ##STR1## compound of formula III to obtain a compound of formula I wherein R, R.sup.1, R.sup.2 and R.sup.3 are selected from hydrogen and lower alkyl. Compounds of formula I are intermediates for pharmaceuticals.
    Type: Grant
    Filed: September 5, 1975
    Date of Patent: May 30, 1978
    Assignee: John Wyeth & Brother Limited
    Inventor: Adrian Charles Ward Curran
  • Certain 1-(N-acyl)-carbothioamides of 1,5-naphthyridine derivatives
    Patent number: 4092320
    Abstract: The invention relates to N-acyl thioureas which are derivatives of 1,5-Naphthyridines. The compounds are intermediates for anti-ulcer agents.
    Type: Grant
    Filed: April 7, 1977
    Date of Patent: May 30, 1978
    Assignee: John Wyeth & Brother Limited
    Inventor: Adrian Charles Ward Curran
  • Certain 1-carbothioamides of 1,5-naphthyridine derivatives
    Patent number: 4092418
    Abstract: The invention relates to thioureas which are derivatives of 1,5-Naphthyridines. The compounds are anti-ulcer agents or intermediates therefor.
    Type: Grant
    Filed: April 7, 1977
    Date of Patent: May 30, 1978
    Assignee: John Wyeth & Brother Limited
    Inventor: Adrian Charles Ward Curran
  • Silicon derivatives of tetrahydroquinolines
    Patent number: 4085108
    Abstract: The invention relates to novel silicon derivatives of tetrahydroquinolines, which are intermediates in a process for preparing 5,6,7,8-tetrahydroquinoline-8-carboxamides and thiocarboxamides.
    Type: Grant
    Filed: September 8, 1976
    Date of Patent: April 18, 1978
    Assignee: John Wyeth & Brother Ltd.
    Inventors: Adrian Charles Ward Curran, Robin Gerald Shepherd
  • Certain 5,6,7,8-tetrahydroquinoline-8-thiocarboxamides
    Patent number: 4085215
    Abstract: The invention relates to novel pyridine derivatives which have a fused 5,6, or 7-membered saturated hydrocarbon ring adjacent to the nitrogen of the pyridine ring, and a group X situated on said hydrocarbon ring and separated by one carbon atom from the pyridine nitrogen atom, said group X is cyano, CONHR.sup.3, CSNHR.sup.3 or CO.sub.2 R.sup.5 wherein R.sup.3 is selected from hydrogen, lower alkyl and lower aralkyl radicals and R.sup.5 is selected from hydrogen, lower alkyl and lower aralkyl radicals which may be substituted by alkyl, alkoxy, halogen, nitro or trifluoromethyl; other substituents may be present. Compounds wherein X is CSNHR.sup.3 are anti-ulcer agents and the other compounds are intermediates therefor.
    Type: Grant
    Filed: July 30, 1975
    Date of Patent: April 18, 1978
    Assignee: John Wyeth & Brother Ltd.
    Inventors: Adrian Charles Ward Curran, Roger Crossley, David George Hill
  • 1,2,3,5,6,7-Hexahydrodicyclopenta[b,e]pyridine derivatives
    Patent number: 4085110
    Abstract: The invention relates to novel cyclopentena[b,e]pyridine derivatives which have a thioamide group in the 7-position. The compounds are anti-ulcer agents.
    Type: Grant
    Filed: December 6, 1976
    Date of Patent: April 18, 1978
    Assignee: John Wyeth & Brother, Ltd.
    Inventors: Adrian Charles Ward Curran, Roger Crossley, David George Hill
  • Benzoquinolizines and hypotensive compositions containing them
    Patent number: 4076820
    Abstract: The invention relates to novel benzoquinolizines of the general formula (I) ##STR1## and the pharmaceutically acceptable acid addition salts thereof, wherein R.sup.1 and R.sup.2 which may be the same or different, each represent hydrogen, lower alkyl, lower alkoxy or halogen, R.sup.3 represents hydrogen, lower alkyl or aryl and R.sup.4 represents --SO.sub.2 R.sup.5 (where R.sup.5 is lower alkyl or aryl, --CONH.sub.2 or --CXNHR.sup.6 (where X is oxygen or sulphur and R.sup.6 is aryl or aryl.CO.--). The compounds have hypotensive activity.
    Type: Grant
    Filed: May 13, 1976
    Date of Patent: February 28, 1978
    Assignee: John Wyeth & Brother, Limited
    Inventors: John Leheup Archibald, John Lambert Jackson
  • Piperidino ureas and thioureas
    Patent number: 4073790
    Abstract: This invention relates to compounds having the formula: ##STR1## and acid addition and quaternary ammonium salts thereof, wherein R represents hydrogen or lower alkyl, R.sup.1 represents hydrogen, lower alkyl, cycloalkyl of 5 to 7 carbon atoms, substituted or unsubstituted aralkyl of 7 to 12 carbon atoms, substituted or unsubstituted aryl (including heterocyclic aryl), or substituted or unsubstituted aroyl, Ar represents a substituted or unsubstituted phenyl radical and X represents oxygen or sulphur, which exhibit action on the cardiovascular system.
    Type: Grant
    Filed: February 12, 1975
    Date of Patent: February 14, 1978
    Assignee: John Wyeth & Brother Limited
    Inventors: John L. Archibald, John L. Jackson
  • Pyrimido 1,2-b!isoquinolines
    Patent number: 4073906
    Abstract: The invention relates to pyrimido 1,2-b!isoquinolines of the formula ##STR1## and their pharmaceutically acceptable acid addition salts. In the formula, R.sup.1 and R.sup.2 each represent hydrogen, hydroxyl, lower alkyl, lower alkoxy, trifluoromethyl, halogen, amino or mono- or di-(lower)alkylamino and R.sup.3 and R.sup.4 each represent hydrogen or lower alkyl. The compounds have utility as anti-gastric ulcer agents.
    Type: Grant
    Filed: November 5, 1975
    Date of Patent: February 14, 1978
    Assignee: John Wyeth & Brother Limited
    Inventors: Alan C. White, Robin M. Black